• International Journal of Advanced Culture Technology
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• v.12 no.2
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• pp.236-248
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• 2024

This study aims to empirically analyze the effects of leadership level and toxic leadership on leadership performance results among male and female military leaders in the Army, and to verify whether the leader's gender has a moderating effect in this process. Additionally, by comparing and analyzing the leadership level, toxic leadership, and leadership performance results of female military leaders by position, this study seeks to examine the characteristics of female military leadership according to position. The research model was established with leadership level and toxic leadership as independent variables, leadership performance results as the dependent variable, and the leader's gender as a moderating variable. Data were collected through a survey of 216 male and female officers serving in the positions of platoon leader, company commander, and battalion commander in the Army. The collected data were analyzed using descriptive statistics, reliability analysis, correlation analysis, and hierarchical regression analysis. The results showed that leadership level had a significant positive effect on leadership performance results, while toxic leadership had a significant negative effect. The leader's gender moderated the relationship between leadership level and leadership performance results, with female leaders receiving lower evaluations than male leaders at the same level of leadership competency. Gender also moderated the relationship between toxic leadership and leadership performance results, with female leaders exhibiting the same level of toxic leadership receiving lower performance evaluations than male leaders. In the comparative analysis of female military leadership characteristics by position, the leadership level of the platoon leader and company commander groups was not significantly different from that of male soldiers, but the battalion commander group showed slightly lower leadership competency compared to male soldiers. Based on these results, this study suggests ways to improve the leadership level of female military leaders, reduce toxic leadership, and prepare support measures to strengthen the leadership competency of female military officers at the battalion commander level and above from policy, institutional, and educational perspectives.

• Environmental Analysis Health and Toxicology
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• v.2 no.1_2
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• pp.43-53
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• 1987

Among the environmental toxic metals, cadmium and lead compounds are very hazard for human health because these may affect the biological function of human body and furthermore enhance the cause of various disease. In recent years, as the view of environmental toxicology, the combination of toxic metals suffering human health is especially significant cadmium chloride (10 mg/kg P. 0., 1 mg/kg I.P.) and lead acetate (20 mg/kg P.O., 2 mg/kg I.P.) were administered to rats for 4 weeks on alternate days and then examined the effect of these on body weight, tissue weight and also biochemical function in blood and tissue were investigated and comparision of the two experimental groups such as single and combined administration. According to the results of this experiment, accumulation of heavy metals increased and biological metabolic function grew worse but, in tissue, toxic effect decreased by combined administration and intraperitoneal administration was more toxic than per OS.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.5
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• pp.1120-1128
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• 2005

To investigate the toxic of herbs used in , the author analyzed herbs with toxic recorded in , , after searched toxic herbs literarily. Herbs with toxicity recorded in both and were total 17 species, and recorded in were total 13 species, and recorded in were total 12 species. The major cause that herbs generates a side effect in a human body is implicit use and abuse, inadequate processing the herbs, use of quack medicines of herbs and clinical use which is improper in symptoms and internal use, differences of constitution. The major toxic component in herbs is an alkaloid, essential oil and hydrargyrum (Hg), and the main invasion route of toxic herbs in human body is the liver, kidney, lungs, and gastrointestinal tract.

• The Journal of Korean Medicine
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• v.24 no.3
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• pp.96-107
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• 2003

Objective : This study was undertaken to determine if Pyunggangaeuljihyul-tang (Pinggankaiyuzhixue-tang, PG) has a protective effect against cell injury induced by various toxic agents in rabbit liver, Methods : Cell injury in vitro was estimated by measuring lactate dehydrogenase (LDH), and that in vivo was estimated by measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity in serum. Lipid peroxidation was examined by measuring malondialdehyde, a product of lipid per oxidation. Results : PG prevented the LDH release by $CCl_4$, mercury, menadione, and tert-butyl hydroperoxide treatment in vitro in liver slices. The extent of protection by 2% PG was similar to that of $10{\mu\textrm{M}}$ N,N'-diphenyl-p-phenylenedianline, a potent antioxidant, in tert-butyl hydroperoxide-induced LDH release. PG also prevented lipid peroxidation and depletion of cellular ATP induced by Hg. Hg causes motphological changes including cell necrosis and its effect was significantly prevented by PG. When rats were treated intraperitoneatly with 0.5 ml/kg of $CCl_4$, serum alanine aminotransferase and aspartate aminotransferase activities were increased compared with the control, which was significantly inhibited by pretreatment of PG. PG also prevented reduction in GSH and lipid peroxidation induced by $CCl_4$ Conclusion : These results suggest that PG exerts aprotective effect against various toxic agents by its antioxidant action in liver tissues. Thus, PG may be used in prevention and treatment of drug-induced liver cell injury. However, the precise mechanisms of PG protection remain to be determined.

• YAKHAK HOEJI
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• v.34 no.4
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• pp.262-266
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• 1990

Acetylshikonine, isolated from the root of Lithospermum erythrorhizon showed a strong cytotoxic activity ($ED_{50}=0.10\;ug/ml$) against L1210 cell and T/C = 182% in ICR mice bearing S-180 at a dose of 5 mg/kg. Administrations of 10 mg/kg and 15 mg/kg reduced the T/C values to 60 and 77% respectively. Higher doses reveal toxicity. Seven naphthazarin derivatives synthesized showed good cytotoxic activities against L1210 cell. Especially, naphthazarin and hydronaphthazarin have strong activities ($ED_{50}=0.05\;ug/ml$ for both). Naphthazarin showed a severe toxic effect on ICR mice bearing S-180; no significant toxic effect was observed at a dose of 1 mg/kg or 2 mg/kg, but a severe toxicity (T/C = 23%) by administration of 5 mg/kg. Alkylation of C-2 of naphthazarin is necessary for reducing the toxic effect on ICR mice bearing S-180.

• Environmental Engineering Research
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• v.9 no.5
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• pp.201-213
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• 2004

• Journal of Environmental Science International
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• v.24 no.11
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• pp.1541-1546
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• 2015

The objective of this research was to evaluate the toxicity of the industial xenobiotic Aroclor 1248 (A) and natural origin substances~elemental sulfur (S80) and oleic acid (OA) and their binary mixtures to V. fischeri bioluminescence during the prolonged exposure time (up to 60 min). The bioluminescence quenching test was used to determine the toxic effects. Full factorial experiment design and multiple regression analysis and the comparison of binary mixture effect with the sum of effects of individual chemicals were used for the evaluation of combined effects of toxicants. The analysis of general trend of mixture toxicity to bioluminescence showed that mixture toxic effects were reversible up to 60 min. Data analysis revealed different joint effects, which were depended on mixture composition. S80 enhanced toxic effect of A and acted additively with synergistic interaction. Hydrophobic OA in mixture with A acted antagonistically and in mixture with sulfur caused an additive effect with antagonistic component of interaction. It was concluded that low concentrations of natural toxic substances present in environmental samples as mixtures of chemicals can define the toxicodynamic character of industrial xenobiotics.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.27 no.4
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• pp.257-268
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• 2017

Objectives: This study was conducted to review the Toxic UseReduction Act of Massachusetts, USA, which has been evaluated as a successfulcase of a chemical reduction policy, and to search for ways to introduce it inKorea. Methods: We analyzed the implementation of the TURA by attending TUR Planning Course of the Toxic Use Reduction Institute in Massachusetts and researching the related literature. Results: As TURA took effect, the use of chemicals in Massachusetts was reduced, and cost savings were achieved in workplaces. The success factors for the legislation are considered to be support form the federal and state governments and the active participation of business and civic group. Domestic efforts to reduce toxic substances have already begun, so if the process of TURA is appropriately applied to domestic legislation of chemicals control, it would be expected to produce visible results. Therefore, we reviewed the 'Act on Chemicals Registration and Assessment', 'Act on Chemical Control' and 'Act on the Integrated Control of Pollutant-Discharging Facilities' and sought solution for applying TURA to each piece of legislation. For the first case, 'Toxic or Hazardous Substance List' and 'Establishment of Toxic Use Fee' is applicable. For the second case, 'Annual Toxic or Hazardous Substance Reports' is applicable. For the third case, 'Toxic Reduction Plans' and 'Toxics Use Reduction Institute and 'Toxic Use Reduction Planners' is applicable. Conclusions: The government should take notice appropriateness for the reduction of toxic chemicals and provide financial support. Businesses should invest in technologies that build trust with local communities, improve productivity, and reduce costs. Finally, civic group should cooperate with government and businesses.

• Journal of the Korean Institute of Gas
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• v.9 no.2 s.27
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• pp.43-49
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• 2005

Today toxic gas has various uses. If there is a release accident, the gas rapidly disperse into the atmosphere. The extent of damage due to toxic gas accident is very wide and fatal to human being. So, it is necessary for toxic gas facilities which have high risk to construct an emergency response system that prepare to toxic release and make immediate response to be possible at accident appearance. In this study accident scenario were selected and frequency analysis was executed using FTA technique. Dispersion effect of toxic gas release was analyzed using DNV company's PHAST(Ver. 6.2). Finally, an emergency response system was developed using results of quantitative risk analysis.

• Journal of the Korean Society of Safety
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• v.9 no.1
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• pp.146-154
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• 1994

A series of numerical calculations are performed in order to investigate the dispersion mechanism of toxic gaseous and solid pollutants in extremely short-term and short range. The calculations are carried out in an open space characterized by turbulent boundary layer. The simulation is made by the use of numerical model, in which a control-volume based finite difference method is used together with the SIMPLEC algorithm for the resolution of the pressure-velocity coupling problem. The Reynolds stresses are solved by two-equation, k-$\varepsilon$ model modified for buoyancy. The major parameters consider-ed in this study are temperature, velocity and Injection height of toxic gases, environmental conditions such as temperature and velocity of free stream air, and topographic factor. The results are presented and discussed in detail. The flow field is commonly characterized by the formation of a strong recirculation zone due to the upward motion of the hot toxic gas and ground shear stress. The driving force of the upward motion is explained by the effect of thermal buoyancy of hot gas and the difference of inlet velocity between toxic gas and free stream.