• 응용통계연구
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• 제26권4호
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• pp.611-622
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• 2013

Mudholkar와 Tian (2002)이 제시한 엔트로피 기반 검정은 위치모수와 척도모수가 모두 알려져 있지 않거나 척도 모수만 알려져 있는 역가우스분포의 적합을 알아보고자 하는 경우에만 사용이 가능하다. 본 논문에서는 위치모수와 척도모수가 모두 알려져 있거나 위치모수만 알려져 있는 역가우스분포의 적합에도 적용할 수 있는 엔트로피 기반 적합도 검정을 소개한다. 이 검정은 확률적분변환에 기초를 두고 있다. 모의실험을 통해서 추정한 표본크기와 윈도크기에 따른 검정통계량의 기각값과 근사기각값을 얻기 위한 계산공식을 제시한다. 제안한 검정과 Mudholkar와 Tian (2002)의 검정을 검정력 측면에서의 성능을 비교하고자 모의실험을 수행한다. 모의실험 결과에서 제안한 검정은 기존의 엔트로피 기반 검정보다 더 좋은 검정력을 가지는 것으로 나타난다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5273-5278
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• 2015

Background: Chronic myeloid leukemia (CML) is a stem cell disorder characterized by the fusion of two oncogenes namely BCR and ABL with their aberrant expression. Autophosphorylation of BCR-ABL oncogenes results in proliferation of CML. The study deals with estimation of rate constant involved in each step of the cellular autophosphorylation process, which are consequently playing important roles in the proliferation of cancerous cells. Materials and Methods: A mathematical model was proposed for autophosphorylation of BCR-ABL oncogenes utilizing ordinary differential equations to enumerate the rate of change of each responsible system component. The major difficulty to model this process is the lack of experimental data, which are needed to estimate unknown model parameters. Initial concentration data of each substrate and product for BCR-ABL systems were collected from the reported literature. All parameters were optimized through time interval simulation using the fminsearch algorithm. Results: The rate of change versus time was estimated to indicate the role of each state variable that are crucial for the systems. The time wise change in concentration of substrate shows the convergence of each parameter in autophosphorylation process. Conclusions: The role of each constituent parameter and their relative time dependent variations in autophosphorylation process could be inferred.

• Structural Engineering and Mechanics
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• 제90권1호
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• pp.83-96
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• 2024

This paper suggests an analytical approach to investigate the free vibration and stability of functionally graded (FG) beams with both perfect and imperfect characteristics using a quasi-3D higher-order shear deformation theory (HSDT) with stretching effect. The study specifically focuses on FG beams resting on variable elastic foundations. In contrast to other shear deformation theories, this particular theory employs only four unknown functions instead of five. Moreover, this theory satisfies the boundary conditions of zero tension on the beam surfaces and facilitates hyperbolic distributions of transverse shear stresses without the necessity of shear correction factors. The elastic medium in consideration assumes the presence of two parameters, specifically Winkler-Pasternak foundations. The Winkler parameter exhibits variable variations in the longitudinal direction, including linear, parabolic, sinusoidal, cosine, exponential, and uniform, while the Pasternak parameter remains constant. The effective material characteristics of the functionally graded (FG) beam are assumed to follow a straightforward power-law distribution along the thickness direction. Additionally, the investigation of porosity includes the consideration of four different types of porosity distribution patterns, allowing for a comprehensive examination of its influence on the behavior of the beam. Using the virtual work principle, equations of motion are derived and solved analytically using Navier's method for simply supported FG beams. The accuracy is verified through comparisons with literature results. Parametric studies explore the impact of different parameters on free vibration and buckling behavior, demonstrating the theory's correctness and simplicity.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 춘계종합학술대회 A
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• pp.505-508
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• 2008

Electrocardiogram (ECG) and blood pressure (BP) are main vital signs which are the standards in most medical settings in assessing the most basic body functions. Multi parameters are desired in providing more information for health professionals in order to detect or monitor medical problems of patients more precisely. This study urges us to develop a robust wireless healthcare monitoring system which has multiple physiological signs measurements on real time that applicable to various environments which integrates wireless sensor network technology and code division multiple access (CDMA) network with extended feature of locally standalone diagnosis algorithms that implemented in tell phone. ECG signal and BP parameter of the patients are routinely be monitored, processed and analyzed in details at cell phone locally to produce useful medical information to ease patients for tracking and future reference purposes. Any suspected or unknown patterns of signals will be immediately forwarded to hospital server using cell phone for doctors' evaluation. This feature enables the patients always recognize the importance of self-health checking so that the preventive actions can be taken earlier through this analytic information provided by this monitoring system because "Prevention is better than Cure".

• 대한기계학회논문집A
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• 제28권12호
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• pp.1833-1844
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• 2004

A controller is proposed for the robust backstepping control of a class of nonlinear multiple-input multiple-output (MIMO) systems which can be converted to a strict feedback form. The proposed robust backstepping control scheme follows a systematic procedure for the design of control laws and uses time delay estimation (TDE) to estimate the uncertainties such as parameter variations, unknown disturbances, and unmodeled dynamics, etc. The proposed controller can be also applied to nonlinear MIMO systems with unmatched uncertainties. Stability analysis of the closed-loop system which contains the plant and the proposed controller is also studied and hereby a sufficient stability condition for the closed-loop system is proposed. The simulation results show that the control scheme works well with uncertainties and the proposed stability condition is valid. The controller is experimentally verified on a single-link flexible arm to show the effectiveness of the proposed scheme in the complicated systems with uncertainties.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7045-7047
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• 2015

Background: Mean platelet volume (MPV) is a marker which has been investigated in many cancers but data for head and neck lesions are limited. We aimed to study the MPV levels in head and neck cancers as a diagnostic marker. Materials and Methods: A total of 96 head and neck cancer patients and 31 control patients who did not meet exclusion criteria were enrolled in the study. The cancer locations, the platelet and MPV levels at the first diagnosis time were collected. Results: The head and neck cancer location distribution between these patients was 2 (2.1%) buccal, 9 (9.4%) tongue, 6 (6.3) lip, 1 (1%) gingiva, 1 (1%) hypopharynx, 1 (1%) ear, 58 (60.4%) larynx, 2 (2.1%) maxilla, 2 (2.1%) nasal, 1 (1%) nasopharynx, 2 (2.1%) palatal, 3 (3.1%) primary unknown, 1 (1%) retromolar, 1 (1%) thyroid, 2 (2.1%) tonsil, and 4 (4.2%) salivary gland. MPV levels were significantly different between cancer and control group (p=0.002). The cut-off point for MPV predicting head and neck cancer is >10 fL (sensitivity=55.21, specificity=87.10). Conclusions: MPV level increase, a readily assessable parameter which does not bring extra costs can warn us regarding head and neck cancer risk.

• Coupled systems mechanics
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• 제5권3호
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• pp.269-283
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• 2016

A two new high-order shear deformation theory for bending analysis is presented for a simply supported, functionally graded plate with porosities resting on an elastic foundation. This porosities may possibly occur inside the functionally graded materials (FGMs) during their fabrication, while material properties varying to a simple power-law distribution along the thickness direction. Unlike other theories, there are only four unknown functions involved, as compared to five in other shear deformation theories. The theories presented are variationally consistent and strongly similar to the classical plate theory in many aspects. It does not require the shear correction factor, and gives rise to the transverse shear stress variation so that the transverse shear stresses vary parabolically across the thickness to satisfy free surface conditions for the shear stress. It is established that the volume fraction of porosity significantly affect the mechanical behavior of thick function ally graded plates. The validity of the two new theories is shown by comparing the present results with other higher-order theories. The influence of material parameter, the volume fraction of porosity and the thickness ratio on the behavior mechanical P-FGM plate are represented by numerical examples.

• 제어로봇시스템학회논문지
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• 제20권12호
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• pp.1238-1245
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• 2014

This paper proposes an RBFN-based adaptive tracking controller for an electrically driven mobile robot with parametric uncertainties and external disturbances. A mobile robot model considered in this paper includes all models of the robot body and actuators with uncertain kinematic and dynamic parameters, and uncertain frictions and external disturbances. The proposed controller consists of an RBFN(Radial Basis Function Network) and a robust adaptive controller. The presented RBFN is used to approximate unknown nonlinear robot dynamic functions. The proposed controller is adjusted by the adaptation laws obtained through the Lyapunov stability analysis. The proposed control scheme does not a priori need the accurate knowledge of all parameters in the robot kinematics, robot dynamics and actuator dynamics. Also, nominal parameter values are not required in the controller. The global stability of the closed-loop robot control system is guaranteed using the Lyapunov stability theory. Simulation results show the validity and robustness of the proposed control scheme.

• 한국지능시스템학회논문지
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• 제10권2호
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• pp.94-102
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• 2000

본 논문에서는 미지의 비선형 계통에 대한 동적 퍼지모델 기반 고장 검출 및 진단(FDI) 계통 설계 기법을 제시한다. 비선형 계통에 대한 일반적인 모델 기반 FDI 계통에서는 선형화된 모델을 이용하고 있다 이러한 방법은 계통에 대한 정확한 수학적 모델을 요구하게 되어 복잡한 비선형 계통에의 적용시 많은 어려움이 있다 제안되는 FDI계통에서는 미지의 비선형 계통을 다수의 선형 모델을 갖는 동적 퍼지모델 형태로 식별한다. 잔차벡터는 온라인 알고리즘에 의해 추정되는 파라미터의 변동치와 비선형 계통의 동작 영역을 나타내는 퍼지 규칙들의 소속값들로 구성된다. 계통의 고장 검출 및 진단은 잔차벡터와 고장종류간의 관계를 학습한 신경망 분류기에 의해 수행된다. 제안된 FDI 계통 설계법을 이용하여 2 탱크 계통에 대한 FDI 계통을 설계하고 시뮬레이션 연구를 통하여 그 유용성을 보였다.

• Journal of Mechanical Science and Technology
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• 제14권8호
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• pp.816-822
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• 2000

In the core of the nuclear power plant of PWR, several cases of fuel failure by unknown causes have been experienced for various fuel types. From the common features of the failure pattern, failure lead time, flow conditions, and flow induced vibration characteristics in nuclear fuel bundles, it is deduced that the fretting wear failure of the fuel rod at the spacer grid position is due to the fluidelastic vibration. In the past, fluidelastic vibration was simulated by quasi -static semi-analytical model, so called the static model, which could not account for the interaction between the rods within a bundle. To overcome this defect and to provide for more flexibilities applicable to the fuel bundle, Tanaka's unsteady model was modified to accomodate the geometrical differences and governing parameter changes during the operations such as the number of rods, pitch to diameter ratio (P/D), spring force, damping coefficient, etc. The critical velocity was calculated by solving the governing equations with the MATLAB code. A comparison between the estimated critical velocity and the test result shows a good agreement. Finally, the level of decrease of the critical velocity due to the reduction in the spring force and reduced damping coefficient due to the radiation exposure is also estimated.