• Title/Summary/Keyword: understanding levels

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Development and its Effect of Elementary School Technology Education Program Using History of Technology (기술사를 활용한 기술교육 프로그램의 개발과 적용 효과)

  • Bak, Hyoung-Seo
    • 대한공업교육학회지
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    • v.39 no.2
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    • pp.122-143
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    • 2014
  • The purpose of this research were to develop program of elementary school technology education using history of technology and to learn about its effect. In order to accomplish the purpose of the research, we developed the program by referring to various records and perform the qualitative experiment study through several questionnaire, pictures and materials, to learn about the program effect. The research took the mixed-model design, consisted of collection of quantitative data by Likert scale and collection of qualitative data including the open-ended questions. And the research results were as below. First, development of elementary school technology education program using history of technology was developed as program for 12 hours, 12 themes, for the elementary levels. Second, seeing the result of program of elementary school technology education using history of technology, the program for history of technology for the primary school students, a majority of answers showed high satisfaction about the program, giving answers such as 'I want to do it again following hands on minds on activity.' Third, according to the analysis on the qualitiative evidence of the program, students were found to take pictures with hands on minds on activity camera obscura with much interest and curiosity. Many students are seen to complete the task on their own with a great a look of self-satisfaction, understanding the principle of camera.

Parathyroid Carcinoma (부갑상선암)

  • Cho Eun-Chol;Sub Jin-Hak;Chung Woong-Yun;Kim Ho-Geun;Park Cheong-Soo
    • Korean Journal of Head & Neck Oncology
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    • v.17 no.2
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    • pp.205-209
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    • 2001
  • Purpose: Most cases of primary hyperparathyroidism are due to parathyroid adenoma or parathyroid hyperplasia. Parathyroid carcinoma is a very rare cause of hyperparathyroidism. Although the diagnosis of parathyroid carcinoma is usually established by pathologic criteria especially of vascular or capsular invasion, some clinical and biochemical features differentiate it from benign forms of hyperparathyroidism. We under-took a retrospective study in 6 patients with parathyroid carcinoma, with the aim of conveying experience from management for this rare cause of hyperparathyroidism. Methods: Clinical symptoms, biochemical laboratory, radiologic, and intraoperative findings, local recurrence and distant metastasis were analyzed in 6 patients diagnosed pathologically as a parathyroid carcinoma after operation from 1992 to 2001. Results: Mean age was 50.2 years (33.0-60.0 years) and male to female ratio was 1:1. Neck mass was found in 5 patients, multiple bone pain in 3 patients and renal stone in 1 patient. One case has suffered from chronic renal failure for 19 years. Although preoperative laboratory evaluations showed the aspects of hyperparathyroidism in all cases, mean serum calcium level was 11.2mg/dl(10.5-12.1mg/dl), slightly elevated. Laboratory values after surgery were within the normal range in 5 cases. However, in one case with chronic renal failure, serum PTH levels, serially checked, were above the normal range. Any of imaging methods failed to suggest a parathyroid carcinoma preoperatively. Parathyroid adenoma was suspected in 3 cases, thyroid cancer in the other cases before surgery. The extent of resection was radical resection of parathyroid lesion with more than unilateral thyroid lobectomy and central compartment neck node dissection and in 2 cases, the resection of recurrent laryngeal nerve or strap muscles was added. During follow-up period, any local or systemic recurrence were not evident in all the cases. Conclusion: Although parathyroid carcinoma is a rare disease and its preoperative diagnosis, in our experience, could not easily be made, the understanding of characteristic clinical and biochemical feature could help diagnosis at first surgery. Radical resection without remaining residual tumor is most important for the management of the parathyroid cancer.

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DNA Methylation Change of IL-4 Gene from T Cell in Allergic Children (영유아기 아토피 환아에서 말초혈액 T 림프구에서 Interleukin-4 유전자의 DNA 메틸화 변화)

  • Oh, Jae Won;Yum, Myung Gul;Kim, Chang Ryul;Seol, In-Joon;Shin, Su A;Lee, Ha Baik;Jang, Se Jin
    • Clinical and Experimental Pediatrics
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    • v.48 no.6
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    • pp.634-639
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    • 2005
  • Purpose : An understanding of the immunological process is required if primary prevention of atopic diseases is to be developed in early childhood. But, it is too hard to distinguish atopy from nonatopy under the age of two clinically, because the expression of phenotype and cytokines is vague in early childhood. We evaluated DNA methylation changes at Th2 interleukin-4 gene in peripheral blood from atopic children. Methods : We selected 15 allergic children(mild : eight, moderate to severe : seven) and seven normal controls by using family allergy scores and clinical histories. We measured Total IgE and Der f II specific IgE levels and cultured peripheral blood mononuclear cells with Der f II stimulation and extracted DNA from Der f II specific T cells. We examined the change of CpG methylation in DNA from atopic and nonatopic children. Results : In T cells from normal children, IL-4 DNA were predominantly methylated; otherwise, CpG demethylation occurred in Der f II specific T cells from allergic children. Conclusion : IL-4 DNA methylation changes occurred in T genes from allergic children and DNA methylation assay in early childhood.

Study of On- and Off-Campus Clinical Practice Satisfaction and Major Satisfaction among Dental Hygiene Students in Some Regions (일부지역 치위생(학)과 학생들의 교내·외 임상실습만족도와 전공만족도에 관한 조사연구)

  • Moon, Seon-Jeong;Ku, In-Young;Choi, Hwa-Young;Ka, Kyung-Hwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.11
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    • pp.6793-6803
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    • 2014
  • A self-administered survey was conducted on dental hygiene students at colleges or universities in Chungcheong Province to increase the levels of practice for them and provide basic data that could improve their major satisfaction after practice. The data was collected from December 2012 to April 2013 and 766 questionnaires, except for 13 containing insincere responses, were finally analyzed using SPSS/Win18.0. The on- and off-campus practice groups formed 59.7% and 57.4%, respectively. The most frequent place for practice was university dental hospitals, followed in order by hospitals/clinics and health centers. University students were more satisfied with on-campus practice in terms of factors, such as practice contents, practice time, and practice performance than those at three-year colleges. The students in the higher grades were more satisfied with the practice time. The university students were also more satisfied with off-campus practice in terms of all the factors than those at three-year colleges. The students in higher grades were more satisfied with the practice time and practice performance. The on- or off-campus practice group was generally more satisfied with their major than the non-practice group, and each of the factors-practice performance, practice time, practice environment, and practice contents-significantly affected the major satisfaction. The results highlight the need to plan and provide satisfactory education based on an understanding and awareness of students so that they can take pride in their major through on- and off-campus practice. In addition, it is also necessary to develop educational guidelines for clinical practice and efficient programs so that clinical practice can create the optimal learning situation.

FNC, a Novel Nucleoside Analogue, Blocks Invasion of Aggressive Non-Hodgkin Lymphoma Cell Lines Via Inhibition of the Wnt/β-Catenin Signaling Pathway

  • Zhang, Yan;Wang, Chen-Ping;Ding, Xi-Xi;Wang, Ning;Ma, Fang;Jiang, Jin-Hua;Wang, Qing-Duan;Chang, Jun-Biao
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6829-6835
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    • 2014
  • Chemotherapy is the primary therapy for malignant lymphoma (ML). However, the clinical outcome is still far from satisfactory. Consequently, an understanding of the mechanism of modulating cancer cell invasion, migration and metastasis is important for the development of more effective chemotherapeutic agents. FNC, 2'-deoxy-2'-${\beta}$-fluoro-4'-azidocytidine, a novel cytidine analogue, has demonstrated significantly inhibitory effects on proliferation of several non-Hodgkin lymphoma (NHL) cell lines. A previous study indicated that FNC effectively inhibited the growth of Raji and JeKo-1 cells in dose-time dependent effects with $IC_{50}$ values of $0.2{\mu}M$ and $0.097{\mu}M$, respectively. This study was focused on investigating the anti-invasive properties of FNC on NHL cells and its potential mechanisms of action. Cell adhesion and transwell chamber assays were utilized to investigate the anti-invasive effects of FNC on Raji and JeKo-1 cells. Real-time PCR and Western blotting were employed to qualify the expression of ${\beta}$-catenin, the glycogen synthase kinase-3 beta (GSK-$3{\beta}$), E-cadherin vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The results revealed that FNC remarkably inhibited the adhesion, migration and invasion of two human aggressive non-Hodgkin lymphoma cell lines in a dose dependent manner. Furthermore, ${\beta}$-catenin, MMP-2, MMP-9, VEGF mRNA and protein levels were decreased after FNC treatment, while GSK-$3{\beta}$ and E-cadherin increased. Our studies thus provide evidence and a rationale that FNC may offer an effective chemotherapeutic agent by regulating the invasion and metastasis of aggressive non-Hodgkin lymphoma via inhibition of the Wnt/${\beta}$-catenin signaling pathway.

Art and Collectivity (미술과 집단성)

  • Kwok, Kian-Chow
    • The Journal of Art Theory & Practice
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    • no.4
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    • pp.181-202
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    • 2006
  • "When it comes to art, nationalism is a goodticket to ride with", says the title of a report in the Indian Express (Mumbai, 29 Oct 2000). The newspaper report goes on to say that since Indian art was kept "ethnic" by colonialism, national liberation meant opening up to the world on India's own terms. Advocacy, at the tail end of the 20th century, would contrast dramatically with the call by Rabindranath Tagore, the founder of the academy at Santiniketan in 1901, to guard against the fetish of nationalism. "The colourless vagueness of cosmopolitanism," Tagore pronounced, "nor thefierce self-idolatry of nation-worship, is the goal of human history" (Nationalism, 1917). This contrast is significant on two counts. First is the positive aspect of "nation" as a frame in art production or circulation, at the current point of globalization when massive expansion of cultural consumers may be realized through prevailing communication networks and technology. The organization of the information market, most vividly demonstrated through the recent FIFA World Cup when one out of every five living human beings on earth watched the finals, is predicated on nations as categories. An extension of the Indian Express argument would be that tagging of artworks along the category of nation would help ensure greatest reception, and would in turn open up the reified category of "art," so as to consider new impetus from aesthetic traditions from all parts of the world many of which hereto fore regarded as "ethnic," so as to liberate art from any hegemony of "international standards." Secondly, the critique of nationalism points to a transnational civic sphere, be it Tagore's notion of people-not-nation, or the much mo re recent "transnational constellation" of Jurgen Habermas (2001), a vision for the European Union w here civil sphere beyond confines of nation opens up new possibilities, and may serve as a model for a liberated sphere on global scale. There are other levels of collectivity which art may address, for instance the Indonesian example of local communities headed by Ketua Rukun Tetangga, the neighbourhood headmen, in which community matters of culture and the arts are organically woven into the communal fabric. Art and collectivity at the national-transnational level yield a contrasting situation of, on the idealized end, the dual inputs of local culture and tradition through "nation" as necessary frame, and the concurrent development of a transnational, culturally and aesthetically vibrant civic sphere that will ensure a cosmopolitanism that is not a "colourless vagueness." In art historical studies, this is seen, for instance, in the recent discussion on "cosmopolitan modernisms." Conversely, we may see a dual tyranny of a nationalism that is a closure (sometimes stated as "ethno-nationalism" which is disputable), and an internationalism that is evolved through restrictive understanding of historical development within privileged expressions. In art historical terms, where there is a lack of investigation into the reality of multiple modernisms, the possibility of a democratic cosmopolitanism in art is severely curtailed. The advocacy of a liberal cosmopolitanism without a democratic foundation returns art to dominance of historical privileged category. A local community with lack of transnational inputs may sometimes place emphasis on neo-traditionalism which is also a double edged sword, as re kindling with traditions is both liberating and restrictive, which in turn interplays with the push and pull of the collective matrix.

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Functional Characterization of Phosphorylation of the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Nucleocapsid Protein (PRRS 바이러스 Nucleocapsid 단백질 인산화의 기능학적 연구)

  • Lee, Chang-Hee
    • Microbiology and Biotechnology Letters
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    • v.37 no.3
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    • pp.287-292
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    • 2009
  • The nucleocapsid (N) protein of porcine reproductive and respiratory syndrome virus (PRRSV) is a basic multifunctional protein which has been reported to be a serine phosphoprotein with yet-identified functions. As a first step towards understanding the general role of N protein phosphorylation during virus replication, the non-phosphorylated mutant N gene was constructed by mutating all serine residues to alanine. This recombinant N protein was identified to be unphosphorylated, confirming that serine residues truly function as core amino acids responsible for N protein phosphorylation. The PRRSV N protein has been shown to possess the biological features of nuclear localization and N-N homodimerization which individually play critical roles in virus infection. In the present study, therefore, it was attempted to investigate whether these two properties of the N protein are modulated by its phosphorylation status. However, experimental results showed that the non-phosphorylated N protein was still present in the nucleus and nucleolus, and was able to associate with itself by non-covalent interactions. Taken together, the data suggest phosphorylation-independent regulation of N protein nuclear transport or oligomerization, thereby implying the potential involvement of phosphorylation in regulating the activities of the N protein at other levels including RNA-binding capacity.

Structure and Determinants of Royalty in Pharmaceutical Licensing (제약분야 기술거래의 로열티 결정구조와 요인)

  • Park, Hyun-Woo
    • Journal of Korea Technology Innovation Society
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    • v.10 no.3
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    • pp.406-430
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    • 2007
  • Most pharmaceutical licensing deals are made in the early stage of drug development. While this development process is not unique for complicated technology, a special feature of drug development is that it is highly regulated and a well-defined process. Its statistics in terms of costs and chances of technical success have been researched extensively. This enables relatively detailed calculations as benchmarks for actual deals to be made. Based on such calculations and on the analysis of licensing terms in published agreements, various companies offer quite expensive information, databases, software programs and consultation services to help establish what might be reasonable economic terms in a licensing deal. Over the years, pharmaceutical royalties have been the subject of various articles in journals. Most specific on this subject was the article on determining pharmaceutical royalties. Many other articles are about a more general nature deal with determining reasonable royalty rates, evaluating and underpinning the empirical value and usefulness of the 25% rule. The object of this article is to provide a relatively simple analytical approach based on the major economic terms underlying pharmaceutical licensing deals. The aim is to enhance the understanding of the relations between the major factors involved. Details are disregarded, as generally, where the terms of licensing deals depend on predictions over a considerable length of time, the value of detail is limited. Some specific issues addressed by the approach are the impact on profits of large investments, high risks and long development times characteristic of drug development, the consequent strong impact that the ultimate sales levels and operating margins may have on what might be considered a reasonable royalty rate, and the relationship between upfront payments and milestone payments to be paid during pharmaceutical development and the royalties due once the drug enters the market.

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Effective Maintenance of Urban Facilities via Smart Phones (스마트폰을 활용한 도시시설물 유지관리 효율화 방안)

  • Roh, Su-Sung;Sohn, Sae-Hyung;Kim, Do-Nyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.1
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    • pp.513-522
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    • 2017
  • Rapid urbanization is being portrayed around the world au causing difficulty to manage public hygiene and maintain public order. Common problems often detected in urban areas including traffic congestion and the deterioration of the ecological environment are also being exacerbated. Despite all the effort being made by the government and local governments to manage urban facilities, urban residents are subjected to various levels of difficulty, due to the number of facilities to be managed exceeding the number of management personnel and the lack of an adequate management system. The aim of this study is to propose a management method using smart phones to improve the maintenance efficiency of urban facilities. First, the one-stop maintenance of urban facilities, including facilities information management, maintenance management and history management, is made possible by using smart phones to collect and transfer pictures and the locations of the urban facilities. Second, maintenance management is based on the location and picture information of the subject, not the location of the smart phones, which enables a prompt understanding of and actions to be taken for the facility. This method is especially effective as the smart phone application sends the facility status information directly to the maintenance personnel. Third, all of the information and figures relating to the facilities is managed using a database, resulting in the easy utilization of the history management and data. Fourth, all of the urban residents have access to this information via smart phone applications and, therefore, expanding the role of the facility maintenance personnel is made possible without any additional investment in infrastructure. Lastly, the location-based information enables the management of roads, trees and trails.

Cross-sectional analysis on recreation specialization of surfing participants (서핑 참여자의 레크리에이션 전문화에 관한 횡단적 분석)

  • Yeom, Sang-geun;Kang, Hyun-Wook
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.2
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    • pp.340-353
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    • 2020
  • The purpose of this study is to introduce surfing which is not a familiar leisure activity in Korea and provide understanding of surfing participants through the cross-sectional analysis on the process of forming recreational specialization from introductory levels with enthusiastic surfing participants. This study employs a qualitative approach to analyze each participant's experience on recreation specialization in detail, and in particular uses ethnographic research methods to derive participants' meaning of life and daily routines and cultural behavioral patterns changed through surfing. First, through the analysis of in-depth interview data, total 531 conceptual words were identified and the first categorization was established. Second, surfing participants mentioned that they had high expectations of surfing even before they first encountered it. Third, surfing participants noted that they experienced leisure constraints and made efforts to resolve this issue before reaching the recreation specialization process. Fourth, surfing participants were found to go through a recreation specialization process. Fifth, surfing participants were found to undergo life changes. They worked hard in their everyday life through physical training, improvement of surfing skills, and analysis of their own videos to be better at surfing.