• Journal of Radiation Protection and Research
• /
• v.36 no.3
• /
• pp.160-167
• /
• 2011

This study conducts cross-comparison through verification of treatment planning of using beam spoiler and bolus, according to the dose variation of different tumor bed and metastatic lymph node cancers, against ionization and optically stimulated luminescence detectors(OSLDs), in head and neck radiotherapy. Verification of treatment planning examined the feasibility of inserting detectors through simulated solid dry water slabs under identical irradiated conditions from treatment planning system to measure beam spoiler and 0.5, 1 cm bolus. In addition, two detectors were cross-compared for verification of treatment planning accuracy and reliability within ${\pm}$2%. The study found that, given a beam spoiler thickness of 0.5 cm and beam spoiler-to-skin distance of 10 cm subjected to optimal dose distribution given for metastatic lymph node cancers, the bolus low-level skin dose was less, and the tumor bed dose reduced slightly. Additionally, two detectors were cross-compared for accuracy within ${\pm}$1%. Accordingly, The use of beam spoiler was determined that reduces skin side effects and can deliver an optimal dose distribution for tumor, and to apply to future clinical studies should be performed.

• Journal of Life Science
• /
• v.22 no.12
• /
• pp.1600-1607
• /
• 2012

The matrix metalloproteinase (MMP) family plays essential roles in physiological processes such as embryonic development, angiogenesis, wound healing, and tissue homeostasis as a consequence of MMPr capacity for breaking down many types of extracellular matrix proteins. Imbalanced regulation of MMP expression can also lead to pathological conditions such as tumor progression. We recently reported that the Drosophila Mmp1 gene is highly expressed in the digestive tract and is required for the maintenance of intestinal homeostasis such as by restriction of uncontrolled intestinal stem cell proliferation. However, the regulatory mechanisms of MMP gene expression in the intestine remain unclear. In this study, we determined that the expression of Mmp1 is regulated by the homeodomain transcription factor Caudal. Experiments using the targeted expression of Caudal under the regulation of Gal4-UAS system indicated that endogenous Caudal is required for the Mmp1 gene expression in the adult Drosophila intestine and that exogenous Caudal induces Mmp1 expression. Transient transfection experiments indicated that Caudal can activate the promoter activity of Mmp1 and that several putative Caudal binding sites in the 5'-flanking region of the Mmp1 gene may be critical to the upregulation by Caudal. Our data suggest that Mmp1 is one of the target genes of Caudal in physiological normal condition and in tumorigenesis.

• Journal of Environmental Science International
• /
• v.2 no.2
• /
• pp.153-160
• /
• 1993

The problem of supply and transport of sediment from a mountainous catchment is very important in explaining dynamic geomorphology and the hydrological cycle. The discharge of suspended sediment is determined by a morphological system. Human interference to environment Is also an important, not negligible factor in sediment production. Moreover, growing concern in recent years for the problems of nonpoint pollution and for the transport of contaminants through terrestrial and aquatic ecosystems has highlighted the role of sediment-associated transport in fluvial systems. This study was conducted in forested and quarried catchments in order to clarify the different discharge process and the mechanism of suspended sediment dynamics for each catchment. As a forested catchment, the Yamaguchi River catchment which drains a $3.12km^2$ area was chosen. On the other hand, the Futagami River basin which is formed by three subbasins (1.07, 1.59 and $1.78km^2$), as a quarried catchment was selected. These catchments are situated to the north and east of Mt. Tsukuba, Ibaraki, Japan. The discharge pattern of suspended sediment from the Futagami River basin is more unstable and irregular than that from forested catchment, the Yamaguchi River catchment. Under the similar rainstorm conditions, suspended sediment concentration from quarried catchment during a rainstorm event increases from 43 to 27,340 mg/l. However, in the case of the forested catchment it changes only from nearly zero to 274 mg/l. Generally, the supply source of suspended sediment is classified into two areas, the in-channel and non-channel source areas. As a result of field measurements, in the case of the forested catchment the in-channel (channel bed, channel bank and channel margin) is the main source area of suspended sediment. On the other hand, remarkable sediment source area on the Quarried catchment is the non-channel that is unvegetated ground.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.61 no.9
• /
• pp.1340-1349
• /
• 2012

Increasing the oxidation of fat through exercise is the recommendable method for weight control. Preceding researches have proposed increase in the usage of fat during exercise in stabilized state and under maximum exertion through aerobic training. However, such researches require additional equipment for gas analysis in order to measure the caloric value or gas exchange of subjects during exercise. Such equipments become highly restrictive for those exercise and cause substantially higher cost. According to this, we have presented the method of estimating the maximal fat oxidation point through changes in LF & HF which reflects changes in heart rate and the autonomic nervous system in order to induce exercise for a less restrictive and efficient fat oxidation than existing methods. We have conducted exercise stress test on subject with similar exercise abilities, and have detected the changes in heart rate and changes in LF & HF by measuring changes in fat oxidation and measuring ECG signals at the same time through a gas analyzer. Changes in heart rate and HRV of the subjects during exercising was detected through only the electrocardiographic signals from exercising and detected the point of maximum fat oxidation that differs from person to person. The experiment was carried out 16 healthy males, and used Modified Bruce Protocol, which is one of the methods of exercise stress test methods that use treadmill. The fat oxidation amount during exercise of all the subjects showed fat oxidation of more than 4Fkcal/min in the exercise intensity from about 5 minutes to 10 minutes. The correlation between the maximal fat oxidation point obtained through gas analysis and the point when 60% starts to be relevant in the range from -0.01 to 0.01 seconds for values of R-R interval from changes in heart rate had correlation coefficients of 0.855 in Kendall's method and in Spearman's rho, it showed significant results of it being p<0.01 with 0.950, respectively. Furthermore, in the changes in LF & HF, we have determined the point where the normalized area value starts to become the same as the maximal fat oxidation point, and the correlation here showed 0.620 in Kendall and 0.780 in Spearma of which both showed significant results as p<0.01.

• Restorative Dentistry and Endodontics
• /
• v.30 no.4
• /
• pp.327-334
• /
• 2005

This study investigated the effect of anticurvature filing method on preparation of the curved root canal using ProFile. Thirty six resin blocks were divided equally into three groups by instrumentation motions: anticurvature filing motion. circumferential filing motion and straight up-and-down motion. Each resin block was sectioned at 8mm level from the apex and at the greatest curvature of the canal and reassembled in metal mold by a modified Bramante technique. All groups were instrumented with the ProFile system. At each levels. image of sectioned surface were taken using CCD camera under a stereomicroscope at $\times40$ magnification and stored. Distances of transportation at the inner and outer area of curvature and the centering ratio were determined and compared by statistical analysis. along with the assessment of the increase of root canal cross-sectional area. The results were as follows; 1. In all groups. there was no statistical difference in the mean increase of root canal cross-sectional area. the centering ratio. and the mean distances of transportation at the inner area of curvature at each level. 2. At 8mm level from the apex. the mean distances of transportation at the outer area of curvature decreases in following order anticurvature filing motion. circumferential filing motion. straight up-and­down motion but. no significant difference at the greatest curvature of the canal among three groups. Effect of anticurvature filing motion using ProFile does not seem to be different from other instrumentation motions at the inner area of curvature in curved root canal.

• Archives of design research
• /
• v.17 no.3
• /
• pp.343-352
• /
• 2004

Under the production system of a free market economy, the modern consumers'goods that feature current trends reveal diverse aspects of the whole society and culture. This phenomenon is progressing at such a rapid speed that theories can barely keep up to explain it dearly. It is believed that the reason for the lag in academic theories is the formation of pluralistic values in human lifestyles due to the development of science and information communication. The pluralism of values in contemporary society is being studied in many academic fields, and the design among these fields often sees such a phenomenon as one of the post-modernism concepts, where post-modernism suggests a diversification and dismantling of modernism. In other words, the current design is closely watching products that are totally different from existing products, from complex and conceptual outcomes in the field of design to products that reflect various trends. Thus, it is true that package design, which proactively reflects current trends, freely traverses among specific domains of various fields that have been determined tacitly. It is also believed that other fields are also reflecting the same developments. Such a phenomenon is strikingly revealed with so-called 'fancy products', while other products 'parody' package design. This study sees the phenomenon as dismantling the border between product design and package design. The examined package design reflects the broader characteristics of the times, based on current concepts and meanings, after reviewing design examples.

• Applied Biological Chemistry
• /
• v.26 no.2
• /
• pp.97-103
• /
• 1983

To get further information on the behavior of phorate(0,0-diethyl S-ethylthiomethyl phosphorodithioate) in soil under the subtropical conditions, a field experiment has been conducted. Phorate granule (10%) was applied to silt loam soil at the rate of 40kg a.i./ha and incorporated to 10cm soil depth. Residues of phorate and its metabolites in soil were determined with GLC and confirmed qualitatively with TLC. Phorate was rapidly oxidized to its sulfoxide and sulfone. Therefore, main metabolic pathway of phorate in soil was the oxidation of phorate to phorate sulfoxide and sulfone. Phorate sulfoxide and sulfone were relatively more persistent than phorate itself. Phoratoxon was detected at low level only up to 30 days after treatment and its sulfoxide and sulfone were not detected during the whole experimental period. Toluene-acetonitrile-nitromethane(40 : 30 : 30, v/v/v) solvent system separated satisfactorily phorate and its five metabolites. Most of the residues was found in the initial incorporation depth $(0{\sim}10cm)$. Consequently, insecticides showed a little downward movement.

• Journal of Korean Society of Transportation
• /
• v.23 no.1
• /
• pp.103-114
• /
• 2005

The transit fare resulted from the renovation of public transit system in Seoul is basically determined based on the distance-based fare policy (DFP). In DFP, the total fare a passenger has to pay for is calculated by the basic-transfer-premium fare decision rule. The fixed amount of the basic fare is first imposed when a passenger get on a mode and it lasts within the basic travel distance. The transfer fare is additionally imposed when a passenger switches from one mode to another and the fare of the latter mode is higher than the former. The premium fare is also another and the fare of the latter begins to exceed the basic travel distance and increases at the proportion of the premium fare distance. The purpose of this study is to propose an algorithm for finding K number of paths, paths that are sequentially sorted based on total amount of transit fare, under DFP of the idstance-based fare policy. For this purpose, the link mode expansion technique is proposed in order to save notations associated with the travel modes. Thus the existing K shortest path algorithms adaptable for uni-modal network analysis are applicable to the analysis for inter-modal transportation networks. An optimality condition for finding the K shortest fare routes is derived and a corresponding algorithms is developed. The case studies demonstrate that the proposed algorithm may play an important role to provide diverse public transit information considering fare, travel distance, travel time, and number of transfer.

• Journal of Korea Water Resources Association
• /
• v.40 no.1 s.174
• /
• pp.39-50
• /
• 2007

This paper presents applications of the log-linear ROCOF(rate-of-occurrence-of-failure) and the Weibull ROCOF to model the failure rate of individual cast iron pipes in a water distribution system and provides a method of estimating the economically optimal replacement time of the pipes using the 'modified time-scale'. The performance of the two ROCOFs is examined using the maximized log-likelihood estimates of the ROCOFs for the two types of failure data: 'failure-time data' and 'failure-number data'. The optimal replacement time equations for the two models are developed by applying the 'modified time-scale' to ensure the numerical convergence of the estimated values of the model parameters. The methodology is applied to the case study water distribution cast iron pipes and it is found that the log-linear ROCOF has better modeling capability than the Weibull ROCOF when the 'failure-time data' is used. Furthermore, the 'failure-time data' is determined to be more appropriate for both ROCOFs compared to the 'failure-number data' in terms of the ROCOF modeling performances for the water mains under study, implying that recording each failure time results in better modeling of the failure rate than recording failure numbers in some time intervals.

• KIPS Transactions on Software and Data Engineering
• /
• v.8 no.6
• /
• pp.243-250
• /
• 2019

Because of a moving UAV has a lot of potential/kinetic energy, if the UAV falls to the ground, it may have a lot of impact. Because this can lead to human casualities, in this paper, the population density area on the UAV flight path is defined as a dangerous area. The conventional UAV path flight was a passive form in which a UAV moved in accordance with a path preset by a user before the flight. Some UAVs include safety features such as a obstacle avoidance system during flight. Still, it is difficult to respond to changes in the real-time flight environment. Using public Big Data for UAV path flight can improve response to real-time flight environment changes by enabling detection of dangerous areas and avoidance of the areas. Therefore, in this paper, we propose a method to detect and avoid dangerous areas for UAVs by utilizing the Big Data collected in real-time. If the routh is designated according to the destination by the proposed method, the dangerous area is determined in real-time and the flight is made to the optimal bypass path. In further research, we will study ways to increase the quality satisfaction of the images acquired by flying under the avoidance flight plan.