• Title/Summary/Keyword: university graduate

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RUNX1-Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors

  • Masamitsu, Mikami;Tatsuya, Masuda;Takuya, Kanatani;Mina, Noura;Katsutsugu, Umeda;Hidefumi, Hiramatsu;Hirohito, Kubota;Tomoo, Daifu;Atsushi, Iwai;Etsuko Yamamoto, Hattori;Kana, Furuichi;Saho, Takasaki;Sunao, Tanaka;Yasuzumi, Matsui;Hidemasa, Matsuo;Masahiro, Hirata;Tatsuki R., Kataoka;Tatsutoshi, Nakahata;Yasumichi, Kuwahara;Tomoko, Iehara;Hajime, Hosoi;Yoichi, Imai;Junko, Takita;Hiroshi, Sugiyama;Souichi, Adachi;Yasuhiko, Kamikubo
    • Molecules and Cells
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    • v.45 no.12
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    • pp.886-895
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    • 2022

  • Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development of novel molecule-targeting therapeutic agents. In this study, we report the importance of the runt-related transcription factor 1 (RUNX1) and RUNX1-Baculoviral IAP (inhibitor of apoptosis) Repeat-Containing 5 (BIRC5/survivin) axis in the proliferation of MRT cells, as it can be used as an ideal target for anti-tumor strategies. The mechanism of this reaction can be explained by the interaction of RUNX1 with the RUNX1-binding DNA sequence located in the survivin promoter and its positive regulation. Specific knockdown of RUNX1 led to decreased expression of survivin, which subsequently suppressed the proliferation of MRT cells in vitro and in vivo. We also found that our novel RUNX inhibitor, Chb-M, which switches off RUNX1 using alkylating agent-conjugated pyrrole-imidazole polyamides designed to specifically bind to consensus RUNX-binding sequences (5'-TGTGGT-3'), inhibited survivin expression in vivo. Taken together, we identified a novel interaction between RUNX1 and survivin in MRT. Therefore the negative regulation of RUNX1 activity may be a novel strategy for MRT treatment.

  • https://doi.org/10.14348/molcells.2022.2031 인용 PDF KSCI

Studies on Root Restoration: Embedding Titanium and Cultured Periodontal Ligament Fibroblasts into the Intradentinal Cavities in Dogs.

  • Yamamoto, T.;Hirata, M.;Iwarnatsu, Y.;Tadatomo, Y.;Shimonishi, M.;Murakami, Y.;Nagaoka, S.;Higuchi, S.;Sato, H.;Kanehira, M.;Kindaichi, K.;Komatsu, M.
    • Proceedings of the KACD Conference
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    • 2001.11a
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    • pp.568.1-568
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    • 2001

  • The purpose of our study is new formation of periodontal ligament (PDL) around titanium implants. In this study, we investigated histologically whether cultured periodontal ligament fibroblasts (CPLFs) would form new PDL on titanium implants in beagle dogs. PDL fibroblasts were obtained from upper premolars of dogs and cultured in ${\alpha}-MEM$ supplemented with 10％ FBS. Some CPLFs were cultured on glass-beads-sandblasted titanium specimen. Artificial intradentinal cavities were prepared through alveolar bone to dentin of lower premolars.(omitted)

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Novel green Sr4ScAl3O10:Eu2+ phosphor prepared by the melt quenching technique

  • Toda, Kenji;Iwaki, Masato;Katsu, Minenori;Kamei, Shin-nosuke;Kim, Sun-Woog;Hasegawa, Takuya;Muto, Masaru;Yamanashi, Ryota;Sakamoto, Tatsuya;Ishigaki, Tadashi;Uematsu, Kazuyoshi;Sato, Mineo;Yoon, Dae-Ho
    • Journal of Ceramic Processing Research
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    • v.20 no.3
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    • pp.276-279
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    • 2019

  • New green-emitting Sr4ScAl3O10:Eu2+ phosphor was prepared using a novel melt quenching synthesis method. The temperature of raw materials irradiated with the strong light of the Xe arc-lamp was rose up to about 2273 K, followed by a sharp drop in the temperature after turn off the lamp. This method is a useful tool for rapid screening of novel phosphor materials.