• Molecules and Cells
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• v.43 no.2
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• pp.176-181
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• 2020

The RUNX transcription factors serve as master regulators of development and are frequently dysregulated in human cancers. Among the three family members, RUNX3 is the least studied, and has long been considered to be a tumor-suppressor gene in human cancers. This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization during the initiation of tumorigenesis. Recently, this paradigm has been challenged, as several lines of evidence have shown that RUNX3 is upregulated over the course of tumor development. Resolving this paradox and understanding how a single gene can exhibit both oncogenic and tumor-suppressive properties is essential for successful drug targeting of RUNX. We propose a simple explanation for the duality of RUNX3: p53 status. In this model, p53 deficiency causes RUNX3 to become an oncogene, resulting in aberrant upregulation of MYC.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.35.1-35.1
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• 2019

One day, a galaxy study suddenly came to me and became a friend of 40 years. The study of galaxies, which began with surface photometry of nearby galaxies, ended up in galaxy morphology through chemical and dynamical evolution of galaxies. All that deviated from the study of galaxies was the study of the open clusters. So it seems to me that I devoted my entire life to the study of galaxies. The most memorable one is the observation at Sobaeksan Observatory. Even though the heavy snow fell, I climbed Sobaeksan to meet galaxies. Galaxies observed at Kiso Observatory, DAO, and BOAO are now beyond memory, but I still enjoy seeing them. There are many memories, but the biggest pleasure I've had in my galaxy studies is when I've encountered the galactic conformity between host and its satellite galaxies. Eureka! Now the night sky is changing from the object of study to the object of awe. I will share this joy.

• Journal of The Korean Association For Science Education
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• v.11 no.2
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• pp.13-21
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• 1991

For development of teaching model for observational experiment and the major contents of science education guide books published for secondary school teacher in America, the actual survey to the secondary schools and the investigation of science education guide were carried out. The results were summarized as follows. 1. The major concepts of contents in science education books are constituted of introduction(9.67%), ability(8.94%), activity(6.61%), curriculum(11.61%), instruction planning(5.25%), instruction strategy(l7.74%), materials and facilities(1O.97%), evaluation(8.62%), society and community(l0.55%), guidelines(4.76%), practice(3.54%), and index(1.74%). 2. The constitution of multimedia teaching model for observational instruction was developed and arranged in order of six steps as observation, materialization, broad understanding, advanced study, application, and synthesis. This model was thought as the most effective for the achievement of the instructive goal for observational unit and others.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2002.05a
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• pp.83-88
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• 2002

This study is to provide the experimental information and basic data on heat transfer characteristics of horizontal liquid film driven by hot wind. Heat transfer characteristics of the liquid film in the rectangular duct was observed and the change of film temperature was measured. The experiments were carried out for a variety of parameter, such as feed water rate and velocity and temperature of feed air. From the observation and the measurement the general understanding of heat transfer characteristics for liquid film driven by hot wind was provided.

• Journal of KSNVE
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• v.6 no.4
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• pp.439-446
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• 1996

This paper introduces a newly designed pendulum system that enables the more accurate boservation of dynamic behaviour arising from both horizontal and vertical(i.e. two dimension) excitation. First, experiments were carried out to examine the frequency responses of the devised pendulum system. Interestingly, experimental results for the three excitation angles of 22, 32 and 48 degree show 'new' jump phenomena. For the further understanding of these phenomena, experimental investigationhas been made to identify the equation of motion of the pendulum system from experimental data. This attempt has revealed that the viscous, coulomb and aerodynamic damping factors are involved in the equation of motion. By applying the Ritz averaging method to the equation, it becomes apparent that the jumping phenomena of the pendulum system in this work is more theoretically understood.

• Proceedings of the KSRS Conference
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• 2007.10a
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• pp.122-125
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• 2007

In recent years, there has been an increasing demand for improved accuracy and reliability of Earth Observation Satellite (EOS) data. Most of the data users in the field of remote sensing require understanding of product accuracy and uncertainty. Especially, EOS application products should be validated for practical application in the field. In order to evaluate the availability and applicability of application products, it will be necessary to establish a systematic validation system including techniques, equipments, ground truth data, etc. The Product Validation Site (PVS) for generation and validation of KOMPSAT application products was designed and established with various in-situ equipment and dataset. This paper presents the status of PVS and summarizes some results from experiment studies at PVS.

• The Journal of Korean Academic Society of Nursing Education
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• v.12 no.2
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• pp.248-256
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• 2006

Purpose: The purpose of this study was to explore the experiences in aromatherapy. Method: The data were collected from 7 women received aromatherapy by interview and observation from July 2006 to 30 September 2006. Van Manen(1990)'s hermeneutic phenominological methodology was applied in analyzing data. Result: 5 essential themes were derived as followings: 'Hesitating', 'Giving it a try' 'Weighing the effects', 'Being fascinated', 'Losing interest'. Conclusion: The results of the study especially the 5 essential themes will promote in understanding of experiences of clients of aromatheray. Also they will facilitate to develope nursing intervention and nursing practice related to aromatherapy.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.1390-1392
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• 2003

The arid regions of western China are currently the focus of extensive exploration and development. This paper reports on recent experience gained by Chinese and Canadian project team members in the use of a variety of Earth observation satellite imagery for oil exploration and environmental assessment exercises in the Kuche area of Xinjiang. Through careful archival data selection and more recent data acquisition schemes, we have established several time series of MODIS, Landsat and Radarsat imagery in order to obtain a better understanding for daily, seasonal as well as decadal changes of the natural environment as well as man-made environmental features.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2004.02a
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• pp.51-59
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• 2004

The geological research as a part of HLW disposal program in Korea is carried out to provide necessary data for the establishment of the reference repository system in term of design and safety assessment in the crystalline rock terrains. Six deep boreholes were drilled to obtain hydrogeological and hydrochemical data from Jurassic granites in the Yuseong area, Korea. The core observation, televiewer logging and hydraulic testing were carried out during and after drilling and multi-packer system were installed in the boreholes of 500m depth for hydraulic and hydrochemical monitoring including environmental isotopes. The integration of hydrogeochemical and hydrodynamic data would be built greater confidence for the understanding of groundwater system in fractured rock mass. This geoscientific program could be possible to suggest a general guideline to develop the reference disposal concept of high-level radioactive waste in Korea.

• Journal of the Korean Home Economics Association
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• v.44 no.4 s.218
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• pp.159-173
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• 2006

The purpose of this study was to investigate the seating style of children between Korea and USA viewed from activity analysis in child-care centers. Observation and depth-interview method were used for data collection. Ninety-eight children aged from 38 to almost 62 months were observed for five minutes three times during an indoor free play period in Korea and USA in 2003 and 2004. The results of the research were as follows. There were significant differences between the postures of Korean and American children. Korean children maintained floor-seating postures longer than chair-seating and standing postures. The factors such as sex, age and physical environment influenced the children's seating style, while playing-type influenced their posture. This study will contribute to our understanding of the physical environment and children's seating style according to culture.