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Uncertainty Assessment: Relative versus Absolute Point Dose Measurement for Patient Specific Quality Assurance in EBRT

  • Mahmood, Talat;Ibrahim, Mounir;Aqeel, Muhammad
    • Progress in Medical Physics
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    • v.28 no.3
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    • pp.111-121
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    • 2017
  • Verification of dose distribution is an essential part of ensuring the treatment planning system's (TPS) calculated dose will achieve the desired outcome in radiation therapy. Each measurement have uncertainty associated with it. It is desirable to reduce the measurement uncertainty. A best approach is to reduce the uncertainty associated with each step of the process to keep the total uncertainty under acceptable limits. Point dose patient specific quality assurance (QA) is recommended by American Association of Medical Physicists (AAPM) and European Society for Radiotherapy and Oncology (ESTRO) for all the complex radiation therapy treatment techniques. Relative and absolute point dose measurement methods are used to verify the TPS computed dose. Relative and absolute point dose measurement techniques have a number of steps to measure the point dose which includes chamber cross calibration, electrometer reading, chamber calibration coefficient, beam quality correction factor, reference conditions, influences quantities, machine stability, nominal calibration factor (for relative method) and absolute dose calibration of machine. Keeping these parameters in mind, the estimated relative percentage uncertainty associated with the absolute point dose measurement is 2.1% (k=1). On the other hand, the relative percentage uncertainty associated with the relative point dose verification method is estimated to 1.0% (k=1). To compare both point dose measurement methods, 13 head and neck (H&N) IMRT patients were selected. A point dose for each patient was measured with both methods. The average percentage difference between TPS computed dose and measured absolute relative point dose was 1.4% and 1% respectively. The results of this comparative study show that while choosing the relative or absolute point dose measurement technique, both techniques can produce similar results for H&N IMRT treatment plans. There is no statistically significant difference between both point dose verification methods based upon the t-test for comparing two means.

Reliable Data Transmission Based on Erasure-resilient Code in Wireless Sensor Networks

  • Lei, Jian-Jun;Kwon, Gu-In
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.4 no.1
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    • pp.62-77
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    • 2010
  • Emerging applications with high data rates will need to transport bulk data reliably in wireless sensor networks. ARQ (Automatic Repeat request) or Forward Error Correction (FEC) code schemes can be used to provide reliable transmission in a sensor network. However, the naive ARQ approach drops the whole frame, even though there is a bit error in the frame and the FEC at the bit level scheme may require a highly complex method to adjust the amount of FEC redundancy. We propose a bulk data transmission scheme based on erasure-resilient code in this paper to overcome these inefficiencies. The sender fragments bulk data into many small blocks, encodes the blocks with LT codes and packages several such blocks into a frame. The receiver only drops the corrupted blocks (compared to the entire frame) and the original data can be reconstructed if sufficient error-free blocks are received. An incidental benefit is that the frame error rate (FER) becomes irrelevant to frame size (error recovery). A frame can therefore be sufficiently large to provide high utilization of the wireless channel bandwidth without sacrificing the effectiveness of error recovery. The scheme has been implemented as a new data link layer in TinyOS, and evaluated through experiments in a testbed of Zigbex motes. Results show single hop transmission throughput can be improved by at least 20% under typical wireless channel conditions. It also reduces the transmission time of a reasonable range of size files by more than 30%, compared to a frame ARQ scheme. The total number of bytes sent by all nodes in the multi-hop communication is reduced by more than 60% compared to the frame ARQ scheme.

An exploratory study for an evidence of electroencephalographic changes in isolated subjects for distant mental intention

  • Kim, Dae-Keun
    • Science of Emotion and Sensibility
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    • v.17 no.4
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    • pp.51-60
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    • 2014
  • This double-blind study, as a human experiment of nonlocality, investigated the effects of senders' intention on the central nervous system of a distant human receiver and it explored the roles that motivation might have in modulating these effects. Whole brain activity was measured in the receiver whom was asked to relax in a distant room for 16 minutes; the sending person directed intention of oneness toward the receiver during repeated variable-second epochs separated by variable-second non-intention epochs. The total length of intention epochs and that of nonintention epochs were balanced. Eighteen sessions were conducted. In 9 of those sessions, the sender was the receiver's lover. In another 9 of those sessions, the sender was just acquainted with the receiver before the session. The receiver's whole brain activity recorded during the intention epochs were compared with the same measures recorded during the nonintention epochs used as controls. The statistical difference between the intentions versus controls across 18 sessions was examined by paired-t test. In addition, subgroup analysis for the 9 couple sessions and 9 non-couple sessions were additionally examined by the same test. The effect of distant intentionality decreased slow waves or increased EEG fast waves mainly in frontal regions, and increased EEG coherence during the intention epochs. The effects was not statistically significant after Bonferroni correction, but the couple sessions combined showed the largest effect followed by all sessions combined. Non-couple sessions combined showed the smallest effect. The changes in EEG power mean that receiver participants became more alert during the intention epochs and the change in EEG coherence might be evidence of coherent heart influence on EEG activity. Planned comparison with specific hypothesis testing for the suggested changes in this study have to be followed for an evidence of electroencephalographic changes in isolated subjects for the distant mental intention.

Autologous Fat Graft in the Reconstructed Breast: Fat Absorption Rate and Safety based on Sonographic Identification

  • Kim, Hong Youl;Jung, Bok Ki;Lew, Dae Hyun;Lee, Dong Won
    • Archives of Plastic Surgery
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    • v.41 no.6
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    • pp.740-747
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    • 2014
  • Background Autologous fat graft has become a useful technique for correction of acquired contour deformity in reconstructed breasts. However, there remains controversial regarding the efficacy and safety of the practice for reconstructive breast surgery. Methods A retrospective review was performed on 102 patients who had secondary fat grafting after breast reconstruction. Fat harvest, refinement and injection were done by Coleman's technique. All patients were followed up postoperatively within 1 month and after 6 months including physical examination and ultrasonography. In 38 patients, the reabsorption rate was calculated by serial changes of thickness between skin and pectoral fascia in the ultrasonic finding. Locoregional recurrence rate was compared with control group of 449 patients who had breast reconstruction without fat graft in the same time period. Results Average 49.3 mL fat was injected into each breast. The most common location of fat graft was upper pole, followed by axilla, lower and medial breasts. During 28.7 months of average follow-up period, 2.9% of total patients had symptoms of palpable mass on fat graft side and ultrasonography identified fat necrosis and cyst formation in 17.6% of the patients. Calculated fat reabsorption rate was 32.9%. Locoregional recurrence was occurred in 1 patient (0.9%) and the rate was not different significantly with control group (2%). Conclusions Although further studies are required to provide surgeons with definitive guidelines for the implementation of fat grafting, we propose autologous fat graft is an efficient and safe technique for secondary breast reconstruction.

Fast Geocoding of UAV Images for Disaster Site Monitoring (재난현장 모니터링을 위한 UAV 영상 신속 지오코딩)

  • Nho, Hyunju;Shin, Dong Yoon;Sohn, Hong-Gyoo;Kim, Seongsam
    • Korean Journal of Remote Sensing
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    • v.36 no.5_4
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    • pp.1221-1229
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    • 2020
  • In urgent situations such as disasters and accidents, rapid data acquisition and processing is required. Therefore, in this study, a rapid geocoding method according to EOP (Exterior Orientation Parameter) correction was proposed through pattern analysis of the initial UAV image information. As a result, in the research area with a total flight length of 1.3 km and a width of 0.102 ㎢, the generation time of geocoding images took about 5 to 10 seconds per image, showing a position error of about 8.51 m. It is believed that the use of the rapid geocoding method proposed in this study will help provide basic data for on-site monitoring and decision-making in emergency situations such as disasters and accidents.

Effect of Pulmonary Arterial Size on Postoperative Right Ventricular Pressure in Tetralogy of Fallot (활로씨 4 증후군에 폐동맥크기가 수술후 우심실압력에 미치는 영향)

  • 김용진
    • Journal of Chest Surgery
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    • v.21 no.5
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    • pp.828-841
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    • 1988
  • To predict the postoperative hemodynamic status of right ventricle preoperatively, a retrospective analysis was undertaken to determine the influence of pulmonary artery size on postoperative right ventricular pressure in 32 consecutive patients with tetralogy of Fallot who underwent total correction between July, 1987 to June, 1988 at the Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital. We have related the ratio of the postrepair peak systolic pressure in the right ventricle and the systemic systolic arterial pressure[PRV/Ao] to the preoperative cineangiographic measurement of pulmonary arterial tree, expressed as pulmonary artery index[PAI], the ratio of diameter of the right pulmonary artery to diameter of ascending aorta[r.PA/A.Ao], the ratio of right and left pulmonary artery to diameter of descending aorta[r.I.PA/D.Ao] There was tendency that the postrepair PRV/Ao seems to be related to the preoperative diameter of right and left pulmonary artery, but there were no statistically significant correlation with PAI, r.PA/A.Ao, r.l.PA/D. Ao to the ratio of the postoperative peak systolic right ventricular pressure and systemic systolic arterial pressure[PRV/Ao]. There was tendency to decrease the postoperative right ventricular pressure[PRV/Ao] about 11.2%[P < 0.025] within several hours than immediately after repair, but after then, there was no change of right ventricular pressure[PRV/Ao] significantly. There was good correlation of pressure change between the immediate and late postrepair right ventricular pressure[48 hour], and the derived linear regression line was; y=0.68534 0.1994[r=0.57294, P < 0.001]. There was no operative death due to residual high right ventricular pressure[PRV/Ao >0.75] related to hypoplastic pulmonary arterial development, thus we expect, for symptomatic patients even infants, that complete repair can be attempted when the pulmonary artery index[PAI] is over 108mm2/BSA, RPA/AAo is over 0.35, RPA LPA/D. Ao is over 1.36.

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ASSESSING CALIBRATION ROBUSTNESS FOR INTACT FRUIT

  • Guthrie, John A.;Walsh, Kerry B.
    • Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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    • 2001.06a
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    • pp.1154-1154
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    • 2001
  • Near infra-red (NIR) spectroscopy has been used for the non-invasive assessment of intact fruit for eating quality attributes such as total soluble solids (TSS) content. However, little information is available in the literature with respect to the robustness of such calibration models validated against independent populations (however, see Peiris et al. 1998 and Guthrie et al. 1998). Many studies report ‘prediction’ statistics in which the calibration and prediction sets are subsets of the same population (e. g. a three year calibration validated against a set from the same population, Peiris et al. 1998; calibration and validation subsets of the same initial population, Guthrie and Walsh 1997 and McGlone and Kawano 1998). In this study, a calibration was developed across 84 melon fruit (R$^2$= 0.86$^{\circ}$Brix, SECV = 0.38$^{\circ}$Brix), which predicted well on fruit excluded from the calibration set but taken from the same population (n = 24, SEP = 0.38$^{\circ}$Brix with 0.1$^{\circ}$Brix bias), relative to an independent group (same variety and farm but different harvest date) (n = 24, SEP= 0.66$^{\circ}$ Brix with 0.1$^{\circ}$Brix bias). Prediction on a different variety, different growing district and time was worse (n = 24, SEP = 1.2$^{\circ}$Brix with 0.9$^{\circ}$Brix bias). Using an ‘in-line’ unit based on a silicon diode array spectrometer, as described in Walsh et al. (2000), we collected spectra from fruit populations covering different varieties, growing districts and time. The calibration procedure was optimized in terms of spectral window, derivative function and scatter correction. Performance of a calibration across new populations of fruit (different varieties, growing districts and harvest date) is reported. Various calibration sample selection techniques (primarily based on Mahalanobis distances), were trialled to structure the calibration population to improve robustness of prediction on independent sets. Optimization of calibration population structure (using the ISI protocols of neighbourhood and global distances) resulted in the elimination of over 50% of the initial data set. The use of the ISI Local Calibration routine was also investigated.

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A Study on a Change of Serum Ionic Calcium after Extracorporeal Circulation (체외순환시 혈청 이온화칼슘 측정치의 변동에 관한 연구)

  • Seo, Dong-Man;Kim, Jong-Hwan
    • Journal of Chest Surgery
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    • v.18 no.2
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    • pp.205-213
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    • 1985
  • It is well documented that calcium is essential to cardiac contraction and the amplitude of contractility is proportional to the ionized calcium not to total calcium. Changes of serum ionic calcium before and after extracorporeal circulation were observed in fifty two patients operated on at Dept. of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, from May 21st, 1984, to July 6th, 1984. They were 28 males and 24 females including 21 acyanotic congenital heart diseases, 21 cyanotic congenital heart diseases, and 10 acquired valvular heart diseases. In general, preoperative serum ionic calcium was around the normal level, but those of immediate postoperative day and postop-first day were decreased subnormally with significance [P<0.05 vs. preop.]. From postop-third day, serum ionic calcium was returned to normal range. No significant difference was noticed in subgroups divided by 10 Kg of body weight and by the methods of myocardial protection. But the change of serum ionic calcium in the patients with prolonged pump time over 90 minutes was remarkable and the values were as follow; on immediate postop-day 1.780.18 mEq/L vs. 1.970.20 mEq/L [P<0.005],on postop-first day, 1.940.20mEq/L vs. 2.060.12 mEq/L [P<0.025], on postop-third day, 2.030.11mEq/L vs. 2.150.13mEq/L [P<0.01], and on postop-seventh day, 2.030.09mEq/L vs. 2.190.11mEq/L [P<0.005]. In summary, the serum ionic calcium was lowered after extracorporeal circulation and even severer degree according to the prolongation of bypass time. So, after extracorporeal circulation esp. in the cases with prolonged bypass time, early correction of lowered serum ionic calcium would be helpful to the postoperative hemodynamics.

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Complications after Senning Operation for TGA with and Wothout VSD (대혈관전위증에서 Senning수술후 합병증에 관한 임상적 고찰)

  • 안재호
    • Journal of Chest Surgery
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    • v.26 no.8
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    • pp.595-603
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    • 1993
  • We analysed 60 consecutive patients who got Senning operation for transposition of the great arteries [TGA] with or without ventricular septal defects [VSD]. There were 41 simple TGA [group I] and 19 TGA with VSD [Group II], the operative mortality was 20 % [in group I 4.9 %, group II 52.6 %]. Among the survivors [n=48], the mean follow-up period was 7 years [range, 1 year to 13.5 years] and the actuarial survival rate at 13 years were 95 % in group I and 42 % in group II. Preoperative high left ventricular pressure and high pulmonary arterial pressure affected the surviving [p<0.01]. There occurred various type of arrhythmia like junctional rhythm, first degree atrioventricular [AV] block, sick sinus syndrome and complete AV block, and we inserted 2 permanent pacemakers for these patients. The incidence of arrhythmia were 28.2 % [11/39] in group I and 55.6 % [5/9] in group II, and the actuarial freedom from arrhythmia at 13 years after operation was 66 % [71 % in group I, 44 % in group II]. Increased aortic cross clamping time had affected the development of arrhythmia [p<0.05] which meant the complexity of the operation. The total incidence of left ventricular outflow tract obstruction [LVOTO] was 31.3 % [15/48], but only 3 patients [6.25 %] showed the significant gradient requiring reoperation. The pulmonary venous pathway obstruction [PVO] were found in 3 patients, all in group I, and among them only one required the reoperation. The estimated freedom from PVO was 89 % at 13 years [87 % in group I, 100 % in group II], but we couldn`t find any significant systemic venous obstruction in our series. There occurred 27.1 % [13/48] mild degree tricuspid valve regurgitation without necessary surgical correction. We experienced 14.6 % [7/48] reoperation rate: 3 residual VSD, 3 LVOTO, 1 PVO, 3 atrial baffle leakage. For this high incidence of complication rate after Senning operation and high mortality in TGA with VSD, We do not use this kind of surgical modality any more and do the Jatene operation for all the TGA patients since several years ago.

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Factors Influencing Self Management Behavior for Patients with Type 2 Diabetes: Comparison of Difference between the Elderly and Adults (제2형 당뇨병 환자의 자기관리행위 예측 요인: 노인과 성인의 비교)

  • Kang, Kyung-Ja;Yu, Su-Jeong;Seo, Hyun-Mi;Yu, Mi;Park, Myung-Sook;Jang, Hak-Chul
    • Journal of Korean Biological Nursing Science
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    • v.14 no.2
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    • pp.112-121
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    • 2012
  • Purpose: The purpose of this study was to investigate the level of self management behavior of patients with type 2 diabetes and to compare the factors influencing self management behavior between the elderly and adults. Methods: The participants consisted of 105 adults and 100 elderly who visited the outpatient department of a hospital from August to December 2011. Data was collected by questionnaires and analyzed using the SPSS/WIN 18.0. Results: The elderly showed higher mean scores of subcategory of self management behavior than adults. In stepwise multiple regression analysis, a total of 42% (adults), 52% (elderly) respectively of variance in self management behavior were accounted for by self-efficacy, perceived barriers, perceived benefits, yes or no smoking and regular exercise in adults and readiness, self efficacy, perceived benefits in the elderly. Conclusion: Therefore, a diabetics intervention program should be designed and provided as a tailored one for adults and elderly separately in Korea. In the strategy for adults with type 2 diabetes in the promotion of self efficacy, perceived benefits and reduction of perceived barriers, and correction of life habits such as smoking and exercise are needed, whereas in the elderly promotion of readiness, self efficacy, perceived benefits are required.