• The Journal of Engineering Geology
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• v.16 no.1 s.47
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• pp.23-30
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• 2006

This study was carried out to understand the relationship between orientation of tecto-lineaments obtained from aero-photograph and orientation of discontinuities measured at field for the rock types of igneous, sedimentary and metamorphic rocks in Andong area. Total 847 tecto-lineaments were extracted from the aero-photographs and total 1,940 discontinuities including joints, foliations and faults were measured during geologic survey. By using the software DIPS, preferred trends of tecto-lineaments were deduced as N30E-N40E for igneous rocks and N50E-N60E for both sedimentary and metamorphic rocks, while the trends of discontinuities were found as N40E-N50E for igneous rocks, N50E-N80E for sedimentary rocks and N50E-N60E for meta morphic rocks. Even though both orientations for a given rock type showed relatively good agreement in its trend, some discrepancy is also appeared. Since construction safety of geo-structures such as tunnel and slope, etc., is significantly affected by the orientation of discontinuities in rock masses, it is highly recommended to perform a detailed geologic survey as well as an aero-photograph interpretation at a design stage.

• School Mathematics
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• v.6 no.1
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• pp.91-118
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• 2004

Since 1998 year, many educational software and its contents have been developed by individuals and public institutes. However, it is not easy to re-use the contents effectively and consistently, because they should be changed and reorganized whenever a curriculum is changed. Therefore, it is important for each subject to establish new system in which the contents or their teaching-learning elements are not changed although new curriculum appears. In this respect, in last year(2003 year), while setting mathematics as a representative subject, KERIS executed a study on developing a system(or method) of classifying teaching-learning materials in mathematics using computers, based on future-oriented curriculum including the current mathematics curriculum. Finally, for this study, the most essential and basic teaching-teaming 'units' were developed and the total number of units were 339. Also, in addition to the development of 'units', the 'elements' were developed for understanding more concrete contents included in each 'unit' and the total number of elements were 1191.

• Herbal Formula Science
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• v.28 no.4
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• pp.313-325
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• 2020

Objectives : To explore the associated potential pathways and molecular targets of Hwangryunhaedok-tang(HHT) by the approaches of network pharmacology and bioinformatics in traditional chinese medicine(TCM). Methods : Hwangryunhaedok-tang constituent drugs(Coptidis Rhizoma, CR; Scutellariae Radix, SR; Phellodendri Cortex, PC; Gardeniae Fructus, GF) and their processing types were searched from TCM systems pharmacology(TCMSP). The databases of TCMSP, Kyoto Encyclopedia of Genes and Genomes(KEGG), MCODE and STRING were used to gather information. The network of bioactive ingredients and target gene was constructed by Cytoscape software(version 3.8). Results : A total of 94 HHT active compounds(CR, 12; SR, 35; PC, 33; GF, 14, respectively) were found, and HHT were identified by TCMSP. Applications of KEGG and MCODE analysis indicates that total of 6 bioactive ingredients in the top 10% ranking were obtained and 32 diseases of HHT were screened. The molecular pathway analysis revealed that HHT exerts cancer, inflammation and cerebrovascular diseases effects by acting on several signaling pathway. In addition, HHT found that three genes(e.g. SPIN1, TRIM25, and APP) correlate with the aforementioned diseases. Conclusions : This study showed that network pharmacology analysis is useful to elucidate the complex mechanisms of action of HHT.

• Journal of Astronomy and Space Sciences
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• v.27 no.3
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• pp.195-204
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• 2010

The optimal Earth-Moon transfer trajectory considering spacecraft's visibility from the Daejeon ground station visibility at both the trans lunar injection (TLI) and lunar orbit insertion (LOI) maneuvers is designed. Both the TLI and LOI maneuvers are assumed to be impulsive thrust. As the successful execution of the TLI and LOI maneuvers are crucial factors among the various lunar mission parameters, it is necessary to design an optimal lunar transfer trajectory which guarantees the visibility from a specified ground station while executing these maneuvers. The optimal Earth-Moon transfer trajectory is simulated by modifying the Korean Lunar Mission Design Software using Impulsive high Thrust Engine (KLMDS-ITE) which is developed in previous studies. Four different mission scenarios are established and simulated to analyze the effects of the spacecraft's visibility considerations at the TLI and LOI maneuvers. As a result, it is found that the optimal Earth-Moon transfer trajectory, guaranteeing the spacecraft's visibility from Daejeon ground station at both the TLI and LOI maneuvers, can be designed with slight changes in total amount of delta-Vs. About 1% difference is observed with the optimal trajectory when none of the visibility condition is guaranteed, and about 0.04% with the visibility condition is only guaranteed at the time of TLI maneuver. The spacecraft's mass which can delivered to the Moon, when both visibility conditions are secured is shown to be about 534 kg with assumptions of KSLV-2's on-orbit mass about 2.6 tons. To minimize total mission delta-Vs, it is strongly recommended that visibility conditions at both the TLI and LOI maneuvers should be simultaneously implemented to the trajectory optimization algorithm.

• Journal of Korean Tunnelling and Underground Space Association
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• v.2 no.3
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• pp.59-69
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• 2000

Three-dimensional total station system which integrated the instrument with Target Pin and TEMS 3D software developed by SKEC R&D center was applied to a tunnel excavation for monitoring of convergence and crown settlement. The efficiency of the system was proved as the result in the aspects of exact monitoring and prediction of rock conditions ahead of the face. To monitor the behavior of tunnel lining at the maintenance stage, DOCS system was applied to the subway tunnel section. Such many effects as the vibration of sensors, verification of the system efficiency, the effect of test trains operation, the variation of temperature and the effect of high voltage was checked. Thus the management scheme for tunnel maintenance was laid out as a proposal.

• Women's Health Nursing
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• v.8 no.4
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• pp.550-558
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• 2002

This study was designed to examine the factors that influence the burnout of nurses practice healthcare in a hospital setting. Subjects for this study were 245 nurses working at University K hospital in Seoul, Korea. Data for this study was collected from 15 to 27 April, 2002. The data collection instruments used for this study are as follows: Maslach Burnout Inventory(1981), Orientation to Life Questionnaire(Sense of Coherence, SOC) by Antonovsky (1987) and Modified Coping Resources Inventory developed by author. The analysis of the data was completed using the descriptive, ANOVA, Pearson correlation analysis, and stepwise multiple regression using the SAS program software. The results of this study were as follows: 1. Total mean score of burnout was 4.0. Mean scores of the subscales were; emotional exhausion 4.7, personalization 3.7, and personal accomplishment 3.4.2. Significant statistical differences according to demographic characteristics of the subjects were found in the variables of age, job position, years of working, perceived job stress, and burnout. 3. Burnout was negatively related to sense of coherence(r=-.65) and coping resources (r=-.40); subscales of SOC of comprehensibility(r=-.57), manageability (r= -.55), and meaningfulness(r= -.52); subscales of coping of self-care(r=-.36), and cognitive coping(r=-.39). 4. Job stress was the highest factor influence burnout. Sixty-one percent of the total variance of burnout was experienced by variables of comprehensibility, meaningfulness, age, self-care, manageability and leisure activities including job stress. In conclusion, it was found that a low level of burnout was related to high scores of SOC and coping resources. Job stress, manageability, and meaningfulness were the highest factors influencing the level of subscale of emotional exhausion, depersonalization, and personal accomplishment. Therefore, it is necessary to search for strategies to promote SOC and coping resources for reducing the level of burnout of nurses.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.7
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• pp.936-942
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• 2015

The purpose of this study was to characterize genetic architecture of behavior patterns in Sapsaree dogs. The breed population (n=8,256) has been constructed since 1990 over 12 generations and managed at the Sapsaree Breeding Research Institute, Gyeongsan, Korea. Seven behavioral traits were investigated for 882 individuals. The traits were classified as a quantitative or a categorical group, and heritabilities ($h^2$) and variance components were estimated under the Animal model using ASREML 2.0 software program. In general, the $h^2$ estimates of the traits ranged between 0.00 and 0.16. Strong genetic ($r_G$) and phenotypic ($r_P$) correlations were observed between nerve stability, affability and adaptability, i.e. 0.9 to 0.94 and 0.46 to 0.68, respectively. To detect significant single nucleotide polymorphism (SNP) for the behavioral traits, a total of 134 and 60 samples were genotyped using the Illumina 22K CanineSNP20 and 170K CanineHD bead chips, respectively. Two datasets comprising 60 (Sap60) and 183 (Sap183) samples were analyzed, respectively, of which the latter was based on the SNPs that were embedded on both the 22K and 170K chips. To perform genome-wide association analysis, each SNP was considered with the residuals of each phenotype that were adjusted for sex and year of birth as fixed effects. A least squares based single marker regression analysis was followed by a stepwise regression procedure for the significant SNPs (p<0.01), to determine a best set of SNPs for each trait. A total of 41 SNPs were detected with the Sap183 samples for the behavior traits. The significant SNPs need to be verified using other samples, so as to be utilized to improve behavior traits via marker-assisted selection in the Sapsaree population.

• Clinical and Experimental Reproductive Medicine
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• v.39 no.2
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• pp.87-93
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• 2012

Objective: Lin28 has been known to control the proliferation and pluripotency of embryonic stem cells. The purpose of this study was to determine the downstream effectors of Lin28 in mouse embryonic stem cells (mESCs) by RNA interference and microarray analysis. Methods: The control siRNA and Lin28 siRNA (Dharmacon) were transfected into mESCs. Total RNA was prepared from each type of transfected mESC and subjected to reverse transcription-polymerase chain reaction (RT-PCR) analysis to confirm the downregulation of Lin28. The RNAs were labeled and hybridized with an Affymetrix Gene-Chip Mouse Genome 430 2.0 array. The data analysis was accomplished by GenPlex 3.0 software. The expression levels of selected genes were confirmed by quantitative real-time RT-PCR. Results: According to the statistical analysis of the cDNA microarray, a total of 500 genes were altered in Lin28-downregulated mESCs (up-regulated, 384; down-regulated, 116). After differentially expressed gene filtering, 31 genes were selected as candidate genes regulated by Lin28 downregulation. Among them, neuropeptide Y5 receptor and oocyte-specific homeobox 5 genes were significantly upregulated in Lin28-downregulated mESCs. We also showed that the families of neuropeptide Y receptor (Npyr) and oocyte-specific homeobox (Obox) genes were upregulated by downregulation of Lin28. Conclusion: Based on the results of this study, we suggest that Lin28 controls the characteristics of mESCs through the regulation of effectors such as the Npyr and Obox families.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.8
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• pp.1171-1176
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• 1999

The precision and reliability of the Computer Image Analysis technique using a desk top computer for extracting information from carcass cross section scans was evaluated by the repeatability (R) and coefficient of variation (CV) for error variance. The 6th and 7th ribs cross section of carcasses from 55 fattened Japanese Black steers were used. The image analysis was conducted using a desk top computer (Macintosh-Apple Vision 1710 Display) connected to a scanner and an image capture camera. Two software applications, Adobe Photoshop and Mac Scope were used interchangeably. The information extracted and measured were individual muscle area, circumference length, long and short axes lengths, muscle direction; distance between any two muscle centers of gravity; cross section total area, lean, fat, and bone. The information was extracted after the processes of scanning, digitization, masking, muscle separation, and binarization. When using the Computer Image Analysis technique by desk top computer, proper digitization and selection of scanning resolution are very important in order to obtain accurate information. The R-values for muscle area, circumference, long and axes lengths, and direction ranged from 0.95 to 0.99, whereas those of the distance between any two muscle centers of gravity ranged from 0.96 to 0.99, respectively. For the cross section total area, lean, fat, and bone it ranged from 0.83 to 0.99. Excellent repeatability measurements were observed for muscle direction and distance between any two muscle centers of gravity. The results indicate that the Computer Image Analysis technique using a desk top computer for extracting information from carcass cross section is reliable and has high precision.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9933-9937
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• 2014

Background: Colorectal cancer is the third most common type of cancer in males and the second in females in Iran. Males are more likely to develop CRC than women and age is considered as a main risk factor for colorectal cancer. Prevalence of colorectal cancer has been increasing in Asian countries. Aim: The object of this study was to determine the clinical and pathology characteristics of colorectal polyps in Iranian patients and to investigate the variation between our populations with other populations. Materials and Methods: A total of 167 patients with colorectal polyps were included in our study. All underwent colonoscopy during 2009-2013 and specimens were taken through polypectomy and transferred to pathology. All data in patient files including pathology reports were collected and analyzed by SPSS 16 software. A two-tailed test was used and a P-value of < 0.05 was considered significant. Results: Mean age of participants was $57{\pm}15$. Some 84 were females (50.3%) and 83 males (49.7%). Total of 225 polyps were detected which 119 (52.9%) were in males and 106 (47.1%) were in females. Solitary polyps were observed in 124 patients (74%), 26 (15.6%) had two polyps and 17 (10.1%) with more than two polyps (three to five). Rectosigmoid was the site of most of the polyps (63.1%), followed by 19.6% in the descending colon, 7.6% in the transverse, 5.8% in the ascending, and 3.1% in the cecum, data being missing in two cases. Conclusions: Recto sigmoid was site of most of the polyps. The most prevalent type of lesion was adenomatous polyps detected in 78 (34.7%). Mixed hyperplastic adenomatous type observed in 70 (31.1%). This high prevalence of adenomatous polyps in Iranian patients implies the urgent need for screening plans to prevent further healthcare problems with colorectal cancer in the Iranian population.