• Laboraroty Animal Research
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• 제34권4호
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• pp.185-194
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• 2018

The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabetic susceptibility in commercial pigs. Growing pigs (Landrace, both sex, 50-60 kg) with the C/C (n=4) and T/T (n=5) TCF7L2 genotypes were identified and intravenously injected with streptozotocin (STZ, 40 mg/kg) twice in weekly intervals, then a high-energy diet was offered. Oral glucose tolerance tests, blood analyses and the homeostasis model assessment-insulin resistance (HOMA-IR) index calculations were performed. The animals were sacrificed at the end of 12 weeks of treatment to reveal the pancreas histomorphometry. The results showed that all of the treated pigs grew normally despite exhibiting hyperglycemia at two weeks after the induction. The glycemic level of the fasting or postprandial pigs gradually returned to normal. The fasting insulin concentration was significantly decreased for the T/T carriers but not for the C/C carriers, and the resulting HOMA-IR index was significantly increased for the C/C genotype, indicating that the models of insulin dependence and resistance were respectively developed by T/T and C/C carriers. The histopathological results illustrated a significant reduction in the pancreas mass and insulin active sites, which suggested increased damage. The results obtained here could not be compared with previous studies because the TCF7L2 background has not been reported. Growing pigs may be an excellent model for diabetic in children if the animals are genetically pre-selected.

• 한국초전도학회:학술대회논문집
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• 한국초전도학회 2002년도 High Temperature Superconductivity Vol.XII
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• pp.35-35
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• 2002

• Bulletin of the Korean Chemical Society
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• 제12권3호
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• pp.271-273
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• 1991

Poly (N-vinylcarbazole) was obtained spontaneously by 1,1,2,2-tetracyanocyclopropylstyrene(1) in polar solvents such as dichloromethane and acetonitrile at room temperature. The polymerization reactions were faster in more polar solvent and were not proceeded in less polar solvents such as chloroform and diethyl ether. The formation of poly (N-vinylcarbazole) was explained by bond-forming initiation theory, in which the initiating species are zwitterionic tetramethylene intermediates.

• Safety and Health at Work
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• 제13권2호
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• pp.155-162
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• 2022

Background: Workers are exposed to several risks in academic laboratories due to the presence of potentially hazardous substances. The main objective of this study was to assess the prevalence of accident occurrence and associated risk factors among laboratory workers at the scientific laboratories of the public university in Lebanon and the impact of safety measures training and availability. Methods: In this observational study, a survey was conducted for one year in scientific laboratories at faculties of the public university. Results: Among the participants (N = 220), 45.0% have had accidents; the main cause was exposure to chemicals (73.7%) and more specifically by inhalation (45.4%). Females (85.9%) were more exposed to accidents than males. Laboratory workers with a master's degree, a full-time schedule, and more than ten years of experience were significantly more exposed to accidents (p < 0.05). A significant association was found between accident occurrence and training on management of hazardous products (p = 0.044), risks related to workplace (p = 0.030), eyewash and emergency shower (p < 0.001), first aid (p = 0.012), and facial protection availability (p = 0.019). In spite of the lack of safety culture and efficient training on laboratory safety, participants have shown a very good perception regarding safety measures to be applied in case of work accidents. Conclusion: Based on our findings, the prevalence of accident occurrence is elevated among lab workers at the public university. The impact of regular training on laboratory safety preventive measures is of great importance to ensure the efficiency of occupational health and safety in scientific laboratories.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -1
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• pp.113-116
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• 2002

In this paper dynamic characteristics were investigated of the perception of a bound image width. Subjective evaluation tests were carried out of the width of a sound image when its presentation region was moved in the horizontal plane. As a result, the sound image width was perceived narrower or wider than the actual presentation region when the sound source width was decreased or increased, respectively. The result obtained shows that a phenomenon which is a kind of auditory motion aftereffects was occurred in the perception of a sound source with changing its width.

• Journal of Information Display
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• 제12권1호
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• pp.43-46
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• 2011

A three-dimensional windshield display (3D-WSD) can present driving information at the same depth as the objects in the outside scene. Herein, a super-multiview 3D-WSD is proposed because the super-multiview display technique provides smooth motion parallax. Motion parallax is the only physiological cue for perceiving the depth of a 3D image displayed at a far distance, which cannot be perceived by vergence and binocular parallax. A prototype system with 36 views was constructed, and the discontinuity of motion parallax and accuracy of depth perception were evaluated.

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2001년도 Korean Environmental Mutagen Society
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• pp.151-152
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• 2001

• 한국동물학회:학술대회논문집
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• 한국동물학회 1999년도 한국생물과학협회 학술발표대회
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• pp.248.2-248
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• 1999

No Abstract, See Full Text

• 한국가스학회지
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• 제16권5호
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• pp.21-27
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• 2012

대학 실험실이나 연구시설에서 실험실 사고에 의해 인적 및 물적 손실이 꾸준히 발생되고 있어서 실험실 사고예방의 필요성이 제기되고 있다. 실험실 사고예방을 위해 무엇보다 중요한 것은 사고의 체계적인 분석이다. 국내에서 산업재해에 관한 분석 연구는 수행되어 왔으나, 실험실 사고 분석에 관한 연구는 수행되지 않았다. 본 연구에서는 실험실 사고예방 대책 수립을 위해 설문지를 개발하였고, 설문지는 대학과 연구기관에 전자우편이나 방문조사로 사고사례를 수집하였다. 사고사례 데이터는 계절별, 사고 분류형태, 발생형태, 기인물 및 상해종류 별로 분석 고찰하였다. 이 연구결과는 실험실 종사자의 안전 확보와 사고예방을 위한 기초자료로 활용하고자 하였다.

• 한국산업보건학회지
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• 제8권1호
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• pp.95-104
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• 1998

This Study was conducted at nine Histological Laboratories in the hospitals located in Seoul from August 20 to October 10, 1996. The main purpose of this study was to assess the TWA & STEL exposure to formaldehyde and to evaluate factors affecting formaldehyde concentration in Histological Laboratory. With evaluated factors, proper improvement strategy to minimize exposure was suggested. The results are summarized as follows ; 1. The TWA concentrations of the personal samples ranged from 0.02 to 3.86 ppm and that of one laboratory out of nine was exceeding 0.75 ppm, USA OSHA standard. The TWA concentrations of the area samples ranged from 0.08 ppm to 1.49 ppm and those of three laboratories out of nine were exceeding OSHA standard. 2. When measurement was conducted on the working tables. around Formaldehyde vessel, fixation container and storage cabinet, the geometric means of TWA concentrations were 0.62 ppm, 0.64 ppm. 0.58 ppm and 0.37 ppm respectively. 3. When overnight fixed specimens were examined, the STEL concentrations of personal samples ranged from 0.59 ppm to 5.01 ppm, those of three laboratories out of nine were exceeding 2 ppm, OSHA standard and the STEL concentrations of area samples ranged from 0.31 ppm to 3.08 ppm, those of four laboratories from nine were exceeding OSHA standard. 4. Factors affecting Formaldehyde exposure level were sanitation state of laboratory, volume of the room and opening state of fixation container & formaldehyde vessel(p<0.05).