• Radiation Oncology Journal
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• 제37권2호
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• pp.73-81
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• 2019

Purpose: There is sparse literature on treatment outcomes research on resectable oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to measure the treatment outcomes, explore the failure patterns, and identify the potential clinicopathological prognostic factors affecting treatment outcomes for resectable OTSCC. Materials and Methods: It is a retrospective analysis of 202 patients with resectable OTSCC who underwent upfront primary surgical resection followed by adjuvant radiotherapy with or without concurrent chemotherapy if indicated. Results: The median follow-up was 35.2 months (range, 1.2 to 99.9 months). The median duration of locoregional control (LRC) was 84.9 months (95% confidence interval, 67.3-102.4). The 3- and 5-year LRC rate was 68.5% and 58.3%, respectively. Multivariate analysis showed that increasing pT stage, increasing pN stage, and the presence of extracapsular extension (ECE) were significantly associated with poorer LRC. The median duration of overall survival (OS) was not reached at the time of analysis. The 3- and 5-year OS rate was 70.5% and 66.6%, respectively. Multivariate analysis showed that increasing pT stage and the presence of ECE were significantly associated with a poorer OS. Conclusion: Locoregional failure remains the main cause of treatment failure in resectable OTSCC. There is scope to further improve prognosis considering modest LRC and OS. Pathological T-stage, N-stage, and ECE are strong prognostic factors. Further research is required to confirm whether adjuvant therapy adds to treatment outcomes in cases with lymphovascular invasion, perineural invasion, and depth of invasion, and help clinicians tailoring adjuvant therapy.

• Journal of Chest Surgery
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• 제28권9호
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• pp.842-846
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• 1995

Recently, the trauma patients have been markedly increasing due to the vast increase of traffic accident, industrial disaster, incidental accident and violence. The authors have analysed of 22 patients of thoracic injuries combined with abdominal injuries and summarized as follows. The ratio of male to female was 3.4:1 and their age distribution was from 5 years to 68 years and mean age was 34.4 years. The etiologies of injury were traffic accident, stab wound, fall down and violence. Associated injuries were fractures, bowel perforation, kidney rupture, head injury, liver laceration, spleen rupture and so forth. The modes of treatment were closed thoracostomy, repair of diaphragm, ruptured bowel repair, explo-thoracotomy, splenectomy, hepatic lobectomy in this order of frequency. The postoperative complications were atelectasis, wound infection, pneumonia, empyema, acute renal failure, respiratory failure and bleeding. The mortality rate was 13.6% [3/22 and the causes of death were respiratory failure 1 case, acute renal failure 1 case and hypovolemic shock 1 case.

• Journal of Chest Surgery
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• 제23권2호
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• pp.275-284
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• 1990

A serious problem after cardiovascular surgery known as Multiple Organ Failure[MOF] whereby several vital organs successively demonstrate dysfunction in spite of intensive postoperative treatment has recently arisen. We have made a retrospective study of the clinical records of 137 patients who underwent cardiovascular surgery during past two years [1987-1988]. Fourteen patients [10%] developed multi-organ failure postoperatively with the results of seven death [50%]. In fatal group, preoperative poor cardiac function [Cardiac Index<2.0L/min/m2] was considered important prognostic factor and infection 5 disseminated intravascular coagulation complicating gastrointestinal bleeding were the leading cause of death. In conclusion, evaluation of multiple factors concerning multi-organ failure demonstrates preoperative poor functional preservation of vital organs is the main factor. So early diagnosis k management for each of the failing organs & prevention of infection are mandatory of the treatment of these critically ill patients.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.244-249
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• 2008

It happened a failure on special bolt which supported main landing gear actuator up-lock rod of 00 aircraft. Fracture was occurred at end of center drilled hole and thread machined on bolt. Metallographic, fractographic, and other characteristics of embrittlement analysis and experiments carried out on the failed bolt to find out the reason. Bolt surface was cadmium electroplated(EP) to give lubrication and provide excellent corrosion resistance. Resultly, Bolt was failed due to cadmium embrittlement occurred during baking treatment as well as center drilled hole. for the failure that are relevant to failure analysis and prevention. For their successful functional application, cadmium EP bolts require proper and adequate baking treatment after electroplating, and is complete with no center drilled hole

• 열처리공학회지
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• 제11권4호
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• pp.283-294
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• 1998

This paper presents an investigation why Mn-steel high pressure gas cylinders have been failed in service. The fractured cylinders have been collected to identify the reason of the failure using various methods. The undamaged, new cylinder has also been tested for the base data. We examined the chemical compositions and fracture facets as well as the mechanical properties of the vessels. The microstructural observations of the fractured regions of the cylinder did not indicate the noticeable defects which might cause the failure. The experiments of cylinders on the compositinal and mechanical tests showed that the cylinder was in good shape according the standards of gas pressure vessel. The morphological analysis of the fracture surfaces concluded that the origin of the failure was the local weak segments induced by the external impact to the cylinder, which result in a sudden, fast fracture.

• 열처리공학회지
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• 제30권5호
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• pp.207-214
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• 2017

In this study, failure behavior of piercing plug for seamless tube manufacturing process was studied. Three different kinds of passed piercing plugs (10, 90, 215 times) were prepared. The shape deformation of the passed piercing plugs was observed by 3D coordinate measuring machine, and the oxidized layer on the surface of piercing plug was observed by optical microscopy. The length reduction of piercing plug presented at 215 times passed plug. It was found that the oxidized layer consisted of outer scale, inner scale and internal oxidation layers, and the inner scale layer had vertical cracks, and interfaces had horizontal cracks. We proposed the failure mechanism of piercing plug during seamless tube manufacturing process based on the formation of vertical and horizontal crack.

• 한국군사과학기술학회지
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• 제13권5호
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• pp.769-774
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• 2010

It happened fractures on special bolt which supported main landing gear actuator up-lock rod of aircraft. Cracks were initiated mainly from the center hole and the external thread of the special bolt. To find out failure root causes, metallographic, fractographic analyses as well as test work were carried out. From the fractographic study by SEM work, fracture occurred by a brittle intergranular type failure. The fracture could be occurred primarily by solid-metal-induced embrittlement due to cadmium embrittler penetrated into the flaw existed after machining work for center hole and thread on the bolt during baking treatment processing to eliminate hydrogen. For its successful application, cadmium EP bolts require proper and adequate baking treatment after electroplating, and make no more drilled center hole on the bolt to prevent same failure.

• The Korean journal of internal medicine
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• 제34권1호
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• pp.11-43
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• 2019

Heart failure (HF) is an important cardiovascular disease because of its increasing prevalence, significant morbidity, high mortality, and rapidly expanding health care cost. The number of HF patients is increasing worldwide, and Korea is no exception. There have been marked advances in definition, diagnostic modalities, and treatment of HF over the past four decades. There is continuing effort to improve risk stratification of HF using biomarkers, imaging and genetic testing. Newly developed medications and devices for HF have been widely adopted in clinical practice. Furthermore, definitive treatment for end-stage heart failure including left ventricular assist device and heart transplantation are rapidly evolving as well. This review summarizes the current state-of-the-art management for HF and the emerging diagnostic and therapeutic modalities to improve the outcome of HF patients.

• 대한환경공학회지
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• 제35권11호
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• pp.763-768
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• 2013

본 논문에서는 하수처리장 주요 장비 고장밀도함수를 기반으로 시스템 가용성 평가가 수행되었다. 프로세스 구성과 구성요소의 고장률에 따른 시스템 가용성 및 위험요소 분석에 초점을 맞추고 있다. 하수처리장 시스템 가용성 분석을 위하여 기자재 분류와 해당기자재의 고장확률밀도함수를 정립하였다. 가용성 평가 과정의 불확실성의 해소를 위하여 몬테카를로 시뮬레이션 기법과 이벤트기법을 도입하였다. 하수처리장 시스템 가용성은 구성장비가 직렬연결 상태인 경우에 50.4%로 평가되었으며, 장비별 보조시스템이 추가 적용된 경우 80.1% 이상으로 증가하였다. 슬러지 탈수 및 농축 공정의 시스템 오작동은 전체 시스템 오작동의 77% 이상에 해당하고 있어 주 위험 요인으로 평가되었다.

• Journal of Chest Surgery
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• 제19권4호
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• pp.584-594
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• 1986

Despite the multivariate improvements in tissue treatment, material, and design of prosthetic heart valves in recent years, numerous complications that may lead to valve dysfunction remain a constant threat after valve replacement. Most common indications for prosthetic valve failure are primary valve failure, infective endocarditis, paravalvular leakage, and thromboembolism. From 1977 to 1986, 15 patients underwent reoperation for prosthetic valve failure in 278 cases of valve surgery. The etiology of prosthetic valve failure were primary valve failure in 12 patients [80 %], infective endocarditis in 2 patients [13.3 %], and a paravalvular leakage [6.7 %]. The average durations of implantation were 45.5 months; 53.9 months in primary valve failure, 16 months in infective endocarditis, and 4 months in paravalvular leakage. The rate of valve failure was high under age of 30 [11/15]. Calcifications and collagen disruption of prosthesis were main cause of primary valve failure in macro- & micropathology. Prosthesis used in reoperation were 5 tissue valves and 10 mechanical valves. Operative mortality were 13.3 % [2/15], due to intractable endocarditis and ventricular arrhythmia.