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검색결과 217건 처리시간 0.025초

Cloning of the Setd1b gene of Mus musculus, a novel histone methyl transferase target in the epigenetic therapy of cancers

  • Morishita, Masayo;Cho, Minju;Ryu, Juhee;Mevius, Damiaan E.H.F.;Di Luccio, Eric
    • Current Research on Agriculture and Life Sciences
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    • 제28권
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    • pp.63-68
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    • 2010
  • The epigenetic therapy of cancers is emerging as an effective and valuable approach to both chemotherapy and the chemoprevention of cancer. The utilization of epigenetic targets that include histone methyltransferase (HMTase), Histone deacetylatase, and DNA methyltransferase, are emerging as key therapeutic targets. SET containing proteins such as the HMTase Setd1b has been found significantly amplified in cancerous cells. In order to shed some light on the histone methyl transferase family, we cloned the Setd1b gene from Mus musculus and build a collection of vectors for recombinant protein expression in E.coli that will pave the way for further structural biology studies. We prospect the role of the Setd1b pathway in cancer therapy and detail its unique value for designing novel anti-cancer epigenetic-drugs.

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패션디자인의 입체적(立體的) 표면효과(表面效果)에 관(關)한 연구(硏究) (A Study on the 3-D Surface Effects of Fashion Design)

  • 김지영;조규화
    • 패션비즈니스
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    • 제9권1호
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    • pp.1-20
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    • 2005
  • This study is purposed to provide new idea for developing high value added fashion goods by studying relief effects of fashion design. Based on prior researches, various ways to give relief effects were searched and then modern fashion design cases were looked for which were referred to fashion-related magazines and collection-related internet sites since the late 1990s. The ways for relief effects are weaving, industrial finishing, sewing technique. Weaving techniques are about fancy yarns, variation of weaving structure, pile weave. Industrial finishing techniques which can make relief effects are embossing, heat-setting, shearing, pliss, burn out, flocking. Sewing techniques are quilting, pleats, embroidery, slash, attachment in accordance with the way to produce relief effects. The forms of relief effects are tactile pattern that cannot be seen in the distance, subtle relief pattern which is more three-dimensional than tactile pattern, rhythmical relief pattern, sculptural pattern, and deep-volumed pattern. The present research can provide practical data for design by studying techniques of relief effects and collecting and arranging design cases that have been sporadically carried out. The study on relief and unique surface effects can be a way to effectively stimulate and express emotions of modern people with various taste and individuality.

Measurement uncertainty evaluation in FaroArm-machine using the bootstrap method

  • Horinov, Sherzod;Shaymardanov, Khurshid;Tadjiyev, Zafar
    • Journal of Multimedia Information System
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    • 제2권3호
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    • pp.255-262
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    • 2015
  • The modern manufacturing systems and technologies produce products that are more accurate day by day. This can be reached mainly by improvement the manufacturing process with at the same time restricting more and more the quality specifications and reducing the uncertainty in part. The main objective an industry becomes to lower the part's variability, since the less variability - the better is product. One of the part of this task is measuring the object's uncertainty. The main purpose of this study is to understand the application of bootstrap method for uncertainty evaluation. Bootstrap method is a collection of sample re-use techniques designed to estimate standard errors and confidence intervals. In the case study a surface of an automobile engine block - (Top view side) is measured by Coordinate Measuring Machine (CMM) and analyzed for uncertainty using Geometric Least Squares in complex with bootstrap method. The designed experiment is composed by three similar measurements (the same features in unique reference system), but with different points (5, 10, 20) concentration at each level. Then each cloud of points was independently analyzed by means of non-linear Least Squares, after estimated results have been reported. A MatLAB software tool used to generate new samples using bootstrap function. The results of the designed experiment are summarized and show that the bootstrap method provides the possibility to evaluate the uncertainty without repeating the Coordinate Measuring Machine (CMM) measurements many times, i.e. potentially can reduce the measuring time.

네트워크 프로세서를 이용한 기가비트 패킷 헤데 수집기 (A Gigabit Rate Packet Header Collector using Network Processor)

  • 최판안;최경희;정기현;심재홍
    • 정보처리학회논문지C
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    • 제12C권1호
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    • pp.11-18
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    • 2005
  • 본 논문에서는 기가비트 트래픽에서도 높은 패킷 헤더 수집률(packet header collection ratio)을 보이는 멀티프로세서(multi-processor), 멀티쓰레드(multi-thread)를 채용한 네트워크 프로세서 기반의 패킷 헤더 수집기를 제안한다. 제안 패킷 수집기는 기가비트 트래픽 패킷 헤더를 분리하여 여러 대의 100Mbps MAC 포트로 분산하여 전달할 수 있는 구조를 가지고 있다. 제안된 구조는 고속 트래픽 처리를 위해 독창적인 버퍼관리 기법과 프로세서간 부하 분산 기법을 사용하고 있으며, 풍부한 실험을 퐁해 그 성능을 검증하였다.

Identification of Initiation Period and Subsequent Development of Floral Primordia in Black Locust (Robinia pseudoacacia L.)

  • Lee, Kyung Joon;Hong, Bongghi
    • 한국산림과학회지
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    • 제94권2호통권159호
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    • pp.67-72
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    • 2005
  • The objectives of this study were to identify the period of initiation of floral primordia in black locust (Robinia pseudoacacia L.) and subsequent development of floral buds until following spring. Four mature trees of black locust located in Suwon, Korea were selected. Bud samples were collected from the current-year shoots, starting from mid June to July every week, from August to October and from February to April every month. The buds were fixed in FAA solution, dehydrated, and imbedded in paraffin for microscopic observation. Buds collected on June 16, and 23, 1997, contained primitive primordia that might be interpreted as early floral primordia. By June 30, a bud showed a positive indication of inflorescence primordium with a well-formed shoot apex. All the inflorescence primordia observed throughout the collection periods were always associated with unique hairy appendages around the primordium and enclosed within a sclerenchymatous chamber. By July 7 and 15, a floral apex had early bud scales. By July 22, primitive inflorescence developed into visible arrangement of individual floral primordial By July 29, the inflorescence developed into whirl arrangement of individual floral primordia in a transverse section, but showed little further development until October 15. The inflorescence primordia seemed to over-winter at this stage. Buds collected from February 15 and March 24 the following year also showed no further development of inflorescence primordia. By April 7 the inflorescence started to show further development with elongated axis. At this time individual flowers were easily recognized.

국내 아동간호단위 간호중재 분석 (A Survey of the Nursing Interventions Performed by Pediatric Care Unit Nurses)

  • 오원옥
    • Child Health Nursing Research
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    • 제7권4호
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    • pp.461-473
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    • 2001
  • The purpose of this study was to identify nursing interventions performed by pediatric care unit nurses. For data collection this study used the taxonomy of Nursing Intervention Classification (NIC : 486 nursing intervention) which was modified by McCloskey & Bulecheck(2000). The 419 nursing interventions were selected by panel group, which consist of pediatric clinical experts and nursing scholars. The data were collected 104 nurses of pediatric care unit. There were 158 nursing interventions identified as being used at least monthly 50% or more of the nurses. The 32 nursing interventions were used at least daily, indication a set of core interventions unique to pediatric care unit practice. The most frequently used nursing interventions were 'Medication administration: intravenous' & 'Medication administration: oral'. The 27 nursing interventions were rarely performed by 90% or more of the nurses. The rarely used interventions were 'Ostomy care' & 'Rectal prolaps management'. The domain received the highest mean score was Health System, followed by Physiolocal: complex, Physiolocal: Basic, Safty, Community, Family, Behavior domain. These findings will help in building of a standardized language for the pediatric care units and enhance the quality of nursing care.

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대학생의 학습활동에 있어 도서관목록의 의미 (Meanings of Library Catalog in Learning Activities of Korean College Students)

  • 이은주;이제환
    • 한국도서관정보학회지
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    • 제43권3호
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    • pp.49-77
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    • 2012
  • 이 연구는 대학생의 다양한 학습활동에 있어서 도서관과 도서관목록의 이용행태를 살펴보고, 이러한 행태 속에서 나타나는 대학도서관 목록의 가치와 의미를 밝혀내고자 하였다. 또한, 다양한 학습활동의 유형과 인적 변인에 따른 행태의 차이를 다각도로 분석함으로서, 이용자 집단의 특성을 고려한 '맞춤형 목록서비스'를 제공하기 위한 기초 자료를 확보하고자 하였다. 이 연구를 위해 대학생 30명을 대상으로 심층인터뷰를 실시하였으며, 보다 면밀한 접근을 위해 도서관목록 탐색행태에 대한 관찰법을 함께 실시하였다. 조사결과, 현재 대학도서관목록은 특정 자료의 소장유무 확인과 서가위치 파악과 같은 최소한의 목적을 위해 사용되고 있었으며, 도서관목록이 대학생의 학습활동을 위한 포괄적인 탐색도구로 기능하려면 대학생들의 정보행태에 기반한 전반적인 품질개선이 필요함을 강조하였다.

19세기 고창지방 의원 은수룡이 남긴 경험의안 (A Study of the Case Records of a Herbalist En Su-ryong in the late Chosun dynasty)

  • 이선아
    • 한국의사학회지
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    • 제18권2호
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    • pp.63-91
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    • 2005
  • This paper analyzes the case records of a herbalist En Su-ryong who lived at the Kochang area of Chollapukdo province in the 19th century. The records, which were included in his collection of works, Tantojip(呑吐集), were consisted of 11 clinical diagnosis and prescriptions. The result of the analysis is as follows. First, En Su-ryong's records are estimated to be valuable enough to contribute to the development of the Korean clinical medicine, in light of the fact that the present established prescriptions or medical theory came from the repetition of trial and error by many herb doctors. Second, his case records are unique in the style of writing, because they were consisted of only his own clinical diagnosis and prescriptions case by case, while those of ordinary herbalists were classified by the types of the symptoms of a disease, with their prescriptions modified from the past established. Third, in the records he minutely wrote not only the names and the addresses of the patients under his care, but also the names of the diseases, the progress and the contents of his treatment, and even the perfect cure or not. Therefore, his case records are appreciated to be very important from the standpoint of the history of the society.

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체면이 명품소비행동에 미치는 영향에 관한 연구 (A Study on How Chemyon Influence Consuming Behaviors for the Luxury Brands)

  • 서용한;오희선;전민지
    • 한국의류산업학회지
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    • 제13권1호
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    • pp.25-31
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    • 2011
  • The purpose of this study was to investigate the influence of luxury brand value on luxury brand preferences according to chemyon(social-face). For data collection, research questionnaires were responded by 222 females over 20 years old consumers living in Pusan and Ulsan. The collected data were analyzed using SPSS 14.0 for windows Package by frequency analysis, the factor analysis using Varimax, reliability analysis, multi-regression analysis, and chow-test. The results of this study were as follows: First, concerning the worth of luxury brands that qualify value, conspicuous value, unique value, and emotional value significantly affected the consumers' luxury brand preferences. On the other hand, only social value of the luxury brand did not have a significant effect on the consumers luxury brand preferences. Second, the study was to investigate whether the luxury brand value has an effect on the brand preferences according the consumer's chemyon or not. The results showed different effects of perceived values on luxury brand preferences between the low chemyon group and the high chemyon group. The high chemyon group had an effect on conspicuous value, social value, and emotional value, while the low chemyon group had an effect on quality value for luxury brand preference.

국내 의류브랜드의 중국진출 현황 및 마케팅전략 제안 (Entry to Chinese Market for Korean Fashion Brands: Current Situations and Suggestions of Marketing Strategies)

  • 고은주;송윤아
    • 한국의류학회지
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    • 제28권2호
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    • pp.212-223
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    • 2004
  • The purpose of this study is 1) to identify Chinese environment for investment and apparel market, 2) to analyze the current situations of Korean fashion brands'entry to Chinese market, 3) to analyze the marketing strategies to China according to product category, and 4) to identify merits and problems of Chinese market. For data collection, secondary resources were collected, and the telephone interview with merchandisers were implemented with brand managers. Twenty-one fashion brands were included for the study. Results of the study were as followed: 1) China was a big potential apparel market due to its rapid economic growth. Apparel purchase behavior and clothing preference of Chinese consumers were various by regional groups. 2) The motives of entry to China were to competition in domestic markets, saving raw material cost. The entry modes to China were direct export, license and regional manufacturing system. 3) Marketing strategies were to pursue high quality branding, high pricing and placing strategies with high-class department stores. Also star marketing were used with "Han Rue". Also various promotion strategies were implemented such as fashion show and unique VMD. 4) The merits of Chinese market were high potential market for export, close proximity, cultural similarity and Han-Ryu syndrome. Problems of Chinese market for export were lack of experts on Chinese market, fierce competition in China, and unstable economic policies.