• Journal of the Korean Institute of Telematics and Electronics S
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• v.35S no.4
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• pp.118-127
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• 1998

In this paper, we propose a voice personality transformation method which makes one person's voice sound like another person's voice. In order to transform the voice personality, vocal tract transfer function is used as a transformation parameter. Comparing with previous methods, the proposed method can obtain high-quality transformed speech with low computational complexity. Conversion between the vocal tract transfer functions is implemented by a linear mapping based on soft clustering. In this process, mean LPC cepstrum coefficients and mean removed LPC cepstrum modeled by the low dimensional vector are used as transformation parameters. To evaluate the performance of the proposed method, mapping rules are generated from 61 Korean words uttered by two male and one female speakers. These rules are then applied to 9 sentences uttered by the same persons, and objective evaluation and subjective listening tests for the transformed speech are performed.

• BMB Reports
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• v.33 no.6
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• pp.476-482
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• 2000

In this paper, we report a new cationic lipid composed of L-lysinamide and cholesterol as a potent gene delivery vector. $3{\beta}$[L-Lysinamide-carbamoyl] cholesterol could self-assemble with plasmid DNA forming discrete lipoplexes. From atomic force microscopic images of the complexes, the size distribution was observed to range from 100 to 150 nm in diameter. The transfection efficiency of this amphiphile on different cell lines was evaluated as a micellar solution in the absence of the fusogenic helper lipid, dioleoyl phosphatidyletbanolamine (DOPE). Transfection experiments were performed as a function of charge ratio (lipid/DNA) and transfection time. Cytotoxicity and in vitro transfection efficiency of the amphiphile was demonstrated and compared with those of commercially available Lipofectin and polyethylenimine (PEI).

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.196-196
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• 2002

p16INK4a tumor suppressor gene transfer in the non-small cell lung cancer cells by transduction of recombinant adenovirus (Ad5CMV-p16) resulted in significant inhibition of cancer cell growth (Anticancer Res., 1998, 18:3257-3261). As a safety concern, we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) in human non-small cell lung cancer (A549) cells by using microarray and 2D gel electrophoresis/ MALDI-TOF.(omitted)

• Journal of Power Electronics
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• v.19 no.4
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• pp.944-955
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• 2019

In this paper, the three-level T-type neutral-point-clamped indirect matrix converter topology and the relative space vector modulation methods are introduced to improve the voltage transfer ratio and output voltage performance. The presented converter topology is based on combinations of cascaded-rectifier and three-level T-type neutral-point-clamp inverter. It can overcome the limitation of voltage transfer ratio of the conventional matrix converter and the high voltage rating of power switches of conventional matrix converter. Two SVPWM strategies for proposed converter are described in this paper to achieve the advantages features such as: sinusoidal input/output currents and three-level output voltage waveforms. Results from Psim 9.0 software simulation are provided to confirm the theoretical analysis. Hence, a laboratory prototype was implemented, and the experimental results are shown to validate the simulation results and to verify the effectiveness of the proposed topology and modulation strategies.

• The Transactions of the Korean Institute of Power Electronics
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• v.3 no.2
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• pp.118-124
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• 1998

This paper describes a relationship of a space vector PWM and a sinusoidal PWM and presents that the space vector PWM can produce linearly the output voltage to the unity MI(modulation index). At first, reference angles and holding angles are derived from expanding a Fourier series of the reference voltage waveform and then the angles are used for the inverter switching to linearize transfer characteristics of the inverter. In addition, the harmonic components of the output voltage are analyzed and on-line control is shown to be feasible by approximating in piecewise-linearization the reference and holding angles versus the MI. In V/f control of the induction motor, it is verified by the experiment that the motor current is changed smoothly for the variation of the inverter input voltage and the change of the reference voltage.

• Environmental Analysis Health and Toxicology
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• v.24 no.1
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• pp.71-77
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• 2009

Adenoviral vector(AdV) has been the most widely used viral vector for delivering an exogenous therapeutic gene to human. As of this date, more clinical trials utilize recombinant AdV to treat cancer and monogenic inherited disease as well as vaccine applications. However, the number of clinical trials had dropped markedly following the tragic death of a patient ongoing an AdV therapy for the treatment of an ornithine transcarbamylase deficiency(OTCD). This review is an attempt to provide the information on toxicity generated by AdVmediated gene transfer. It would serve as a sobering reality to researchers and clinicians exploring the use of AdV, as to the complications involved in human application.

• The Transactions of the Korean Institute of Power Electronics
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• v.7 no.4
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• pp.377-383
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• 2002

To obtain a high performance in a direct vector controlled induction machine, it is essential to obtain the current rotor flux. The accuracy of flux observers for induction machines inherently depends on parameter sensitivity. This paper proposes an analysis method for conventional flux observers using "parameter sensitivity". The "parameter sensitivity" is defined as the ratio of the percentage change in the system transfer function to the percentage change of the parameter variation. We define the ratio between real flux and estimated no as the transfer function, and analyze a parameter sensitivity of this transfer function. Practical verification is presented to conform the capabilities of the proposed analysis method.sed analysis method.

• Reproductive and Developmental Biology
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• v.32 no.1
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• pp.15-20
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• 2008

Pronuclear DNA microinjection has been the most universal method in transgenic animal production but its success rate of transgenesis in mammals are extremely low. To address this long-standing problem, we used retrovirus- and lentivirus-based vectors carrying the enhanced green fluorescent protein (EGFP) gene under the control of ubiquitously active cytomegalovirus (CMV) promoter to deliver transgenes to bovine embryos. The rate of transgenesis was evaluated by counting EGFP positive blastocysts after injection of concentrated virus stock into the perivitelline space of the bovine oocytes in metaphase II. Among two different types of lentivirus vectors derived from FIV (feline immunodeficiency virus) and HIV (human immunodeficiency virus), the former scored the higher gene transfer efficiency; almost 100% of the blastocysts developed from the oocytes infected with FIV-based vector were EGFP positive. As for the vectors derived Com HIV lentivirus, the transgenesis rate of the blastocysts was reduced to 39%.

• The Bulletin of The Korean Astronomical Society
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• v.22
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• pp.13.1-13.1
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• 1997

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1993.04a
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• pp.75-79
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• 1993

본 연구에서는 원통형 셀을 Donnell-Mushitari의 Thin Shell로 모델링하고, 유체의 거동은 Hankel 함수를 배제하고 유한차분법(Finite Difference Method)으로 모델링하여, 상태 벡터(State Vector)해석법, 전달 행렬 및 푸리 에 변환(Fourier Transform)을 사용, 무한 원통형 몰수체의 강제 진동을 해 석하였다.