• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.125-128
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• 1996

A new type of motor-driven total artificial heart system with a moving-actuator mechanism has been developed. The prototype system consists of a brushless do motor inside of actuator, two polyurethane sacs, and peripheral devices with internal controller. In this research work, the moving-actuator type electromechanical total artificial heart was redesigned for a good anatomical fitting. For total implantation we are developing the internal controller with high reliability and stability, and automatic control algorithm in response to the physiological requirements of animal. Contents and scope of the research work on ";Development of a totally implantable artificial heart of pre-clinical stage"; is summerized below 1) Animal experiment using sheep(55-60kg) 2) Development of implantable controller 3) Automatic control algorithm 4) Improvement of biocompatibility 5) Redesign of Actuator/blood pump.

• Journal of Chest Surgery
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• v.28 no.6
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• pp.542-548
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• 1995

The goal of this study is to develop an effective control system for cardiac output regulation based upon the preload and afterload conditions without any transducers and compliance chambers in the moving actuator type total artificial heart. Motor current waveforms during the actuator movement are used as an input to the automatic control algorithm. While the current waveform analysis is performed, the stroke length and velocity of the actuator are gradually increased up to the maximum pump output level. If the diastolic filling rate of either right or left pump begins to exceed the venous return, atrial collapse will occur. Since the diastolic suction acts as a load to the motor, this critical condition can be detected by analyzing the motor current waveforms. Every time this detection criterion is met, the control algorithm decreases the stroke velocity and length of the actuator step by step just below the critical detection level. Then, they start to increase. In this way the maximum pump output under given venous return can be achieved. Additionally the control algorithm provides some degree of afterload sensitivity. If the aortic pressure is detected to exceed 120 mmHg, the stroke length and velocity decrease in the same way as the response to the preload. Left-right pump output balance is maintained by proper adjustment of the asymmetry of the stroke angle. In the mock circulatory test, this control system worked well and there was a considerable range of stroke volume difference with adjustment of the asymmetry value. Two ovine experiments were performed. It was confirmed that the required cardiac output regulation according to the venous return could be achieved with adequate detection of diastolic function, at least in the in vivo short-term survival cases[2-3 days . We conclude that this control algorithm is a promising method to regulate cardiac output in the moving actuator type total artificial heart.

• Journal of Biomedical Engineering Research
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• v.18 no.1
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• pp.25-36
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• 1997

To regulate cardiac output of the Total Artificial Heart(TAH) physiologically, the hemodynamic information must be toed back to the controller. So far, our group has developed an automatic cardiac output control algorithm using the motor current waveform, It is, however difficult to detect the preload level such as a filling status of ventricular inflow and the variation of atrial pressures within normal physiologic range(0-15 mmHg) by analyzing the motor current which simultaneously reflects the afterload effect. On the other hin4 the interventricular volume pressure(IVP) which is not influenced by arterload but by preload is a good information source for the estimation of preload states. In order to find the relationship between preload and IVP waveform, we set up the artificial heart system on the Donovan type mock circulatory system and measured the IVP waveform, right and left atrial pressures, inflow and outflow waveforms and the signals represented the information of moving actuator's position. We shows the feasibility of estimating the hemodynamic changes of inflow by using IVP waveform. fife found that the negative peak value of IVP waveform is linearly related to atrial pressures. And we also found that we could use the time to reach the negative peak in IVP waveform, the time to open outflow valve, the area enclosed IVP waveform as unfu parameters to estimate blood filling volume of diastole ventricle. The suggested method has advantages of avoiding thrombogenesis, bacterial niche formation and increasing longterm reliability of sensor by avoiding direct contact to blood.

• Proceedings of the KTCVS Conference
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• 1993.06a
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• pp.128-128
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• 1993

• Journal of Biomedical Engineering Research
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• v.8 no.2
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• pp.161-170
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• 1987

A new type of motor-driven total artificial heart system with a rolloing-cylinder mechanism has been developed. The prototype system consists of a brushless DC motor inside of a rolling-cylinder, two arc shaped pusher-plate s, and two ventricles of smooth, seamless polyurethane sacs. The motor-driven pump has the advantages of being portable and quiet compared to the present air-driven pump. It can also be controlled more accurately. This rolling-cylinder type electromechanical pump has several structural advantages including small size and weight, as compared to other research groups' motor-driven pumps. The results of mock circulation tests confirm sufficient pump output capacity(cardiac output . 9 L/min, at aortic pressure'120mmHg, with heart rate . 120 BPM) for animal implantation of our prototype system.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.51-54
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• 1997

Lumbrokinase, potent fibrinolytic enzyme purified from earthworm, was immobilized onto the total artificial heart valves using photoreaction. This valve were implanted into the lamb for three days. After experiments, thrombus was observed in the untreated valves whereas no thrombus was observed in the lumbrokinase immobilized valves. The fibrinolytic activity and proteolytic activity of the implanted valve was examined. The fibrinolytic activity of the valve was remained after the implantation. The lumbrokinase could be a suitable fibrinolytic agents in the vascular contacting devices to reduce the thrombus.

• Journal of Chest Surgery
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• v.28 no.6
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• pp.533-541
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• 1995

We recently developed a new model of moving actuator type totally implantable artificial heart[TIAH , based on the reverse position of the aortic and pulmonary conduits. This concept was proposed by one of surgeons in our team[Joon-Ryang Rho, M.D. to facilitate anatomical fitting of TIAHs. The moving actuator type electromechanical TIAH consisted of the left and right blood sacs, and the moving actuator including a motor. The inverted umbrella type polyurethane valves were used in the blood pumps. The aortic conduit was positioned anterior to the pulmonary conduit, which was the opposite relation to the conventional configuration of other total artificial hearts. We also adapted slip-in connectors for the aortic and pulmonary conduits. Two sheep , weighing 60-69 kg, were used for implantation. After small cervical incision and trans-sternal bilateral thoracotomy, cardiopulmonary bypass [CPB was administered using an American Optical 5-head pump and a membrane oxygenator[Univox-IC, Bentley . The anterior and posterior vena cavae were drained separately for venous return. An arterial return cannula was inserted into the right common carotid artery. During CPB, almost all of the ventricular myocardium was excised down to the atrioventricular groove and the artificial heart was implanted. We achieved 3-day survival in the first sheep and 2-day survival in the second. The day after operation the first sheep was successfully extubated and the second sheep was weaned from a respirator with good condition. After extubation, the first sheep walked around in the cage and fed herself. Serial laboratory and hemodynamic examinations were done during the experiments. In both sheep, pulmonary dysfunction was gradually developed, which was accompanied by acute renal failure. The animals were sacrificed and autopsy was done. Unexpected pregnnacy was incidentally found in both sheep. To our knowledge this is the first report of significant survival cases in the orthotopic implantation of electric TIAH using sheep.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.3
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• pp.855-868
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• 1991

본 연구에서는 위에서 언급한바와 같은 제반사항들에 대해 이론적인 해석을 행하고, 그 결과를 이용하여 설계된 모델이 생체내에 이식될 수 있는 가능성의 여부를 판단하며 생체내에 이식 되었을 때의 성능과 생체에 미치는 영향등을 예측하고자 한다.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.59-63
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• 1997

It is needless to say that the hemodynamic variables estimation is a very important study for the artificial heart. Even though its importance there have not been satisfactory results which can be applied to the real-world situations. This paper surveys and recommends how to cope with the problem of hemodynamic variable estimation for the moving-actuator type total artificial heart (MA-TAH).

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.383-391
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• 1993

In this paper, a new automatic cardiac output control algorithm without any pressure sensors for the motor-driven electromechanical total artificial heart(TAH) was developed using motor current information. In the previous studies, many transducers were utilized to obtain informations of hemodynamic states for the automatic cardiac output control. But. such automatic control with sensors has some problems. To solve these problems, I proposed a new "sensorless" automatic cardiac output control algorithm providing the adequate cardiac output to the time-varying physiological demand without right atrial collapse. In-vitro tests were performed to evaluate the performance of a new algorithm and it satisfied the basic three requirements on the pump output response through the mock circulation tests.