• Korean Journal of Animal Reproduction
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• v.17 no.2
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• pp.75-83
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• 1993

Purine has been identified in the preparation of follicular fluid and shown an activity in maintaining oocyte meiotic arrest. Therefore this study was performed to examine the inhibitory effect of purine on germinal vesicle break down(GVBD) in the presence and absence of human fetal cord serum(HFCS) or human mature follicular fluid(HMFF), as a protein source, in vitro culture. Immature oocytes(GV stage) were collected from ovaries of 21∼28 days old ICR mice by puncturing the antral follicles with a fine needle, at 48 hrs after PMSG injection. Some of the oocytes were denuded by drawing the cumulus-enclosed(complex) oocytes in and out of a pasteur pipet. Complex oocytes and denuded oocytes were cultured 3 hrs. in T6 media containing 0.75mM adenosine or/and 4mM hypoxanthine, with HFCS or HMFF. Their GVBD rates were observed at every 1 hr. during the culture time. Both adenosine and hypoxanthine have shown a time-dependent inhibitory effect on GVBD in complex and denuded oocytes and the inhibitory effect was maximized in culture medium containing hypoxanthine and adenosine. HFCS and HMFF increased the GVBD rates in the presence of the purines, thus HFCS and HMFF may contain a factor that could reverse the inhibitory effect of purines. Also complex oocytes were more sensitive to not only the inhibitory effect of purines but the promoting action of HMFF on GVBD than denuded oocytes. Therefore it was reconfirmed that granulosa cells play an important part in meiotic arrest and resumption.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.26 no.2
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• pp.193-198
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• 2017

Rubber materials are widely used for anti-vibration in various industries such as railways, automobile, and aviation. However, various factors hinder the accurate prediction of mechanical properties and lifetime of these materials. Particularly, a stress softening phenomenon Mullins effect greatly affects the accuracy of test results by reducing the initial peak stress. Although the Mullins effect has been studied previously, research on its temperature dependence is lacking. In this study, we performed experiments to estimate the temperature dependence of the Mullins effect. Dumbbell specimens made of natural rubber (NR65) was mounted on a stress softening tester and placed in a heat chamber, where they were tested at temperature of 25, 50, and $80^{\circ}C$. Further, five test sets, each consisting of 10 loading/unloading cycles were sequentially performed at predetermined time intervals. Based on the test results, we assessed the effect of temperature and time interval on stress softening and recovery.

• Journal of Environmental Impact Assessment
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• v.21 no.2
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• pp.297-314
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• 2012

This study investigates the stigma effect of unwelcomed facilities on apartment prices through multiple regressions based on hedonic price method. The areas studied are Sang-gye Jugong 7, 9, 10 apartment complexes. The facilities analyzed are the Chang-dong Electric Subway Depot and the Do-bong Driver's License Agency. The factors studied include the environmental variable (the elapsed time since the announcement of the re-location of these facilities), the view commanding, the distance from Chang-dong Depot, the distance from Do-bong Driver's License Test Course, the distance from neighboring facilities (subway stations, schools, parks and so on), the floor and each dwelling's exclusive space. The data used are 2,822 sales which have been collected since January 1, 2006. The facts found are as follows; first, the view commanding and the distance from the unwelcomed facilities are statistically significant. second, the environmental variable, 'days' turns out to have a positive (+) and a negative (-) significant relationship with the dependent variable, 'price', in period II and period IV respectively. This implies that the stigma effect is real. third, there are significant differences in the influence on the apartment prices among the independent variables according to time. fourth, the stigma effect is estimated as 33,686,920 Korean won in the case of the apartments which have the view commanding and 30,311,844 won in the other case before the global economic crisis. This effect seems to decrease to 22,085,078 won after the crisis. These facts suggest that stigma effects could be considered as one of the benefits in the cost-benefit analysis of Chang-dong Depot re-location project to produce somewhat higher NPV or B/C ratio.

• Journal of the Korea institute for structural maintenance and inspection
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• v.10 no.4
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• pp.127-135
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• 2006

In this study, steel deck bridges are chosen as analytic model to show the structural behaviors generated by high temperature of pavement and to formulate the simplified approximate analysis of thermal effects. In general, the thermal effect is changed by the material property of pavements and environmental temperature as well as shape, size and boundary conditions of bridge. Specially, this effect is the representative initial stress problem dependent on time. The thermal effect, however, does not depend on time and thermal effect is regarded as initial load in this study. After these thermal loading is modelled as moving loads, influence lines of reactions of shoes are calculated and the successive pavement steps with arbitrary segments are determined to minimize the thermal effect of shoes by influence line.

• Science of Emotion and Sensibility
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• v.26 no.4
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• pp.15-28
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• 2023

Considering the necessity for individuals to check and manage their wellness to promote happiness, this study conducted preliminary research on the effect of wellness enhancement of the self-life coaching app. Thirty-six participants were randomly assigned to experimental groups 1 and 2 and a control group, respectively. In particular, the experimental groups were asked to perform self-life coaching for 4 weeks using a research app. Weekly feedback was provided to experimental group 1, but not to experimental group 2. The wellness index for workers (WIW) and the Korean wellness scale (KWS) were used as dependent variables. The analysis results of interaction effects between pre-, post-, and follow-up time points and groups reveal no statistically significant effects in both dependent variables, but the tendency of the effects was confirmed. Moreover, no difference was determined in terms of the presence or absence of weekly feedback in the experimental treatment effect. As a result of repeated measures variance analysis on KWS measured at five times, the wellness enhancement effect over time was statistically significant. Meanwhile, the polynomial trend analysis result confirmed the linear effect of the experimental treatment on wellness. The participation opinion survey also revealed that 84.2% of the participants perceived the activity to be helpful, and 78.9% responded that they would use it once every 1 or 2 weeks if the app is commercially available. This study is meaningful in that it suggests a methodology for utilizing the self-life coaching app so that anyone can use it to promote their wellness and partially confirms the effectiveness of this method.

• Journal of the Korean Ceramic Society
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• v.29 no.7
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• pp.558-564
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• 1992

The effect of composed phase in the hot pressed CaO-MgO-Al2O3-SiO2 glass-ceramic has been investigated through microstructure studies, thermal, physical and mechanical properties. Sintering was done in the condition at the temperature range 900~95$0^{\circ}C$ for 20~120 mins under 7.5 MPa unilateral pressure. Sintered ceramics were composed of diopside, anorthite, residual glass and the portion of each phase was dependent on the sintering temperature and the holding time: as the temperature increases, the amount of diopside increased and then the rate of increase of diopside reduced with increasing anorthite. The thermal expansion coefficient of hot pressed was reduced with increasing crystallinity of hot pressed and was in the range of 6.69~7.46$\times$10-6 K-1 below $600^{\circ}C$. The elastic constant of hot pressed increased with increasing crystallinity up to about 80%, but after that was reduced due to the change of microstructure. The flexural strength of sintered ceramics was decreased with higher temperature and holding time, while the fracture toughness of those increased. It was shown that the physical and mechanical properties of hot pressed ceramic were related to the fraction of composed sintered ceramics, similar to a particulate composite, to the crystallinity of 80% of the glass-ceramic.

• Journal of Pharmaceutical Investigation
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• v.36 no.3
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• pp.157-160
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• 2006

This study investigated the effect of clarithromycin on the pharmacokinetics of ambroxol in rats. The pharmacokinetic parameters of ambroxol in rats were determined after the oral administration of ambroxol (12 mg/kg) in the presence or absence of clarithromycin (5 or 10 mg/kg). Compared with the control (given ambroxol alone), coadministration of clarithromycin significantly (p<0.05 at 5 mg/kg; p<0.01 at 10 mg/kg) increased the area under the plasma concentration-time curve (AUC), peak plasma concentrations $(C_{max})$ and absorption rate constant $(K_a)$ of ambroxol. Clarithromycin increased the AUC of ambroxol in a dose dependent manner within the dose range of 5 to 10 mg/kg. The absolute bioavailability (AB%) of ambroxol in the presence of clarithromycin was significantly higher than that of the control (p<0.05 at 5 mg/kg; p<0.01 at 10 mg/kg), and the relative bioavailability (RB%) of ambroxol with clarithromycin was increased by 1.32-to 1.71-fold. However, there were no significant changes in time to reach peak concentration $(T_{max})$ and terminal half-life $(T_{1/2})$ of ambroxol in the presence of clarithromycin. Coadministration of clarithromycin enhanced the bioavailability of ambroxol, which may be due to the inhibition of intestinal and hepatic metabolism of ambroxol by CYP 3A4. Further studies for the potential drug interaction are necessary since ambroxol is often administrated concomitantly with clarithromycin in humans.

• The Journal of Engineering Geology
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• v.9 no.2
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• pp.135-145
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• 1999

Dynamic Shear modulus (G) is one of the imfortant dynamic soil properties to estimate the response of soil to dynamic loading. Problems in engineering geo1ogy practice the require the knowledge of soil properties subjected to dynamic loadings include soil-structure interaction during earthquakes, bomb blasts, construction operations, and mining. Although the dynamic shear modulus (G) is a time-dependent property, G change with time is often neglected. In this study, the effect of duration of confinement and its affecting factors (previous stress and strain, particle size and sustained pressure, and plasticity index) on the low-amplitude shear modulus ($G_{max}$) of soils are reviewed, and some empirical correlations based on mean particle diameter and plasticity index are proposed.

• Computational Structural Engineering
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• v.8 no.3
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• pp.91-102
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• 1995

For the wave propagation problems, the influence of time-dependent dynamic behavior must be accounted in the analysis. In this study, the dynamic analysis method which combines finite elements and boundary elements is developed for the wave propagation problem modelling the infinity of medium through 3-D boundary elements and underground structure through degenerated finite shell elements. Performing dynamic analysis of underground tunnels by the proposed coupling method of boundary and finite elements, it is found that the change of the stiffness of structures has a good effect on the response. It is also found that the consideration of the repeating effect due to moving traffic loads which is difficult with existing 2-D dynamic analysis can be possible with the 3-D analysis in time domain.

• Magazine of the Korean Society of Agricultural Engineers
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• v.18 no.4
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• pp.4242-4250
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• 1976

The determination of the pre-consolidation load known to have a great effect on the consolidation characteristics of the soil have been researched and discussed in detail by many other researchers. A study was undertaken to investigate and compare the effect of pre-consolidation loads on the coefficient of permeability and the consolidation characterisics of soil through the consolidation test on the three types of soil samples. The results of this study are follows; 1. Large compression index is dependent on initial void ratio of the sample being used and the pressure-void ratio curve shows a curved linear relationship in over-consolidated area but a linear relationship in normally consolidated area.2. Settlement-time curve is S-shaped where the pressure is larger than pre-consolidation load and regardless of over-burden pressure, it is a similar straight line respectively in the secondary consolidation area. 3. Primary consolidation ratio of the sample increases almost linearly with the increase of over-burden pressure but the coefficient of volume compressibility decreases linearly with the increase of it. 4. Time factor of a certain degree of consolidation increases with over-burden pressure but the coefficient of consolidation decreases with it in over-consolidated area. There is a linear relationship between them in normally consolidated area. 5. The void ratio of completion point of primary consolidation decreases linearly with over-burden pressure. 6. The coefficient of permeability of sample decreases linearly with over-burden pressure in normally consolidated area, also it increases linearly with increment of the void ratio of the sample.