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Does Vitex Agnus-Castus L. Have Deleterious Effect on Fertility and Pregnancy Outcome? An Experimental Study on Rats for Prediction of Its Safety

  • Najib, Fateme Sadat;Poordast, Tahereh;Mahmudi, Monireh Sufi;Shiravani, Zahra;Namazi, Niloofar;Omrani, Gholamhossein Ranjbar
    • Journal of Pharmacopuncture
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    • v.25 no.2
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    • pp.106-113
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    • 2022
  • Objectives: Herbal medicine is a worldwide health topic. Vitex agnus-castus L. (VAC) is a popular plant used for gynecologic problems due to its hormonal effects. The aim of this study is to reveal VAC extract effect on fetus when this herb is used started from antenatal period or during pregnancy. Methods: Performed from starting day of January 2019 till February 2019, 48 rats were assigned in randomly divided eight-member six groups: control (C1), treated group with 365 mg/kg VAC from initiation of insemination (T1) and 30 days prior to pregnancy (T2), control that underwent caesarean section on 15th day of gestational age (C2) and treated group with 365 mg/kg VAC from initiation of insemination (T3) and 30 days prior to pregnancy (T4) that underwent caesarean section. Weight, sex and number of fetuses, abortion and still birth rate and estradiol level were evaluated using t-test by SPSS software. Results: We showed increased weight among T1 group considering totally and sex-dependent which is significant (all p-value < 0.05). We also detected significantly decreased weight in T2 in total (p-value < 0.0001) and when considering female fetuses (0.043) but not males (0.17). Although the results showed slightly non-significant increased weight among fetuses of T3 (totally or based on the fetus sex) compared to the control group (C2), T4 group had statistically decreased weight compared to control group. Pregnancy rate and pregnancy outcome were affected by VAC usage. The time of VAC initiation also affected live birth and abortion rates. Conclusion: VAC extract may affect pregnancy rate, live birth rate, abortion and stillbirth rates. Its effect on the weight and the sex showed dual pattern depends on the time of initiation and pregnancy trimester of evaluation. Prescribing this medicinal plant for patients being prone to pregnancy should be with caution. Further study is recommended.

A Study on the Lifestyle Assessment Tools of Children and Adolescents: A Systematic Review (아동 및 청소년의 라이프스타일 평가도구에 관한 조사: 체계적 고찰)

  • Kim, Ah-Ram;Park, Ji-Hyuk
    • Therapeutic Science for Rehabilitation
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    • v.11 no.2
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    • pp.7-24
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    • 2022
  • Objective : To develop standardized assessment tools that evaluate the multi-aspect lifestyles of children and adolescents, we aimed to systematically analyze lifestyle assessment tools and lifestyle component-specific assessment tools. Methods : The study period was 2001-2020, with search engines using CINANL, NDSL, PubMed, and RISS. Search key words used 'lifestyle assessment' OR 'lifestyle profile' OR 'lifestyle test', 'physical activity assessment' OR 'physical activity participation profile', 'nutrition assessment' OR 'nutrition profile', 'activity participation assessment' OR 'activity participation profile'. Results : A total of 24 evaluation tools were selected after 5,883 studies reviewed the title, abstract, and full text after deduplication. The detailed results resulted in five lifestyle assessment tools, seven physical activity assessment tools, nine nutrition assessment tools, and three activity participation assessment tools. Conclusion : For the lifestyle assessment tools for children and adolescents, the component items, measurement methods, and age of assessment of each item were analyzed. It is hoped that this will be used as a basis for the development of standardized assessment tools to assess the multi-aspect lifestyles of children and adolescents in the future.

Biometry of width between labial transitional line angles in anterior teeth: an observational study

  • Wen, Chao;Ye, Hongqiang;Chen, Hu;Zhou, Yongsheng;Huang, Mingming;Sun, Yuchun
    • The Journal of Advanced Prosthodontics
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    • v.14 no.1
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    • pp.1-11
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    • 2022
  • PURPOSE. The maximum width between the mesial and distal labial transitional line angles, described as "esthetic width" herein, could significantly influence the visual perception of the teeth and smile. This study aimed to conduct biometric research on esthetic width and to explore whether regular distribution exists in the esthetic width of human teeth. MATERIALS AND METHODS. A total of 4,264 maxillary and mandibular anterior teeth were measured using the Geomagic studio software program. The proportions of maxillary to mandibular homonymous teeth and proportions between the adjacent teeth were calculated. Bilateral symmetry and the correlation between the esthetic and mesiodistal widths were both accounted for during the measurement procedures. RESULTS. The mean esthetic widths were 6.773 ± 0.518 mm and 4.329 ± 0.331 mm for maxillary and mandibular central incisors, respectively, 5.451 ± 0.487 mm and 5.008 ± 0.351 mm for maxillary and mandibular lateral incisors, respectively, and 3.340 ± 0.353 mm and 5.958 ± 0.415 mm for maxillary and mandibular canines, respectively. Except for the mandibular canines, no significant difference in esthetic width was found among homonymous teeth from the same jaw. A high linear correlation was found between the esthetic and mesiodistal widths of the same tooth, except for the maxillary canines. Esthetic width proportions among different tooth categories showed some regular patterns, which were similar to those of the mesiodistal width. CONCLUSION. Esthetic width is regularly distributed among the teeth in the Chinese population. This could provide an important reference for anterior dental restorations and dimension recovery in esthetic reconstruction of anterior teeth.

Efficiency of Equilume light mask on the resumption of early estrous cyclicity and ovulation in Thoroughbred mares

  • Kim, Seongmin;Jung, Heejun;Murphy, Barbara Anne;Yoon, Minjung
    • Journal of Animal Science and Technology
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    • v.64 no.1
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    • pp.1-9
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    • 2022
  • Equilume light masks had no impact on hastening the resumption of estrous cyclicity in mares maintained in outdoor pastures on the mainland of Korea due to the cold weather conditions. Jeju Island is a major horse-breeding site in Korea and is warmer than the mainland during the winter season. Therefore, the primary objective of this study was to explore the efficiency of the Equilume light mask on the resumption of seasonal estrous cycles in Thoroughbred mares on Jeju Island. A total of 20 nonpregnant mares were randomly divided into the Equilume light mask (n = 9) and stable lighting (n =11) groups. The experiment was performed at seven different horse-breeding farms located on Jeju Island from November 15, 2020, to February 15, 2021. The mares were exposed to the respective lights from 16:00 to 23:00. Follicle size and uterine edema were measured by ultrasound scanning. Body condition scores (BCS) were also monitored during the experiment. Statistical analysis was conducted using the SAS and SPSS software, and p-values of < 0.05 were considered statistically significant. Two of the nine (22.2%) mares in the Equilume light mask group and three of the 11 (27.28%) mares in the stable lighting group were still cycling in December and January, which were considered as all-year-round cycling mares. On February 15, there was no difference between groups in the resumption of early seasonal estrus cycle, which was determined by follicles > 25 mm in addition to uterine edema. All mares in the Equilume light mask group and five of the eight mares (62.5%) in the stable lighting group had resumed cycling. Interestingly, six of the seven mares (87.5%) in the Equilume light mask and four of eight mares (50%) in the stable lighting group had already ovulated on February 15 (p > 0.05), as determined by the presence of a recent corpus luteum. No difference was observed in BCS and uterine edema between groups (p > 0.05). In conclusion, the Equilume light mask can be an effective approach to induce early seasonal estrus cycles of mares in Jeju Island, and it also enhances the efficiency of farm management by reducing labor.

Identification of polymorphic loci in the deiodinase 2 gene and their associations with head dimensions in geese

  • Deng, Yan;Hu, Qian;Tang, Bincheng;Ouyang, Qingyuan;Hu, Shenqiang;Hu, Bo;Hu, Jiwei;He, Hua;Chen, Guohong;Wang, Jiwen
    • Animal Bioscience
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    • v.35 no.5
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    • pp.639-647
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    • 2022
  • Objective: This study was conducted to clone and compare the molecular characteristics of the deiodinase 2 (DIO2) gene between Sichuan White geese and Landes geese, and to analyze the association between polymorphisms of the DIO2 gene and head dimensions in Tianfu meat geese. Methods: The coding sequence of the DIO2 gene was cloned by polymerase chain reaction and vector ligation and aligned by DNAMAN software. A total of 350 Tianfu meat geese were used to genotype the polymorphisms of the DIO2 gene and measure the head dimensions. Association analysis between the polymorphisms of the DIO2 gene and head dimensions was carried out. Results: An 840-bp coding sequence of the DIO2 gene was obtained and comparison analysis identified four polymorphic loci between Sichuan White geese and Landes geese. Further analysis showed that the dominant alleles for the four polymorphic loci were G, G, A, and T and the frequency of the heterozygous genotype was higher than that of the homozygous genotype in Tianfu meat geese. Compared to that in the population of non-knob geese of Tianfu meat geese, the head dimensions in the population of knob geese were significantly higher except for nostril height. However, in the non-knob geese, beak width 1, beak width 2, nostril length, cranial width 1, and maxillary length had significant differences among different genotypes or haplotypes/diplotypes. Conclusion: These results suggested that polymorphisms of the DIO2 gene could be considered molecular markers to select larger heads of geese in the population of non-knob geese.

Sign Language Dataset Built from S. Korean Government Briefing on COVID-19 (대한민국 정부의 코로나 19 브리핑을 기반으로 구축된 수어 데이터셋 연구)

  • Sim, Hohyun;Sung, Horyeol;Lee, Seungjae;Cho, Hyeonjoong
    • KIPS Transactions on Software and Data Engineering
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    • v.11 no.8
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    • pp.325-330
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    • 2022
  • This paper conducts the collection and experiment of datasets for deep learning research on sign language such as sign language recognition, sign language translation, and sign language segmentation for Korean sign language. There exist difficulties for deep learning research of sign language. First, it is difficult to recognize sign languages since they contain multiple modalities including hand movements, hand directions, and facial expressions. Second, it is the absence of training data to conduct deep learning research. Currently, KETI dataset is the only known dataset for Korean sign language for deep learning. Sign language datasets for deep learning research are classified into two categories: Isolated sign language and Continuous sign language. Although several foreign sign language datasets have been collected over time. they are also insufficient for deep learning research of sign language. Therefore, we attempted to collect a large-scale Korean sign language dataset and evaluate it using a baseline model named TSPNet which has the performance of SOTA in the field of sign language translation. The collected dataset consists of a total of 11,402 image and text. Our experimental result with the baseline model using the dataset shows BLEU-4 score 3.63, which would be used as a basic performance of a baseline model for Korean sign language dataset. We hope that our experience of collecting Korean sign language dataset helps facilitate further research directions on Korean sign language.

The Application of NIRS for Soil Analysis on Organic Matter Fractions, Ash and Mechanical Texture

  • Hsu, Hua;Tsai, Chii-Guary;Recinos-Diaz, Guillermo;Brown, John
    • Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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    • 2001.06a
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    • pp.1263-1263
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    • 2001
  • The amounts of organic matter present in soil and the rate of soil organic matter (SOM) turnover are influenced by agricultural management practice, such as rotation, tillage, forage plow down direct seeding and manure application. The amount of nutrients released from SOM is highly dependent upon the state of the organic matter. If it contains a large proportion of light fractions (low-density) more nutrients will be available to the glowing crops. However, if it contains mostly heavy fractions (high-density) that are difficult to breakdown, then lesser amounts of nutrients will be available. The state of the SOM and subsequent release of nutrients into the soil can be predicted by NIRS as long as a robust regression equation is developed. The NIRS method is known for its rapidity, convenience, simplicity, accuracy and ability to analyze many constituents at the same time. Our hypothesis is that the NIRS technique allows researchers to investigate fully and in more detail each field for the status of SOM, available moisture and other soil properties in Alberta soils for precision farming in the near future. One hundred thirty one (131) Alberta soils with various levels (low 2-6%, medium 6-10%, and high >10%) of organic matter content and most of dry land soils, including some irrigated soils from Southern Alberta, under various management practices were collected throughout Northern, Central and Southern Alberta. Two depths (0- 15 cm and 15-30 cm) of soils from Northern Alberta were also collected. These air-dried soil samples were ground through 2 mm sieve and scanned using Foss NIR System 6500 with transport module and natural product cell. With particle size above 150 microns only, the “Ludox” method (Meijboom, Hassink and van Noorwijk, Soil Biol. Biochem.27: 1109-1111, 1995) which uses stable silica, was used to fractionate SOM into light, medium and heavy fractions with densities of <1.13, 1.13-1.37 and >1.37 respectively, The SOM fraction with the particle size below 150 microns was discarded because practically, this fraction with very fine particles can't be further separated by wet sieving based on density. Total organic matter content, mechanical texture, ash after 375$^{\circ}C$, and dry matter (DM) were also determined by “standard” soil analysis methods. The NIRS regression equations were developed using Infra-Soft-International (ISI) software, version 3.11.

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A Systematic Literature Review of School Readiness Programs for Children With Disabilities (장애아동의 학교준비도 프로그램(School Readiness Program)에 대한 체계적 문헌 고찰)

  • Kim, Eun Ji;Kwak, Bo-Kyeong;Park, Hae Yean
    • Therapeutic Science for Rehabilitation
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    • v.12 no.3
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    • pp.7-18
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    • 2023
  • Objective : This study aimed to confirm the research characteristics by analyzing the literature that applied the school readiness programs for children with disabilities. Methods : Studies were collected from the PubMed, Embase, Web of Science, and Research Information Sharing Service databases. The key terms were "School readiness" AND ("Occupational Therapy" OR "Rehabilitation") in English and Korean. Total eight articles were selected through the selection and exclusion criteria. Results : The programs included multi-type training, motor skill training, parent training, and mobile application training. The providers were psychologists, occupational therapists, physical therapists, speech pathologists, community workers, educators, and the psychologists who conducted most of the research. The program factors can be classified into academic function, motor function, social function, parental training, and others. Academic and social functions accounted for the largest proportion of the respondents. The intervention improved multiple skills, literacy, parenting skills, and gross fine motor function. Conclusion : This study aimed to provide basic data for school-based occupational therapy by analyzing school readiness programs for children with disabilities. Recently, interest in and research on school readiness has increased. Occupational therapists should also establish their roles in the field of school-related rehabilitation and provide various school-based occupational therapies.

The Effect of Emotional Intelligence, Empathy Ability and Calling Consciousness of Nursing Students on Happiness (간호대학생의 감성지능, 공감능력 및 소명의식이 행복에 미치는 영향)

  • Kang, Hye-Seung;Lee, Hyun-Ji;Park, Bo-Ha;Lee, Yeon-Gyeong
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.2
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    • pp.243-252
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    • 2019
  • The purpose of this study was to evaluate the effect of emotional intelligence, empathy ability, and calling consciousness of nursing students on happiness. The survey was conducted 217 nursing students attending in G city from September 3th to September 14th, 2018. Data was collected from self-administered questionnaires about happiness, emotional intelligence, empathy ability and calling consciousness. Data were analyzed by SPSS software version 21 using descriptive statistics (frequency) and analytical statistics (t-test, ANOVA, Pearson's correlation coefficient, linear regression). As a result, Happiness was significantly different by gender, grade, satisfaction in major, collegiate-life satisfaction, personal relationship, health status, perceived economic status. Also happiness showed positive correlation with emotional intelligence, empathy ability, and calling consciousness. Multiple regression analysis revealed that the predictors of happiness were grade, collegiate-life satisfaction, health status, empathy ability, calling consciousness, and emotional intelligence accounting for a total of 49.1% of the variance. Results of this study suggest that it is necessary for nursing students to intervention program aimed at enhance the happiness and it would be effective to focus on strengthening emotional intelligence and empathy ability for them.

Building Sentence Meaning Identification Dataset Based on Social Problem-Solving R&D Reports (사회문제 해결 연구보고서 기반 문장 의미 식별 데이터셋 구축)

  • Hyeonho Shin;Seonki Jeong;Hong-Woo Chun;Lee-Nam Kwon;Jae-Min Lee;Kanghee Park;Sung-Pil Choi
    • KIPS Transactions on Software and Data Engineering
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    • v.12 no.4
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    • pp.159-172
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    • 2023
  • In general, social problem-solving research aims to create important social value by offering meaningful answers to various social pending issues using scientific technologies. Not surprisingly, however, although numerous and extensive research attempts have been made to alleviate the social problems and issues in nation-wide, we still have many important social challenges and works to be done. In order to facilitate the entire process of the social problem-solving research and maximize its efficacy, it is vital to clearly identify and grasp the important and pressing problems to be focused upon. It is understandable for the problem discovery step to be drastically improved if current social issues can be automatically identified from existing R&D resources such as technical reports and articles. This paper introduces a comprehensive dataset which is essential to build a machine learning model for automatically detecting the social problems and solutions in various national research reports. Initially, we collected a total of 700 research reports regarding social problems and issues. Through intensive annotation process, we built totally 24,022 sentences each of which possesses its own category or label closely related to social problem-solving such as problems, purposes, solutions, effects and so on. Furthermore, we implemented four sentence classification models based on various neural language models and conducted a series of performance experiments using our dataset. As a result of the experiment, the model fine-tuned to the KLUE-BERT pre-trained language model showed the best performance with an accuracy of 75.853% and an F1 score of 63.503%.