• Toxicological Research
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• v.31 no.4
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• pp.347-354
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• 2015

Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout ($Hfe^{-/-}$) and their control wild-type ($Hfe^{+/+}$) mice to $MnCl_2$ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed $Hfe^{+/+}$ compared with water-drinking $Hfe^{+/+}$ mice. However, Mn-exposed $Hfe^{-/-}$ mice spent more time to find the target hole than Mn-drinking $Hfe^{+/+}$ mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.

• Nutrition Research and Practice
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• v.7 no.5
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• pp.347-351
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• 2013

Food-dependent exercise-induced anaphylaxis (FDEIAn) is induced by different types and various intensities of physical activity, and is distinct from food allergies. It has been shown that consumption of allergenic food followed by exercise causes FDEIAn symptoms. Intake of allergenic food or medication before exercise is a major predisposing factor for FDEIAn. Urticaria and severe allergic reactions are general symptoms of FDEIAn. Dermatological tests and serum IgE assays are the typical prescreening methods, and have been used for several decades. However, these screening tests are not sufficient for detecting or preventing FDEIAn. It has been found that exercise may stimulate the release of mediators from IgE-dependent mast cells that can result in FDEIAn when a certain threshold level has been exceeded. Mast cell degradation might be a major factor to induce FDEIAn but this has not been determined. A number of foods have been reported to be involved in the onset of FDEIAn including wheat, eggs, chicken, shrimp, shellfish, nuts, fruits, and vegetables. It is also known that aspirin increases the occurrence of type I allergy symptoms when combined with specific foods. Moreover, high intensity and frequent exercise are more likely to provoke an attack than low intensity and less frequent exercise. In this paper, we present the current views of the pathophysiological mechanisms underlying FDEIAn within the context of exercise immunology. We also present a detailed FDEIAn definition along with etiologic factors and medical treatment for cholinergic urticaria (UC) and exercise-induced anaphylaxis (EIA).

• Structural Engineering and Mechanics
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• v.61 no.3
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• pp.347-357
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• 2017

The applications of active control is being more popular nowadays. Several control algorithms have been developed to determine optimum control force. In this paper, a Chaotic Particle Swarm Optimization (CPSO) technique, based on Logistic map, is used to compute the optimum control force of active tendon system. A chaotic exploration is used to search the solution space for optimum control force. The response control of Multi-Degree of Freedom (MDOF) shear buildings, equipped with active tendons, is introduced as an optimization problem, based on Instantaneous Optimal Active Control algorithm. Three MDOFs are simulated in this paper. Two examples out of three, which have been previously controlled using Lattice type Probabilistic Neural Network (LPNN) and Block Pulse Functions (BPFs), are taken from prior works in order to compare the efficiency of the current method. In the present study, a maximum allowable value of control force is added to the original problem. Later, a twenty-story shear building, as the third and more realistic example, is considered and controlled. Besides, the required Central Processing Unit (CPU) time of CPSO control algorithm is investigated. Although the CPU time of LPNN and BPFs methods of prior works is not available, the results show that a full state measurement is necessary, especially when there are more than three control devices. The results show that CPSO algorithm has a good performance, especially in the presence of the cut-off limit of tendon force; therefore, can widely be used in the field of optimum active control of actual buildings.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.347.2-347.2
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• 2014

최근, 비정질 산화물 반도체 thin film transistor (TFT)는 수소화된 비정질 실리콘 TFT와 비교하여 높은 이동도와 큰 on/off 전류비, 낮은 구동 전압을 가짐으로써 빠른 속도가 요구되는 차세대 투명 디스플레이의 TFT로 많은 연구가 진행되고 있다. 한편, 기존의 Thin-Film-Transistor 제작 시 우수한 박막을 얻기 위해서는 $500^{\circ}C$ 이상의 높은 열처리 온도가 필수적이며 이는 유리 기판과 플라스틱 기판에 적용하는 것이 적합하지 않고 높은 온도에서 수 시간 동안 열처리를 수행해야 하므로 공정 시간 및 비용이 증가하게 된다는 단점이 있다. 이러한 점을 극복하기 위해 본 연구에서는 간단하고, 낮은 제조비용과 대면적의 박막 증착이 가능한 용액공정을 통하여 박막 트랜지스터를 제작하였으며 thermal 열처리와 microwave 열처리 방식에 따른 전기적 특성을 비교 및 분석하고 각 열처리 방식의 열처리 온도 및 조건을 최적화하였다. P-type bulk silicon 위에 산화막이 100 nm 형성된 기판에 spin coater을 이용하여 Al-Zn-Sn-O 박막을 형성하였다. 그리고, baking 과정으로 $180^{\circ}C$의 온도에서 10분 동안의 열처리를 실시하였다. 연속해서 Photolithography 공정과 BOE (30:1) 습식 식각 과정을 이용해 활성화 영역을 형성하여 소자를 제작하였다. 제작 된 소자는 Junctionless TFT 구조이며, 프로브 탐침을 증착 된 채널층 표면에 직접 접촉시켜 소스와 드레인 역할을 대체하여 동작시킬 수 있어 전기적 특성을 간단하고 간략화 된 공정과정으로 분석할 수 있는 장점이 있다. 열처리 조건으로는 thermal 열처리의 경우, furnace를 이용하여 $500^{\circ}C$에서 30분 동안 N2 가스 분위기에서 열처리를 실시하였고, microwave 열처리는 microwave 장비를 이용하여 각각 400 W, 600 W, 800 W, 1000 W로 15분 동안 실시하였다. 그 결과, furnace를 이용하여 열처리한 소자와 비교하여 microwave를 통해 열처리한 소자에서 subthreshold swing (SS), threshold voltage (Vth), mobility 등이 비슷한 특성을 내는 것을 확인하였다. 따라서, microwave 열처리 공정은 향후 저온 공정을 요구하는 MOSFET 제작 시의 훌륭한 대안으로 사용 될 것으로 기대된다.

• The Journal of the Korea Contents Association
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• v.8 no.11
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• pp.347-355
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• 2008

This research has been conducted against Cheong-Ju undergraduate students. A total of 213 questionnaires was used for the data. The first purpose of this research is to analyze eating habits of food-related lifestyle of the students. The second purpose is to classify them into groups depending on their food-related lifestyle. The third purpose of this research is to identify eating out behavior patters among the groups classified by food-related lifestyle. Based on the information obtained from those results, this study would help restaurants have their marketing strategies. From the factor analysis, 6 factors of "popular-oriented group", "health-oriented group", "safety-oriented group", "decoration-oriented group", "tasted-oriented group" and "wellbeing-oriented group" were extracted. Additionally, "safety type group", "passive food groups" and "high-interest in foods group" were classified from the cluster analysis.

• Wind and Structures
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• v.27 no.5
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• pp.347-356
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• 2018

In this paper, stress distribution for a structurally stable greenhouse is considered in the present paper with subsequent investigation into the detailed stress distribution contour with the variation of self-weight and wind pressure level designation method under wind velocity of less than 30 m/sec. For reliable analysis, wind pressure coefficients of a single greenhouse unit were modeled and compared with experiment with correlation coefficient greater than 0.99. Wind load level was designated twofold: direct mapping of fluid dynamic analysis and conversion of modeled results into wind pressure coefficients ($C_P$). Finally, design criteria of EN1991-1-4 and NEN3859 were applied in terms of their wind pressure coefficients for comparison. $C_P$ of CFD result was low in the most of the modeled area but was high only in the first roof wind facing and the last lee facing areas. Besides, structural analysis results were similar in terms of stress distribution as per EN and direct mapping while NEN revealed higher level of stress for the last roof area. The maximum stress levels are arranged in decreasing order of mapping, EN, and NEN, generating 8% error observed between the EN and mapping results under 30 m/sec of wind velocity. On the other hand, effect of dead weight on the stress distribution was investigated via variation of high stress position with wind velocity, confirming shift of such position from the center to the forward head wind direction. The sensitivity of stress for wind velocity was less than 0.8% and negligible at wind velocity greater than 20 m/sec, thus eliminating self-weight effect.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.2
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• pp.347-355
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• 2012

A biometric hardware security module is a physical device that comes in the form of smartcard or some other USB type security token is composed with biometric sensor and microcontroller unit (MCU). These modules are designed to process key generation and electronic signature generation inside of the device (so that the security token can safely save and store confidential information, like the electronic signature generation key and the biometric sensing information). However, the existing model is not consistent that can be caused by the disclosure of an ID and password, which is used by the existing personal authentication technique based on the security token, and provide a high level of security and personal authentication techniques that can prevent any intentional misuse of a digital certificate. So, this paper presents a model that can provide high level of security by utilizing the biometric security token and Public Key Infrastructure efficiently, presenting a model for privacy preserving personal authentication that links the biometric security token and the digital certificate.

• The Journal of the Convergence on Culture Technology
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• v.9 no.1
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• pp.347-353
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• 2023

Currently, soldiers enlisted in the military (Army) are receiving measurements (automatic, manual) of body parts and trying on sample clothing at boot training centers, and then receiving clothing in the desired size. Due to the low accuracy of the measured size during the measurement process, in the military, which uses a relatively more detailed sizing system than civilian casual clothes, the supplied clothes do not fit properly, so the frequency of changing the clothes is very frequent. In addition, there is a problem in that inventory is managed inefficiently by applying the measurement system based on the old generation body shape data collected more than a decade ago without reflecting the western-changed body type change of the MZ generation. That is, military uniforms of the necessary size are insufficient, and many unnecessary-sized military uniforms are in stock. Therefore, in order to reduce the frequency of clothing replacement and improve the efficiency of stock management, deep learning-based automatic measurement of body size, big data analysis, and machine learning-based "Personalized Combat Uniform Automatic Recommendation System for Enlisted Soldiers" is proposed.

• Journal of Food Hygiene and Safety
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• v.38 no.5
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• pp.347-355
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• 2023

In this study, polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) were compared in terms of their ability to detect shiga-toxin-producing Escherichia coli (STEC). Various foods were artificially inoculated with STEC to evaluate the limit of detection (LOD), limit of quantification (LOQ), sensitivity, specificity, and efficiency of PCR and LAMP. The LODs were ≤10⁴ and ≤10³ CFU/mL for PCR and LAMP, respectively. The LOQs did not differ between PCR and LAMP. However, of the four considered food types, the sensitivities differed by a maximum of 11.1% for seasoned meat and by a minimum of 8.1% for ground beef. LAMP had higher sensitivity than that of PCR and 100% specificity for all four food types. Therefore, LAMP is a reliable molecular method for detecting STEC as comparable to PCR assay, and its specificity and sensitivity are superior to those of PCR, depending on the food type.

• BMB Reports
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• v.47 no.6
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• pp.342-347
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• 2014

Histone acetylation/deacetylation has been known to be associated with the transcriptional regulation of various genes. The role of histone deacetylase-3 in the expression regulation of MDR1 was investigated. The expression level of HDAC3 showed an inverse relationship with the expression level of MDR1. Wild-type HDAC3, but not catalytic mutant $HDAC3^{S424A}$, negatively regulated the expression of MDR1. Wild-type HDAC3, but not catalytic mutant $HDAC3^{S424A}$, showed binding to the promoter sequences of HDAC3. HDAC3 regulated the expression level, and the binding of Ac-$H3^{K9/14}$ and Ac-$H4^{K16}$ around the MDR1 promoter sequences. The nuclear localization signal domain of HDAC3 was necessary, and sufficient for the binding of HDAC3 to the MDR1 promoter sequences and for conferring sensitivity to microtubule-targeting drugs.