• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1105-1109
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• 2012

Breast cancer is the second most common cancer in women in India and the disease burden is increasing annually. The lack of awareness initiatives, structured screening, and affordable treatment facilities continue to result in poor survival. We present a breast cancer survival scenario, in urban population in India, where standardised care is distributed equitably and free of charge through an employees' healthcare scheme. We studied 99 patients who were treated at our hospital during the period 2005 to 2010 and our follow-up rates were 95.95%. Patients received evidence-based standardised care in line with the tertiary cancer centre in Mumbai. One-, three- and five-year survival rates were calculated using Kaplan-Meier method. Socio-demographic, reproductive and tumor factors, relevant to survival, were analysed. Mortality hazard ratios (HR) were calculated using Cox proportional hazard method. Survival in this series was compared to that in registries across India and discrepancies were discussed. Patients mean age was 56 years, mean tumor size was 3.2 cms, 85% of the tumors belonged to T1 and T2 stages, and 45% of the patients belonged to the composite stages I and IIA. Overall 5-year survival was 74.9%. Patients who presented with large-sized tumors (HR 3.06; 95% CI 0.4-9.0), higher composite stage (HR 1.91; 0.55-6.58) and undergone mastectomy (HR 2.94; 0.63-13.62) had a higher risk of mortality than women who had higher levels of education (HR 0.25; 0.05-1.16), although none of these results reached the significant statistical level. We observed 25% better survival compared to other Indian populations. Our results are comparable to those from the European Union and North America, owing to early presentation, equitable access to standardised free healthcare and complete follow-up ensured under the scheme. This emphasises that equitable and affordable delivery of standardised healthcare can translate into early presentation and better survival in India.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.747-752
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• 2013

Oncostatin M (OSM) is a multifunctional cellular regulator acting on a wide variety of cells, which has potential roles in the regulation of gene activation, cell survival, proliferation and differentiation. Previous studies have shown that OSM can induce morphological and/or functional differentiation and maturation of many tumor cells. However, the action of OSM on the induction of differentiation of human hepatocellular carcinoma (HCC) has not been reported. Here, we investigated the effects of different concentrations of OSM on human HCC cell line SMMC-7721 growth, proliferation, cell cycling, apoptosis and differentiation in vitro. Cell growth was determined via MTT assay, proliferation by cell cycle analysis, apoptosis by flow cytometry, morphology by transmission electronic microscopy, and cell function by detection of biochemical markers. Our results demonstrated that OSM strongly inhibited the growth of SMMC-7721 cells in a dose-dependent manner, associated with decreased clonogenicity. Cell cycle analysis revealed a decreased proportion of cells in S phase, with arrest at G0/G1. The apotosis rate was increased after OSM treatment compared to the control. These changes were associated with striking changes in cellular morphology, toward a more mature hepatic phenotype, accompanied by significant reduction of the expression of AFP and specific activity of ${\gamma}$-GT, with remarkable increase in secretion of albumin and ALP activity. Taken together, our findings indicate that OSM could induce the differentiation and reduce cell viability of SMMC-7721 cells, suggesting that differentiation therapy with OSM offers the opportunity for therapeutic intervention in HCC.

• 한국통신학회논문지
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• 제41권12호
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• pp.1933-1941
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• 2016

본 논문에서는 항공기의 내부 네트워크를 유선에서 무선으로 대체하기 위해 무선 통신망 기술들의 성능을 비교한다. 기존 항공기의 유선 네트워크가 가지는 다양한 장비와 센서의 복잡한 구조에 따른 무게증가 그리고 유지보수 문제 및 비용 등의 단점과, 차세대 항공기 네트워크에서 요구되는 통신 속도 및 통신량 등의 성능적인 측면에 대한 요구사항이 증가하고 있다. 국제전기통신연합(ITU)에서 제안한 WAIC(Wireless Avionics Intra-Communications)는 기존 유선 항공기 네트워크의 요구사항을 기반으로 항공기 내/외부 환경 등을 고려한 무선네트워크 구조를 정의했다. 본 논문에서는 WAIC에서는 제안한 무선네트워크 구조에 적용할 수 있는 무선 통신망 기술들의 특징과 장단점을 고려한다. 또한 항공기 무선네트워크에 적용 가능한 무선 통신망 기술들을 비교 분석하여 WAIC에서 제안한 무선 항공기 토폴로지 환경 구조에 적합한 무선 통신망 기술 후보군을 알아본다.

• 노동경제논집
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• 제24권2호
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• pp.125-162
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• 2001

사업체 설문조사에 근거하여 비정형근로의 실태를 분석한 결과 비정형근로자들은 여성, 서비스업, 그리고 기업특수적 숙련을 요구하지 않는 직종들에서 많이 존재한다. 그 임금은 비슷한 속인적 특성을 가진 정형근로자에 비하여 대체로 10~19% 더 낮은 수준으로 결정되는 것으로 나타난다. 비정형근로자의 경우 기본급 결정기준으로 직무내용과 직무능력은 상대적으로 적게 고려되고, 퇴직금과 상여금 등의 혜택이 크게 낮으며, 휴가, 노동조합 가입자격, 4대 사회보험이나 교육 훈련 면에서의 혜택도 전체적으로 크게 낮아서 경제성장의 혜택으로부터 소외될 가능성이 높다. 비정형근로자의 노동조합 가입비율은 매우 낮아서 노동조합에 의한 근로조건 개선도 기대하기 어렵다. 비정형근로자의 활용이유는 개별 사업체의 입장에서는 주로 수량적 유연성에 대한 요구 때문이고 거시경제적으로는 기업의 소형화와 산업의 서비스화 때문이며 따라서 비정형근로자의 수는 앞으로도 계속 늘어날 것으로 예측된다.

• 대한족부족관절학회지
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• 제10권2호
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• pp.150-155
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• 2006

Purpose: The purpose of this study is to assess the results of the autologous osteochondral grafting harvested from medial side of talus for relatively large osteochondral lesion of the medial talar dome. Materials and Methods: From October 2004 to September 2005, 12 patients with osteochondral lesion measured more than 10 mm in axial MRI who were followed up more than 1 year after operation were analyzed. We evaluated postoperative symptoms by Mann and Reynolds scale, morbidity of donor site, and compared the range of both ankle motion. We also evaluated the union at the medial malleolar osteotomy site, trabecular connection between the grafted osteochondral mass and talus, irregularity of the articular surface in lesion. Results: Clinical results were rated as excellent in 4, good in 7, fair in 1. The mean angle of the total range of motion in affected ankle was decreased by 3 degrees compared to that in unaffected ankle. We did not observe abnormal findings at donor site. The osteotomized bone was united at mean 9 weeks (range, 8-12 weeks). We observed trabecular connection between grafted osteochondral mass and talus at mean 14 weeks (range, 12-16 weeks). We also observed irregular articular surface in osteochondral lesions in 6, smooth articular surface in 6. Conclusion: The local autologous osteochondral graft for relatively large osteochondral lesion of the medial talar dome is useful operative method with advantages of wide operative field, low morbidity of donor site, and high satisfaction rate.

• Archives of Plastic Surgery
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• 제38권2호
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• pp.212-216
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• 2011

Purpose: Ameloblastomas are rare benign tumors of odontogenic origin, and compose about 1% of all oral and maxillomandibular cysts and tumors. Because this neoplasm has a high rate of local recurrence, segmental mandibulectomy with a 1~2 cm safety margin and immediate microsurgical reconstruction is an accepted treatment modality. The authors experienced four mandibular reconstruction cases that underwent secondary dental implantation. Here, the authors describe these cases and their long-term results. Methods: Four patients with ameloblastoma of the mandible underwent segmental mandibulectomy and reconstruction with a free fibula osseous flap from January 1999 to May 2005, followed by secondary dental implantation. Recurrence, bony union, implant osseointegration, and functional and aesthetic results were evaluated by radiologic imaging, by physical examination, and by using photographs. Results: All free flaps survived with no evidence of flap loss. To date, no recurrence has been noted clinically or radiologically. Imaging after mandibular reconstruction with a free fibular flap revealed satisfactory bony unions and mandibular contours. The patients achieved good aesthetic and functional results after the secondary implantation. Conclusion: Mandibular reconstruction using a fibular osseous flap and secondary dental implantation can produce good functional and aesthetic results after segmental mandibulectomy for ameloblastoma.

• 대한예방한의학회지
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• 제21권3호
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• pp.29-42
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• 2017

Background : Efforts towards increasing insurance coverage for traditional Korean medicine (TKM) are being continued. However, various difficulties are faced in generating evidence for TKM due to limited financial support and the low quality of research methodology. Objectives : The objectives of this study were to review the Swiss evaluation program for complementary and alternative medicine (CAM) and assess the expansion in public health insurance coverage of complementary medicine as approved by referendum in Switzerland. Methods : The regulations of CAM in the European Union were assessed. Research articles, reports, government publications and websites which deal with the 'Programm Evaluation $Komplement{\ddot{a}}rmedizin$ (PEK)' and the referendum in Switzerland were searched for and analyzed. Results : The PEK was conducted from 1998 to 2005. The PEK evaluated the efficacy, utilization and cost-effectiveness of anthroposophical medicine, homeopathy, neural therapy, phytotherapy and traditional Chinese medicine. However, clear conclusions could not be drawn from the evaluation according to the PEK Report. Later, a referendum was implemented in which 5 therapies would be added to the Switzerland Constitution with the support of the public. The coverage of CAM was approved by Swiss a plebiscite with an approval rate of 67.0%. Conclusions : The reason for the successful referendum is suggested to be public support and the solidarity with CAM experts and politicians. It may be surmised that recognition of the political efforts and scientific aspects required to expand insurance coverage of TKM, and towards obtaining public support, is necessary.

• 자원ㆍ환경경제연구
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• 제19권4호
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• pp.875-896
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• 2010

본 논문은 DID(Difference in Differences) 추정모형을 이용하여 유럽공동체 25개 회원국에 대해 2005년~2007년간 1단계 시행이 완료된 바 있는 배출권거래제도가 참여 국가들의 이산화탄소 배출량을 감소시키는 효과가 있었는지를 분석하였다. 이를 위해 이러한 배출권거래제 1단계 시행이 적용되지 않았던 17개국을 포함한 유럽 대륙 42개국에 대한 1990년~2007년까지의 패널자료를 구축하였다. 추정결과를 도출함에 있어서 계열 상관이 존재하는 경우 DID 추정에서 발생할 수 있는 통상적 표준오차의 편차 문제를 고려하여 두 가지의 강건한 표준오차 값들을 추가적으로 계산하여 제시하였다. 그 결과 배출권거래제의 시행이 이산화탄소 배출량을 감소시키는 효과가 표준오차의 계산방법에 무관하게 상당히 일관되고 강건하게 나타나는 것으로 분석되었다. 아울러 잠재에너지세율의 증가 역시 일관되게 일인당 이산화탄소 배출량을 감소시키는 효과가 있는 것으로 나타났다. 반면에 일인당 GDP나 인구밀도 등이 일인당 이산화탄소 배출량에 미치는 영향은 표준오차의 계산방법에 따라 일관되지 못한 결과를 나타내었다. 특히 환경쿠즈네츠가설은 강건한 표준오차를 사용하는 경우 통계적으로 뒷받침되지 못하였다.

• 대한한방소아과학회지
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• 제32권1호
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• pp.30-43
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• 2018

Objectives The purpose of this study is to analyze the clinical research literature of TCM (traditional Chinese medicine) which is applicable to pediatric fracture and to broaden the field about clinical application of Korean medicine treatment for pediatric fracture. Methods We searched randomized controlled trials about TCM treatment of pediatric fracture from the CNKI (China National Knowledge Infrastructure) January 2013 to December 2017. We searched the literature and analyzed the treatment methods and the results. Results 31 papers were selected from 63 studies. In most studies, the total effective rate of the treatment group was significantly higher than that of the control group, and the bone healing time of the treatment group was significantly lower than that of the control group. Methods of herb treatment include internal medicine (IM), fumigation (FG) and external application (EA). The most commonly used herb medicine were Angelicae Gigantis Radix (當歸), Carthami Flos (紅花), Drynaria Fortunei (骨碎補), Paeonia Lactiflora Pallas (芍藥), Persicae Semen (桃仁), Lycopodii Herba (伸筋草), Ligusticum Chuanxiong Hort (川芎), Olibanum (乳香), Salviae Miltiorrhizae Radix (丹蔘), and Panax Noto Ginseng (三七). Conclusions The use of herb medicine in pediatric fractures has resulted in faster and more effective restoration of fracture union than the Western medical therapy alone. Based on the results of this study, it is possible to widen the scope of Korean medicine if additional clinical studies on pediatric fracture were conducted.

• 한국사회복지학
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• 제63권1호
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• pp.85-111
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• 2011

다차원적 빈곤접근에 있어 빈자의 구분방식에는 복합지수방식, 합집합 및 교집합방식이 있는데 이들 방식들은 타당하지 않은 문제들이 있었다. Alkire와 Foster는 이 문제를 해소하는 방법으로 합집합과 교집합의 중간 형태로서 결핍차원들의 개수를 경계선으로 이용하는 차원계수방식을 이론화하였다. 차원계수방식에 의해 우리나라의 다차원적 빈곤을 측정한 결과, 3개 결핍차원을 정책적 차원빈곤선으로 하는 경우 다차원적 빈곤율은 20% 수준으로서 10명 중 2명이 다차원적으로 빈곤하였다. 다차원적 빈곤율이 높은 것은 자산, 소득, 사회보장, 건강 등 여러 차원으로 결핍의 폭이 넓은데 기인하였다. 여성, 한 부모, 노인, 비경제활동인구 등 취약계층일수록 다차원 빈곤의 폭이 넓고 가중되고 있었다. 연구결과 현행 기초생활보장제도가 탈 빈곤유도와 기초생활보장이라는 두 가지 정책목표를 각각 효과적으로 달성하기 위해서는 근로능력 유무에 따라 수급자선정과 지원체제를 이원화하고 차원계수방식을 적용하는 것이 유용하다고 본다.