• Toxicological Research
• /
• 제30권4호
• /
• pp.261-266
• /
• 2014

Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) have been implicated in cancer development and progression. However, the effects of PAHs on carcinogenesis are still poorly understood. Here, we characterized a mouse cancer cell line BNL 1ME A. 7R.1 (1MEA) derived by transformation of non-tumorigenic liver cell line BNL CL.2 (BNL) using 3-methylcholanthrene (3MC), a carcinogenic PAH. RT-PCR and immunoblot analysis were used to determine the expression level of mRNA and proteins, respectively. To determine functionality, cell motility was assessed in vitro using a transwell migration assay. Both mRNA and protein levels of E-cadherin were significantly decreased in 1MEA cells in comparison with BNL cells. While the expression levels of mesenchymal markers and related transcription factors were enhanced in 1MEA cells, which could lead to increase in cell motility. Indeed, we found that 7-day exposure of BNL cells to 3-MC reduced the level of the adhesion molecule and epithelial marker E-cadherin and increased reciprocally the level of the mesenchymal marker vimentin in a dose-dependent manner. Taken together, these results indicate that the process of epithelial-mesenchymal transition (EMT) may be activated during premalignant transformation induced by 3-MC. A mechanism study to elucidate the relation between 3-MC exposure and EMT is underway in our laboratory.

• 대한기계학회논문집B
• /
• 제33권3호
• /
• pp.186-193
• /
• 2009

In this article, the effect of silica addition on the phase transformation characteristics of $TiO_2$ nanoparticles synthesized by using an $O_2$-enriched coflow, hydrogen, diffusion flame was investigated. TTIP(titanium tetra-isopropoxide) and TEOS(tetraethyl-orthosilicate) were used as precursors for $TiO_2$ and $SiO_2$ nanoparticles, respectively. Based on the results from TEM and XRD analysis, it is believed that the silica addition on the flame synthesis of $TiO_2$ nanoparticles reduces the particle size distribution and raises the temperature of the phase transition from anatase to rutile. But the reduced sizes of the synthesized particles due to the silica addition made the sintering and phase transformation of particles more easily.

• 대한기계학회논문집A
• /
• 제24권10호
• /
• pp.2552-2559
• /
• 2000

Most of ferrous b.c.c weld materials have martensitic transformation during rapid cooling after welding. It is well known that volume expansion due to the phase transformation could influence on the relaxation of welding residual stress. To apply this effect practically, it is necessary to establish a numerical model which is able to estimate the effect of phase transformation on residual stress relaxation quantitatively. For this purpose, the analysis is carried out in two regions, i.e., heating and cooling, because the variation of material properties following a phase transformation in cooling is different in comparison with the case in heating, even at the same temperature. The variation of material properties following phase transformation is considered by the adjustment of specific heat and thermal expansion coefficient, and the distribution of residual stress in analysis is compared with that of experiment by previous study. In this study, simplified numerical procedures considering phase transformation, which based on a commercial finite element package was established through comparing with the experimental data of residual stress distribution by other researcher. To consider the phase transformation effect on residual stress relaxation, the transition of mechanical and thermal property such as thermal expansion coefficient and specific heat capacity was found by try and error method in this analysis. In addition to, since the transformation temperature changes by the kind and control of alloying elements, the steel with many kinds of transformation temperature were selected and the effect of transformation on stress releasement was investigated by the numerical procedures considering phase transformation.

• 한국디지털건축인테리어학회논문집
• /
• 제4권1호
• /
• pp.17-25
• /
• 2004

The architectural space is the involuntary place where man lives and experiences, and as a 3 dimensional space through the continuous experience with the concept of 4th dimension of time, it provides the observers with the dramatic space imagery. These kinds of space experiences are experienced mentally and perceptively through the physical elements of inner and outer space of the architectural buildings, and this space imagery is created here by all the space composing elemensts of the building. These space experiences are caused by the changing processes of the space characteristics, and the observers perceive the changes in space characteristics. These changing processes of inner and outer space, space versus space, and unit space, which are perceived by the observer, could be called as 'the transition' and thd changes of the space characteristics as 'the transition characteristics'.

• 한국디지털건축인테리어학회논문집
• /
• 제6권1호
• /
• pp.13-23
• /
• 2006

The architectural space is the involuntary place where man lives and experiences, and as a 3 dimensional space through the continuous experience with the concept of 4th dimension of time, it provides the observers with the dramatic space imagery. These kinds of space experiences are experienced mentally and perceptively through the physical elements of inner and outer space of Museum, and this space imagery is created here by all the space composing elemensts of Museum. These space experiences are caused by the changing processes of the space characteristics, and the observers perceive the changes in space characteristics. These changing processes of inner and outer space, space versus space, and unit space, which are perceived by the observer, could be called as 'the transition' and the changes of the space characteristics as 'the transition characteristics'.

• 전자공학회논문지A
• /
• 제33A권10호
• /
• pp.195-204
• /
• 1996

We suggest a transform method form asynchronous finite state machines (AFSMs) into signal transition graphs (STGs) for speed-independent circuit synthesis. Existing works synthesize nodes in the state graph increases exponentially as the number of input and output signals increases. To overcome the problem of the exponential data complexity, we transform AFSMs into STGs so that the previous synthesis algorihtm form STGs can be applied.Accoridng to the experimental results, it turns out that our synthesis method produces more efficient circuit than the previous synthesis methods.

• Nuclear Engineering and Technology
• /
• 제56권4호
• /
• pp.1267-1276
• /
• 2024

The emerging technologies at the industrial level have deployed rapidly within the energy transition process innovations. The nuclear industry incorporates several technologies like Artificial Intelligence (AI), Machine Learning (ML), Digital Twins, High-Performance-Computing (HPC) and Quantum Computing (QC), among others. Factors identifications are explained to set up a regulatory framework in the digitalization era, providing new capabilities paths for nuclear technologies in the forthcoming years. The Analytical Network Process (ANP) integrates the quantitative-qualitative decision-making analysis to assess the implementation of different aspects in the digital transformation for the New-Energy Transition Era (NETE) with a Nuclear Power Infrastructure Development (NPID).

• 한국세라믹학회지
• /
• 제30권10호
• /
• pp.803-810
• /
• 1993

PbxZr0.4Ti0.6O3 thin films were prepared by reactive co-sputtering and annealed by RTA(Rapid Thermal Annealing) process. Effect of Pb content in PbxZr0.4Ti0.6O3 films on the phase transformation was intensively studied. It has been found out that depending on the Pb content as well as RTA temperature, crystal structure of PbxZr0.4Ti0.6O3 films change greatly. It turned out that transformation temperature for perovskite can be lowered and the width of transition temperature region was reduced by increasing Pb content in the film. And the lattice was expanded with increasing Pb content. With increasing RTA temperature, as-deposited phase was transformed into perovskite through three different transformation paths depending on Pb content. It was confirmed that activation energies for nucleation of perovskite structure are much larger than those of its growth.

• 열처리공학회지
• /
• 제3권4호
• /
• pp.41-52
• /
• 1990

This research has been performed in order to investigate the effect of prior deformation on the Ms temperature and reversed As of Fe-Ni alloy. The Ms temperature rose with increment of strain to 30% but lowered over 50%. It can be analysed that martensitic transformation was promoted by partial dislocation in low strain, but suppressed by dislocation cell structures in high strain. The As temperature was substantially increased with higher deformation to 20% but slowly above 50%. It may be caused that as the transition bands formed by deformation constrained shear strain, therefore austenitic transformation was hindered.

• 동아시아경상학회지
• /
• 제9권4호
• /
• pp.103-111
• /
• 2021

Purpose - We attempt to provide a background, a review of current development of the digital technologies and their effect on the digital transformation process, and then offer our recommendations for identifying and taking strategic actions to exploit them. More importantly, we also aim to offer important recommendations for policymakers and practitioners how to better advance the innovation system by facilitating the development of digital technologies and take advantage of improvements in digital technologies. Research design, data, and methodology - This study undertakes an extensive and critical review of the digital transformation literature and identifies several important issues with relevant practical examples of best practices in the transition to digital transformation process. Results - This paper finds that digital technologies with strong technological backing have brought technological spillovers to the economy while also generating shocks. Conclusion - To maintain a healthy and developing market order, it is necessary for governments to innovate regulatory models. This study offers several important suggestions for government regulatory innovation that we believe should help to better deploy digital transformation initiatives and enhance the efficiency and effectiveness of government regulation in contributing more to the high-quality and healthy development of the digital economy.