• The Korean Journal of Physiology and Pharmacology
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• v.7 no.1
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• pp.9-14
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• 2003

Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing of cancer cells and reduce drug resistance by inhibiting DNA repair pathways that tumor cells rely on to escape chemotherapy. There are a number of key human DNA repair pathways which depend on multimeric polypeptide activities. For example, Ku heterodimer regulatory DNA binding subunits (Ku70/Ku80) on binding to double strand DNA breaks (DSBs) are able to interact with 470-kDa DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and are essential for DNA-dependent protein kinase (DNA-PK) activity. It has been known that DNA-PK is an important factor for DNA repair and also is a sensor-transmitting damage signal to downstream targets, leading to cell cycles arrest. Our ultimate goal is to develop a treatment of breast tumors by targeting proteins involved in damage-signaling pathway and/or DNA repair. This would greatly facilitate tumor cell cytotoxic activity and programmed cell death through DNA damaging drug treatment. Therefore, we designed a domain of Ku80 mutants that binds to Ku70 but not DNA end binding activity and used the peptide in co-therapy strategy to see whether the targeted inhibition of DNA-PK activity sensitized breast cancer cells to irradiation or chemotherapy drug. We observed that the synthesized peptide (HNI-38) prevented DNA-PKcs from binding to Ku70/Ku80, thus resulting in inactivation of DNA-PK activity. Consequently, the peptide treated cells exhibited poor to no DNA repair, and became highly sensitive to IR or chemotherapy drugs, and the growth of breast cancer cells was inhibited. Additionally, the results obtained in the present study also support the physiological role of resistance of cancer cells to IR or chemotherapy.

• Korean journal of communication and information
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• v.44
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• pp.44-75
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• 2008

The candle rally against the import of American beef which lasted for a long time was full of various types of social movement. That is, new media including mobile phone, Internet, Internet cafes played an important role in mobilizing people around the rally. Thus, this research focuses on the meaning and effect of these kinds of movement. In particular, it analyzed the possibility of real time broadcasting through the Internet as civic journalism, which received much attention in the rally. For this, this research used case study and interview as main research method. Case study focused on Internet cafes based on the media coverage of the rally. Interviews were conducted with workers at OhmyTV, Color TV, and 615TV. These workers at progressive media emphasized on the scene coverage as the advantage of real time delivery. Transmitting many citizens' voices was another advantage. It is expected that personal media and progressive media which try to show the scent as it is will play an important role in the future journalism with the expansion of Wibro.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.10
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• pp.42-51
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• 1998

This paper suggests a congestion control scheme for CL (ConnectionLess) overlay network using the feedback loops between CL user and CL server, between CL servers, and between end-to-end CL users, and the header translation table of CL server. The CL overlay network for CBDS(Connectionless Broadhand Data Service) defined by ITU-T((International Telecommunication Union-Telecommunication) consists of CL servers which route frames and links which connect between CL user and CL server or between CL servers. In the CL overlay network, two kinds of congestion, CL link congestion and CL server congestion, may occur. We considered the schemes to solve the congestion. link-by-link method[18] has used the ABR feedback loops of ATM layer between CL user and CL server or between CL servers, and the congestion table using header translation table of CL server. As in congestion of output virtual channel this method has an effect on all the traffic transmitting through the link, then it has an effect on the traffic that has not caused the congestion. As a result, the link utilization of output virtual channel that does not bring the congestion and outputs the traffic is decreased. To overcome this drawback of link-by-link, we proposed the hybrid method that are using the ABR feedback loops of link-by-link method, the feedback loop between CL users in end-to-end, the congestion table using and the header translation table. This scheme deals with teh congestion immediately by link-by-link loops and the header translation table, and then regulates the sending rate of CL user that causes the congestion by end-to-end loop.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.6
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• pp.32-40
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• 2015

In this paper, the optimum antenna placement is analyzed by considering the interference between airborne antennas mounted on the unmanned aerial vehicle(UAV). The analysis is implemented by selecting the antennas that the distance and operational frequency band between airborne antennas is close to each other among the omni-directional antennas. The analyzed antennas are the control datalink, TCAS(Traffic Collision & Avoidance System), IFF(Identification Friend or Foe), GPS(Global Positioning System), and RALT(Radar ALTimeter) antennas. There are three steps for the optimum antenna placement analysis. The first step is selecting the antenna position having the optimum properties by monitoring the variation of radiation pattern and return loss by the fuselage of UAV after selecting the initial antenna position considering the antenna use, type, and radiation pattern. The second one is analyzing the interference strength between airborne antennas considering the coupling between airborne antennas, spurious of transmitting antenna, and minimum receiving level of receiving antenna. In case of generating the interference, the antenna position without interference is selected by analyzing the minimum separation distance without interference. The last one is confirming the measure to reject the frequency interference by the frequency separation analysis between airborne antennas in case that the intereference is not rejected by the additional distance separation between airborne antennas. This analysis procedure can be efficiently used to select the optimum antenna placement without interference by predicting the interference between airborne antennas in the development stage.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.9 no.4
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• pp.515-525
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• 1998

In this paper, for both transmission and reception with single antenna system of satellite communication, dual-frequency antennas which operate simultaneously at 12.5 GHz and at 14.25 GHz are designed, constructed and measured. Also by using dual feeding structure, the problems of single-fed dual-frequency antenna such as the separation of transmitting and receiving signals and single polarization, are solved. Microstrip patch as a radiation element of dual-fed dual-frequency antenna has width and length which are the resonance lengths of the corresponding frequencies for transmission and reception, respectively. The effects of the feed line on the other frequency feeding are minimized with the optimal matching scheme for the feed lines. For solving the space problems of dual-fed two-dimensional array antennas, microstrip-line and coaxial probe feedings are used for each frequency and a two-dimensional $2\times2$ array antenna was designed and measured their characteristics. The experimental results show that errors of resonance frequencies are less than 1.44%, the return losses are less than -21 dB and the isolations between two feeding ports are less than -21 dB. The characteristics of radiation patterns of dual frequency microstrip antenna are measured and evaluated. The directivities, sidelobe levels and cross polarizations are also measured and compared with the simulations. The results show some errors due to the misalignment of coaxial probe feeding.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.7
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• pp.716-725
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• 2002

In this paper, we showed the applicability of power symmetric MSSI(Mid-Span Spectral Inversion) to the long-haul WDM system with the channel interference due to FWM(Four Wave Mixing). And we showed the degree of performance improvement. We used 1 dB EOP(Eye-Opening Penalty) criterion so as to evaluate the degree of compensation dependent on the variation of chirp parameter of optical pulse for the various input power in high speed tansmission system. And we evaluated the maximum input power of channel be able to be the signal to crosstalk noise (SNR) above 20 dB in the transmission link with the channel interference due to FWM. Consequently the proposed MSSI compensation method is capable to transmitting the total 68 WDM channels simultaneously with a 0.4 nm channel spacing and 5.3 dBm maximum input power in a 10 Gbps transmission link. Therefore the proposed power symmetric MSSI compensation method may be very useful for the implementation of long-haul wideband WDM transmission systems with relatively high power and improved performance.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.11
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• pp.1307-1314
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• 2012

To reduce the effects of clutters with subsurface inhomogenities in ground-penetrating radar(GPR) images, an eigenimage based signal-processing technique is presented. If the conventional eigenimage filtering technique is applied to B-scan images of a GPR survey, relatively homogeneous clutters such as antenna ringing, direct coupling between transmitting and receiving antennas, and soil-surface reflection, can be removed sufficiently. However, since random clutters of subsurface inhomogenities still remain in the images, target signals are distorted and obscured by the clutters. According to a comparison of the eigenimage filtering results, there is different coherency between subsurface clutters and target signals. To reinforce the pixels with high coherency and reduce the pixels with low coherency, the pixel-by-pixel geometric-mean process after the eigenimage filtering is proposed here. For the validity of the proposed approach, GPR survey for detection of a metal target in a randomly inhomogeneous soil is numerically simulated by using a random media generation technique and the finite-difference time-domain(FDTD) method. And the proposed signal processing is applied to the B-scan data of the GPR survey. We show that the proposed approach provides sufficient enhancement of target signals as well as remarkable reduction of subsurface inhomogeneous clutters in comparison with the conventional eigenimage filtering.

• Journal of Radiation Protection and Research
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• v.40 no.4
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• pp.202-210
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• 2015

The low dose radiation is done for a long period, thus researchers have to know the exact dose distribution for the irradiated mouse. This research has been conducted in order to find out methods in transmitting an exact dose to mouse in a mouse irradiation experiment carried out using $^{137}Cs$ irradiation equipment installed in the DIRAMS (Dongnam Institution of Radiological & Medical Sciences) research center. We developed a single mouse housing cage and shelf with adjustable geometric factors such as distance and angle from collimator. The measurement of irradiated dose showed a maximal 42% difference of absorbed dose from the desired dose in the conventional irradiation system, whereas only 6% difference of the absorbed dose was measured in the self-developed mouse apartment system. In addition, multi mice housing showed much difference of the absorbed dose in between head and body, compared to single mouse housing in the conventional irradiation system. This research may allow further research about biological effect assessment for the low dose irradiation using the self-developed mouse apartment to provide more exact doses which it tries to transmit, and to have more reliability for the biological analysis results.

• Journal of IKEEE
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• v.24 no.1
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• pp.25-32
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• 2020

In this paper, we propose an image generator for OLED panel test that can compensate for color coordinates and luminance by using panel defect inspection and optical measurement while displaying images on OLED panel. The proposed image generator consists of two processes: the image generation process and the process of compensating color coordinates and luminance using optical measurement. In the image generating process, the panel is set to receive the panel information to drive the panel, and the image is output by adjusting the output setting of the image generator according to the panel information. The output form of the image is configured by digital RGB method. The pattern generation algorithm inside the image generator outputs color and gray image data by transmitting color data to a 24-bit data line based on a synchronization signal according to the resolution of the panel. The process of compensating color coordinates and luminance using optical measurement outputs an image to an OLED panel in an image generator, and compensates for a portion where color coordinates and luminance data measured by an optical module differ from reference data. To evaluate the accuracy of the image generator for the OLED panel test proposed in this paper, Xilinx's Spartan 6 series XC6SLX25-FG484 FPGA was used and the design tool was ISE 14.5. The output of the image generation process was confirmed that the target setting value and the simulation result value for the digital RGB output using the oscilloscope matched. Compensating the color coordinates and luminance using optical measurements showed accuracy within the error rate suggested by the panel manufacturer.

• Convergence Security Journal
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• v.15 no.7
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• pp.111-118
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• 2015

The violent crime has increased dramatically in our society. This is because our society has to change quickly. Strong police force, but this is not enough to solve the crime. And there are a lot of police to investigate the situation difficult to go out to the crime scene. So inevitably increase in the risk of crime. Researchers have conducted a number of studies to solve this problem. However, the proposed study how realistic are many points still lacking. herefore, we to take advantage of smartphones and high-speed Internet access technology to provide security services using the push service for rapid identification and crime situation in this study. Therefore, we would like to provide rapid service to identify criminal security situation using smart-phone app and push services on the high speed internet environments. The proposed system is to record the voice information received from the smart phone near the user presses the hot key is set in advance in real-time, and stores the audio information stored in the LBS information to the server through the authentication procedure. And the server uses the stored voice data and LBS Push service information to inform their families. We have completed the design of the proposed system. And it has implemented a smart phone app, the user authentication server. And using the state in which the push service from the authentication server by transmitting a message to a user to inform a family. But more must examine whether the proposed research is relevant in future studies.