• 동의생리병리학회지
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• 제24권5호
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• pp.848-853
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• 2010

Bone maintains its homeostasis through balance between bone resorbing osteoclasts and bone forming osteoblasts. Thus, unusual balance between osteoclasts and osteoblasts leads to pathological bone diseases, such as osteoporosis, rheumatoid arthritis, autoimmune arthritis, periodontitis. Schisandra chinensis well known traditional herbal has been used for treatment of diseases in China, Korea, Japan, andothers. Recently, research studies have demonstrated that the lignans found in Schisandra chinensis stimulate osteoblasts and suggest that it may be helpful against osteoporosis. However, the inhibitory effect of water extract of Schisandra chinensis on osteoclast differentiation remains largely unknown. In this study, Water extract of Schisandra chinensis markedly suppressed RANKL-induced osteoclast differentiation in cultures of BMMs without cytotoxicity. The mRNA expression of c-Fos, NFATc1, and TRAP induced by RANKL was inhibited by water extract of Schisandra chinensis. It also suppressed c-Fos and NFATc1 protein expression. Taken together, these results suggest that water extract of Schisandra chinensis has the potential to serve as a treatment of bone disease such as osteoporosis.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.298-304
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• 2016

Dianthus superbus (D. superbus) is a traditional crude drug used for the treatment of urethritis, carbuncles and carcinomas. The objective of this study was to confirm the cognitive enhancing effect of D. superbus in memory impairment induced mice and to elucidate the possible potential mechanism. Effect of D. superbus on scopolamine induced memory impairment on mice was evaluated using the Morris water maze and passive avoidance tests. We also investigated acetylcholinesterase (AChE) activity and brain-derived neurotropic factor (BDNF) expression in scopolamine-induced mice. HPLC-DAD analysis was performed to identify active compounds in D. superbus. The results revealed that D. superbus attenuated the learning and memory impairment induced by scopolamine. D. superbus also inhibited AChE levels in the hippocampi of the scopolamine-injected mice. Moreover, D. superbus increased BDNF expression in the hippocampus. Eight compounds were identified using HPLC-DAD analysis. The content of 4-hydroxyphenyl acetic acid was higher than contents of other compounds. These results indicated that D. superbus improved memory functioning accompanied by inhibition of AChE and upregulation of BDNF, suggesting that D. superbus may be a useful therapeutic agent for the prevention or treatment of Alzheimer's disease.

• 한국패션뷰티학회지
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• 제1권1호
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• pp.143-151
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• 2003

As korean women despised to transform their appearance into totally different shape, and they regarded to enhance a inherent beauty ideal beauty, korean traditional make-up culture was natural. But in modern society, make-up has been developing as one of the beauty industry and it means make-up involves more meanings than primitive period and needs to study its multi-dimensional connotation to understand in the culture. The purposes of this study were to find out what was represented in make-up ad and how it has been changed. The data of this study were collected from make-up advertisement printed in 'Hyang Jang' which is a periodical of amole pacific cosmetic industry from 1972-2001, and qualitatively analysed. As a results of content analysis were: The characteristics of non-verbal expression in make-up advertisements were different by the time. Generally person-appeal advertisements were more than product-appeal advertisements. And in the 1970s and early 1980s, person-appeal advertisements were appeal to the lifestyle, but after that person itself was appealed. And also after early 1980s, image-appeal advertisements were increased.

• 한국정보과학회논문지:소프트웨어및응용
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• 제35권8호
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• pp.463-478
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• 2008

본 논문에서는 유전자 사이의 상관계수가 높은 마이크로어레이 데이타에 대하여 제안하는 알고리즘을 통해 상관계수가 낮은 유전자들의 부집합을 만들고, 이에 대해 적합 함수를 통한 평가로 기존 방법론이 가지는 한계를 극복할 수 있도록 하였다. 기존 방법론은 개별 특징의 평가를 통해 중복 특징을 제거하며, 상관계수에 대한 고려가 없어 선택된 유전자 부집합들의 상관계수가 논은 문제가 있었다. 이에 따라 제안하는 알고리즘은 특징간의 관계를 평가하는 Feature Wrapping 기법을 활용하여, 추출된 유전자 부집합에 포함된 유전자 사이의 상관관계가 낮고, 클래스 구분력이 높은 특징을 갖도록 하였다.

• 복식
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• 제41권
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• pp.153-168
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• 1998

The purpose of this study is to examine, specifically, the external and internal characteristics of anti-fashion expression in the Korean student movement after the 1945 Liberation. The dress expressed in the student movement represented the purity of student and characterized resistance, and this character expressed strongly in 80s, faded from middle of 90s. Until the 60s, the student movement was not characterized by, so activist students wore dress and suits. It symbolized students as an elite group of society. They added on head-bands to express resistance. In the 70s, activist students wore school uniforms, school military training wear, blue jeans and loose shirts in demonstrations. They tried to express re-bellion against the government and the older gen-eration. In the 80s, the period was remarkably distingusihing by the economic growth at that time. Activist students wore T-shirts with Korean letters and popular paintings specially made, Korean costumes, wrapped in the Taggeuki (Korean national flag), and refused wear on jeans because of anti-Americanism. They also wore masks, muffled their faces, and got their heads shaved. These anti-fashions are very strong expressions for the national independence spirit, national traditional heitage, anti-foreign power and anti-American. In the early 90s, activist students wore reformed Korean costumes specially made group uniforms, after that they wore casual everyday clothes with caps. They tried to express remarkable resistance in the early 90s, but after the mid-90s expression of resistance weakened and faded, so there was no distinction between activist and non-activist. There are the reasons why the student movement changed after the peaceful transfer of political power.

• Journal of Plant Biotechnology
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• 제37권3호
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• pp.250-261
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• 2010

The expression of vaccine antigens in transgenic plants has the potential to provide a convenient, stable, safe approach for oral vaccination alternative to traditional parenteral vaccines. Over the past two decades, many different vaccine antigens expressed via the plant nuclear genome have elicited appropriate immunoglobulin responses and have conferred protection upon oral delivery. Up to date, efforts to produce antigen proteins in plants have focused on potato, tobacco, tomato, banana, and seed (maize, rice, soybean, etc). The choice of promoters affects transgene transcription, resulting in changes not only in concentration, but also in the stage tissue and cell specificity of its expression. Inclusion of mucosal adjuvants during immunization with the vaccine antigen has been an important step towards the success of plant-derived vaccines. In animal and Phase I clinical trials several plant-derived vaccine antigens have been found to be safe and induce sufficiently high immune response. Future areas of research should further characterize the induction of the mucosal immune response and appropriate dosage for delivery system of animal and human vaccines. This article reviews the current status of development in the area of the use of plant for the development of oral vaccines.

• 패션비즈니스
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• 제21권4호
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• pp.34-43
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• 2017

Paperweave wallcoveing is necessary to develop new designs based on the analysis of global trend and reflection of Korean traditional image to improve commercial value in the worldwide market. The purpose of this study was to understand design trend and share valuable data by product analyzing of major paperweave wallcovering brands - Yeomyung (Korea), Phillip Jeffries (USA) and Omexco (Belgium). In the dominant color, the largest proportion is YR. Analysis of each brand color, Omexco is using the widest range of colors, the colors of each brand uses an exclusive of its own brand compared to other brands are Green (Yeomyung), Blue (Phillip Jeffries), Red (Omexco). The number of colors, Yeomyung and Philip Jeffries have a high ratio of bi-color, Omexco is revealing various color expression methods such as 55% solid color, two or three multi-color are each half of the balance. Analysis of weaving, Yeomyung has a high ratio of balanced plain, at number of mixture, Yeomyung and Phillip Jeffries are using mostly paper-yarn but Omexco is using multi-mixture materials in some part of theirs. Regarding analysis of finishing, all three brands are mostly selling unfinished paperweave wallcovering but some solid coated are appearing at Yeomyung and Omexco. Yeomyung has more foil transfer compared with the other brands, Phillip Jeffries has some digital printed products.

• Journal of Microbiology and Biotechnology
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• 제17권6호
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• pp.1018-1023
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• 2007

Bacillus subtilis CH3-5 was isolated from cheonggukjang prepared according to traditional methods. CH3-5 secreted at least four different fibrinolytic proteases (63, 47, 29, and 20 kDa) into the culture medium. A fibrinolytic enzyme gene, aprE2, encoding a 29kDa enzyme was cloned from the genomic DNA of CH3-5, and the DNA sequence determined. aprE2 was overexpressed in heterologous B. subtilis strains deficient in extracellular proteases using a E. coli-Bacillus shuttle vector. A 29 kDa AprE2 band was observed and AprE2 seemed to exhibit higher activities towards fibrin rather than casein.

• Journal of Microbiology and Biotechnology
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• 제25권9호
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• pp.1485-1492
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• 2015

Makgeolli is a traditional wine in Korea and has been traditionally believed to exhibit health benefits. However, the inhibitory effect of dealcoholized makgeolli (MK) on cancer has never been investigated scientifically. In this study, MK exhibited an anti-angiogenic effect by inhibiting tube formation in human umbilical vein endothelial cells, without cytotoxicity. Treatment with MK reduced the proliferation of AGS human gastric adenocarcinoma cells in a dose-dependent manner and increased the sub-G1 population. Next, we evaluated whether MK could induce apoptosis in AGS cells by using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay or Annexin V method. Treatment with MK at 500 and 1,000 μg/ml increased the number of TUNEL-positive AGS cells. Under the same conditions, MK-treated (500 and 1,000 μg/ml) cells showed significant induction of early or late apoptosis, compared with untreated cells (no induction). In addition, MK also induced phosphatase and tensin homolog (PTEN) expression in AGS cells. However, p53 expression in AGS cells was not changed by MK treatment. Furthermore, MK at 500 mg/kg·d reduced the tumor size and volume in AGS tumor xenografts. Taken together, MK may be useful for the prevention of cancer cell growth.

• Journal of Microbiology and Biotechnology
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• 제25권9호
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• pp.1519-1527
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• 2015

Biogenic amines in some food products present considerable toxicological risks as potential human carcinogens when consumed in excess concentrations. In this study, we investigated the degradation of the biogenic amines histamine and tyramine and the presence of genes encoding histidine and tyrosine decarboxylases and amine oxidase in Bacillus species isolated from fermented soybean food. No expression of histidine and tyrosine decarboxylase genes (hdc and tydc) were detected in the Bacillus species isolated (B. subtilis HJ0-6, B. subtilis D'J53-4, and B. idriensis RD13-10), although substantial levels of amine oxidase gene (yobN) expression were observed. We also found that the three selected strains, as non-biogenic amineproducing bacteria, were significantly able to degrade the biogenic amines histamine and tyramine. These results indicated that the selected Bacillus species could be used as a starter culture for the control of biogenic amine accumulation and degradation in food. Our study findings also provided the basis for the development of potential biological control agents against these biogenic amines for use in the food preservation and food safety sectors.