• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3087-3091
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• 2014

Purpose: To determine the utility of digital rectal examination (DRE), serum total prostate specific antigen (tPSA) estimation, and transrectal ultrasound (TRUS) for the detection of prostate cancer (PCa) in men with lower urinary tract symptoms (LUTS). Materials and Methods: All patients with abnormal DRE, TRUS, or serum tPSA >4ng/ml, in any combination, underwent TRUS-guided needle biopsy. Eight cores of prostatic tissue were obtained from different areas of the peripheral prostate and examined histopathologically for the nature of the pathology. Results: PCa was detected in 151 (50.3%) patients, remaining 149 (49.7%) showed benign changes with or without active prostatitis. PCa was detected in 13 (56.5%), 9 (19.1%), 26 (28.3%), and 103 (74.6%) of patients with tPSA <4 ng/ml, 4-10 ng/ml, 10-20 ng/ml and >20 ng/ml respectively. Only 13 patients with PCa had abnormal DRE and TRUS with serum PSA <4 ng/ml. The detection rate was highest in patients with tPSA >20 ng/ml. The association between tPSA level and cancer detection was statistically significant (p<0.01). Among 209 patients with abnormal DRE and raised serum PSA, PCa was detected in 128 (61.2%). Conclusions: The incidence of PCa increases with increasing serum level of tPSA. The overall screening and detection rate can be further improved by using DRE, TRUS and TRUS-guided prostate needle biopsies.

• KIEE International Transaction on Electrical Machinery and Energy Conversion Systems
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• 제5B권4호
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• pp.366-373
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• 2005

This paper presents two new circuit topologies of the dc busline side active resonant snubber assisted voltage source high frequency link soft switching PWM full-bridge dc-dc power converters acceptable for either utility ac 200V-rms or ac 400V-rms input grid. These high frequency switching dc-dc converters proposed in this paper are composed of a typical voltage source-fed full-bridge PWM inverter, high frequency transformer with center tap, high frequency diode rectifier with inductor input filter and dc busline side series switches with the aid of a dc busline parallel capacitive lossless snubber. All the active switches in the full-bridge arms as well as dc busline snubber can achieve ZCS turn-on and ZVS turn-off transition commutation with the aid of a transformer leakage inductive component and consequently the total switching power losses can be effectively reduced. So that, a high switching frequency operation of IGBTs in the voltage source full bridge inverter can be actually designed more than about 20 kHz. It is confirmed that the more the switching frequency of full-bridge soft switching inverter increases, the more soft switching PWM dc-dc converter with a high frequency transformer link has remarkable advantages for its power conversion efficiency and power density implementations as compared with the conventional hard switching PWM inverter type dc-dc power converter. The effectiveness of these new dc-dc power converter topologies can be proved to be more suitable for low voltage and large current dc-dc power supply as arc welding equipment from a practical point of view.

• 한국항만경제학회지
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• 제28권3호
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• pp.91-110
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• 2012

현대 경영학에서 지식은 기업의 경쟁력을 창출할 수 있는 새로운 전략적 자원으로서 인식되고 있다. 치열한 경쟁구도 하에 있는 해운기업 지식경영의 효용성에 주목할 필요가 있다. 해운서비스 네트워크 내외부에서 획득되는 자료와 정보, 지식을 효과적으로 분류, 공유, 이전함으로써 기업특유의 역량을 발전시킬 수 있을 것이다. 본 연구에서는 정기선사의 지식경영이 해운서비스 역량의 강화에 어떠한 영향을 미치는지를 분석하였다. 이를 위해 해운기업의 지식경영의 수준을 측정하기 위해 지식사슬모형을 설계하였으며 국적 및 외국적 선사로부터 수거한 80부의 설문지를 바탕으로 모형의 타당성과 신뢰성을 검증하였다. 실증분석 결과 지식사슬모형을 구성하는 지원활동과 주요활동이 선사의 해운서비스 역량을 강화하는데 유의적인 효과를 미치는 것으로 나타났다. 본 연구는 지식경영의 효용성이 해운산업분야에서도 적용될 수 있음을 보여주고 있으며 해운기업들이 지식의 전략적 중요성을 인식하고 전사적 차원에서 지식경영을 추구해야함을 권고하고 있다.

• 한국환경복원기술학회지
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• 제12권3호
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• pp.116-129
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• 2009

This study is to enhance the provincial leisure plans through various programs and infrastructure facilities and to establish a network of natural leisure areas in Gyeonggi-do. According to the result, first, in terms of analyzing the locations of natural leisure areas by types, the rest of urban parks is formed in the Capital area outside Seoul as centering around the central area. Moreover, with regard to the rest of forest and the rest of natural ecology learning, the area of the detention exceeds the total area of Gyeonggi-do. The rest of valleys and swamps showed a dotted pattern of the detention area while the rest of tideland and fishing village experience indicated a distribution of the detention area along the West Coast as an axis. Second, according to result of analyzing the accessibility of natural leisure areas by types, the rest of valleys and swamps showed the highest accessibility among the natural leisure areas : the rest of natural ecology learning had the medium level of accessibility; the rest of forest indicated the lowest accessibility. Therefore, it is necessary to create more leisure areas concerning the futures demands. In addition, they should be constructed in the places adjacent to the urban district area exhibiting higher usability and accessibility. In the places where there are many natural leisure area with higher utility, management plans should be deliberated as well. Based on the result of analyzing the rest of valleys and swamps and the rest of tideland and fishing village experience, it was found that the natural leisure area should improve the quality of water intensively and hydrophile property and create hydrophilic spaces. The development of natural leisure areas need to be carried out under the principle of environmental protection while considering historic sites and nearby rivers and lakes. Moreover, water leisure programs should be developed actively as well with further utilization of water resources in order to enhance the usability of natural leisure.

• 여성건강간호학회지
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• 제17권5호
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• pp.439-446
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• 2011

Purpose: Early diagnosis is the primary method aimed at controlling breast cancer. The purpose of this study was to analyze some factors affecting the performance of mammography screening among women with a family history of breast cancer in Korea. Methods: This study applied a descriptive design method through structured self-report questionnaires. The Care Seeking Behavior Theory provided a theoretical framework for the study. Factors measured in this study represent demographic, clinical, and psychosocial variables including anxiety, barriers, utility, habits, perception, and facilitators. A total of 212 participants, of at least 20 years old, were sampled from April 8, 2010 to March 31, 2011. The data was analyzed by logistic regression method using the Statistical Package for the Social Science 18.0 software. Results: Of the 212 participants, 122 women (57.5%) went through mammography screening. The results of the analysis showed that (a) age (Odds Ratio [OR] =1.10, p<.001), (b) facilitating influences (OR=1.83, p=.008), (c) perception of mammography importance (OR=1.92, p=.011), (d) barriers to mammography (OR=0.60, p=.031), and (e) utility of mammography (OR=2.01, p=.050) significantly affect mammography screening. Conclusion: The results underscore the impact that psychosocial variables in obtaining mammography have on adherence to screening. Women with a family history of breast cancer should be given accurate information and recommendation about mammography by healthcare provider and a regular source of healthcare.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제30권3호
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• pp.116-120
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• 2019

Objectives: This study was conducted to re-validate the clinical efficacy of the Korean Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Rating Scale (K-AARS), which is a self-report scale for ADHD in adults, and to determine the clinical utility and cut-off scores of K-AARS. Methods: The participants were 135 drug naïve adults with ADHD and 144 healthy controls. To diagnose ADHD based on the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, two board-certified pediatric psychiatrists interviewed the participants and completed the Mini International Neuropsychiatric Interview. K-AARS was applied to all participants. K-AARS comprises six clinical subscales, one impairment subscale, and one driving behavior subscale. The receiver operating characteristic analysis was conducted to calculate the cut-off scores of K-AARS. Results: All subscale scores, including six clinical subscale, impairment subscale, and driving behavior subscale scores, were found to be significant in distinguishing adults with ADHD from healthy controls. The sensitivity and specificity of the six clinical subscales were 63.0-77.0% and 66.7-79.9%, respectively. The combined total score of the six clinical subscales, had a sensitivity of 80.0% and specificity of 79.9%. Conclusion: The discriminative power of K-AARS for the diagnosis of ADHD in adults was excellent, and K-AARS and the empirical diagnosis of adults can be useful in diagnosing ADHD in adulthood.

• 융합정보논문지
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• 제11권4호
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• pp.146-152
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• 2021

본 연구는 그림책을 활용한 시각화 기억훈련 프로그램의 프로토콜을 개발하고 임상에 적용하기 위하여 유용성을 확인하고자 한다. 경도치매 환자 5명을 대상으로 총 5회기의 시각화 기억훈련 프로그램을 진행하였다. 프로그램 진행 전후 단어 기억력, 전반적 기억력검사, 및 우울감검사를 시행하여 그 변화를 관찰하였다. 그 결과 프로그램 시행 후 전반적 기억력의 향상이 있었으나 통계적으로 유의하지 않았다. 반면 우울감에는 통계적으로 유의미한 긍정적인 효과가 있는 것으로 나타났다. 단어 기억력에 있어 일부 대상자는 인출 및 재인의 향상을 보였고 일부 대상자는 변화가 없거나 더 나빠진 것으로 나타났다. 본 프로그램은 일부 경도치매 환자의 기억력 향상에 도움이 되며 우울감이 감소하는 정서적 효과가 있는 것으로 판단된다. 향후 그룹 인지치료 모델로 널리 활용되길 바라며 더 많은 대상자 수의 연구가 필요할 것으로 사료된다.

• Plant Breeding and Biotechnology
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• 제5권2호
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• pp.134-142
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• 2017

Resource plants are important and have strong potential for a variety of utilities as crops or pharmaceutical materials. However, most resource plants remain wild and thus their utility for breeding and biotechnology is limited. Molecular markers are useful to initiate genetic study and molecular breeding for these understudied resource plants. We collected various wild collections of Peucedanum japonicum which is indigenous resource plants utilized as oriental medicine and leafy vegetables in Korea. In this study, we produced two independent whole genome sequences (WGSs) from two collections and identified large scale polymorphic simple sequence repeat (pSSR) based on our pipeline to develop SSR markers based on comparison of two WGSs. We identified a total of 452 candidate pSSR contigs. To confirm the accuracy and utility of pSSR, we designed ten SSR primer pairs and successfully applied those to seven collections of P. japonicum. The WGS and pSSR candidates identified in this study will be useful resource for genetic research and breeding purpose for the valuable resource plant, P. japonicum.

• 대한토목학회논문집
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• 제40권6호
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• pp.563-569
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• 2020

기상현상 발생에 대한 기존 기상예보 방식에서 벗어나 기상재해가 사회와 인간생활에 끼치는 영향을 제공함으로써 사전에 영향범위에 대한 피해예방 및 행동예방을 취할 수 있는 영향예보를 제공하는 것이 필요하다. 이를 위해 미국, 영국, 프랑스 등 세계 각국에서는 호우, 폭설, 한파 등의 영향예보를 시행하고 있으며, 보다 효율적인 예보방안에 대해 고민하고 있다. 본 연구에서는 여러 기상현상 중 호우에 대한 영향예보를 국내의 실정에 맞도록 개선하고, 적용하기 위해 33개의 호우영향인자(Impact Library)를 격자단위(1 km)로 구축하고, 표준정규분포법을 이용하여 4개의 위험등급(Minimal, minor, significant, severe)의 기준을 산정하였다. 산정된 기준은 호우영향 대상체인 사람, 시설, 농업, 교통을 중심으로 한 6개의 카테고리(Residential, commercial, utility, community, agriculture, transport)에 대한 호우위험영향(Heavy rain risk impact)를 산정하기 위한 지표로 활용된다.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.76-84
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• 2022

Purpose: Whole-exome sequencing (WES) has been a useful tool for novel gene discovery of various disease categories, further increasing the diagnostic yield. This study aimed to investigate the clinical utility of WES prospectively in undiagnosed genetic diseases. Materials and Methods: WES tests were performed on 110 patients (age range, 0-28 years) with suspected rare genetic diseases. WES tests were performed at a single reference laboratory and the variants reported were reviewed by clinical geneticists, pediatricians, neurologists, and laboratory physicians. Results: The patients' symptoms varied with abnormalities in the head or neck, including facial dysmorphism, being the most common, identified in 85.4% of patients, followed by abnormalities in the nervous system (83.6%). The average number of systems manifesting phenotypic abnormalities per patient was 3.9±1.7. The age at presentation was 2.1±2.7 years old (range, 0-15 years), and the age at WES testing was 6.7±5.3 years (range, 0-28 years). In total, WES test reported 100 pathogenic/likely pathogenic variants or variants of uncertain significance for 79 out of 110 probands (71.8%). Of the 79 patients with positive or inconclusive calls, 55 (50.0%) patients were determined to have good genotype-phenotype correlations after careful review. Further clinical reassessment and family member testing determined 45 (40.9%) patients to have been identified with a molecular diagnosis. Conclusion: This study showed a 40.9% diagnostic yield for WES test for a heterogeneous patient cohort with suspected rare genetic diseases. WES could be the feasible genetic test modality to overcome the diversity and complexity of rare disease diagnostics.