• Journal of The Korean Astronomical Society
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• v.47 no.6
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• pp.319-325
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• 2014

We map two molecular clouds located in the exact anticenter region emitting in the (J = 1-0) transition of $^{12}CO$ and $^{13}CO$ using the 3-mm SIS mixer receiver on the 14-m radio telescope at Taeduk Radio Astronomy Observatory. The target clouds with anomalous velocities of $V_{LSR}{\sim}-20km\;s^{-1}$ are distinguished from other clouds in this direction. In addition, they are located in the interarm region between the Orion Arm and the Perseus Arm. Sizes of the clouds are estimated to be about 8.6 and 10.8 pc, respectively. The total mass is estimated to be about $4{\times}10^3$ $M_{\odot}$ using CO luminosity of the clouds. Several cores are detected, but no sign of star formation is found according to the IRAS point sources. Their larger linewidths, anomalous velocities, and their location at the interarm region make these clouds more distinguished, though their physical properties are similar to the dark clouds in the solar neighborhood in terms of mass and size.

• Biomedical Science Letters
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• v.23 no.3
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• pp.272-276
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• 2017

HOX genes are transcription factors that play important roles in body patterning and cell fate specification during normal development. In previous study, we found aberrant overexpression of HOXB5 in breast cancer tissues and cell lines, and demonstrated that HOXB5 is important in regulation of cell proliferation, tamoxifen resistance, and invasiveness through the epithelial-mesenchymal transition (EMT). Although the relationship between HOXB5 and phenotypic changes in MCF7 breast cancer cells has been studied, the molecular function of HOXB5 as a transcription factor remains unclear. IL-6 has been reported to be involved in not only inflammation but also cancer progression, which is characterized by the increase of growth speed and invasiveness of tumor cells. In this study, we selected Interleukin-6 (IL-6) as HOXB5 putative downstream target gene and discovered that HOXB5 transcriptionally up-regulated the expression of IL-6 in HOXB5 overexpressing MCF7 cells. The upstream region (~1.2 kb) of IL-6 promoter turned out to contain several putative HOX consensus binding sites. Chromatin immunoprecipitation assay confirmed that HOXB5 directly binds to the promoter region of IL-6 and positively regulated the expression of IL-6. These data all together, indicate that HOXB5 promotes IL-6 transcription by actively binding to the putative binding sites located in the upstream region of IL-6, which enable to increase its promoter activity in MCF7 breast cancer cells.

• 한국가시화정보학회:학술대회논문집
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• 2007.11a
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• pp.134-137
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• 2007

The temporal evolution of wake behind a circular cylinder oscillating rotationally with a relatively high forcing frequency has been investigated experimentally using a dynamic PIV technique. Experiments were carried out with varying the frequency ratio $F_R\;(=f_f/f_n)$ in the range from 0.0 (stationary) to 1.6 at oscillation amplitude of ${\theta}_A=30^{\circ}$ and Reynolds number of $Re=4.14{\times}10^3$. Depending on the forcing condition ($F_R$), the flow was divided into three regimes; non-lock-on ($F_R=0.4$), transition ($F_R=0.8$, 1.6) and lock-on regimes ($F_R=1.0$) with markedly different flow structure in the near-wake region behind the cylinder. When the frequency ratio was less than 1.0 ($F_R{\le}1.0$), the rotational oscillatory motion of the cylinder decreased the length of the vortex formation region and enhanced the mutual interaction between large-scale vortices across the wake centerline. The entrainment of ambient fluid seemed to play an important role in controlling the near-wake flow and shear-layer instability. However, the flow characteristics changed markedly beyond the lock-on flow regime ($F_R=1.0$) due to high-frequency forcing. At $F_R=1.6$, the mutual interactions between the vortices shed from both sides of the cylinder were not so strong. Thereby, the flow entrainment and momentum transfer into the wake center region were reduced. In addition, the size of the large-scale vortices decreased since the lateral extent of the wake was suppressed.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.5
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• pp.477-485
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• 2012

Fluid flow and heat transfer in horizontal ducts are strongly coupled with large changes in thermodynamic and transport properties near the critical region as well as the gravity force. Numerical analysis has been carried out to investigate convective heat transfer in horizontal rectangular ducts for water near the thermodynamic critical point. Convective heat transfer characteristics, including velocity, temperature, and the properties as well as local heat transfer coefficients along the ducts are compared with the effect of proximity on the critical point. When there is flow acceleration because of a density decrease, convective heat transfer characteristics in the ducts show transition behavior between liquid-like and gas-like phases. There is a large variation in the local heat transfer coefficient distributions at the top, side, and bottom surfaces, and close to the pseudocritical temperature, a peak in the heat transfer coefficient distribution resulting from improved turbulent transport is observed. The Nusselt number distribution depends on pressure and duct aspect ratio, while the Nusselt number peak rapidly increases as the pressure approaches the critical pressure. The predicted Nusselt number is also compared with other heat transfer correlations.

• 한국가시화정보학회:학술대회논문집
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• 2001.12a
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• pp.86-99
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• 2001

Vortex lock-on or resonance in the flow behind a circular cylinder is investigated from a time-resolved PIV when a single frequency oscillation is superimposed on the mean incident velocity. Measurements are made of the $K\acute{a}rm\acute{a}n$ and streamwise vortices in the wake-transition regime at the Reynolds number 360. Streamwise vortices at the lock-on and natural shedding states are observed, as well as the changes in the wake region with the change of the shedding frequency of lock-on state. When lock-on occurs, the vortex shedding frequency is found to be half the oscillation frequency as expected from previous experiments. At the lock-on state, the $K\acute{a}rm\acute{a}n$ vortices are observed to be more disordered by the increased strength and spanwise wavelength of the streamwise vortices, which leads to a strong three-dimensional motion. Recirculation and vortex formation region at the lock-on state is reduced as the oscillating frequency is increased. By comparing the Reynolds stresses at the lock-on and natural shedding states, $\bar{u'u'}\;and \;\bar{u'u'}$ at the lock-on state are concentrated on the shear layer around the cylinder. The $\bar{u'u'}\;at\;f_o/f_n=2.0$ has a large value near the centerline, compared with that of other cases. Considering the traces of maximum of u', in the wake region near the cylinder, wake width at the lock-on state is wider than that at the natural shedding state.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.29.2-29.2
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• 2010

The Extreme ultraviolet Imaging Spectrometer (EIS) on board Hinode provide us with excellent imaging spectroscopic data with very good spatial and spectral resolutions, which can be used for detecting Doppler flows in transition region and coronal lines as well as diagnosing plasma properties such as temperature, density, and non-thermal velocity. In this study we have made an EUV-imaging spectroscopic study of the source region of a partial halo coronal mass ejection (CME) that occurred on 2007 July 9 in NOAA 10961. Dopplergrams are obtained before and after the CME eruption using 12 EIS spectral lines (Log T= 4.9~7.2). Major results are summarized as follows. First, it is noted that either red shifts disappeared or blue shifts newly appeared for all spectral lines lower than Log T =6.0. Second, there were significant intensity increases for all wavelengths. Third, there were no significant variations in non-thermal motions for all wavelengths. We found one interesting bright point that newly appeared after the CME eruption. We discuss the implication on the results in terms of the CME eruption.

• International Journal of Fluid Machinery and Systems
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• v.10 no.3
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• pp.287-295
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• 2017

The most detrimental pressure pulsations in high-head pump-turbines is caused by the rotor-stator interaction (RSI) between the guide vanes and runner blades. When the pump-turbine operates in the S-shaped region of the characteristic curves, the deteriorative flow structures may significantly strengthen RSI, causing larger pressure pulsations and stronger vibration with an increased risk of mechanical failure. CFD simulations were carried out to analyze the impacts of flow evolution on the pressure pulsations in the S-shaped region of a model pump-turbine. The results show that the reverse flow vortex structures (RFVS) at the runner inlet have regular development and transition patterns when discharge reduces from the best efficiency point (BEP). The RFVS first occur at the hub side, and then shift to the mid-span near the no-load point, which cause the strongest pressure pulsations. The locally distributed RFVS at hub side enhance the local RSI and makes the pressure fluctuations at the corresponding sections stronger than those at the rest sections along the spanwise direction. Under the condition of RFVS at the mid-span, the smaller flow rate make the smaller difference of pressure pulsation amplitudes in the spanwise direction. Moreover, the rotating stall, rotating at 35.7%-62.5% of the runner rotational frequency, make the low frequency components of pressure pulsations distribute unevenly along the circumference in the vaneless space. However, it have little influence on the distributions of high components.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.140-150
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• 2004

In this study, the effect of relative position of the blade for the fixed vane has been investigated on blade surface heat transfer. The experiments were conducted in a low speed stationary annular cascade, and heat transfer of blade was examined for six positions within a pitch. Turbine test section has one stage composed of sixteen guide vanes and blades. The chord length of the tested blade is 150 mm and the mean tip clearance of the blade having flat tip is about $2.5\%$ of the blade chord. For the detailed mass transfer measurements on the blade surfaces, a naphthalene sublimation technique was used. The inlet flow Reynolds number is fixed to $1.5{\times}10^5$. Complex heat transfer characteristics are observed on the blade surface due to various flow characteristics, such as separation bubble, relaminarization, transition to turbulence and leakage vortices. The distributions of velocity and turbulence intensity change significantly with the relative position due to the blockage effect of the blade. This causes the variation of heat transfer patterns on the blade surface. The results show that the flow near the leading edge get highly disturbed and deflected toward the either side of the blade when the blade leading edge is positioned close to the trailing edge of the vane. Therefore, separation bubble disappears on the pressure side and overall heat transfer on the relaminarization region is increased. But, due to reduced tip gap flow at the upstream region, the effect of leakage flow on the upstream region of the blade surface is weakened. Thus, the heat transfer characteristics significantly change with the blade positions.

• Nuclear Engineering and Technology
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• v.16 no.4
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• pp.181-194
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• 1984

The in-core fuel management problem was studied by use of the calculus of variations. Two functions of interest to a public power utility, the profit function and the cost function, were subjected to the constraints of criticality, the reactor turnup equations and an inequality constraint on the maximum allowable power density. The variational solution of the initial profit rate demonstrated that there are two distinct regions of the reactor, a constant power region and a minimum inventory or flat thermal flux region. The transition point between these regions is dependent on the relative importance of the profit for generating power and the interest charges for the fuel. The fuel cycle cost function was then used to optimize a three equal volume region reactor with a constant fuel enrichment. The inequality constraint on the maximum allowable power density requires that the inequality become an equality constraint at some points in the reactor. and at all times throughout the core cycle. The finite difference equations for reactor criticality and fuel burnup in conjunction with the equality constraint on power density were solved, and the method of gradients was used to locate an optimum enrichment. The results of this calculation showed that standard non-linear optimization techniques can be used to optimize a reactor when the inequality constraints are properly applied.

• Journal of the Korean Vacuum Society
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• v.7 no.s1
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• pp.15-19
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• 1998

Structural and optical properties of $In_xGa_{1-X}N$ as well as $In_{0.1}Ga_{0.9}N$/GaN single quantum we11 (SQW) grown on sapphire (0001) substrate with an based GaN using rf-plasma assisted MBE have been investigated. The quality of the InXGal.,N fdm was improved as the growth temperature increased. In PL measurements at low temperatures, the band edge emission peaks of $In_xGa_{1-X}N$ was shifted to red region as an indium cell and substrate temperature increased. For $In_{0.1}Ga_{0.9}N$/GaN SQW, the optical emission energy has blue shift about 15meV in PL peak, due to the confined energy level in the well region. And, the FWHM of the $In_{0.1}Ga_{0.9}N$/GaN SQW was larger than that of the bulk Ino,la.9N films. The broadening of FWHM can be explained either as non-uniformity of Indium composition or the potential fluctuation in the well region. Photoconductivity (PC) decay measurement reveals that the optical transition lifetimes of the SQW measured gradually increased with temperatures.