• Macromolecular Research
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• 제11권4호
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• pp.207-223
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• 2003

For last five years, we are developing the novel local drug delivery devices using biodegradable polymers, especially polylactide (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) due to its relatively good biocompatibility, easily controlled biodegradability, good processability and only FDA approved synthetic degradable polymers. The relationship between various kinds of drug [water soluble small molecule drugs: gentamicin sulfate (GS), fentanyl citrate (FC), BCNU, azidothymidine (AZT), pamidronate (ADP), $1,25(OH)_2$ vitamin $D_3$, water insoluble small molecule drugs: fentanyl, ipriflavone (IP) and nifedipine, and water soluble large peptide molecule drug: nerve growth factor (NGF), and Japanese encephalitis virus (JEV)], different types of geometrical devices [microspheres (MSs), microcapsule, nanoparticle, wafers, pellet, beads, multiple-layered beads, implants, fiber, scaffolds, and films], and pharmacological activity are proposed and discussed for the application of pharmaceutics and tissue engineering. Also, local drug delivery devices proposed in this work are introduced in view of preparation method, drug release behavior, biocompatibility, pharmacological effect, and animal studies. In conclusion, we can control the drug release profiles varying with the preparation, formulation and geometrical parameters. Moreover, any types of drug were successfully applicable to achieve linear sustained release from short period ($1{\sim}3$ days) to long period (over 2 months). It is very important to design a suitable formulation for the wanting period of bioactive molecules loaded in biodegradable polymers for the local delivery of drug. The drug release is affected by many factors such as hydrophilicity of drug, electric charge of drug, drug loading amount, polymer molecular weight, the monomer composition, the size of implants, the applied fabrication techniques, and so on. It is well known that the commercialization of new drug needs a lot of cost of money (average: over 10 million US dollar per one drug) and time (average: above 9 years) whereas the development of DDS and high effective generic drug might be need relatively low investment with a short time period. Also, one core technology of DDS can be applicable to many drugs for the market needs. From these reasons, the DDS research on potent generic drugs might be suitable for less risk and high return.

• 한국축산식품학회지
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• 제40권1호
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• pp.132-144
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• 2020

The aim of this study was to optimize staining procedures for muscle fiber typing efficiently and rapidly in bovine and porcine skeletal muscles, such as longissimus thoracis, psoas major, semimembranosus, and semitendinosus muscles. The commercially available monoclonal anti-myosin heavy chain (MHC) antibodies and fluorescent dye-conjugated secondary antibodies were applied to immunofluorescence histology. Two different procedures, such as cocktail and serial staining, were adopted to immunofluorescence analysis. In bovine muscles, three pure types (I, IIA, and IIX) and one hybrid type, IIA+IIX, were identified by the cocktail procedure with a combination of BA-F8, SC-71, BF-35, and 6H1 anti-MHC antibodies. Porcine muscle fibers were typed into four pure types (I, IIA, IIX, and IIB) and two hybrid types (IIA+IIX and IIX+IIB) by a serial procedure with a combination of BA-F8, SC-71, BF-35, and BF-F3. Unlike for bovine muscle, the cocktail procedure was not recommended in porcine muscle fiber typing because of the abnormal reactivity of SC-71 antibody under cocktail procedure. Within the four antibodies, combinations of two or more anti-MHC antibodies allowed us to distinguish pure fiber types or all fiber types including hybrid types. Application of other secondary antibodies conjugated with different fluorescent dyes allowed us to get improved image resolution that clearly distinguished hybrid fibers. Muscle fiber characteristics differed depending on species and muscle types.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2008년도 춘계학술발표대회 논문집
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• pp.342-347
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• 2008

A Microsoft $Access^{(R)}$ application that estimates hourly building energy load is developed based on statistical field measurements. Hourly patterns of heating, hot water, cooling, and electricity loads are evaluated for an energy consuming community composed of various types of buildings. Popular building types such as apartments, offices, hotels and accomodations, stores, churches, schools and educational institutes are included in the model. For each type of buildings, hourly patterns for a month are measured and compiled to derive a 24-hour load distributions. Daily sum of heating, hot water, cooling, and electricity loads are also measured for the building types. The annual energy need profiles are generated by combining the 24-hour distribution and 365-day consumption patterns. The annual maximum values of the 8760 hours of a year for each load type serves as a guide for selecting a device capacity. A user-friendly interface that ushers users throughout the whole process is provided.

• 한국과학교육학회지
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• 제14권1호
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• pp.24-33
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• 1994

This study is aimed at categorizing the CAl programs through analyzing the 82 science CAl programs developed by KEDI( Korean Educational Development Institutes ) and the 19 science CAl programs developed by the teachers who won the prizes in the first national educational software contest. The findings are as follows. 1) The main types of science CAl programs developed by KEDI are hybrid design type of tutorials and simulations, tutorials, and hybrid design type of instructional games and drill and practice. The other type of programs are very few. 2) The main types of science CAl programs developed by the teachers, who won the prizes in 1st educational software contest, are tutorials and hybrid design type of tutorials and simulations. There is no other type of programs except only two simulation type programs. 3) The science CAl programs developed by KEDI as well as by teachers who won the prizes in the contest are biased in two or three types, and the trend is severe in the programs developed by the teachers.

• Journal of Pharmaceutical Investigation
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• 제32권3호
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• pp.173-179
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• 2002

Solid dispersions of ipriflavone with PVP were prepared by a spray-drying method in order to improve the bioavailability. They were measured with scanning electron microscopy, differential scanning calorimetry, x-ray powder diffraction, and Fourier transform infrared spectroscopy to evaluate the physicochemical interaction between ipriflavone and PVP and study the correlation between these physicochemical characteristics and bioavailability. Ipriflavone exhibited crystallinity, whereas PVP was almost amorphous. The area of the endotherm $({\Delta}H)$ of freezer milled ipriflavone, freezer milled ipriflavone physically mixed with freezer milled PVP, and physically mixed ipriflavone with PVP was almost the same, whereas ${\Delta}H$ of the solid dispersed ipriflavone with PVP was much smaller than that of the other preparation types. Also, the crystallinity and the crystal size of ipriflavone in the solid dispersed ipriflavone with PVP were much smaller than those of the other preparation types. From the in vivo test, the AUC of the solid dispersed ipriflavone with PVP was approximately 10 times higher than that of the physically mixed ipriflavone with PVP. The solid dispersion using the spray-drying method with a water-soluble polymer, PVP, may be effective for the improvement of the bioavailability.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2002년도 Proceedings of International Symposium on Remote Sensing
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• pp.191-196
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• 2002

From this year, KIGAM, one of Korean government-supported research institutes, has started new national program for digital geologic/natural resources infrastructure building. The goal of this program is to prepare digitally oriented infrastructure for practical digital database building, management, and public services of numerous types of paper maps related to geo-scientific resources or geologic thematic map sets: hydro-geologic map, applied geologic map, geo-chemical map, airborne radiometric/magnetic map, coal geologic map and off-shelf bathymetry map and so forth. As for digital infrastructure, several research issues in this topic are composed of: ISP (Information Strategy Planning), geo-framework modeling of each map set, pilot database building, cyber geo-mineral directory service system, and web based geologic information retrieval system upgrade which services Korean digital geologic maps scaled 1:50K. In this study, UML (Unified Modeling Language)-based data modeling of geo-data sets by and in KIGAM, among them, is mainly discussed, and its results are also presented in the viewpoint of digital geo-modeling ISP. It is expected this model is further progressed with the purpose of being a guidance or framework modeling for geologic thematic mapping and practical database building, as well as other types of national thematic map database building.

• Plant Biotechnology Reports
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• 제5권4호
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• pp.345-352
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• 2011

The rheological and diffusion properties of blends of agar/guar gum, agar/Phytagel and Phytagel/guar gum were analysed and compared to those properties of agar or Phytagel applied alone at two different gelling concentrations. Moreover, their effects on the shoot multiplication of the apple scion Galaxy and two black locust clones (SF63, SF82) were studied, and their cost benefits over agar were calculated. Elastic hydrogel formation was demonstrated for each blend by rheological measurements, but the gel strength depended on the types and concentrations of the applied gelling agents and blends. Guar gum was able to speed the diffusion in the different blends, and diffusion was independent of gel strength. The rate of shoot multiplication increased (to 8.9 shoots per explant) and the percent of hyperhydrated shoots decreased (to 12%) when the blend of agar/guar gum was used for the shoot multiplication of apple. Similarly, the highest multiplication rates of black locust clones (between 3.9 and 4.1) were obtained on media solidified by blends containing guar gum. The best shoot performance with the lowest percent of hyperhydrated shoots (11-12% in SF63 and 2-23% in SF82) was achieved using agar alone or the agar/guar gum blend. The shoot multiplication was improved of both species and the production cost was reduced by 42% by using the agar/guar gum blend.

• 경영과학
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• 제32권4호
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• pp.193-207
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• 2015

Government-funded research institutes (GRIs) have played a pivotal role in national R&D in Korea. To achieve desired goals of GRIs with the limited R&D budget, their performance along with time needs to be measured and compared so that appropriate R&D policies can be formulated and implemented. This study measures the dynamic performance of GRIs from the efficiency perspective using the window model of data envelopment analysis (DEA). DEA is a non-parametric approach to measuring the relative efficiency of decision-making units (DMUs) with multiple inputs and outputs, and the DEA window model can capture the dynamic changes in efficiency of DMUs during multiple periods. The relative efficiency of GRIs is measured from the two perspectives: R&D and R&BD. Patents, papers, technology transfers are selected as outputs for R&D while compensated technology transfers and technology royalty are employed as outputs for R&BD. This study measures and compares the two types of performance of 20 Korean GRIs under the control of National Research Council of Science and Technology during the period of six years from 2008 to 2013. The results are expected to provide fruitful implications for national R&D policy making.

• Korean Journal of Acupuncture
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• 제35권3호
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• pp.123-129
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• 2018

Objectives : Electroacupuncture is a procedure in which pulses of weak electrical current are sent through acupuncture needles into acupuncture points in the skin. Since the 1970s, electroacupuncture has been widely used for treating various diseases including pain, inflammatory diseases and neurodegenerative diseases and electroacupuncture research has also been actively conducted in Korea. This study was designed to assess the tendencies and research performances in Korea. Methods : Articles referring to electroacupuncture in Korea were searched in Korean Studies Information Service System, Oriental Medicine Advanced Searching Integrated System, DBpia, Pubmed and Scopus, and assessed by distribution of document types, published articles, source institutes, journals, and subject categories. Results : Total 677 articles were included in this study. Among them, basic researches were 395, clinical researches were 210, reviews were 68 and others were 4. Kyung Hee university published the most articles, followed by Wonkwang univresity, Daejeon university and Pusan national university in Korean institutes. Journal of Acupuncture Research published the most articles, followed by Korean Journal of Acupuncture, Journal of Korean medicine rehabilitation and Journal of physiology & pathology in Korean medicine among journals. Animals were used in the most articles, followed by human, literatures and protocol in subject categories. The number of articles per year was related to the increase of research fund and the number per institution was related to the number of professors and researchers. Conclusions : In order to carry out better electroacupuncture researches, it is necessary to cultivate electroacupuncture researchers and increase in research funds.

• 한국경제지리학회지
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• 제7권2호
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• pp.315-328
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• 2004

본 연구는 자치단체의 행정구역을 넘어서서 확장되고 있는 산업클러스터를 지원하기 위한 산업지원체계의 구축에 관한 것이다. 많은 산업클러스터들은 두 개 혹은 그 이상의 자치단체를 넘어서서 확대되는 경향이 있는 바, 이렇듯 산업클러스터가 행정구역의 범위를 넘어서 성장함에 따라, 이를 뒷받침하는 행정지원체계에 있어서 다양한 문제가 발생할 수 있다. 무엇보다도 산업클러스터가 필요로 하는 산업지원서비스나 인프라공급이 원활히 되지 않거나 자치단체간의 이해 상충에 의해 서비스나 인프라 구축의 효율성이 저하될 수 있는 것이다. 본 연구에서는 산업클러스터를 지방정부간 협력에 의해 광역적 차원에서 구축하거나 지원하는 다양한 사례들을 검토하여 이들의 유형을 네 가지로 구분하였다. 그리고 이러한 분석으로부터 정책적 시사점을 추출한 바, 광역적 산업지원체계의 구축은 주로 '지역개발기구 설립에 의한 외자유치', '광역적 산업단지의 협력적 개발', '광역적 클러스터를 지원하는 통계 및 정책 개발, '클러스터내 기업들을 중심으로 대학, 연구기관간의 전자네트워크 구축' 등에 중점을 두는 것이 바람직한 것으로 종합되었다.