• 한국시뮬레이션학회논문지
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• 제27권3호
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• pp.45-52
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• 2018

대기행렬에 고객 (또는 패킷 등)이 몰리는 오버로드(overload)가 발생하는 경우 긴 대기열이 발생하여 서비스 품질에 좋지 않은 영향을 줄 수 있다. 오버로드 상황에서 혼잡을 완화하기 위해 대기하는 고객숫자에 기반한 다양한 오버로드 제어 정책들이 고안, 적용되고 있다. 본 연구는 대기 중인 고객 숫자에 한계점 (threshold)을 두고, 한계점을 넘으면 서비스 속도를 빠르게 하거나 고객의 도착 간격(시간)을 증가시키는 제어정책을 대상으로 한다. 이러한 정책을 갖는 M/G/1 대기행렬에 대해 바쁜 기간(busy period)을 분석하는데, 연구결과는 비용구조가 주어졌을 때 최적 시스템 제어 정책을 찾는데 필수적이다.

• The Korean Journal of Physiology and Pharmacology
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• 제24권6호
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• pp.545-553
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• 2020

Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage-gated ion channels such as transient A-type K⁺ channels, which are important for the repolarization of cardiac and neuronal action potentials. Here, we investigated the effects of aripiprazole on Kv1.4 currents expressed in HEK293 cells using a whole-cell patch-clamp technique. Aripiprazole blocked Kv1.4 channels in a concentration-dependent manner with an IC₅₀ value of 4.4 μM and a Hill coefficient of 2.5. Aripiprazole also accelerated the activation (time-to-peak) and inactivation kinetics. Aripiprazole induced a voltage-dependent (δ = 0.17) inhibition, which was use-dependent with successive pulses on Kv1.4 currents without altering the time course of recovery from inactivation. Dehydroaripiprazole, an active metabolite of aripiprazole, inhibited Kv1.4 with an IC₅₀ value of 6.3 μM (p < 0.05 compared with aripiprazole) with a Hill coefficient of 2.0. Furthermore, aripiprazole inhibited Kv4.3 currents to a similar extent in a concentration-dependent manner with an IC₅₀ value of 4.9 μM and a Hill coefficient of 2.3. Thus, our results indicate that aripiprazole blocked Kv1.4 by preferentially binding to the open state of the channels.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.195-198
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• 1997

This paper proposes the effective compensation method of the rotor time constant of induction motor. An indirect vector control method is highly dependent on the motor parameters. To solve the problem of performance degradation due to parameter variation in an indirect vector control of induction motor, we compensate the rotor time constant by current error feedback. The proposed method is a simple on-line rotor time constant compensation method using the information from terminal voltages and currents. As the current error, difference between current command and estimated current, approaches to zero, the value of rotor time constant in an indirect vector controller follows the real value of induction motor. This scheme is valid transient region as well as steady state region regardless of low or high speed. This method is verified by computer simulation. For this, we constructed the simulation model of induction motor, indirect vector controller and current regulated PWM (CRPWM) voltage source inverter (VSI) using SIMULINK in MATLAB.

• 대한수의학회지
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• 제30권1호
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• pp.41-49
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• 1990

These experiments were carried out to develop a novel, simple, and rapid method to determine urinary sulfonamides using fluorescamine by spectrofluorometry. To get optimal conditions for the sulfonamide-fluorescamine reaction, sulfonamides such as sulfamethazine, sulfamerazine, sulfadimethoxine and sulfamonomethoxine, dissolved in buffers with various pH ranges were reacted with various concentrations of fluorescamine. and then, the fluorescence intensity and stability of the fluorophore were measured. To eliminate the interfering substances in urine, the fluorophore in buffers and urine with a definite pH range was extracted with some organic solvents. After then the fluorescence intensity was measured in organic and aquous phases. The results obtained were summarized as follows: 1. The maximal fluorescence of sulfonamides was presented in acidic state, pH 4.5~5.0, at 30 minutes after reaction. 2. The optimal concentration ratio of sulfamethazine and ffuorescamine was more than 1 : 40 in mole. 3. In pH 4.0, the intensity was maximal but was time-dependent, whereas in pH 8.0, the intensity was time-independent. 4. Sulfamethazine-fluorescamine conjugate could be dissolved in some of organic solvents in acidic state such as chloroform, n-butanol, and ethylacetate. 5. Sulfamethazine-flnorescamine conjugate in swine urine coule be extracted with ethylacetate in acidic state, pH 4.0~5.0.

• International Journal of Control, Automation, and Systems
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• 제4권4호
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• pp.448-455
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• 2006

This paper deals with the observer design problem for a class of state-delayed nonlinear systems with or without time-varying norm-bounded parameter uncertainty. The nonlinearities under consideration are assumed to satisfy the global Lipschitz conditions and appear in both the state and measured output equations. The problem we address is the design of a nonlinear observer such that the resulting error system is globally asymptotically stable. For the case when there is no parameter uncertainty, a sufficient condition for the solvability of this problem is derived in terms of linear matrix inequalities and the explicit formula of a desired observer is given. Based on this, the robust observer design problem for the case when parameter uncertainties appear is considered and the solvability condition is also given. Both of the solvability conditions obtained in this paper are delay-dependent. A numerical example is provided to demonstrate the applicability of the proposed approach.

• Wind and Structures
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• 제33권6호
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• pp.423-435
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• 2021

Although existing algorithms can predict wind speed using historical observation data, for engineering feasibility, most use moment methods and probability density functions to estimate fitted parameters. However, extreme wind speed prediction accuracy for long-term return periods is not always dependent on how the optimized frequency distribution curves are obtained; long-term return periods emphasize general distribution effects rather than marginal distributions, which are closely related to potential extreme values. Moreover, there are different wind speed parent sample types; how to theoretically select the proper extreme value distribution is uncertain. The influence of different sampling time intervals has not been evaluated in the fitting process. To overcome these shortcomings, updated steps are introduced, involving parameter sensitivity analysis for different sampling time intervals. The extreme value prediction accuracy of unknown parent samples is also discussed. Probability analysis of mean wind is combined with estimation of the probability plot correlation coefficient and the maximum likelihood method; an iterative estimation algorithm is proposed. With the updated steps and comparison using a Monte Carlo simulation, a fitting policy suitable for different parent distributions is proposed; its feasibility is demonstrated in extreme wind speed evaluations at Longhua and Chuansha meteorological stations in Shanghai, China.

• Advances in nano research
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• 제9권3호
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• pp.133-145
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• 2020

In this study, nonlinear vibrations and dynamic instabilities of a smart embedded micro shell conveying varied fluid flow and subjected to the combined electro-thermo-mechanical loadings are investigated. With the aim of designing new hydraulic sensors and actuators, the piezoelectric materials are employed for the body and the effects of applying electric field on the stability of the system as well as the induced voltage due to the dynamic behavior of the system are studied. The nonlocal piezoelasticity theory and the nonlinear cylindrical shell model in conjunction with the energy approach are utilized to mathematically modeling of the structure. The fluid flow is assumed to be isentropic, incompressible and fully develop, and for more generality of the problem both steady and time dependent flow regimes are considered. The mathematical modeling of fluid flow is also carried out based on a scalar potential function, time mean Navier-Stokes equations and the theory of slip boundary condition. Employing the modified Lagrange equations for open systems, the nonlinear coupled governing equations of motion are achieved and solved via the state space problem; forth order numerical integration and Bolotin's method. In the numerical results, a comprehensive discussion is made on the dynamical instabilities of the system (such as divergence, flutter and parametric resonance). We found that applying positive electric potential field will improve the stability of the system as an actuator or vibration amplitude controller in the micro electro mechanical systems.

• Computers and Concrete
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• 제11권1호
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• pp.39-49
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• 2013

The use of ground fly ash in concrete can increase the risk of slump loss due to the drastic surface change of the particles after the grinding treatment and the accelerated reaction compared to the untreated ash. This study is aimed at the early age hydration and time-dependent rheology changes of cement paste containing ground fly ash. An original fly ash is ground into different fineness and the hydration of cement paste containing the ground fly ash is monitored with the ultrasound propagation method. The zeta potentials of the solid particles are measured and the changes of rheological parameters of the cement pastes with time are analyzed with a rheometer. A particle packing model is used to probe packing of the solid particles. The results show that the early age hydration of the paste is strongly promoted by replacing Portland cement with fly ash up to 30 percent (by mass), causing increase of the yield stress of the paste. The viscosity of a paste containing ground fly ash is lower than that containing the untreated ash, which is explained by the denser packing of the solid particles.

• 한국농공학회논문집
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• 제51권6호
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• pp.69-76
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• 2009

Soils exhibit creep behavior in which deformation and movement proceed under a state of constant stress or load. In Korea, weathered soil is abundant and occupies around one-third of the country. Weathered soil is visually described as a sandy or gravelley soil, but the behavior is quite different from the behavior of usual sand and gravel. In particular, the permeability of weathered soil is similar to sand, but the durability of settlement is similar to clay. Therefore analysis of time-dependent behavior of weathered soil is very important. In this study, Creep tests with weathered soils were carried out under constant principal stress differences of various stress levels which were experimentally obtained by triaxial compression test. The results of these tests showed the creep behavior for which the deformation increased with time, and the results are consistent with phenomenological model by creep equation of Singh-Mitchell.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1994년도 Proceedings of the Korea Automatic Control Conference, 9th (KACC) ; Taejeon, Korea; 17-20 Oct. 1994
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• pp.747-752
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• 1994

Ussing's flux ratio theorem (1978) reflects a reciprocal relationship behavior between the unidirectional fluxes in asymmetric steady diffusion-convection in a membrane slab. This surprising result has led to many subsequent studies in a wide range of applications, in particular involving linear models of time dependent problems in biology and physiology. Ussing's theorem and its extensions are inherently linear in character. It is of considerable interest to ask to what extent these results apply, if at all, in situations involving, for example, nonlinear reaction. A physiologically interesting situation has been considered by Weisiger et at. (1989, 1991, 1992) and by McNabb et al. (1990, 1991) who studied the role of albumin in the transport of ligands across aqueous diffusion barriers in a liver membrane slab. The results are that there exist reciprocal relationships between unidirectional fluxes in the steady state, although albumin is chemically interacting in a nonlinear way of the diffusion processes. However, the results do not hold in general at early times. Since this type of study first started, it has been speculated about when and how the Ussing's flux ratio theorem fails in a general diffusion-convection-reaction system. In this paper we discuss the validity of Ussing-type theorems in time-dependent situations, and consider the limiting time behavior of a general nonlinear diffusion system with interaction.