• Korean Journal of Acupuncture
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• v.27 no.1
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• pp.31-47
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• 2010

Objectives: To investigate the anti-inflammatory effects of cultivated wild ginseng pharmacopuncture in lipopolysaccharide (LPS)-induced inflammatory rat model. Methods: Sprague-Dawley rats were divided into 4 groups; LPS control (n=6), LPS+cultivated wild ginseng pharmacopuncture at CV4 (n=6), LPS+cultivated wild ginseng pharmacopuncture at CV17 (n=6), and LPS+cultivated wild ginseng pharmacopuncture at Ex-HN1 (n=6). Pharmacopuncture (0.1 ml) was given every two days for 4 weeks followed by inflammation induction by peritoneal LPS injection (5 mg/kg). Blood, liver tissue, and peritoneal lavage fluid were taken and proinflammatory cytokines and other related factors were analysed. Results: Compared with the control group, CV4 and Ex-HN1 pharmacopuncture groups significantly attenuated plasma IL-$1{\beta}$, IL-6, and TNF-$\alpha$ increase at 2h and 5h after LPS injection (P<0.05). A significant difference from control group emerged at 5 h for plasma IL10 (P<0.05). For liver cytokines analyzed at 5 h after LPS injection, only CV4 pharmacopuncture group showed significant difference in TNF-$\alpha$ and IL-10 (P<0.05). Blood CD4/CD8 ratio and the phagocytic activities of polymorphonuclear neutrophils were not different from those of control group in all pharmacopuncture groups (P>0.05). CV4 pharmacopuncture significantly attenuated increase of plasma ${NO_3}^-/{NO_2}^-$, Intracellular adhesion molecule-1 (ICAM-1), cytokine-induced neutrophil chemoattractant-1 (CINC-1), and prostaglandin $E_2$ ($PGE_2$) compared with the control group (P<0.05). Monocyte chemoattractant protein-1, $PGE_2$, and CINC-1 level of CV4 pharmacopuncture group was significantly different from those from the control group (P<0.05). Conclusions: These results indicate that cultivated wild ginseng pharmacopuncture at CV4 may have a potent anti-inflammatory effect in an LPS-induced inflammatory rat model.

• Journal of The Korean Society of Agricultural Engineers
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• v.63 no.5
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• pp.63-71
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• 2021

Windbreak forests, which have a windproof effect against strong winds, are known to be effective in reducing the spread of odors and dust emitted from livestock farms. The effect of reducing the spread of odors and dust can be estimated through numerical models such as computational fluid dynamics, which require aerodynamic coefficients of the windbreaks for accurate prediction of their performance. In this study, we aimed to evaluate the aerodynamic coefficients, Co, C₁, C₂, and α, of two windbreaks, Thuja occidentalis and a mesh net, through wind tunnel experiments. The aerodynamic coefficients were derived by the relation between the incoming wind speed and the pressure loss due to the windbreaks which was measured by differential pressure sensors. In order to estimate the change in the aerodynamic coefficient concerning various leaf density, the experiments were conducted repeatedly by removing the leaves gradually in various stages. The results showed that the power law regression model more suitable for coefficient evaluation compared to the Darcy-Forchheimer model.

• Steel and Composite Structures
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• v.31 no.6
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• pp.575-589
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• 2019

The main focus of this study is to numerically investigate the influence of strong earthquake and tsunami-induced wave impact on the response and behavior of a cable-stayed steel bridge with large caisson foundations, by assuming that the earthquake and the tsunami come from the same fault motion. For this purpose, a series of numerical simulations were carried out. First of all, the tsunami-induced flow speed, direction and tsunami height were determined by conducting a two-dimensional (2D) tsunami propagation analysis in a large area, and then these parameters obtained from tsunami propagation analysis were employed in a detailed three-dimensional (3D) fluid analysis to obtain tsunami-induced wave impact force. Furthermore, a fiber model, which is commonly used in the seismic analysis of steel bridge structures, was adopted considering material and geometric nonlinearity. The residual stresses induced by the earthquake were applied into the numerical model during the following finite element analysis as the initial stress state, in which the acquired tsunami forces were input to a whole bridge system. Based on the analytical results, it can be seen that the foundation sliding was not observed although the caisson foundation came floating slightly, and the damage arising during the earthquake did not expand when the tsunami-induced wave impact is applied to the steel bridge. It is concluded that the influence of tsunami-induced wave force is relatively small for such steel bridge with large caisson foundations. Besides, a numerical procedure is proposed for quantitatively estimating the accumulative damage induced by the earthquake and the tsunami in the whole bridge system with large caisson foundations.

• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.892-901
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• 2020

We used a numerical method to estimate the hydrodynamic maneuvering derivatives for the heave-pitch coupling motion of an underwater glider. It is very important to assess the hydrodynamic maneuvering characteristics of a specific hull form of an underwater glider in the initial design stages. Although model tests are the best way to obtain the derivatives, numerical methods such as the Reynolds-averaged Navier-Stokes (RANS) method are used to save time and cost. The RANS method is widely used to estimate the maneuvering performance of surface-piercing marine vehicles, such as tankers and container ships. However, it is rarely applied to evaluate the maneuvering performance of underwater vehicles such as gliders. This paper presents numerical studies for typical experiments such as static drift and Planar Motion Mechanism (PMM) to estimate the hydrodynamic maneuvering derivatives for a Ray-type Underwater Glider (RUG). A validation study was first performed on a manta-type Unmanned Undersea Vehicle (UUV), and the Computational Fluid Dynamics (CFD) results were compared with a model test that was conducted at the Circular Water Channel (CWC) in Korea Maritime and Ocean University. Two different RANS solvers were used (Star-CCM+ and OpenFOAM), and the results were compared. The RUG's derivatives with both static drift and dynamic PMM (pure heave and pure pitch) are presented.

• Journal of the Korean Society of Safety
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• v.35 no.4
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• pp.84-91
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• 2020

The Korean nuclear industry developed the SPACE (Safety and Performance Analysis Code for nuclear power plants) code and this code adpots two-phase flows, two-fluid, three-field models which are comprised of gas, continuous liquid and droplet fields and has a capability to simulate three-dimensional model. According to the revised law by the Nuclear Safety and Security Commission (NSSC) in Korea, the multiple failure accidents that must be considered for accident management plan of nuclear power plant was determined based on the lessons learned from the Fukushima accident. Generally, to improve the reliability of the calculation results of a safety analysis code, verification work for separate and integral effect experiments is required. In this reason, the goal of this work is to verify calculation capability of SPACE code for multiple failure accident. For this purpose, it was selected the experiment which was conducted to simulate a Multiple Steam Generator Tube Rupture(MSGTR) accident with Passive Auxiliary Feedwater System(PAFS) operation by Korea Atomic Energy Research Institute (KAERI) and focused that the comparison between the experiment results and code calculation results to verify the performance of the SPACE code. The MSGR accident has a unique feature of the penetration of the barrier between the Reactor Coolant System (RCS) and the secondary system resulting from multiple failure of steam generator U-tubes. The PAFS is one of the advanced safety features with passive cooling system to replace a conventional active auxiliary feedwater system. This system is passively capable of condensing steam generated in steam generator and feeding the condensed water to the steam generator by gravity. As the results of overall system transient response using SPACE code showed similar trends with the experimental results such as the system pressure, mass flow rate, and collapsed water level in component. In conclusion, it could be concluded that the SPACE code has sufficient capability to simulate a MSGTR accident.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.6
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• pp.347-355
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• 2016

This study presents a Lattice Boltzmann Method (LBM) coupled with a momentum-exchange approach/fictitious domain (MEA/FD) method for the simulation of particle suspensions. The method combines the advantages of the LB and the FD methods by using two unrelated meshes, namely, a Eulerian mesh for the flow domain and a Lagrangian mesh for the solid domain. The rigid body conditions are enforced by the momentum-exchange scheme in which the desired value of velocity is imposed directly in the particle inner domain by introducing a pseudo body force to satisfy the constraint of rigid body motion, which is the key idea of a fictitious domain (FD) method. The LB-MEA/FD method has been validated by simulating two different cases, and the results have been compared with those through other methods. The numerical evidence illustrated the capability and robustness of the present method for simulating particle suspensions.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.8
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• pp.739-747
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• 2010

Numerical calculations are carried out for evaluating the natural convection induced by the temperature difference between a hot inner circular cylinder and a cold outer square enclosure. A two-dimensional solution for unsteady natural convection is obtained by using the finite volume method to model an inner circular cylinder that was designed by using the immersed boundary method (IBM) for a Rayleigh number of $10^7$. In this study, we investigate the effect of the location ($\delta$) of the inner cylinder, which is located along the vertical central axis of the outer enclosure, on the heat transfer and fluid flow. The natural convection changes from unsteady to steady state depending on the $\delta$. The two critical lower bound and upper bound positions are ${\delta}_{C,L}$ = 0.05 and ${\delta}_{C,U}$ = 0.18, respectively. Within these defined bounds, the thermal and flow fields are in steady state.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.11
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• pp.3253-3259
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• 2009

In this study, a computer simulation has been performed for the refrigeration cycle using mixed refrigerants in order to decrease the process stream temperature to $-20^{\circ}C$. Refrigerant supply temperature was assumed to be $-30^{\circ}C$ considering the temperature difference as $10^{\circ}C$ with process stream. Peng-Robinson equation of state model was selected for the computer simulation. A new alpha function proposed by Twu et al was used for an accurate prediction of pure component vapor pressure experimental data. One fluid mixing rules were used for the estimation of mixture vapor-liquid equilibria calculations. A commercial process simulator, PRO/II with PROVISION was utilized for the simulation of the overall refrigeration process. In order to minimize the compressor power consumption, we have optimized the two-stage compression system by varying the first stage compressor outlet pressure. Finally, we could obtain the minimum total power 755.7kW at the first stage compressor outlet pressure, 6 bar.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.17 no.4
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• pp.386-395
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• 2005

With the development of a living standard, the importance of indoor air conditioning system in all kinds of buildings and vehicles has increased. A lot of researches on energy losses in a duct and various kinds of flow pattern in branches or junctions have been carried out over many years, because the primary object of a duct system used in HVAC is to provide equal flow rate in the interior of each room by minimizing pressure drop. In this study, to get equal flow distribution in each branch, a blockage is applied to the rectangular duct system. The flow analysis for flow distribution of a rectangular duct with two branches was performed by CFD. By using SIMPLE algorithm and finite volume method, flow analysis is performed in the case of 3-D, incompressible, turbulent flow. Also, the standard $k-{\varepsilon}$ model and wall function method were used for analysis of turbulent fluid flow. The distribution diagrams of static pressure, velocity vector, turbulent energy and kinetic energy in accordance with variation of Reynolds number and blockages location in a rectangular duct show that flow distribution at duct outlets is improved by a blockage. In this rectangular duct system, mean velocity and flow rate distribution in two branch outlets are nearly constant regardless of variation of Reynolds number, and a flow pattern of the internal duct has a same tendency as well.

• Journal of Biomedical Engineering Research
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• v.19 no.4
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• pp.369-377
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• 1998

This paper describes the results of investigations comparing the relative in vitro responses of different signal processing algorithms for laser Doppler flowmetry(LDF) using self-mixing effect of laser diode(LD). A versatile laser Doppler system is described which enabled complex signal processing to be implemented relatively simply using digital analysis. The flexibility of the system allowed a variety of processing algorithms to be studied by simply characterising the algorithm of interest under software control using a personal computer. Two in-vitro physical models are also presented which was used to maintain reproducible fluid flows Flows of particles were studied in two physical models using a 780nm laser diode source. The results show that frequency weighted algorithms(first and second moments, rate to zero moment) are responsive to particle velocity more than concentration, whereas non-weighted algorithm (zero moment responds to concentration and velocity.