• Title/Summary/Keyword: triggering factor

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Inter-Factor Determinants of Return Reversal Effect with Dynamic Bayesian Network Analysis: Empirical Evidence from Pakistan

  • HAQUE, Abdul;RAO, Marriam;QAMAR, Muhammad Ali Jibran
    • The Journal of Asian Finance, Economics and Business
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    • v.9 no.3
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    • pp.203-215
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    • 2022
  • Bayesian Networks are multivariate probabilistic factor graphs that are used to assess underlying factor relationships. From January 2005 to December 2018, the study examines how Dynamic Bayesian Networks can be utilized to estimate portfolio risk and return as well as determine inter-factor relationships among reversal profit-generating components in Pakistan's emerging market (PSX). The goal of this article is to uncover the factors that cause reversal profits in the Pakistani stock market. In visual form, Bayesian networks can generate causal and inferential probabilistic relationships. Investors might update their stock return values in the network simultaneously with fresh market information, resulting in a dynamic shift in portfolio risk distribution across the networks. The findings show that investments in low net profit margin, low investment, and high volatility-based designed portfolios yield the biggest dynamical reversal profits. The main triggering aspects related to generation reversal profits in the Pakistan market, in the long run, are net profit margin, market risk premium, investment, size, and volatility factor. Investors should invest in and build portfolios with small companies that have a low price-to-earnings ratio, small earnings per share, and minimal volatility, according to the most likely explanation.

The Clinical Significance of Serum Vascular Endothelial Growth Factor Levels Measured at Ovulation Triggering Day In Intrauterine Insemination Cycles (자궁강 내 인공수정을 위한 과배란유도 시 hCG 투여 일에 측정한 혈중 Vascular Endothelial Growth Factor의 임상적 의의)

  • Kim, Hyun-Jun;Jee, Byung-Chul;Suh, Chang-Suk;Kim, Seok-Hyun;Choi, Young-Min;Kim, Jung-Gu;Moon, Shin-Yong
    • Clinical and Experimental Reproductive Medicine
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    • v.34 no.1
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    • pp.33-39
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    • 2007
  • Objective: The objective of this study was to investigate whether serum levels of vascular endothelial growth factor (VEGF) measured at ovulation triggering day reflect ovarian response in intrauterine insemination (IUI) cycles. Methods: Forty-nine fertile women who undergoing superovulation and IUI were included. Superovulation was performed using clomiphene citrate (100 mg/d on day 3$\sim$7) in combination with human menopausal gonadotropin (150 IU every other day starting on day 5). Serum samples were obtained on the day of hCG administration and the levels of VEGF-A and estradiol were measured. The numbers of mature follicle $\geq$17 mm in diameter were also counted. Results: Serum VEGF-A levels did not correlate with the numbers of mature follicle count nor serum estradiol levels. Serum estradiol level was positively associated with mature follicle count. Serum VEGF-A levels tended to be lower in women with mature follicle count less than three or women with more than five. Conclusion: Our results indicate that serum VEGF-A levels do not have an association with superovulation outcome in IUI cycles. However, a tendency of lower VEGF-A level in poor and high responder suggests that those with extreme response to superovulation may be related with abnormal angiogenesis. Further studies should be warranted in larger populations.

Proteases and Protease Inhibitors Produced in Streptomycetes and Their Roles in Morphological Differentiation

  • KIM DAE WI;KANG SUNG GYUN;KIM IN SEOP;LEE BYONG KYU;RHO YONG TAIK;LEE KYE JOON
    • Journal of Microbiology and Biotechnology
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    • v.16 no.1
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    • pp.5-14
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    • 2006
  • Streptomycetes are Gram-positive microorganisms producing secondary metabolites through unique physiological differentiation [4]. The microbes show unusual morphological differentiation to form substrate mycelia, aerial mycelia, and arthrospores on solid medium [19]. Substrate mycelium growth is sustaining with sufficient nutrients in the culture medium. The concentration of a specific individual substrate in the culture environment is the most important extracellular factor allowing vegetative mycelia growth, where extracellular hydrolytic enzymes participate in the utilization of waterinsoluble substrates. However, with starvation of nutrients in the culture medium, the vegetative mycelia differentiate to aerial mycelia and spores. It has been considered that shiftdown of essential nutrients for mycelia growth is the most important factor triggering morphological and physiological differentiation in Streptomyces spp. Since proteineous macromolecule compounds are the major cellular components, these are faced to endogenously metabolize following a severe depletion of nitrogen source in culture nutrients (Fig. 1). Various proteases were identified of which production was specifically related with the phase of mycelium growth and also morphological differentiation. The involvement of proteases and protease inhibitor is reviewed as a factor explaining the mycelium differentiation in Streptomyces spp.

Effects of Stress-Induced Sterile Inflammation on the Development of Depression (스트레스로 유발된 무균 염증이 우울증 발생에 미치는 영향)

  • Mi Kyoung Seo;Jung Goo Lee;Dae-Hyun Seog;Se Young Pyo;Won Hee Lee;Sung Woo Park
    • Journal of Life Science
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    • v.33 no.12
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    • pp.1062-1073
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    • 2023
  • Although depression is a common psychiatric disorder that negatively affects individuals and societies, its exact pathogenesis is not well understood. Stress is a major risk factor for depression and is known to increase susceptibility by triggering inflammation. Indeed, many preclinical and clinical studies have suggested a strong link between depression and inflammation. Depression is associated with increased levels of pro-inflammatory cytokines, such as interleukin (IL-)1β, IL-6, IL-12, tumor necrosis factor-α, and interferon-γ, and decreased levels of the anti-inflammatory IL-4, IL-10, and transforming growth factor-β. Administering pro-inflammatory cytokines causes depression-like behaviors in rodents. Conversely, administering anti-inflammatory drugs appears to ameliorate depressive symptoms. Although the importance of inflammation as a mediator of depression has been demonstrated, the mechanisms by which inflammation is activated in depression remain unclear. To address this issue, recent studies have focused on the importance of stress-induced sterile inflammation. Sterile inflammation refers to the activation of inflammatory processes due to physical and/or psychological stress in the absence of pathogens. Stress promotes the release of endogenous factors known as damage-associated molecular patterns (DAMPs), thereby triggering sterile inflammation. In turn, DAMPs are recognized by pattern recognition receptors, leading to the production of pro-inflammatory cytokines. Here, we review the role of DAMPs in depression based on preclinical and clinical evidence on the dysregulation of sterile inflammation.

Clinical Characteristics of Failure to Thrive in Infant and Toddler: Organic vs. Nonorganic

  • Yoo, Suk Dong;Hwang, Eun-Ha;Lee, Yeoun Joo;Park, Jae Hong
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.16 no.4
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    • pp.261-268
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    • 2013
  • Purpose: To investigate the clinical characteristics and outcomes among infants and toddlers with failure to thrive (FTT). Methods: This retrospective study was done with 123 patients who had visited Pusan National University Children's Hospital during their first two years of life and had received an FTT diagnosis. We compared the clinical characteristics of the patients based on the causes of their FTT and their ages at the time of first hospital visit. We investigated triggering factors, feeding practices, and outcomes in 25 patients with nonorganic FTT (NOFTT). Results: Eighty cases (65.0%) were NOFTT. The gestational ages, birth weights, and weights at the first visits were significantly lower in patients with organic FTT (OFTT) (p<0.05). Infants who had first visited the clinic at age <6 months had the least z-score. The percentage of patients with severe weight decline was higher in OFTT than in NOFTT (60.0% vs. 17.3%). The z-scores at the follow-up visits were improved after treatment in both of the groups. Preceding infection was the most common triggering factor of NOFTT and persecutory feeding as abnormal behavior of caregiver was observed in 22 cases (88.0%). After treatment with feeding method modification, all patients with NOFTT showed normal growth. Conclusion: Weight decline is more severe in OFTT patients and in younger patients at the first visit. Infants with FTT can attain normal weight gain growth by treating organic diseases and supplying proper nutrition in OFTT, and by correcting abnormal dietary behavior of caregiver in NOFTT.

A Study On The Three-Phase Bridge Type Converter Furnished Diode-Bridge Circuits (Diode-Bridge방식 3상 Thyristor순역전력 변환장치의 개발에 관한 연구)

  • Cheul U Kim
    • 전기의세계
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    • v.23 no.4
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    • pp.60-65
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    • 1974
  • This paper is to study on the pilot work of bi-directional S.C.R. power converter adopted by the method of diode-bridge type circuit. This apparatus acts as a converter when it is used in convering 3-phase a.c source to d.c output, and it can be used as an inverter which recovering surplus d.c power to a.c source when d.c load become active to cause the induced voltage higher than the presetted point of d.c output voltage. At the same time, its d.c voltage varies continuously in the presetted range of positive and/or negative polarity. As a result of test, the AC/DC bi-directional power converter represents maximum converting efficiency of 91% and power factor of 0.98. Furthermore, this converter also can be applied as a cycleconverter by varying the period of gate triggering signal.

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Acute Onset of Intracerebral Hemorrhage due to Autonomic Dysreflexia

  • Eker, Amber;Yigitoglu, Pembe Hare;Ipekdal, H. Ilker;Tosun, Aliye
    • Journal of Korean Neurosurgical Society
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    • v.55 no.5
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    • pp.277-279
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    • 2014
  • Autonomic dysreflexia is a clinical emergency syndrome of uncontrolled sympathetic output that can occur in patients who have a history of spinal cord injury. Despite its frequency in spinal cord injury patients, central nervous system complications are very rare. We report a man with traumatic high level incomplete spinal cord injury who suffered hypertensive right thalamic hemorrhage secondary to an episode of autonomic dysreflexia. Prompt recognition and removal of the triggering factor, the suprapubic catheter obstruction which led to hypertensive attack, the patient had a favorable functional outcome after the resorption of the hematoma and effective rehabilitation programme.

A Study on factor of Mathematical Abilities Lowering of small middle schools in the rural community (농촌지역 소규모 중학교 수학학력 저하의 변인 연구)

  • 최택영;신용국
    • Journal of the Korean School Mathematics Society
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    • v.5 no.1
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    • pp.1-11
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    • 2002
  • The purpose of this study is to find out if there are meaningful differences between small rural middle schools and nearby urban ones In the mathematical diagnostic evaluation. It also says how to improve students' scholastic abilities, making up a question of attitudes towards math to know the mathematical abilities lowering cause in small rural middle schools. Findings are, 1. Students must recognize that studying math is essential and be interested in it. 2. The mathematical confidence is needed. 3. A strong will of studying math hard is important. 4. Students must have a motivational triggering, while solving math problems and then checking answers for themselves. 5. Backward countries' humanistic and social environmental factors should be overcome. In conclusion, we expect the mathematical abilities improvement, making students remove the mathematical abilities lowering cause after having a learning experience suitable for the rural community instead of the negative attitudes towards math.

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Estimation of Saturation Depth by Reflecting Water-redistribution Phenomena at a Natural Slope (수분 재분포를 고려한 강우 침투 시 자연 사면에서의 포화깊이 산정)

  • Kim, Woong-Ku;Chang, Pyoung-Wuck;Cha, Kyung-Seob
    • Journal of The Korean Society of Agricultural Engineers
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    • v.48 no.1
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    • pp.71-79
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    • 2006
  • In Korea, most landslides occurred during the rainy season and had a shallow failure plane parallel to the slope. For these types of rainfall-induced failures, the most important factor triggering slope unstability is decrease in the matric suction of unsaturated soils with increasing saturation depth by rainfall infiltration. The saturation depth was readily estimated using modified Green-Ampt model proposed by Chu et al. (Chu Model) at present. But Chu Model involves some problems for application, because water-redistribution phenomena were not effected. So the modified Chu Model (MCGAM) which reflect water redistribution phono mens was developed. The results showed that the MCGAM had a better agreement with measured volumetric water contents than existing Chu Model.

Saturation Depth and Slope Stability considering Unsteady Rainfall in Natural Slope (비정상강우를 적용한 자연사면에서의 포화깊이 산정 및 사면안정성 평가)

  • Kim, Sang-Hoon;Kim, Seong-Pil;Son, Young-Hwan;Heo, Joon;Chang, Pyoung-Wuck
    • Journal of The Korean Society of Agricultural Engineers
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    • v.49 no.1
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    • pp.57-65
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    • 2007
  • In Korea, most landslides occurr during the rainy season and have shallow failure planes parallel to the slope. For these types of rainfall-induced failures, the most important factor triggering slope unstability is decrease in the matric suction of unsaturated soils with increasing saturation depth by rainfall infiltration. For this reason, estimation of cumulative infiltration has a significance. In this study, infiltration rate and cumulative infiltration are estimated by using both Mein & Larson model based on Green-Ampt infiltration model and using modified Mein & Larson model to which unsteady rainfall is applied. According to the results, the modified model is more reasonable than Mein & Larson method itself in estimation of infiltration rate and saturation depth because of considering real pending condition.