• Journal of Korean Society of Forest Science
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• v.101 no.1
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• pp.28-35
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• 2012

Rainfall is widely recognized as a major landslide-triggering factor. Most of the latest landslides that occurred in South Korea were caused by short-duration heavy rainfall. However, the relationship between rainfall characteristics and landslide occurrence is poorly understood. To examine the effect of rainfall on landslide occurrence, cumulative rainfall(mm) and rainfall intensity(mm/hr) of serial rain and antecedent rainfall(mm) were analyzed for 18 landslide events that occurred in the southern and central regions of South Korea in June and July 2011. It was found that all of these landslides occurred by heavy rainfall for one or three days, with the rainfall intensity exceeding 30 mm/hr or with a cumulative rainfall of 200 mm. These plotted data are beyond the landslide warning criteria of Korea Forest Service and the critical line of landslide occurrence for Gyeongnam Province. It was also found that the time to landslide occurrence after rainfall start(T) was shortened with the increasing average rainfall intensity(ARI), showing an exponential-decay curve, and this relation can be expressed as "T = $94.569{\cdot}exp$($-0.068{\cdot}ARI$)($R^2$=0.64, p<0.001)". The findings in this study may provide important evidences for the landslide forecasting guidance service of Korea Forest Service as well as essential data for the establishment of non-structural measures such as a warning and evacuation system in the face of sediment disasters.

• Korean Journal of Plant Resources
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• v.32 no.6
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• pp.714-722
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• 2019

Oxidative DNA damage negatively affects humans and the research is currently ongoing to find ways to reduce oxidative stress. Oxidative stress has been identified as a key factor in triggering various diseases. Thus, its alleviation is important for human health. Broussonetia kazinoki (B. kazinoki) has been used in traditional Korean medicine as a dermatological therapy to treat burns, pruritus, and acne. B. kazinoki is generally segregated into peeled root (PR), root bark (RB), peeled stem (PS), and stem bark (SB). To assess these components for their antioxidant activity and protection against DNA damage, their ethyl acetate fractions were examined by 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging assay. As a result of confirming the expression of factors involved in attenuating DNA damage, the protective effect of SB on oxidative stress suppressed the expression of p-p53 and γ-H2AX. Additionally, the levels of p53 and H2AX mRNA were significantly downregulated. In conclusion, these results indicated that the SB component of B. kazinoki had the potential to be used as an effective natural antioxidant compared to the other parts of the plant.

• The Journal of Engineering Geology
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• v.14 no.2
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• pp.211-222
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• 2004

In this study, a probabilistic prediction model for debris flow occurrence was developed using a logistic regression analysis. The model can be applicable to metamorphic rocks and granite area. order to develop the prediction model, detailed field survey and laboratory soil tests were conducted both in the northern and the southern Gyeonggi province and in Sangju, Gyeongbuk province, Korea. The seven landslide triggering factors were selected by a logistic regression analysis as well as several basic statistical analyses. The seven factors consist of two topographic factors and five geological and geotechnical factors. The model assigns a weight value to each selected factor. The verification results reveal that the model has 90.74% of prediction accuracy. Therefore, it is possible to predict landslide occurrence in a probabilistic and quantitative manner.

• ALGAE
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• v.25 no.3
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• pp.133-140
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• 2010

Using chlorophyll fluorescence, the vertical migration of benthic diatoms responding to light intensity and affected by sediment grain size was studied. Minimal fluorescence ($F_o$) of surface sediment was measured by imaging pulse amplitude modulated (Imaging-PAM) fluorometer, and used to monitor diatom biomass variation in surface sediments. The test diatoms, Amphora coffeaeformis (C. Agardh) K$\ddot{u}$tzing and Cylindrotheca closterium (Ehrenberg) Reimann & Lewin, migrated to the sediment surface under irradiance from 50 to 500 ${\mu}mol$ photons $m^{-2}s^{-1}$. However, the diatoms exhibited no evident increase of surface biomass under dark conditions, and even showed slightly decrease of surface biomass under irradiances over 1,000 ${\mu}mol$ photons $m^{-2}s^{-1}$. The light intensity inducing the maximum surface migration of A. coffeaeformis was 100 ${\mu}mol$ photons $m^{-2}s^{-1}$, while the light intensity producing the same effect for C. closterium was 250 ${\mu}mol$ photons $m^{-2}s^{-1}$. C. closterium showed higher motility than A. coffeaeformis. Faster diatom surfacing was observed in larger grain size sediments (125-335 ${\mu}m$) than smaller ones (63-125 ${\mu}m$). This study confirmed the significant influence of light as a main triggering factor behind migration, indicated the distinct effect of different sediment grain size, and highlighted the species-specific migratory ability.

• Molecular & Cellular Toxicology
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• v.4 no.2
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• pp.144-149
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• 2008

Despite versatile activity (cancericidal, antimicrobial, hypoxia inducible factor (HIF) inhibition, immune deactivation of DNA bis-intercalation agent, echinomycin, its specific mechanism has been elusive. Of these novel mechanisms, we reported that using human colon cancer cells (HT-29), apoptotic machinery induced by echinomycin might be dependent of caspase-3 pathway. Despite a partial enlightenment of prototypic signal path triggered by echinomycin, the role of Bcl-2 in this signaling pathway is unclear. To address this issue, we explored whether or not echinomycin would overcome the anti-apoptotic impact of Bcl-2 in HT-29 cells by the controlled Bcl-2 overexpression. Prior to this proof, we confirmed that echinomycin induces mitochondrial depolarization, then triggering the mitochondrial pathway of apoptosis with an involvement of upstream cas-pases-3. Transiently transfection with inactive Bax-DNA failed to prevent echinomycin-induced apoptosis in HT-29 cells. To dissect the role of Bcl-2 in echinomycin-induced apoptosis, HT-29 cells were transiently transfected with Bcl-2 DNA for overexpression and then treated with echinomycin for 24h. Combined analyses of DNA fragmentation and flow cytometric analysis clearly verified that echinomycin-induced apoptosis was drastically attenuated by Bcl-2 overexpression, whereas a control vector rarely affected echinomycin-induced apoptosis. Collectively, these data verify that Bcl-2 regulates echinomycin-induced apoptosis in HT-29 cells. To my knowledge, this is the first evidence that of diverse, structured minor groove binders (MGB), the prototypic echinomycin might control the apoptotic signaling via Bcl-2-mitochondrial pathway.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.4
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• pp.659-665
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• 2016

The limit equilibrium method (LEM) is commonly used for slope design and stability analysis because it is easy to simulate slope and requires short calculating time. However, LEM cannot adequately simulate ploughing failure in a footwall slope with a joint set dipping parallel with slope, e.g. bedding joint set. This study performed parametric study to analyze the influence factors on ploughing failure using UDEC which is a commercial two-dimensional DEM (Distinct Element Method)-based numerical program. The influence of joint structure and properties on stability of a footwall slope against ploughing failure was investigated, and the factor of safety was estimated using the shear strength reduction method. It was found that the stability of footwall slope against ploughing failure strongly relies on dip angle of conjugate joint, and the critical bedding joint spacing and the critical length of slab triggering ploughing failure are also affected by dip angle of conjugate joint. The results obtained from this study can be used for effective slope design and construction including reinforcement.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.6
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• pp.413-417
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• 2010

To understand the function of edges in perception of moving objects, we defined four questions to answer. Is the focus point in visual motion detection of a moving object: (1) the body or the edge of the object, (2) the leading edge or trailing edge of the object, (3) different in scotopic, mesopic and photopic luminance levels, or (4) different for colored objects? We measured the Optomotor Response (OMR) and Edge Triggering Response (ETR) of goldfish. We used a square and sine wave patterns with black and red stripes and a square wave pattern with black and grey stripes to generate OMR's and ETR's in the goldfish. When we used black and red stripes, the black leading edges stimulated an ETR under scotopic conditions, red leading edges stimulated an ETR under photopic conditions, and both black and red leading edges stimulated an ETR under mesopic luminance levels. For black and gray stripes, only black leading edges stimulated an ETR in all three light illumination levels. We observed less OMR and ETR results using the sine wave pattern compared to using the square wave pattern. From these results, we deduced that the goldfish tend to prefer tracking the leading edge of the pattern. The goldfish can also detect the color of the moving pattern under photopic luminance conditions. We decided that ETR is an intriguing factor in OMR, and is suitable as a method of behavioral measurement in visual system research.

• Clinical and Experimental Reproductive Medicine
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• v.32 no.4
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• pp.337-346
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• 2005

Objective: The oligosaccharide moieties of glycoproteins and proteoglycans have a vital function in blastocyst differentiation. Concanavalin (ConA), a lectin, is known to bind on the preimplantation embryos, especially on blastocyst. In this study, we investigated whether ConA can modulate the trophoblast development and about the regulating mediator. Also, we investigated whether expansion is enough for hatching procession of the mouse blastocyst. Method: Embryos were collected at 72 h post hCG injection and chemicals were treated after 24 h (96 hr post hCG injection). ConA or calcium ionophore A23187 were exposed to blastocyst and than analysis the developmental process for 48 hr. Intracellular free-$Ca^{2+}$ concentration in trophectoderm was measured with confocal laser microscope after exposing to ConA or calcium ionophore A23187. ConA-pretreated blastocyst exposed to the calcium ionophore A23187 and then analyzed the developmental process. Otherwise ouabain was treated to the blastocyst to block the $Na^+/K^+$-ATPase activity. Results: In contrast to the control blastocyst, the ConA-exposed blastocysts developed beyond the expansion stage with significantly high rate (90.4%) at 12 h post administration. ConA induced an increase the intracellular $Ca^{2+}$ concentration in trophectoderm. Calcium ionophore A23187 also stimulated expansion of blastocyst. Most of the control blastocysts developed to the hatching stage at 144 h post hCG injection. However, strongly 65% of the ConA-exposed embryos were arrested at expanded stage at same time point. The developmental progression rates to hatching stage of both ConA- and calcium ionophore A23187-expose blastocysts were significantly lower than that of the control. However ConA-pretreated embryos developed to the hatching stage like control embryos. Ouabain showed a tendency to delayed the progress to expansion stage but did not inhibit the development to the hatching stage. Conclusion: ConA-mediated expansion is the result of the increase of intracellular free-calcium in blastocyst stage embryo. It is suspected that expansion of the blasocyst is a essential indirect factor in hatching and the calcium may triggering the cellular mechanisms for the both expansion and hatching progression.

• Journal of Applied Biological Chemistry
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• v.49 no.4
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• pp.148-153
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• 2006

While the underlying molecular mechanism remains to be elucidated, recent studies suggest that polar auxin transport is a key controlling factor in triggering differential growth responses to gravity. Identification of regulatory components in auxin-mediated differential cell expansion would improve our understanding of the gravitropic response. In this study, we identify a mutant designated aux1-like(later changed to aux1), an allele of the aux1 mutant that exhibits a severely disrupted root gravitropic response, but no defects in developmental processes. In Arabidopsis, AUX1 encodes an auxin influx carrier. Since in-depth characterization of the gravitropic response caused by mutations in this gene has been performed previously, we focused on identifying the downstream genes that were differentially expressed compared to wild-type plants. Consistent with the mutant phenotype, the transcription of the auxin-responsive genes IAA17 and GH3 were altered in aux1 plants treated with IAA, 2, 4-D and NAA. In addition, we identified two expansin genes EXP10 and EXPL3 that exhibited different expression in wild-type and mutant plants.

• Korean Journal of Applied Biomechanics
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• v.30 no.1
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• pp.7-16
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• 2020

Objective: It is to find factors related to stability through analysis of plantar pressure factors according to the level of instability when performing Snatch. Method: Foot pressure analysis was performed while 10 weightlifters performed 80% of the highest level of Snatch, and motion was classified and analyzed in 3 grades according to the level of instability. Results: First, in Bad Motion, the movement distance of the pressure center in the direction of ML and AP was larger significantly in Phase 2. Second, in Phase 2, the number of zero-crossing in the AP direction was larger statistically significantly in Good Motion. Third, in the bad motion in Phase 3, the number of zero-crossing in the ML direction showed a significantly larger value. Fourth, in Phase 4, it was found that the more stable the lock out motion, the greater the activity of foot controlling in the left and right directions. Fifth, Phase 3, the greater the Maximum/Mean foot pressure value, the more stable the pulling action. Sixth, in Phase 2, the foot pressure was concentrated with a wide distribution in the midfoot and rearfoot. Seventh, the triggering number of the forefoot region was small in the last pull phase. Eighth, the number of triggers in the toe area was significantly higher during Good Motion in Phase 4. Conclusion: Summarizing the factors of instability in Snatch, there was no significant difference in Phase 1 for each condition. In order to enhance the stability in Phase 2, the sensory control ability in the AP direction is required, and focusing the foot pressing motion with a wide distribution in the middle and rear parts increases the instability. In Phase 3, it was found that the more unstable, the more sensory control activity was performed in the ML direction, the stronger the forefoot pressing action should be performed for a stable Snatch. In Phase 4, It is important that the feet sensory control activity in ML directions and the control ability of the toes in order to have stable Lock out motion.