• 대한수의학회지
• /
• 제55권4호
• /
• pp.221-225
• /
• 2015

This study evaluated the effects of alfaxalone (3 mg/kg, intravenously) on echocardiographic examination in healthy dogs using echocardiography. Six adult Beagle dogs were used for this study. Left ventricular dimensions with systolic indexes, trans-blood flow at all cardiac valvular annulus and trans-mitral tissue Doppler values were measured from routine transthoracic echocardiography. Although the changes were not statistically significant, heart rate, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, peak velocities of tricuspid A-wave and transpulmonic flow were increased after alfaxalone induction, while systolic blood pressure, fractional shortening, left ventricular ejection fraction, peak velocities of mitral E-wave, mitral A wave, tricuspid E-wave, transaortic flow and medial e'-, a'- and s'-peaks decreased after alfaxalone induction. No dogs showed hypoxemia during sedation, regardless of intubation and oxygen supply. Although alfaxalone showed mild cardiovascular depression, this protocol could be a good alternative sedative protocol for echocardiographic examination in healthy dogs because the cardiovascular depression was statistically and clinically insignificant. However, further studies in dogs with heart diseases should be conducted to confirm these findings after alfaxalone induction.

• 한국정보통신설비학회:학술대회논문집
• /
• 한국정보통신설비학회 2006년도 하계학술대회
• /
• pp.241-245
• /
• 2006

In the examination of Steam Generator (SG) tube in Nuclear Power Plant (NPP) Eddy Current Testing (ECT) probes play an Important role in detecting the defects. Bobbin probe and Rotating Pancake Coil (RPC) probe is usually used for the inspection of SG tube. Bobbin probe is good at high speed inspection, but ability of detection of circumferential defect is very weak. On the contrary RPC probe, which moves for inspection in the direction of axial and circumferential simultaneously, has very slow inspection speed, but it was excellent detection capability fur small cracks, which is hardly detected by bobbin probe. Many examinations of SG tube examination of NPP are achieved during short period. Therefore, solution about this must develop probe of new form for examination performance and examination time shortening of other probe. In this paper, analyzed technological present condition of Bob-bin probe and RPC probe been using in Nondestructive Testing (NDT) for SG tube defect detection and Appeared about background theory and view of developed probe newly.

• Journal of mucopolysaccharidosis and rare diseases
• /
• 제4권1호
• /
• pp.21-25
• /
• 2018

Fabry disease is a hereditary lysosomal storage disorder caused by the reduction or absence of lysosomal enzyme alpha-galactosidase A and the accumulation of glycosphingolipids, such as globotriaosylceramide (Gb3), in various organs, including the heart. The prevention of cardiac involvement in Fabry disease can only be achieved by enzyme replacement therapy (ERT), and the method of assessing the efficacy of ERT should be confirmed. Changes in the electrocardiogram, such as the shortening of PQ interval, prolongation of QTc and repolarization abnormalities as well as left ventricular hypertrophy in voltage criteria, can be used to identify Fabry disease patients; however, the usefulness of electrocardiograms for evaluating the efficacy of ERT is limited. The assessment of left ventricular hypertrophy using echocardiography has been established to evaluate the efficacy of ERT during long-term period. A new technique involving speckled tracking method might be useful for detecting early cardiac dysfunction and identifying the effect of ERT for a relatively short period. The estimation of left ventricular hypertrophy using cardiac magnetic resonance (CMR) is also useful for assessing the efficacy of ERT. Identifying late gadolinium enhancement in CMR may affect the effectiveness of ERT, and the new technique of T1 mapping might be useful for monitoring the accumulation of Gb3 during ERT. Histopathology in cardiac biopsy specimens is another potentially useful method for identifying the accumulation of GB3; however, the use of histopathology to evaluate of the efficacy of ERT is limited because of the invasive nature of an endomyocardial biopsy.

• 한국정보통신학회논문지
• /
• 제8권1호
• /
• pp.158-169
• /
• 2004

독립전원으로 널리 사용되고 있는 납 축전지는 도서산간 벽지나 태양광을 이용하는 가로등 시스템과 같이 관리자가 없는 곳에서는 과 방전으로 납 축전지의 수명이 급격히 단축되어 고가의 시스템을 효율적으로 용하지 못하는 사례가 많이 발생한다. 이렇게 관리가 잘 되지 않는 곳에 설치된 납 축전지의 문제점인 과 방전을 방지하여 납 축전지의 수명단축을 예방하고자 마이크로프로세서를 사용한 효율적인 관리 시스템을 구축하였다. 제안된 관리시스템은 납 축전지의 충$.$방전 시 전류의 특성을 제어에 이용하였으며, 시스템 작동 중에는 납 축전지의 현재 잔량을 표시하여 관리자가 잔량을 표시할 수 있도록 하였다.

• 대한토목학회논문집
• /
• 제12권3호
• /
• pp.107-114
• /
• 1992

불투수성 면적의 증가로 인한 유출량의 증가와 홍수도달시간의 단축은 도시홍수에 의한 피해를 가중시키고 있어 이에 대한 대책이 시급한 실정이다. 본 연구에서는 이러한 도시홍수의 방재대책중 하나로 우수배제펌프의 조작기법으로 퍼지제어기법을 적용하여 내수배제능력을 검토하였으며, 기존의 수위기준에 의한 펌프조작기준과 비교하였다. 유수지의 유입량을 산출하기 위해 재현기간 10, 30, 50년의 성계호우를 ILLUDAS 모형에 적용하였다. 퍼지제어규칙의 효용성을 검토하기 위해 퍼지제어규칙 1, 2를 설정하여 가상조작한 결과 조작자의 경험이 포함된 퍼지제어규칙에 의한 펌프제어가 실용적인 면을 보였으며, 내수방재면에서 효과가 있다는 것을 알 수 있었다.

• 한국연초학회지
• /
• 제7권2호
• /
• pp.179-188
• /
• 1985

From the combination of cigarette papers, tipping papers and plug wrapping papers, whose physical properties and effect of cigarette smoke dilution were studied. The result obtained from this study are as follows. Envelop ventilation (Env-V'R) cigarettes used high porous cigarette papers showed less changes of unencapsulated pressure drop VPD) compared to tip ventilation (Tip-VR) cigarettes. Higher cigarette paper porosity increased, more decreased the WD of cigarette by Tip-VR. With cigarette length shortening, the UPD or VR changed a little in Tip-VR cigarette, while changed very much in Env-VR cigarettes. The ratio of nicotine/tar was higher in Env-VB cigarettes than in Tip-VR cigarettes, and CO/nicotine value of the former was lower than those of the later. The effect of Tip-VR cigarettes on the delivery reduction of tar and nicotine was more effective compared to Env-VR cigarettes and the reduction prefer Env-VR cigarettes to Tip-VR cigarettes in CO delivery. From the results investigated above it was noted that each defect appeared in the Tip-VR and the Env-VR cigarettes could be complemented by the combination of them.

• Biomolecules & Therapeutics
• /
• 제17권1호
• /
• pp.1-11
• /
• 2009

Since the Committee for Proprietary Medicinal Products (CPMP) of the European Union issued in 1997 a "points to consider" document for the assessment of the potential for QT interval prolongation by non-cardiovascular agents to predict drug-induced torsades de pointes (TdP), the QT liability has become the critical safety issue in the development of pharmaceuticals. As TdP is usually linked to delayed cardiac repolarization, international guideline (ICH S7B) has advocated the standard repolarization assays such as in vitro IKr (hERG current) and in vivo QT interval, or in vitro APD (as a follow up) as the best biomarkers for predicting the TdP risk. However, the recent increasing evidence suggests that the currently used above biomarkers and/or assays are not fully predictive for TdP, but also does not address potential new druginduced TdP due to the selective disruption of hERG protein trafficking to the cell membrane or VT and/or VF with QT shortening. There is, therefore, an urgent need for other surrogate markers or assays that can predict the proarrhythmic potential of drug candidate. In this review, we provide an ideal pre-clinical strategy to predict the potentials of QT liability and lethal arrhythmia of the drug candidates with recent issues in this field in mind, not at the expense of discarding therapeutically innovative drugs.

• 한국정밀공학회지
• /
• 제13권6호
• /
• pp.102-113
• /
• 1996

An experimental and theoretical study on a pneumatic servo system has been conducted using on-off valves and a pneumatic cylinder. A V/I converter has been designed for rapid rising and falling of the solenoid current, which significantly improves the positioning accuracy and settling time of the servo system by shortening the valve opening time. Pulse width modulation was modified to operate on-off valves effectively. A state feedback controller which feeds back position, velocity and acceleration is used to control the system. The influence of controller gains on the system performance is studied to develop a scheme that automatically adjusts the gains using fuzzy logic theory. It is shown experimentally that the proposed fuzzy logic tuner works satisfactorily. A new method for measurements of valve effective areas is proposed, and a partially polytropic model is applied to simulation of the pneumatic system. Simulated results show good agreement with experimental data.

• Archives of Plastic Surgery
• /
• 제39권3호
• /
• pp.257-260
• /
• 2012

This report describes the use of a tubularized random flap for the curative treatment of recurrent anterior urethral stricture. Under the condition of pendulous lithotomy and suprapubic cystostomy, the urethral stricture was removed via a midline ventral penile incision followed by elevation of the flap and insertion of an 18-Fr catheter. Subcutaneous buried interrupted sutures were used to reapproximate the waterproof tubularized neourethra and to coapt with the neourethra and each stump of the urethra, first proximally and then distally. The defect of the penile shaft was covered by advancement of the surrounding scrotal flap. The indwelling catheter was maintained for 21 days. A 9 month postoperative cystoscopy showed no flap necrosis, no mechanical stricture, and no hair growth on the lumen of the neourethra. The patient showed no voiding discomfort 6 months after the operation. The advantages of this procedure are the lack of need for microsurgery, shortening of admission, the use of only spinal anesthesia (no general anesthesia), and a relatively short operative time. The tubularized unilateral penile fasciocutaneous flap should be considered an option for initial flap urethroplasty as a curative technique.

• 융합신호처리학회논문지
• /
• 제2권4호
• /
• pp.46-52
• /
• 2001

방사광을 이용한 형강 X선 CT 이미징의 고속화를 위한 촬상 시스템과 처리 알고리즘을 검토하였다. 본 논문에서 사용된 촬상시스템은 고계수율 영역에서 안정된 동작을 한 전자 시스템으로 불감시간이 약 6%로 감소되고 계측시간의 경우도 1 점 당 3초로 단축되었다. 또한 재구성 알고리즘의 효율화를 증명하였고, 메모리와 계산량을 약 1/100로 감소시켰다. 물리적 phantom으로 그 정량성을 확인하였고, 시험관내의 갑상선의 화상으로부터 요드 분포를 추정하였다. 이러한 결과는 생체내에서 형광 X선 CT 계측의 실현 가능성을 보여준 것이다.