• Bulletin of Food Technology
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• v.25 no.4
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• pp.308-312
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• 2012

• Journal of Ginseng Research
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• v.47 no.3
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• pp.408-419
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• 2023

Background: Ginsenoside compound K (CK), the main active metabolite in Panax ginseng, has shown good safety and bioavailability in clinical trials and exerts neuroprotective effects in cerebral ischemic stroke. However, its potential role in the prevention of cerebral ischemia/reperfusion (I/R) injury remains unclear. Our study aimed to investigate the molecular mechanism of ginsenoside CK against cerebral I/R injury. Methods: We used a combination of in vitro and in vivo models, including oxygen and glucose deprivation/reperfusion induced PC12 cell model and middle cerebral artery occlusion/reperfusion induced rat model, to mimic I/R injury. Intracellular oxygen consumption and extracellular acidification rate were analyzed by Seahorse multifunctional energy metabolism system; ATP production was detected by luciferase method. The number and size of mitochondria were analyzed by transmission electron microscopy and MitoTracker probe combined with confocal laser microscopy. The potential mechanisms of ginsenoside CK on mitochondrial dynamics and bioenergy were evaluated by RNA interference, pharmacological antagonism combined with co-immunoprecipitation analysis and phenotypic analysis. Results: Ginsenoside CK pretreatment could attenuate mitochondrial translocation of DRP1, mitophagy, mitochondrial apoptosis, and neuronal bioenergy imbalance against cerebral I/R injury in both in vitro and in vivo models. Our data also confirmed that ginsenoside CK administration could reduce the binding affinity of Mul1 and Mfn2 to inhibit the ubiquitination and degradation of Mfn2, thereby elevating the protein level of Mfn2 in cerebral I/R injury. Conclusion: These data provide evidence that ginsenoside CK may be a promising therapeutic agent against cerebral I/R injury via Mul1/Mfn2 mediated mitochondrial dynamics and bioenergy.

• Journal of Convergence Korean Medicine
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• v.6 no.1
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• pp.37-42
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• 2024

Objectives: This study aims to evaluate the clinical validity of the system by conducting a clinical study to assess the diagnostic agreement between the system and Korean medical doctors. Methods: This study was conducted from September 7, 2023, to December 7, 2023, across five Korean medicine institutions, involving 100 adult participants aged 20-64 who consented to participate. Participants first entered their symptoms into a web-based program, which utilized an AI-based algorithm to diagnose 36 types of pattern differentiation. Subsequently, Korean medical doctors conducted face-to-face diagnoses using the same 36 types. The diagnostic agreement between the system and the doctors' diagnoses was analyzed using descriptive statistical analysis, and the results were expressed as a percentage agreement. Results: Analysis of the diagnostic data from 100 participants revealed that the web-based diagnosis support system identified an average of 7.76±0.79 patterns per patient, while Korean medical doctors identified an average of 7.99±0.10 patterns per patient. The diagnostic agreement between the system and the doctors showed an average of 7.08±1.08 patterns per patient, with an overall diagnostic agreement rate of 88.57±13.31%. Conclusion: This study developed a web-based diagnosis support system for traditional Korean medicine and evaluated its clinical validity by assessing diagnostic agreement. Comparing the diagnoses of the system with those of Korean medical doctors for 100 patients, the system showed an approximately 89% agreement rate with the clinical diagnoses. The system holds potential for aiding Korean medical doctors in pattern differentiation diagnosis in clinical practice.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.19 no.40
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• pp.301-309
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• 1996

The operation of the traditional pull Kanban system in Domestic is limited because the production circumstance of the Domestic industries have the characteristics of dynamic production circumstance such as high variability of demand, frequent machine breakdown or defect, high absence or separation rates of the employees. The purpose of this study is to find the optimal Kanban system for the production circumstance of the Domestic industry. By using the computer simulation, selected models are tested for the susceptibility to the production factors and with the analysis of the data from the simulations.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.549-556
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• 2010

Reliable fast working maglev switch is one of the key technologies needed for the maglev system to be commercialized. Switch for the maglev system is large, heavy, complicated, expensive compared with that of the traditional wheel-on-rail system. This paper reports the development of a segmented maglev switch for urban transit maglev system under construction for the 6.1 km long double track maglev commercialization line in Inchon international airport in 2012. Test results along with details of the segmented maglev switch components are reported.

• Composites Research
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• v.16 no.6
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• pp.56-61
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• 2003

In this Paper, a fiber Bragg grating(FBG) sensor system is described and FBGs are well-suited for long term and extremely severe experiments, where traditional strain gauges fail. In the system. a reflect wave-length measurement method which employs a tunable light source to find out the center wave-length of FBG sensor is used. We apply the FBG system to nuclear energy Power Plant for structural integrity test to measure the displacement of the structure under designed pressure and to check the elasticity of the structure by measuring the residual strain. The system works very well and it is expected that it can be used for a real-time strain, temperature and vibration detector of smart structure.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.5
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• pp.965-967
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• 2000

An on-line FIA system in place of traditional Conway method was used for quicker and simpler analysis of volatile basic nitrogen of pork. The on-line system was developed by connecting an FIA apparatus with an ammonia electrode as a detector to a personal computer. The data from Conway method and from the on-line FIA system were in good agreement and the correlation coefficient was 0.981. One sample could be analyzed in about 4 min.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.12 no.19
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• pp.89-98
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• 1989

This research addresses the most sophisticated level of complexity of current electronic data processing(EDP) technology realtime, distributed data base(DDB) system. The major objective is to develop guidelines for the control and audit of these sophisticated system, since the control and audit philosophies, control features, and audit techniques applicable to traditional EDP systems are no longer fully appropriate for, or relevant to, these stat-of-art systems. An attempt is made to develop an internally consistent audit and control Conceptual Framework summarizing and integrating the material developed in this research, which then leads into the analysis of the control and audit model.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.18 no.3
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• pp.205-216
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• 2014

Objectives The purpose of this study is to help improve the management of traditional Korean medical(TKM) clinics and the policies for supporting them, by conducting a survey of the practitioners of TKM. Methods Stratified sampling was conducted based on regional location, and 700 samples were selected in a random manner from the membership list. The questionnaire was delivered and returned by mail. The survey was conducted between 20 July and 31 August 2010. A total of 177 questionnaires (recovery rate: 25.28%) were recovered and analyzed for the study. Results 1. The the survey indicate that the overall size of TKM clinics has fallen compared with previous survey, while the average number of beds per clinic has remained unchanged at 7.9. The sale of medicine as a proportion of total monthly sales has increased. 2. There has been no change in the composition of clinical staff as there are three nursing assistants. Although the average daily number of patients to clinics has remained at around 33.90 compared with ten years ago, the number of patients requiring seeking acupuncture treatment has increased while the number of those treated with medication has decreased. 3. Clinicians in TKM have indicated their preference for a binary system that separates TKM from western medicine (57.4%). The respondents do not favor the separation of dispensary from medical practice (81.5%), marks of origin for medicinal herbs (68.9%), disclosure of the prescriptions (67.2%), and the overseas expansion of Korean medical services (70.4%). However, they indicated that they are very much in favor of being granted the authority to employ and give orders to medical technicians (96.0%). 4. The respondents selected Korea as the country that maintains a proper academic system for traditional medicine (45.5%), and are not in favor of opening Korea's traditional medicine market under an Free Trade Agreement(FTA) with China (72.7%). Conclusion The overall status of the management of TKM clinics has declined compared with the preceding decade. There has been only a slight change in clinicians' opinion of the related policies and regulatory issues.

• Journal of Korea Multimedia Society
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• v.5 no.3
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• pp.331-341
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• 2002

Traditional slicing techniques make slices through dependence graph and improve the accuracy of slices. However, traditional slicing techniques require many vertices and edges in order to express a data communication link because they are based on static slicing techniques. Therefore the graph becomes very complicated. We propose the representation of a dynamic system dependence graph so as to process the slicing of a software system that is composed of related programs in order to process certain jobs. We also propose programs on efficient slicing algorithm using relations of relative tables in order to compute dynamic slices of a software system. Using a marking table from results of the proposed algorithm can make dynamic system dependence graph for dynamic slice generation. Tracing this graph can generate final slices. We have illustrated our example with C program environment. Consequently, the efficiency of the proposed dynamic system dependence graph technique is also compared with the dependence graph techniques discussed previously. As the results, this is certifying that the dynamic system dependence graph is more efficient in comparison with system dependence graph.