• IMMUNE NETWORK
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• v.22 no.1
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• pp.5.1-5.22
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• 2022

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferation, differentiation and function of multiple immune cell types, including CD8 T-cells and NK cells, which are at the center of the anti-tumor response. While the short halflife of recombinant cytokines initially limited their application in the clinic, advancements in protein engineering have led to the development of several next-generation drug candidates with dramatically increased half-life and bioactivity. When combining these cytokines with other immunotherapies, strong evidence of synergy has been observed in preclinical and clinical cancer settings. This promising data has led to the initiation of 70 ongoing clinical trials including IL-2, IL-7, IL-15 and IL-21. This review summarizes the recent advancements of common gamma-chain cytokines and their potential as a cancer immunotherapy.

• Phonetics and Speech Sciences
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• v.4 no.2
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• pp.127-134
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• 2012

The purpose of this study is to present evidence for a particular processing approach based on the language-specific characteristics of Korean. To compare individuals' sentence-comprehension abilities, this study measured the accuracy and reaction times (RT) of 12 aphasic patients (AP) and 12 normal controls (NC) during a sentence-picture matching task. Four versions of a sentence were constructed with the two types of voice (active/passive) and two types of word order (agent-first/patient-first). To examine the effects of increased processing demand, picture stimuli were manipulated in such a way that they appeared immediately after the sentence was presented. As expected, the AP group showed higher error rates and longer RT for all conditions than the NC group. Furthermore, Korean speakers with aphasia performed above a chance level in sentence comprehension, even with passive sentences. Aphasics understood sentences more quickly and accurately when they were given in the active voice and with agent-first order. The patterns of the NC group were similar. These results confirm that Korean adults with aphasia do not completely lose their knowledge of sentence comprehension. When the processing demand was increased by delaying the picture stimulus onset, the effect of increased processing demands on RT was more pronounced in the AP than in the NC group. These findings fit well with the idea that the computational system for interpreting sentences is intact in aphasics, but its ability is compromised when processing demands increase.

• Journal of Korean Medicine for Obesity Research
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• v.5 no.1
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• pp.109-119
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• 2005

Objective : The purpose of this study was to evaluate the effectiveness of obesity management program on height and body Composition and its correlationship with constitution types, obesity grade, and the frequency of attendance among the elementary school student. Methods : The subjects consisted of 75 elementary school student who participated in the obesity management program and got the constitution type test and height and height-body composition test(2 times). The program contained proper lifestyle education, dietary education, exercise and so on once a week for nine weeks. The data were analyzed with SPSS 12.0 for Windows. Results : Height and body composition were significantly improved at the post-test. Among constitution types, obesity grade, and the frequency of attendance, obesity grade by BMI was correlated with the change of height and body composition. Conclusion : These results provides evidence that obesity management program is effective in improving height and body composition for elementary school student.

• Language and Information
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• v.15 no.1
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• pp.1-12
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• 2011

This study investigates morphologically complex nouns in Korean through a series of priming studies. Two experiments examined whether morphological affixes on Korean nouns were decomposed or processed as a whole. Two types of morphological affixes were examined: morpho-syntactic case markers and the plural marker '-tul'. Results showed that priming occurred for the plural marker with SOAs of 80 ms and 160 ms, but no priming occurred for the morpho-syntactic case markers. These results suggest that the morphological processing for these two types of affixes differ. We argue that Korean nouns with the plural suffix are decomposed into the stem and affix, supporting the Decomposition Model (Pinker & Ullman, 2002). We suggest that while plural markers are truly morphological affixes, case markers in Korean are morpho-syntactic, and thus presuppose the existence of other syntactic elements, such as the matrix verb, hence the lack of priming effects.

• The Journal of Information Systems
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• v.24 no.4
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• pp.117-138
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• 2015

Purpose To meet changing social demands and fulfill the needs of the information and communications technology industry, the curriculum of MIS related department should develop and implement new conceptual frameworks. In response, the purpose of this study was to develop curriculum for students in the Department of e-Business at Kyungnam University. Design/methodology/approach We conducted a demands analysis of educational demanders, NCS(National Competency Standards) based curricular analysis, and benchmarking from other management information systems related departments. The expert panel committee consisting of e-Business department faculty members was held to examine and discuss the student-oriented curriculum developed during this study. Findings Results show that the contents and types of curriculum should be organized so that students can maximize their professional job competency to apply to their core professional tasks. Given these findings, we reconstructed the curriculum with both basic and advanced courses, all systematically organized according to the job requirements they offer toward meeting the industry's needs. We also implemented the web-based JSSS(Job Searching Support System) with which educational demanders can search among 13 job types, estimate their performances, and obtain the information about course registration. In all this study presents specific, practical evidence of the job-related curriculum for students in the Department of e-Business at Kyungnam University.

• Journal of Distribution Science
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• v.12 no.3
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• pp.55-63
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• 2014

Purpose - This study aims to examine differences in donation behavior as surrogates of prosocial consumption behavior among three generation types. Further, it attempts to examine the moderator roles that affect donation behavior influenced by the difference in generations. Research design, data, and methodology - This study used the statistical ANOVA technique to examine generational difference. Surveys were structured differently by ages, as 20th, 30th, 40th, 50th, 60th, and 70th to classify generations into each group. A survey to measure the psychological distance was performed to identify whether the respondents intended to donate to a domestic or overseas target. Results - First, subjective judgment of psychological distance has no effect on objective donation behavior. Second, though the result of the relationship with moral identity is not statistically significant, it provides evidence that a higher moral identity level possesses more donation behavior. Further, groups with higher symbolization tend to donate more than the others. This was especially evident among the young and baby boomer generation. Conclusion - This empirical study suggests that marketers need to differentiate the market segment of the baby-boomer generation with high purchasing power of prosocial consumption.

• KSBB Journal
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• v.32 no.1
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• pp.46-53
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• 2017

There are four types (So-Eum, So-Yang, Tae-Eum, Tae-Yang type) in Sasang constitutional medicine (SCM). In SCM, not only people but also herbal medicine are classified into four types. To date, there has been very little evidence of experimental classifications in SCM. So, we adapted Issatchenkia orientalis in two different culture media made from the herbal medicines for So-Eum and for So-Yang type. And the adapted Issatchenkia orientalis was inoculated into another eight culture media made from the herbal medicines for So-Eum and for So-Yang type. The mass reduction was measured every 12 hours for 2 days. Then, we analyzed the statistical differences of herbal medicines for So-Eum and for So-Yang type. There were significant differences of variables (R: rate of change in mass reduction, S: convex degree of mass reduction graph) in herbal medicine media for So-Eum (p=0.001, 0.001, respectively.). Suggesting a microbiological method of Sasang medicine research, current study may contribute to the establishment of experimental Sasang constitutional herbal medicine.

• Fisheries and Aquatic Sciences
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• v.27 no.1
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• pp.17-22
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• 2024

Diabetes Mellitus (DM) is a major health issue increasing worldwide. Currently, nearby half a billion people have diabetes. Two major types of DM that type 1 and type 2-DM have different etiologies but feature a crucial common pathological transition into dysfunction of pancreatic β-cells and consequently leading hyperglycemia and finally go into DM. Therefore, maintaining of β-cells such as preventing β-cells degeneration, and promoting β-cells regeneration and proliferation will be essential approaches in prevention and/or treatment of DM. There are many reports that various types of seaweed control metabolic diseases such as obesity, high blood pressure, and blood sugar control. However, no new drug candidates have been developed yet. Additionally, although seaweed has excellent blood sugar control effects, there is no evidence that it directly proliferates or regenerates beta cells. Therefore, we studied on the promotion of β-cell regeneration by a seaweed, Polysiponia morrowii extract (PME) which preserves β-cells and maintains its function. As a result, it was confirmed that PME directly promotes the proliferation of pancreatic islet β-cells with insulin secretion function in in vivo. Therefore, PME shows potential as a candidate for β-cell regeneration that may play a fundamental role in the treatment of diabetes.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.32 no.2
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• pp.124-134
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• 2024

This study is based on the Expectation Confirmation Theory (ECT) and categorizes trust types in non-face-to-face boarding services into three dimensions: structural assurance, platform, and service provider. It analyzes the impact of these trust types on users' perceived usefulness, satisfaction, and continuous usage intentions. Using a structural equation model, the study found that the three dimensions of trust positively influence users' satisfaction and perception of usefulness, thereby promoting intentions for continuous use. However, perceived risk weakens the positive relationship between trust and continuous usage intentions. By exploring the moderating role of perceived risk in non-face-to-face boarding services, this study analyzes its impact on user behavior patterns, contributing to the optimization of service design and enhancement of user trust. This study promotes widespread acceptance and continuous use of the service, and is crucial for developing effective non-contact service strategies that meet the needs and expectations of Chinese travelers in the post-pandemic travel environment. The findings provide a new perspective and empirical evidence for understanding user attitudes and behaviors towards non-face-to-face services, holding significant theoretical and practical implications.

• Language and Information
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• v.19 no.2
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• pp.81-107
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• 2015

This paper explores the 1st person restrictions on the evidential -te, focusing on the cases where it appears with the speaker-oriented psych-predicates in Korean. It has been widely discussed that the 1st person restriction can be freely circumvented when -te is used with the speaker-oriented psych-predicates. However, based on the novel observation that such an obviation can be varied with respect to the types of the subordinate clauses which modify the evidential sentences, we propose that the 1st person restriction should be explained in terms of the situation-based felicity condition of -te, as discussed in Lim (2014): it arises if the situation where the speaker acquires evidence cannot be the same as, or be included by, the situation where the prejacent is true. To show this, we discuss how the meaning of the speaker-oriented psych-predicates interacts with the felicity condition of -te, and how this interaction makes the distinctive obviation environments of the 1st person restriction on -te, unlike other types of predicates.