• Korean Journal of Clinical Pharmacy
• /
• v.13 no.1
• /
• pp.1-4
• /
• 2003

Cyclosporine (CsA) has become well established as a potent immunosuppressive agent in the renal transplantation. However, therapy is complicated by large intraindividual and interindividual variability in pharmacokinetics of CsA and frequent undesirable clinical outcomes such as graft rejection and nephrotoxicity. The objective of this study was to determine the CsA trough blood concentrations that were associated with acute graft rejection and renal toxicity in renal transplant patients. Also, the ability of the current recommendation of therapeutic range for CsA to prevent graft rejections and CsA-associated renal toxicity was assessed. The clinical courses of the patients on CsA as an immusuppressive agent for preventing the graft rejection with renal ransplantation performed at Seoul National University Hospital from January 1995 to September 1998 were retrospectively reviewed. Total of 78 patients were included and three of them were retransplantation cases. Twenty-two acute episodes of rejection were identified, but only 16 episodes were clinically significant. Of these all the episodes occurred during the first month after transplantation except one. Mean daily doses of CsA were $427.2\pm72.1,\;352.6\pm56.8,\;308.62\pm48.3\;and\;268.47.1\;mg$ at posttransplant 1, 3, 6, and 12 months, respectively. Mean CsA whole blood though levels were $259.8\pm36.2,\;238.5\pm39,\;200.8\pm45.8\;and\;161.9\pm25.8\;ng/ml$ at posttransplant 1, 3, 6 and 12 months, respectively. Mean daily doses/weight were $7.9\pm1,\;6.4\pm1,\;5.3\pm0.7\;and\;4.6\pm0.7\;mg/kg$ at posttransplant 1, 3, 6 and 12 months, respectively. CsA doses decreased significantly as months progressed (p<0.001). During the first month after transplantation, only $12.5\%$ of the patients in rejection group had CsA concentration in therapeutic range, and 87.5, 93.8, and $100\%$ were within the therapeutic range at posttransplant 3, 6, and 12 months, respectively. These results suggested that CsA concentrations of $250\sim300\;ng/ml$ might be appropriate for preventing the acute rejection during the first posttransplant month.

• Korean Journal of School Psychology
• /
• v.17 no.2
• /
• pp.181-198
• /
• 2020

This study examined how the rejection sensitivity model might be applied to the link between rejection sensitivity and dating relationship satisfaction by means of investigating the mediating effect of cognitive emotion regulation strategy and conflict resolution strategy. A total of 668 college students in Seoul (232 males, 436 females, mean age of 21.59 years [SD=2.08]) participated in this study. The results illustrated that the adaptive emotion regulation strategy, among cognitive emotion regulation strategies, and the integration and compromise strategies, among conflict resolution strategies, had the double mediation effect on the association between rejection sensitivity and dating relationship satisfaction. In other words, a direct negative correlation between rejection sensitivity and dating relationship satisfation resulted in high rejection sensitivity, which was expected to generate low satisfaction in dating relationships. However, it was confirmed that the use of these two strategies-the cognitive emotion regulation and the conflict resolution strategy-could bring positive effects in terms of the dating relationship satisfaction; the former helped couples to see situations more broadly and increase positive perceptions, while the latter solve their problems each other. Based on these findings, we discuss their implications for counseling practice and therapeutic interventions

• Korean Journal of Culture and Social Issue
• /
• v.29 no.4
• /
• pp.477-496
• /
• 2023

The purpose of this study is to examine the relationship between rejection sensitivity and reactive aggression among college students, as well as to determine the mediating effects of self-concept clarity and hostile attribution bias on the relationship between rejection sensitivity and reactive aggression. A self-report questionnaire was conducted online for the purpose of gathering data from university students aged 18 years and older. A total of 250 participants were included in the analysis. SPSS 27.0 was used for data analysis to check the basic statistics of the variables, frequency analysis, reliability analysis, and correlation analysis. In addition, the model fit was checked using Amos 21.0, and the bootstrapping method verified the significance of the indirect effect. The results of this study are as follows. The results of this study are as follows. First, rejection sensitivity positively affects reactive aggression through self-concept clarity. Second, rejection sensitivity increases the hostile attribution bias, leading to an increase in reactive aggression. Third, rejection sensitivity positively influences reactive aggression in an indirect way by sequentially affecting self-concept clarity and hostile attribution bias. These findings have implications as they identify psychological factors that affect reactive aggression in college students. This suggests the importance of utilizing psychological interventions to address reactive aggression associated with social problems, such as crime, and provides a foundation for both treatment and prevention. Finally, implications for further research and limitations of this study are suggested.

• Korean Journal of Childcare and Education
• /
• v.12 no.2
• /
• pp.239-262
• /
• 2016

This study investigates how naturally occurring parent groups form by using Schaefer's two axes of affection-rejection and autonomy-control, it also aims to verify whether there is a significant difference in the parent groups' emotional expressiveness and children's peer competence. A total of 201 kindergarten children between the age of 3 to 5 and their parents were given a questionnaire in order to investigate parenting attitudes and emotional expression. And children's teachers measured their peer competence. SPSS 18.0 was used and clustering analysis was conducted according to different parenting attitudes. The first fathers' group was named the lacking-affection group, the second was the democratic-reception group, the third was the ignorance group and the last was the rejection group. For mothers' groups, the first was named the rejection group, the second was the autonomous-control group and the third was the reception-respect group. Parents' emotional expressiveness of each group had a considerable difference while there was no significant difference between children's peer competence. This study was dedicated in deriving meaningful implications on the role of parents by investing the differences between each naturally occurring cluster.

• Korean Journal of Childcare and Education
• /
• v.14 no.5
• /
• pp.117-136
• /
• 2018

Objective: This study examined the mediating roles of preschoolers' self-regulation in the relationship between maternal parenting behaviors and preschoolers' excessive immersion in smartphones. Methods: A total of 268 mothers of preschoolers responded to questionnaires on three research variables. Data were analyzed by correlation analyses and regression analyses. Results: First, maternal warmth/encouragement was negatively related to preschoolers' excessive immersion in smartphones, while maternal overprotectiveness/permission and rejection/neglect were positively related to preschoolers' excessive immersion in smartphones. Second, maternal warmth/encouragement and limit setting were positively linked to preschoolers' self-regulation, but maternal overprotectiveness/permission and rejection/neglect were negatively linked to preschoolers' self-regulation. Third, preschoolers' self-regulation was negatively associated with their excessive immersion in smartphones. Finally, preschoolers' self-regulation fully mediated the relationship between maternal warmth/encouragement and preschoolers' excessive immersion in smartphones, and preschoolers' self-regulation partially mediated the relationship between maternal overprotectiveness/permission, rejection/neglect and preschoolers' excessive immersion in smartphones. Conclusion/Implications: The results of this study suggest that positive maternal parenting behaviors and preschoolers' effective self-regulation are important in order to decrease preschoolers' smartphone overuse. These findings provide empirical evidence to develop programs for prevention and intervention of preschoolers' smartphone addiction.

• Membrane and Water Treatment
• /
• v.12 no.2
• /
• pp.65-73
• /
• 2021

Sponge ball cleaning can generate an abrasion effect, which leads to an attractive increasing in both permeate flux and membrane rejection. The aim of this study was to investigate the influence of the daily sponge ball cleaning (SBC) on the performance of different UF cross-flow membrane modules integrated with a bioreactor. Two 1"-membrane modules and one 1/2"-membrane module were tested. The parameters measured and controlled are temperature, pH, viscosity, particle size, dissolved organic carbon (DOC), total suspended solids (TSS), and permeate flux. The permeate flux could be improved by 60%, for some modules, after 11 days of daily sponge ball cleaning at a transmembrane pressure of 350 kPa and a flow velocity of 4 m/s. Rejection values of all tested modules were improved by 10%. The highest permeate flux of 195 L/㎡.h was achieved using a 1"-membrane module with the aid of its negatively charged membrane material and the daily sponge ball cleaning. In addition, the enhancement in the permeate flux caused by daily sponge ball cleaning improved the energy specific demand for all tested modules. The negatively charged membrane showed the lowest energy specific demand of 1.31 kWh/㎥ in combination with the highest flux, which is a very competitive result.

• Korean Chemical Engineering Research
• /
• v.52 no.2
• /
• pp.272-277
• /
• 2014

In this study the nanofiltration (NF) membrane treatment of a sulfuric acid waste solutions containing copper ion ($Cu^{+2}$) discharging from the etching processes of the printed circuit board (PCB) manufacturing industry has been studied for the recycling of acid etching solution. SelRO MPS-34 4040 NF membrane from Koch company was tested to obtain the basic NF data for recycling of etching solution and separation efficiency (total rejection) of copper ion. NF experiments were carried out with a cross-flow membrane filtration laboratory system. The permeate flux was decreased with the increasing copper ion concentration in sulfuric acid solution and lowering pH of acid solution, and its value was the range of $4.5{\sim}23L/m^2{\cdot}h$. Total rejection of copper ion was decreased with the increasing copper ion concentration, lowering pH of acid solution and decreasing cross-flow rate. The total rejection of copper ion was more than 70% at the experimental condition. The SelRO MPS-34 4040 NF membrane was represented the stable flux and rejection for 1 year operation.

• 제어로봇시스템학회:학술대회논문집
• /
• 2005.06a
• /
• pp.1846-1850
• /
• 2005

This paper presents a constrained-based routing (CBR) algorithm called, Dynamic Possible Path per Link (D-PPL) routing algorithm, for MultiProtocol Label Switching (MPLS) networks. In MPLS on-line routing, future traffics are unknown and network resource is limited. Therefore many routing algorithms such as Minimum Hop Algorithm (MHA), Widest Shortest Path (WSP), Dynamic Link Weight (DLW), Minimum Interference Routing Algorithm (MIRA), Profiled-Based Routing (PBR), Possible Path per Link (PPL) and Residual bandwidth integrated - Possible Path per Link (R-PPL) are proposed in order to improve network throughput and reduce rejection probability. MIRA is the first algorithm that introduces interference level avoidance between source-destination node pairs by integrating topology information or address of source-destination node pairs into the routing calculation. From its results, MIRA improves lower rejection probability performance. Nevertheless, MIRA suffer from its high routing complexity which could be considered as NP-Complete problem. In PBR, complexity of on-line routing is reduced comparing to those of MIRA, because link weights are off-line calculated by statistical profile of history traffics. However, because of dynamic of traffic nature, PBR maybe unsuitable for MPLS on-line routing. Also, both PPL and R-PPL routing algorithm we formerly proposed, are algorithms that achieve reduction of interference level among source-destination node pairs, rejection probability and routing complexity. Again, those previously proposed algorithms do not take into account the dynamic nature of traffic load. In fact, future traffics are unknown, but, amount of previous traffic over link can be measured. Therefore, this is the motivation of our proposed algorithm, the D-PPL. The D-PPL algorithm is improved based on the R-PPL routing algorithm by integrating traffic-per-link parameters. The parameters are periodically updated and are dynamically changed depended on current incoming traffic. The D-PPL tries to reserve residual bandwidth to service future request by avoid routing through those high traffic-per-link parameters. We have developed extensive MATLAB simulator to evaluate performance of the D-PPL. From simulation results, the D-PPL improves performance of MPLS on-line routing in terms of rejection probability and total throughput.

• Journal of the Korea Convergence Society
• /
• v.11 no.2
• /
• pp.261-269
• /
• 2020

The purpose of the study was to investigate the relationship among children's perception of parenting style, their social anxiety, aggression, and school adjustment. A total of 267 children(male 117, female 150) and 10 homeroom teachers participated. Each child completed questionnaires on perception of parenting style, and social anxiety. Children's aggression and school adjustment was measured by their homeroom teachers' reports. The results of the structural equation model showed that children's perception of parenting style high in rejection and control significantly influenced aggression as well as school adjustment, but didn't influence social anxiety. Both parenting style high in rejection and control and aggression had significant effect on school adjustment. Our results showed that parenting style high in rejection and control directly influenced school adjustment, and mediated by their aggression.

• Membrane and Water Treatment
• /
• v.9 no.4
• /
• pp.221-231
• /
• 2018

A new procedure to produce poly(vinylidene fluoride)/boron nitride hybrid membrane is presented for application in membrane distillation (MD) process. The influence of hexagonal boron nitride (h-BN) incorporation on the performance of the polymeric membranes is studied through the present investigation. For this aim, h-BN nanopowders were successfully synthesized using the simple chemical vapor deposition (CVD) route and subsequent solvent treatments. The resulting h-BN nanosheets were blended with poly(vinylidene fluoride) (PVDF) solution. Then, the prepared composite solution was subjected to phase inversion process to obtain PVDF/h-BN hybrid membranes. Various examinations such as scanning electron microscopy (SEM), wettability, permeation flux, mechanical strength and liquid entry pressure (LEP) measurements are performed to evaluate the prepared membrane. Moreover, Air gap membrane distillation (AGMD) experiments were carried out to investigate the salt rejection performance and the durability of membranes. The results show that our hybrid PVDF/h-BN membrane presents higher water permeation flux (${\sim}18kg/m^2h$) compared to pristine PVDF membrane. In addition, the experimental data confirms that the prepared nanocomposite membrane is hydrophobic (water contact angle: ${\sim}103^{\circ}$), has a porous skin layer (>85%), as well competitive fouling resistance and operational durability. Furthermore, the total salt rejection efficiency was obtained for PVDF/h-BN membrane. The results prove that the novel PVDF/h-BN membrane can be easily synthesized and applied in MD process for salt rejection purposes.