• Maxillofacial Plastic and Reconstructive Surgery
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• 제41권
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• pp.3.1-3.9
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• 2019

Background: The infratemporal fossa (ITF) is an anatomical lateral skull base space composed by the zygoma, temporal, and the greater wing of the sphenoid bone. Due to its difficult approach, surgical intervention at the ITF has remained a heavy burden to surgeons. The aim of this article is to review basic skull base approaches and ITF structures and to avoid severe complications based on the accurate surgical knowledge. Methods: A search of the recent literature using MEDLINE (PubMed), Embase, Cochrane Library, and other online tools was executed using the following keyword combinations: infratemporal fossa, subtemporal fossa, transzygomatic approach, orbitozygomatic approach, transmaxillary approach, facial translocation approach, midface degloving, zygomatico-transmandibular approach, and lateral skull base. Aside from our Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) trial, there have been very few randomized controlled trials. The search data for this review are summarized based on the authors' diverse clinical experiences. Results: We divided our results based on representative skull base approaches and the anatomy of the ITF. Basic approaches to the ITF include endoscopic endonasal, transzygomatic, orbitozygomatic, zygomatico-transmandibular, transmaxillary, facial translocation, and the midfacial degloving approach. The borders and inner structures of the ITF (with basic lateral skull base dissection schemes) are summarized, and the modified zygomatico-transmandibular approach (ZTMA) is described in detail. Conclusions: An anatomical basic knowledge would be required for the appropriate management of the ITF pathology for diverse specialized doctors, including maxillofacial, plastic, and vascular surgeons. The ITF approach, in conjunction with the application of microsurgical techniques and improved perioperative care, has permitted significant advances and successful curative outcomes for patients having malignancy in ITF.

• 대한교통학회지
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• 제32권5호
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• pp.462-472
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• 2014

RPSD는 기존 PSD의 설치 운영 효율성 및 철도 이용자 안전관리 제고를 위해 개발되어 대구도시철도 2호선 문양역에서 2013년 3월부터 시범적으로 운영되어 왔다. 본 연구는 RPSD의 운영 시 비정상적인 상황에 관한 장애보고서와 로그파일을 이용하여 장애발생 내역의 분석 및 시범사업동안의 RPSD 기술 안전성에 대한 신뢰성 평가를 실시하였다. 또한 철도 이용자의 안전시설에 대한 인식과 주관적 감성을 반영하기 위해 RPSD 이용자의 감성평가 결과를 분석하여 요약하였다. 이러한 시스템 신뢰성과 감성평가를 기반으로 RPSD 시스템의 기술 안전성과 구조물 디자인 등에 대한 대중의 만족도 조사를 실시하여 기능 및 감성설계 개선점을 제시하였다.

• Journal of Biosystems Engineering
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• 제38권4호
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• pp.287-294
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• 2013

Purpose: Greenhouses for a protected horticulture covered with a plastic or glass are easy to have weakness in a heat loss by deterioration, damage, poor construction, and so on. To grasp the vulnerable points of heat loss of the greenhouses is important for heating energy saving. In this study, an on-site heat loss audit and energy consulting system were developed for an efficient energy usage of a greenhouse. Method: Developed system was mounted with infrared thermal and visual cameras to grasp the heat loss from the greenhouse quickly and exactly, and a trial calculation program of heating load of greenhouse to provide farmers with the information of heating energy usage. Results: Developed system could print out the reports about the locations and causes of the heat losses and improvement methods made up by an operator. The mounted trial calculation program could print out the information of the period heating load and fuel cost according to the conditions of greenhouse and cultivation. The program also mounted the databases of the information on the 13 horticultural energy saving technologies developed by the Korea Rural Development Administration and simple economic analysis sub-program to predict the payback period of the technologies. Conclusion: The developed system was expected to be used as the basic equipment for an instructors of district Agricultural Technology and Extension Centers to conduct the energy consulting service for the farmers within the jurisdiction.

• 한국약용작물학회지
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• 제23권3호
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• pp.190-197
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• 2015

In this study, we tried to offer the possibility of White Hibiscus syriacus L. (WHS) flower extracts as a preventive and improving agent of osteoporosis that bone mass reduction is induced by an decrease of osteoblast involved in bone formation and increase of bone resorption by osteoclast activity. As a results, it was found to have antioxidant activity and contain a flavonoid contents ($47.74 mg/g) of the WHS flower. There was cytotoxicity at more than $250{\mu}g/m{\ell}$ concentration of WHS flower extract of RANKL-induced osteoclast in RAW264.7. There were no significant inhibited TRAP activity in the WHS leaf and stem. However, it was confirmed that it is significantly inhibited the differentiation activity of osteoclasts in 50 and $100{\mu}g/m{\ell}$ concentration of cells of stability levels of only WHS flower extracts (p < 0.01). The WHS flower prominently inhibited RANKL-induced osteoclast differentiation activity by decreased calcitonin receptor and TRAP mRNA (p < 0.01). These results indicate that of osteoclasts differentiation activity is inhibited by protection of oxidative stress due to the antioxidant activity of the WHS flower. Therefore, suggesting the WHS flower may be a presents the possibility as a preventive and therapeutic agents for osteoporosis.

• 한국지능시스템학회논문지
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• 제22권3호
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• pp.273-280
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• 2012

의료 환경의 변화로 인해 개인의 건강관리를 위한 유비쿼터스 헬스케어(u-헬스케어) 서비스 및 시스템에 관한 관심이 증대되고 있다. u-헬스케어 시스템은 기본적으로 생체신호를 측정하기 위한 개인건강기기, 무선통신을 통해 개인건강기기로부터 전송되는 정보를 수집하는 정보수집기, 그리고 정보수집기로부터 전송되는 개인건강정보를 저장하고 관리하기 위한 건강정보시스템 등과 같은 다양한 기기와 시스템이 결합된 복합적인 환경으로 구성되어 있다. 이러한 기기 및 시스템 사이의 상호운용성을 위해 국제적으로 IEEE 11073이나 HL7과 같은 건강정보 교환 표준들이 발표되었으나, 국내에서는 이러한 표준을 적용한 u-헬스케어 시스템의 개발하여 실제 환경에 적용한 연구가 많지 않다. 따라서 본 논문에서는 건강정보 교환을 위한 국제 표준에 기반하여 혈당, 혈압, 체성분과 같은 건강정보를 관리할 수 있는 u-헬스케어 시스템을 개발한다. 또한 경북대학교병원 내분비계 질환자 대상의 임상시험을 통해 개발한 시스템의 안정성을 검증하고, 운영 과정에서의 문제점 및 개선 방안을 찾는다.

• 한국약용작물학회지
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• 제23권2호
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• pp.117-124
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• 2015

Osteoporosis induces a bone mineral density loss due to imbalance of bone homeostasis that is achieved by osteoclasts (which are involved in bone resorption) and osteoblasts (which are involved in bone formation). Thus, this study was performed to evaluate the effects of hot water extract of the Achyranthes bidentata Blume (ABB) and Panax ginseng (Gin) on osteoclast and osteoblast differentiation. In this study, there was no cytotoxicity by ABB, 50 and $100{\mu}g/ml$ of Gin significantly decreased cell viability of RANKL-induced osteoclast in RAW264.7 cell (p < 0.01). But, it was $50{\mu}g/ml$ of ABB and Gin mixtures increased due to protective action of ABB. Furthermore, Gin contained groups (Gin, ABB and Gin mixtures) were inhibitory effects on osteoclast differentiation and bone resorption, and increased in osteoblast differentiation activity. Gin clearly inhibited RANKL-induced osteoclast differentiation by decreased calcitonin and TRAP (p < 0.01). Also, these extracts significantly increased calcium accumulation formation of osteoblastic differentiation reagents-induced osteoblast in MC3T3-E1 cell (p < 0.05). These results suggest that ABB and Gin mixtures may be a potential as drug for the treatment of osteoporosis.

• 한국컴퓨터정보학회논문지
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• 제15권1호
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• pp.23-30
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• 2010

의료 분야의 정보화와 다양화로 인해 한의학 분야에서도 지능화된 서비스를 제공해주는 온톨로지 기반의 지능형 의료 시스템에 관한 연구가 진행되고 있다. 지능형 의료 시스템은 온톨로지를 이용하여 복잡한 의료지식 및 개인의 의료정보등을구조화함으로써진단을과학화시키고보다나은의료서비스를제공하게해준다. 본 논문에서는 온톨로지를 이용하여 기본적인 의학 데이터, 진단 시 발생되는 임상데이터, 개인의 신체정보와 같은 세 가지 지식을 표현하여 온톨로지로 구축함으로써 개인 맞춤형 진단을 내리는데 중요한 데이터로 활용한다. 특히, 한의학진단에서는 환자 개인의 병증과 체질 등에 따라 상이한 진단 및 처방이 내려질 수 있기 때문에 개개인의 신체정보 및 질병 정보를 이용하여 사용자의 상황에 맞는 맞춤형의 진단 및 처방 서비스를 제공 해주는 지능형 진단보조시스템이 유용하다. 따라서 본 논문에서는 환자 개개인에게 맞춤형의 진단 서비스를 제공하기 위한 방법으로 개인의 신체정보 및 질병정보를 이용하여 한의학 온톨로지를 구축하고, 추론을 통해 진단을 내리는 한의학 진단보조시스템을 구현하였다.

• 대한한방내과학회지
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• 제39권6호
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• pp.1105-1115
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• 2018

Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords 'Aphasia', 'Oriental medicine', 'Stroke' 'Cerebral infarction', 'Cerebral hemorrhage', and 'Clinic', we searched domestic databases, including "NDSL (National Discovery for Science Leaders)", "Korean Traditional Knowledge Portal", "OASIS (Oriental Medicine Advanced Searching Integrated System)", and "RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject "Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in 'Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.

• 대한한방내과학회지
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• 제45권1호
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• pp.1-10
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• 2024

Objectives: This study investigated the pattern identification (PI) and clinical index of Parkinson's disease (PD) for personalized diagnosis and treatment. Methods: This prospective observational multi-center study recruited 100 patients diagnosed with PD from two Korean medicine hospitals. To cluster new subtypes of PD, items on a PI questionnaire (heat and cold, deficiency and excess, visceral PI) were evaluated along with pulse and tongue analysis. Gait analysis was performed and blood and feces molecular signature changes were assessed to explore biomarkers for new subtypes. In addition, unified PD rating scale II and III scores and the European quality of life 5-dimension questionnaire were assessed. Results: The clinical index obtained in this study analyzed the frequency statistics and hierarchical clustering analysis to classify new subtypes based on PI. Moreover, the biomarkers and current status of herbal medicine treatment were analyzed using the new subtypes. The results provide comprehensive data to investigate new subtypes and subtype-based biomarkers for the personalized diagnosis and treatment of PD patients. Ethical approval was obtained from the medical ethics committees of the two Korean medicine hospitals. All amendments to the research protocol were submitted and approved. Conclusions: An objective and standardized diagnostic tool is needed for the personalized treatment of PD by traditional Korean medicine. Therefore, we developed a clinical index as the basis for the PI clinical evaluation of PD. Trial Registration: This trial is registered with the Clinical Research Information Service (CRIS) (KCT0008677)

• 한국육종학회지
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• 제43권6호
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• pp.587-590
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• 2011

'윤흑'은 내병성이 개선되고 다수성인 품종을 육성하기 위하여 다수성 계통인 유성깨에 고품질 내병성인 건흑깨를 1995년에 인공교배하여 육성한 품종으로 6년간의 계통육성을 통하여 유망계통을 선발하고 2002년부터 3년간 생산력 검정시험을 거친 후 전국 9개의 지역에서 3년간의 적응시험을 통하여 선발된 것으로 '윤흑'은 수량성이 높고 내도복성이면서 검정색 착색도가 진하고 레놀렌산 함량이 많은 고품질 품종이다. 또한 우리나라 기후조건에서 단작 및 이모작형의 광지역 적응품종으로 검정깨의 특산단지화 등 고품질화 및 차별화 가능성이 큰 품종이다.