• Analytical Science and Technology
• /
• v.23 no.2
• /
• pp.179-186
• /
• 2010

The oxidative metabolism of ibuprofen in healthy male urine collected at 3, 6, 9, 12 and 15 h after oral administration of ibuprofen was studied by GC/MS assay. To detect conjugated metabolites of ibuprofen, urine sample was acid-hydrolyzed with 6 M HCl at $100^{\circ}C$ for 30 min. To effectively extract ibuprofen and its metabolites, liquid-liquid extraction (LLE) was conducted at pH 3, 5, and 7, respectively. As a result, LLE at pH 3 was shown to be the best extraction condition. For the determination of trace amounts of ibuprofen and its metabolites in extract, trimethylsilylation (TMS) with BSTFA was applied and followed by GC/MS analysis. In this study, main 5 metabolites including parent drug were detected and these metabolites were assigned as three hydroxylated forms and one carboxylated form. Each metabolite was tentatively identified by both interpretation of mass spectrum and comparison with previously reported results. In addition, time profile of urinary excretion rate for parent drugs and metabolites was studied. Finally, the metabolic pathways of ibuprofen were suggested on the basis of the structural elucidation of its metabolites and excretion profiles.

• Smart Media Journal
• /
• v.9 no.1
• /
• pp.75-83
• /
• 2020

Compensation services that are indispensable during large-scale public utilities projects have been gradually increasing with the recent increase in construction, but there are no systematic compensation services due to the complicated procedures and manual work. For this reason, various problems such as construction period delays due to various complaints, corruption in compensation work, and impossible to trace the history of compensation data in the past are emerging. In this paper, in order to solve this problem, in-depth interviews and questionnaires were conducted to find out the problems of each compensation status. Based on this, 3 core technologies and 10 technical needs based on ICT were selected to improve the compensation work by deriving STEEP analysis and Issue Tree. The three core technologies are big data-based decision-making and prediction technology, advanced measurement technology, and open cloud-based compensation platform technology. In order to introduce the derived technologies to the institutions in charge of compensation, the possibility of technology diffusion by project operators was suggested based on the results of the current status of informatization by institution. Based on the core technology derived from this paper, it is necessary to make a prototype that can be advanced in compensation work and apply it to each institution and analyze the effect.

• Journal of the Korea Society of Computer and Information
• /
• v.13 no.6
• /
• pp.117-125
• /
• 2008

The Object tracking by real-time image analysis is one of the major concerns in computer vision and its application fields. The Object detection process of real-time images must be preceded before the object tracking process. To achieve the stable object detection performance in the exterior environment, adaptive background model generation methods are needed. The adaptive background model can accept the nature's phenomena changes and adapt the system to the changes such as light or shadow movements that are caused by changes of meridian altitudes of the sun. In this paper, we propose a robust background model generation method effective in an illegal parking auto-detection application area. We also provide a evaluation method that judges whether a moving vehicle stops or not. As the first step, an initial background model is generated. Then the differences between the initial model and the input image frame is used to trace the movement of object. The moving vehicle can be easily recognized from the object tracking process. After that, the model is updated by the background information except the moving object. These steps are repeated. The experiment results show that our background model is effective and adaptable in the variable exterior environment. The results also show our model can detect objects moving slowly. This paper includes the performance evaluation results of the proposed method on the real roads.

• Korean Journal of Medicinal Crop Science
• /
• v.21 no.6
• /
• pp.474-485
• /
• 2013

Pharmacological studies and clinical practices have indicated that Radix Astragali, a dried root of Astragalus membranaceus possesses a lot of biological activities, including antioxidant, hepatoprotective, anti-diabetic, tonic, diuretic, antimicrobial, antiviral, and immunological activities. These biological activities approved by the modern pharmacological studies are mainly due to the constituents of Astragalus membranaceus including polysaccharides, saponins, flavonoids, amino acids, and trace elements. In resent, the main constituents in the root part showing a lot of biological activities has been isolated also from the aboveground parts such as leaves and sprouts in our laboratory. However, the safety evaluation for the aboveground parts of Astragalus membranaceus should be checked before expanding their application as one of food. In the study, a 90-day rat oral gavage study has been conducted with the extracts from Astragalus membranaceus-above-ground parts at doses of 1000, 3000, and 5000mg/kg/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000mg/kg/day of the water-extracts from Astragalus membranaceus-aboveground parts.

• Journal of Conservation Science
• /
• v.27 no.1
• /
• pp.31-40
• /
• 2011

Copper-red (Dongwha, Jinsa) is Korean traditional inorganic pigment used for red-coloring on the porcelain surface during Goryeo and Joseon Periods. Trace amounts of copper-red porcelains are handed down because of the technical difficulty of making and coloring of the pigment. It is known that copper ore sources were extensively distributed in Korea according to old literatures and some of them are still producing copper ore at this present. Main types of copper-bearing mineral in Korea are chalcopyrite ($CuFeS_2$) and malachite ($Cu_2CO_3(OH)_2$), and they are easily collected from the ground surface. This means Korea had geographical and economic geological advantages for supplying raw material of the pigment. These two minerals showed good red-coloring in color test for porcelain pigment. As a coloring element, copper showed micro size less than $5{\mu}m$ in diameter in glaze matrix. The dispersion of copper particle is the most decisive factor for red chromaticity of copper-red porcelain, as well as copper content of the pigment.

• Journal of Conservation Science
• /
• v.30 no.3
• /
• pp.249-261
• /
• 2014

This study aims to examine production technique of white wares from the Guyre-2ri 1st and 2nd kiln sites, Wonju, Gangwon Province and characteristics of the used materials, and to find a correlation among materials of the excavated white wares. X-ray fluorescence sequential spectroscopy(XRF), X-ray diffraction(XRD), Dilatometer and Inductively coupled plasma mass spectrometry(ICP-MS), Inductively coupled plasma automic emission spectrometer(ICP-AES) were applied to determine the chemical composition, crystalline phase of samples, firing temperatures, trace elements and rare earth elements. White wares from the Guyre-2ri kiln sites contained high contents of coloring oxides and fluxes. Though firing temperature of each sample was different, they were mostly fired at a temperature below $1200^{\circ}C$ and some of them experienced a low temperature of $1000^{\circ}C{\pm}20^{\circ}C$ and a high temperature above $1200^{\circ}C$. When analyzing body crystalline phases of the white wares using the XRD method, quartz and mullite were extracted from all the samples, and the proportions were similar to each other. When analyzing the excavated white wares using the Seger formula, also, all the samples showed similar clay sources and production techniques. Moreover, the white wares were made of host rocks of the same geological origin, according to the result of rare earth elements analysis.

• Journal of KIISE:Computing Practices and Letters
• /
• v.11 no.3
• /
• pp.235-245
• /
• 2005

The rapid development of computer network technology has brought the Internet as the major infrastructure to our society. But the rapid increase in malicious computer intrusions using such technology causes urgent problems of protecting our information society. The recent trends of the intrusions reflect that the intruders do not break into victim host directly and do some malicious behaviors. Rather, they tend to use some automated intrusion tools to penetrate systems. Most of the unknown types of the intrusions are caused by using such tools, with some minor modifications. These tools are mostly similar to the Previous ones, and the results of using such tools remain the same as in common patterns. In this paper, we are describing design and implementation of attacker-traceback system, which traces the intruder based on the multi-agent architecture. The system first applied SOM to classify the unknown types of the intrusion into previous similar intrusion classes. And during the intrusion analysis stage, we formalized the patterns of the tools as a knowledge base. Based on the patterns, the agent system gets activated, and the automatic tracing of the intrusion routes begins through the previous attacked host, by finding some intrusion evidences on the attacked system.

• Spatial Information Research
• /
• v.23 no.5
• /
• pp.1-7
• /
• 2015

Twitter has the fast propagation and diffusion of information compare to other SNS. Therefore, many researches about detecting real-time event using twitter are progressing. Twitter real-time event detecting system assumes every twitter user as a sensor and analyzes their written tweet in order to detect the event. Researches that are related to this twitter have already obtained good results but confronted the limits because of some problems. Especially, many existing researches are using the method that can trace an event location by using GPS coordinate. However, it can be suggested a definite limitation through the present user's skeptical responses about making personal location information public. Therefore, this paper suggests the method that traces the location information in tweet contents text without using the provided location information from twitter. Associated words were grouped by using the keyword that extracted in tweet contents text. The place that the events have occurred and whether the events have surely occurred are detected by this experiment using this algorithm. Furthermore, this experiment demonstrated the necessity of the suggested methods by showing faster detection compare to the other existing media.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.35 no.5
• /
• pp.64-72
• /
• 2007

This study investigated the types, forms, and origination of litter found along one hiking course in Moaksan Provincial Park, 'Jungin-ri Course'(entrance-ridge-valley-peak). In addition, a survey was conducted to understand hikers' litter control awareness in order to determine possible backcountry litter control measures. The following are the results of this study: 1. For the litter Sequency investigation, 199 recyclable pieces of litter were found on the mid-slope(61.6%), 89 by the entrance(27.6%), 19 in the valley(5.9%) and 16 on the peak(4.9%). A total of 323 pieces of litter were found. Paper materials were the most common, followed by plastic containers such as PET bottles and yogurt containers. Of particular interest, 288 papers and cans were found on the mid-slope(46.9%). By the entrance, more plastics and bottles were found. 2. There were 614 pieces of flammable litter collected and only 19 pieces of non-flammable. Most of the flammable litter, including snack pacts, plastic bags, processed lumber, cigarette butts, tissues, cigarette boxes, and fabric was found on the mid-slope. 3. Very little food waste was found throughout the whole site proving that the policy prohibiting hikers from cooking and eating at the designated sites has been effective. However, food waste is difficult to find because it naturally decays with time. 4. $X^2$-test was used to find different types of litter and their verified origination frequency. It was found that recyclable litter, and food waste took about 1%. In addition, recyclable litter, especially bottles, was found relatively frequently by the entrance. Flammable litter was found most often at the peak. 5. The questionnaire results showed that 48.2% of the respondents "shorten their hiking journey and purchase food outside the entrance" and 29.6% said that they "bring a packed meal from home". Only 8.2% said that they "cook something when an appropriate location is found". At the Jungin-ri course, a few hikers brought their own food to eat or cook, but most hikers purchased something to eat onsite. 6. The results of the question about having experience littering while hiking showed that 19.3% litter and 79.2% do not. Those that responded "yes" gave various reasons for littering. 63.6% claimed, "there are no designated trash containers". 15.9% said they litter subconsciously. Finally, 3.2% insist that they litter "because food naturally decomposes". 7. As a result of the overall satisfaction according to the Likert scale and the analysis with an average of 14 variables, it was found that the average "toxic litter control convenience" was 2.41 with very low satisfaction. Thus, the results indicate the importance of providing appropriate back country litter control facilities.

• Geophysics and Geophysical Exploration
• /
• v.13 no.4
• /
• pp.323-329
• /
• 2010

Three deconvolution methods were applied to stacked seismic data obtained to investigate gas-hydrates in the Ulleung Basin, East Sea: (1) minimum-phase spiking deconvolution, (2) minimum-phase spiking deconvolution using an averaged wavelet from all traces, and (3) deterministic deconvolution using a wavelet with phases computed from well-logs. We analyzed the resolving property of these methods for lithological boundaries. The first deconvolution method increases temporal resolution but decreases lateral continuity. The second method shows, in an overall sense, similar results to the spiking deconvolution using a minimum phase wavelet for each trace; however, it results in a more consistent and continuous bottom-simulating reflector (BSR) and better resolved sub-BSR reflectors. The results from the third method reveal more detailed internal structures of debris-flow deposits and increased continuity of reflectors; in addition, the seafloor reflection and the BSR appear to have changed to a zero-phase waveform. These properties help more precisely estimate the distribution and reserves of gas hydrates in the exploration area by improving analysis of facies and amplitude of the BSR.