• Parasites, Hosts and Diseases
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• v.54 no.5
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• pp.679-684
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• 2016

Clonorchiasis, caused by direct contact with Clonorchis sinensis worms and their excretory-secretory products (ESPs), is associated with chronic inflammation, malignant changes in bile ducts, and even cholangiocarcinogenesis. Our previous report revealed that intracellular free radicals enzymatically generated by C. sinensis ESPs cause NF-${\kappa}B$-mediated inflammation in human cholangiocarcinoma cells (HuCCT1). Therefore, the present study was conducted to examine the role of upstream Toll-like receptors (TLRs) on the initial host innate immune responses to infection. We found that treatment of HuCCT1 cells with native ESPs induced changes in TLR mRNA levels in a time-dependent manner, concomitant with the generation of free radicals. ESP-mediated free radical generation was markedly attenuated by preincubation of the cells with TLR1-4-neutralizing antibodies, indicating that at least TLR1 through 4 participate in stimulation of the host innate immune responses. These findings indicate that free radicals triggered by ESPs are critically involved in TLR signal transduction. Continuous signaling by this pathway may function in initiating C. sinensis infection-associated inflammation cascades, a detrimental event leading to progression to more severe hepatobiliary diseases.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.1
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• pp.114-130
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• 2021

With the drastic growth of Information and Communication Technology (ICT) industry, global energy consumption is exponentially increased by mobile communications. The huge energy consumption and increased environmental awareness have triggered great interests on the research of dynamic distribution of cell user and traffic, and then designing the energy efficient cellular network. In this paper, we explore the temporal and spatial characteristics of human mobility and traffic distribution using real data set. The analysis results of cell traffic illustrate the tidal effect in temporal and spatial dimensions and obvious periodic characteristics which can be used to design Base Station (BS) dynamic with sleeping or shut-down strategy. At the same time, we designed a new Cell Zooming and BS cooperation mode. Through simulation experiments, we found that running in this mode can save about 35% of energy consumption and guarantee the required quality of service.

• The Southeast Asian review
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• v.20 no.3
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• pp.41-64
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• 2010

The recent global financial crisis triggered by the sub-prime mortgage debacle in the United States hit hard most ASEAN countries that have just recovered from the unprecedented economic crisis ten years ago. This paper, using individual time-series and panel data from 1990 to 2009, intends to investigate and compare the impacts of the two aforementioned economic crises on trade in the four developing ASEAN countries that encompass Indonesia, Malaysia, the Philippines and Thailand. In doing so, the paper traces the behaviors of main macroeconomic variables before and after the crises on graphs, and then estimates classical export and import demand functions that include real exchange rate, home and foreign GDPs as explanatory variables. In the estimation functions, two dummy variables are added to consider the effects of the two economic crises separately. Individual country data analyses reveal that by and large the 1997 economic crisis seems hit those ASEAN countries' exports and imports harder than the recent global financial crisis. Surprisingly the recent financial crisis turns out more or less statistically insignificant for those countries' export and import performances. The fixed effect model estimation using panel data of those four ASEAN countries also shows that the 1997 economic crisis had affected exports and imports of those countries negatively while the recent global financial crisis was not statistically significant. These results indicate that overall the effect from the 1997 crisis was more devastating than that of the recent global crisis for those ASEAN countries.

• Advances in nano research
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• v.12 no.5
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• pp.489-499
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• 2022

Nanofluids have recently triggered a substantial scientific interest as cooling media. However, their stability is challenging for successful engagement in industrial applications. Different factors, including temperature, nanoparticles and base fluids characteristics, pH, ultrasonic power and frequency, agitation time, and surfactant type and concentration, determine the nanofluid stability regime. Indeed, it is often too complicated and even impossible to accurately find the conditions resulting in a stabilized nanofluid. Furthermore, there are no empirical, semi-empirical, and even intelligent scenarios for anticipating the stability of nanofluids. Therefore, this study introduces a straightforward and reliable intelligent classifier for discriminating among the stability regimes of alumina-water nanofluids based on the Zeta potential margins. In this regard, various intelligent classifiers (i.e., deep learning and multilayer perceptron neural network, decision tree, GoogleNet, and multi-output least squares support vector regression) have been designed, and their classification accuracy was compared. This comparison approved that the multilayer perceptron neural network (MLPNN) with the SoftMax activation function trained by the Bayesian regularization algorithm is the best classifier for the considered task. This intelligent classifier accurately detects the stability regimes of more than 90% of 345 different nanofluid samples. The overall classification accuracy and misclassification percent of 90.1% and 9.9% have been achieved by this model. This research is the first try toward anticipting the stability of water-alumin nanofluids from some easily measured independent variables.

• Journal of Fashion Business
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• v.27 no.1
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• pp.1-15
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• 2023

This study divided articles into two time periods, from 2012 to 2022, with the aim of using big data analysis to look at patterns in the ecosystem of fashion start-ups. The research method extracted top keywords based on TF(Term Frequency) and TF-IDF(Term Frequency-Inverse Document Frequency), analyzed the network, and derived centrality values. As a result of comparing the first and second fashion startup ecosystems, elements of policy, support, market, finance, and human capital were derived in the first period. In addition, in the second period, elements of policy, support, market, finance, and culture were derived. In the first period, the fashion startup ecosystem focused on fostering new designer startups by emphasizing support, finance, and human capital factors and focusing on policies. Meanwhile, in the second period, online-based fashion platform startups and fashion tech startups appeared with the support of digital transformation and fulfillment services triggered by COVID-19(Corona Virus Disease 19), private finances were emphasized, and cultural factors were derived along with success stories of fashion startups. This study is meaningful in that it helps in developing strategies for fashion startups to grow into sustainable companies.

• Geomechanics and Engineering
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• v.29 no.5
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• pp.497-508
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• 2022

Tailings fluidization (i.e., tailings behave as being fluidized) under cyclic loading is one concern during the construction of tailings dams, especially in the shallow tailings layers. The primary goal of this study is to evaluate the responses of tailings under cyclic loadings and the tailings potential for fluidization. A series of cyclic triaxial undrained and drained tests were performed on medium and dense tailings samples under various cyclic stress ratios (CSR). The results indicated that axial strain and excess pore water pressure accumulated over time due to cyclic loading. However, the accumulations were dependent on CSR values, densities, and drainage conditions. The fluidization potential analysis in this study was then evaluated based on the obtained cyclic axial strain and excess pore water pressure. As a result, tailings samples were stable (unfluidized) under small CSR values, and the critical CSR values, where the tailings fluidized, varied depending on the density of tailings samples. Tailings fluidization is triggered as cyclic stress ratios reach critical values. In this study, the critical CSR values were found to be 0.15 and 0.40 for medium and dense samples, respectively.

• Analyses & Alternatives
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• v.3 no.2
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• pp.33-57
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• 2019

After the tragic incident of the sinking of Sewol in spring 2014, Korean migrants in Britain began to hold street protests in London. These protestors condemned the Korean government for the lack of appropriate responses to the accident, and for its failure to conduct proper investigation on the issue. The small group of protestors held silent street protests every month at Trafalgar Square, despite not gaining much media coverage nor public attention. These migrants' almost three-year long protest outside their homeland is puzzling. Not only did they live in Britain for a long time to the extent that they regard the country as their second home, but they also exert scant amount of influence on the political landscape in South Korea. What can then account for these individuals' participation in activism related to their homeland politics? In this paper, we utilize the concept of 'moral identity' to explain the behaviors of Korean migrants involved in the street protests. These migrants had strong 'moral identity', which triggered a sense of responsibility to act when their cherished moral values were jeopardized. Korean migrants who possessed a strong sense of moral identity placed huge importance on living in accordance with their moral values. It is a way of upholding their self-esteem and sustaining their ideal self.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.15-15
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• 2023

The chloroplast (cp) is an autonomous plant organelle with an individual genome that codes for essential cellular functions. The architecture and gene content of the cp genome is highly conserved in angiosperms. The plastome of Corydalis belongs to the Papaveraceae family, and the genome is comprised of unusual rearrangements and gene content. Thus far, no extensive comparative studies have been carried out to understand the evolution of Corydalis chloroplast genomes. Therefore, the Corydalis platycarpa cp genome was sequenced, and wide-scale comparative studies were conducted using publicly available twenty Corydalis plastomes. Comparative analyses showed that an extensive genome rearrangement and IR expansion occurred, and these events evolved independently in the Corydalis species. In addition, the protein-coding genes accD and the ndh gene loss events occurred in the common ancestor of the Corydalis and sub-clade of the Corydalis lineage, respectively. The gene ndh lost in the Corydalis-sub clade species is distributed predominantly in the Qinghai-Tibetan plateau (QTP) region. The molecular clock analysis suggests that the divergence time of all the ndh gene lost Corydalis sub-clade species occurred in the 44.31 - 15.71 mya. These results coincide very well with the uplift of the Qinghai-Tibet Plateau in the Oligocene and Miocene periods, and maybe during this period, it probably triggered the radiation of the Corydalis species. To the best of the authors' knowledge, this is the first large-scale comparative study of Corydalis plastomes and their evolution. The present study may provide insights into the plastome architecture and the molecular evolution of Corydalis species.

• Journal of fish pathology
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• v.36 no.2
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• pp.191-211
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• 2023

Rock bream iridovirus (RBIV) causes high mortality and economic losses in rock bream (Oplegnathus fasciatus) aquaculture industry in Korea. Although, the immune responses of rock bream under RBIV infection have been studied, there is not much information at the different stages of infection (initial, middle and recovery). Gene expression profiling of rock bream under different RBIV infection stages was investigated using a microarray approaches. In total, 5699 and 6557 genes were significantly up- or down-regulated over 2-fold, respectively, upon RBIV infection. These genes were grouped into categories such as innate immune responses, adaptive immune responses, complements, lectin, antibacterial molecule, stress responses, DNA/RNA binding, energy metabolism, transport and cell cycle. Interestingly, hemoglobins (α and β) appears to be important during pathogenesis; it is highly up-regulated at the initial stage and is gradually decreased when the pathogen most likely multiplying and fish begin to die at the middle or later stage. Expression levels were re-elevated at the recovery stage of infection. Among up-regulated genes, interferon-related genes were found to be responsive in most stages of RBIV infection. Moreover, X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) expression was high, whereas expression of apoptosis-relate genes were low. In addition, stress responses were highly induced in the virus infection. The cDNA microarray data were validated using quantative real-time PCR. Our results provide novel inslights into the broad immune responses triggered by RBIV at different infection stages.

• Herbal Formula Science
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• v.14 no.2
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• pp.21-32
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• 2006

The purpose of this study was to investigate the effect of Imyosan on apoptosis in human colorectal cancer HCT116 cells. Phellodendron amurense Rupr. and Atratylodes lancea D.C. compose Imyosan. First of all, to study the cytotoxic effect of methanol extract of Imyosan (IMS-MeOH) on HCT116 cells, the cells were treated with various concentrations of IMS-MeOH and then cell viability was determined by XTT reduction method. IMS-MeOH reduced viability of HCT116 cells in a dose and time-dependent manner. To confirm the induction of apoptosis, the c1eavage of poly ADP-ribose polymerase (PARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of caspase-3, procaspase-8 and procaspase-9 were examined by western blot analysis. IMS-MeOH decreased procaspase-3, procaspase-8 and procaspase-9 levels in a dose-dependent manner and induced the clevage of PARP. IMS-MeOH triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome c from mitochondria to cytosol. Furthermore, IMS-MeOH also downregulated the anti-apoptotic Bcl-2 and upregulated the pro-apoptotic-Bax. Therefore, these results suggest that IMS-MeOH induced HCT1l6 cell death through the mitochondrial pathway. To explore whether the activities of caspases was required for induction of apoptosis by IMS-MeOH, caspase-3, -8, -9 activity measured by using substrates, respectively. IMS-MeOH increased caspase-3, -8, -9 activity. Co-treatment with inhibitors of caspase-3, -8, -9 and IMS-MeOH significantly blocked IMS-MeOH-triggered apoptosis in HCT1l6 cells. These results suggest that IMS-MeOH induces caspases-mediated apoptosis.