• The Korean Journal of Pain
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• v.37 no.3
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• pp.211-217
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• 2024

Background: Tolerance to the analgesic effects of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) is a major concern for relieving pain. Thus, it is highly valuable to find new pharmacological strategies for prolonged therapeutic procedures. Biguanide-type drugs such as metformin (MET) are effective for neuroprotection and can be beneficial for addressing opioid tolerance in the treatment of chronic pain. It has been proposed that analgesic tolerance to NSAIDs is mediated by the endogenous opioid system. According to the cross-tolerance between NSAIDs, especially sodium salicylate (SS), and opiates, especially morphine, the objective of this study was to investigate whether MET administration can reduce tolerance to the anti-nociceptive effects of SS. Methods: Fifty-six male Wistar rats were used in this research (weight 200-250 g). For induction of tolerance, SS (300 mg/kg) was injected intraperitoneally for 7 days. During the examination period, animals received MET at doses of 50, 75, or 100 mg/kg for 7 days to evaluate the development of tolerance to the analgesic effect of SS. The hot plate test was used to evaluate the drugs' anti-nociceptive properties. Results: Salicylate injection significantly increased hot plate latency as compared to the control group, but the total analgesic effect of co-treatment with SS + Met50 was stronger than the SS group. Furthermore, the effect of this combination undergoes less analgesic tolerance over time. Conclusions: It can be concluded that MET can reduce the analgesic tolerance that is induced by repeated intraperitoneal injections of SS in Wister rats.

• Toxicological Research
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• v.34 no.4
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• pp.297-302
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• 2018

Cells are constantly exposed to endogenous and exogenous chemical and physical agents that damage their genome by forming DNA lesions. These lesions interfere with the normal functions of DNA such as transcription and replication, and need to be either repaired or tolerated. DNA lesions are accurately removed via various repair pathways. In contrast, tolerance mechanisms do not remove lesions but only allow replication to proceed despite the presence of unrepaired lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS), which is an error-prone strategy and an accurate strategy based on homologous recombination (homology-dependent gap repair [HDGR]). Thus, the mutation frequency reflects the relative extent to which the two tolerance pathways operate in vivo. In the present paper, we review the present understanding of the mechanisms of TLS and HDGR and propose a novel and comprehensive view of the way both strategies interact and are regulated in vivo.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.05a
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• pp.241-244
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• 2004

Dimension and tolerance are very important factors both in a design stage and in a manufacturing stage. As a part of process planning, the tolerance transfer aims at determining the method for converting design dimensions and tolerances into manufacturing dimensions and tolerances based on a given drawing. A procedure for the tolerance transfer is proposed in this paper. Tolerance chart is a valuable graphical tool for a process planner to determine the manufacturing dimensions and tolerances, and consisted of several steps. Among several steps necessary for making up the tolerance chart, the methods for the identification of dimension chain, the determination of tolerances, and the calculation of operational dimensions are presented by using concepts and new presentation methods. A solution method for each step is derived which will be used to establish the tolerance transfer techniques.

• Microbiology and Biotechnology Letters
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• v.23 no.1
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• pp.17-23
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• 1995

We studied the influence of culture conditions on the acid tolerance of Lactobacillus casei YIT 9018 in artificial gastric juice with respect to relative amount of membrane bound ATPase and their biochemical characteristics. With raising incubation temperature from 30.5$\circ$C to 40.5$\circ$C and lengthening incubation time from exponential phase to late stationary phase, the acid tolerance of L. casei YIT 9018 was increased. As acid tolerance enhanced, C$_{18:1}$ content of membrane fatty acid was reduced and C$_{19:0 cyclo}$ was enriched but the others were not changed greatly. At high ATPase activity, proton permeability was relatively low but this phenomenon did not correspond to acid tolerance. In conclusion, it was considered that changes of C$_{18:1}$ and C$_{19:0 cyclo}$ were closely related to the acid tolerance of L. casei YIT 9018.

• International Journal of Industrial Entomology and Biomaterials
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• v.7 no.1
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• pp.87-91
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• 2003

BmNPV (Bombyx mori nuclear polyhedrosis virus) causes nuclear polyhedrosis in silkworms. The tolerance of silkworms to BmNPV is controlled by polygenes. This paper reports on the relative tolerance of silkworm breeds among the germplasm maintained at Andhra Pradesh State Sericultural Research ＆ Development Institute (APSSRDI), Hindupur, India. The silkworm larvae out of second moult were per orally inoculated with BmNPV polyhedra $(l{\times}l0^{th}//ml)$ and reared upto spinning. The response to BmNPV had been categorized into apparent tolerance, real tolerance and susceptibility. Among the 145 silkworm breeds screened, 18 bivoltines and 16 polyvoltines were found to have real tolerance to BmNPV.

• Journal of Korean Society for Quality Management
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• v.42 no.4
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• pp.563-578
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• 2014

Purpose: The purpose of this paper is integrated tolerance design process by advantages of engineering design and 6 sigma statistical tolerances design. Methods: Integrated tolerance design process can determine the goals by using engineer's experience and clarify tolerance by 6 Sigma statistical methods. Integrated design process can be applied by using non-linear simulations. Results: We applied integrated design process to the optical disc drive spindle motor and get good result. Conclusion: If this method is applied test method in the early stages of development, then Design can be reduced development time and cost.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.529-536
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• 2003

The majority of previous studios on tolerance synthesis have viewed the issue as a design methodology to determine optimal component tolerances on behalf of a manufacturer. while meeting given assembly tolerance requirements Although a considerable amount of research has been done on this issue. a couple of important questions still remain unanswered First. how ran a design engineer quantitatively incorporate a customer's perception on a product quality into a tolerance synthesis scheme at the early design stage Second. how ran component tolerances and assembly tolerance be optimized in a simultaneous way? To answer these questions. this article presents the customer-driven concurrent tolerance synthesis which is facilitated by the notion of truncated distribution and the use of mathematical programming techniques. while adopting the major principles of Tagurhl philosophy. The work presented in the article is an effort to gain insight, which can be useful in practice when setting up guidelines for an overall tolerance synthesis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.3
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• pp.452-460
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• 2001

Most of researches of tolerance optimization have used a simple sum of tolerance-cost functions with several constraint equations as an optimization model. However, if there is a machining sequence with more than one processes to complete a part, and machining failure, i.e., out-of-tolerance occurs at one of the intermediate processes, the tolerance-cost of this process should be added by the machining cost of all the previous processes already completed on the part. In this study, an accumulated scrap cost model(ASCM) is proposed considering the scrapped machining cost, and applied to a simple assembly example. The result of tolerance optimization using ASCM is compared with that of using a traditional optimization model to confirm its effectiveness.

• Toxicological Research
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• v.19 no.4
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• pp.311-314
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• 2003

This study was performed to investigate the effects of glycine on the development of tolerance to and physical dependence on morphine. Repeated administration of morphine (10 mg/kg) developed tolerance and physical dependence. Glycine (100, 200 and 400 mg/kg) was administered intraperitoneally (i.p.) to mice for 7 days prior to the morphine injection. Analgesic effects were estimated by the tail flick methods. The inhibitory degree of the development of morphine-induced analgsic tolerance by i.p. administration of glycine was evidenced by the increase in analgesic response to morphine. Glycine inhibited the development of tolerance to morphine. In addition, we separately measured jumping response as the naloxone-precipitated withdrawal sign in mice that had received the same morphine. Glycine reduced the number of jumping behaviors in morphine dependent mice. These results suggest that glycine might be useful the prevention or treatment of morphine tolerance and physical dependence.

• Journal of Microbiology
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• v.33 no.4
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• pp.322-327
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• 1995

Tolerance of Mycobacterium sp. against organic solvents has been induced for the cholesterol side chain degradation by adding chemicals associated with synthesis of fatty acids or alcohols. Biotin of 300 .mu.g/1 and 0.5% aqueous ethanol solution were optima for the enhancement of ethanol tolerance of the microorganism. The induction of ethanol tolerance by biotin was found to be due to increase of degree of unsaturation of the fatty acids in membranous phospholipid of the cell, especially due to increase of oleic acid content. However when 0.5% of ethanol was added for the ethanol tolerance induction, there was an ambiguous correlation between ethanol tolerance and degree of unsaturation of the fatty acids, in spite of the fact that the induction increased the content of unsaturated fatty acids. Addition of 0.5% of ethanol induced several ethanol shock proteins having molecular weight similar to that of heat shock proteins.