• Journal of Nutrition and Health
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• v.27 no.1
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• pp.12-22
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• 1994

Effects of very low level of lead in diet and exposure time on the accumulation and distribution in organs and tissues was investigated with growing rats. 21 days old Sprague-Dawley rats were exposed to lead for 7, 14 and 21 days by feeding of 0.03, 0.42, 0.92 and 1.46mg/kg Pb as Pb-acetate containing diet, respectively. Lead concentrations in blood, liver, kidney and bone exhibit a linear relationship with lead levels in diet. After 7 days of exposure, the greatest dose dependent accumulation of lead was found in kidney and followed in bone. However, after 14 and 21 days, the dose dependent accumlation of lead in bone was about two fold greater than that in kidney. The accumulation of lead in liver and blood was relatively low. As continuous exposure to lead, the concentrations of lead in liver, kidney, blood and intestinal tracts were rather not increased with exposure time. However, bone lead concentration was increased with exposure time by feeding of 0.92 and 1.46mg/kg Pb in diet, but not 0.42mg/kg. The lead concentration in gastrointestinal tracts tends also to increasing with lead levels in diet after 7 and 14 days of exposure. However, by 21 days of exposure the lead concentration revealed relatively constant value regardless of the dietary lead levels. It is concluded that the binding capacity of the lead in blood, liver, kidney and bone seems to be increased with increasing lead levels in diet. The lead concentration in these organs, with the exception of the lead in bone, seems, however, to be standing under steady state regulation by continued exposure with the same dietary lead level. Therefore, by chronic exposure condition with environmental relevant lead level bone might be a principle targe organ for lead and blood lead repesents better the current lead exposure than the lead body burden.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.51 no.1
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• pp.1-13
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• 2006

Response of grain yield and milled-rice protein content to nitrogen topdress (N) timing at panicle initiation stage (PIS) is critical for quantifying real-time N requirement for target grain yield and milled-rice protein content. Two split-split-plot experiments with three replications, one in 2004 and the other in 2005, were conducted in Experimental Farm, Seoul National University, Suwon, Korea. The experiments included three N rates at tillering stage (TS), three N timing treatments at panicle initiation stage (PIS) and two rice cultivars. The N rates at TS, N timing at PIS, and rice cultivars were randomly assigned to main plot, sub plot, and sub-sub plot, respectively. Results showed that the delayed N application at PIS reduced grain yield in 2004 and increased milled-rice protein content in both years significantly at 0.05 probability level. The calculated optimum N timing at PIS from pooled data by N rates and rice cultivars in two years was at 28 days before heading (DBH). However, real-time of N timing at PIS was dependent on plant growth and N status around PIS that in turn was dependent on applied N rates at TS. The optimum N timing at PIS was at 30 DBH for no N treatments at TS while at 27 DBH for 3.6 and 7.2 kg N/10a treatments and at 27 and 29 DBH for Hwaseongbyeo and Daeanbyeo, respectively. In general, earlier applied N at PIS resulted in lower milled-rice protein content but the highest grain yield was expected to be obtained when N topdress at PIS was applied at the time when shoot N concentration started to drop below about 23 mg/g due to dilution effect after transplanting. In conclusion, the results of our experiments imply that the currently recommended N topdress time (24DBH) at PIS in Korea should be reconsidered for the higher grain yield and the better quality of rice.

• Earthquakes and Structures
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• v.24 no.4
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• pp.275-288
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• 2023

Based on the crucial role of high-speed railway bridges (HSRBs) in the safety of high-speed railway operations, it is an important approach to mitigate earthquake hazards by proceeding with seismic risk assessments in their whole life. Bridge seismic risk assessment, which usually evaluates the seismic performance of bridges from a probabilistic perspective, provides technical support for bridge risk management. The seismic performance of bridges is greatly affected by the degradation of material properties, therefore, material damage plays a nonnegligible role in the seismic risk assessment of the bridge. The effect of material damage is not considered in most current studies on seismic risk analysis of bridges, nevertheless. To fill the gap in this area, in this paper, a nonlinear dynamic time-history analysis has been carried out by establishing OpenSees finite element model, and a seismic vulnerability analysis is carried out based on the incremental dynamic analysis (IDA) method. On this basis, combined with the site risk analysis, the time-dependent seismic risk analysis of an offshore three-span HSRB in the whole life cycle has been conducted. The results showed that the seismic risk probabilities of both components and system of the bridge increase with the service time, and their seismic risk probabilities increase significantly in the last service period due to the degradation of the material strength, which demonstrates that the impact of durability damage should be considered when evaluating the seismic performance of bridges in the design and service period.

• Journal of the Korean housing association
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• v.23 no.2
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• pp.99-106
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• 2012

Compared to Packaged Terminal Air Conditioning Systems, Radiant Cooling Systems have the advantage of energy saving and thermal comfort. Thermally Activated Building System (TABS) is one of the radiant heating and cooling systems. The main difference between TABS and other radiant systems lies in the usage of the time-lag effect of storing heat energy in the concrete. Current energy usage in summer time is concentrated within a specific time by using Packaged Terminal Air-Conditioner (PTAC). Due to the time-lag effect of TABS, energy usage can be distributed to other time zones. To maximize this effect, it is important to determine the appropriate operating mode, which for TABS is dependent upon the cooling load generated by the occupancy schedule. In this study, occupancy schedules are determined for various residential types. The operating modes of TABS for these residential types are estimated by using a dynamic computational simulation method. The results indicate that the operating modes of TABS can be determined by residential type and occupancy schedule. The load handled ratio by TABS is set up differently according to the cooling load profile obtained from residential type and occupancy schedule. By using TABS, energy consumption could be reduced by 20% compared to PTAC.

• Journal of the Korea Concrete Institute
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• v.25 no.1
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• pp.45-51
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• 2013

Short beam tests of GFRP and CFRP specimens exposed to high temperature were conducted to measure the inter-laminar shear strength. For the phase I test, the exposure time and temperature were varied to measure reduction in the strength due to the applied conditions. As a results, the critical temperature was found to $270^{\circ}C$ for the both FRP reinforcements. The high temperature, which causes 50% loss of inter-laminar shear strength, is defined as the critical temperature in this study. It should be noted that the critical temperature for the inter-laminar shear strength is mainly dependent on resin properties not on fiber type. In the phase II test, the effect of exposure time was investigated at intervals of 0.25hour for the critical temperature. All test results demonstrate that the exposure time effect is not significant compared to the maximum exposure temperature, but it is not negligible and, moreover, is significant at the critical temperature.

• Korean Journal of Food Science and Technology
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• v.33 no.3
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• pp.294-300
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• 2001

Effect of bean water concentration and incubation time of Yukwa paste as well as packaging method on the quality of Yukwa was investigated. Quality loss in Yukwa during storage was dependent on the packaging method such as bamboo packaging at $30^{\circ}C$, nitrogen packaging at $30^{\circ}C$ and LDPE packaging at $-18^{\circ}C$. Peroxide value increased with bean water concentration, but showed no significant difference by incubation time. The hardness of Yukwa decreased with the increase of bean water concentration, incubation time, and storage time but showed no significant difference by packaging method. Sensory evaluation after storage for 3 months showed that Yukwa color was significantly influenced by packaging method and bean water concentration. The volume was also significantly influenced by bean water concentration and incubation time. Off-flavor showed significant difference by storage method. Tenderness, taste and overall desirability showed significant difference by bean water concentration. Crispness showed significant difference by storage method and bean water concentration.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.6
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• pp.65-72
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• 2016

Service life evaluation for RC Structures exposed to chloride attack is very important, however the previous two methods(deterministic and probabilistic method) show a big difference. The paper presents a service life simulation using deterministic and probabilistic method with time-dependent diffusion coefficient. Three different cases are considered for diffusion coefficient, concrete cover depth, and surface chloride content respectively, and then the PDF(probability of durability failure) and the related service life are obtained. Through adopting time-dependent diffusion, the discrepancy between the two methods can be reduced, which yields reasonable service life. When diffusion coefficient increases from $2.5{\times}10^{-12}m^2/sec$ to $7.5{\times}10^{-12}m^2/sec$, the service life decreases to 25.5~35.6% level, and cover depth does from 75 mm to 125 mm, it increases to 267~311% level as well. In the case of surface chloride content from $5.0kg/m^3$ to $15.0kg/m^3$, it changes to 40.9~54.5%. The effect of cover depth is higher than the others by 8~10 times and also implies it is a key parameter to service life extension.

• Korean Journal of Food Science and Technology
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• v.44 no.4
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• pp.452-459
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• 2012

This study was conducted in order to investigate the effect of resveratrol on the induction of apoptosis in MDA-MB-231 breast cancer cells. The result of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl terazolium bromide (MTT) assay shows that cell viability significantly decreased in a dose and time-dependent manner. 4',6-diamidino-2-phenylindole (DAPI) staining shows significantly increased chromatin condensation in a dose and time-dependent manner. Resveratrol increased the expression of p53, cleaved-caspase-3, and cleaved-caspase-9, whereas the expression of PI3K/Akt decreased in a time-dependent manner. We investigated the in vivo tumor growth inhibitory effect of resveratrol. Tumor volume was significantly decreased in the 50 mg/kg resveratrol-administration group compared to the control group. In the 50 mg/kg treated group. Apoptosis cells were frequently observed by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) assay. Immunohistochemistry staining shows increased the expression of p53, cytochrome-C, and cleaved-caspase-3 in the 50 mg/kg treated group. These results indicate that resveratrol induced apoptosis through PI3K/Akt and p53 signal pathway in MDA-MB-231 cell.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.3
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• pp.233-239
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• 2014

The present study was designed to investigate the effect Hypericum Perforatum (HP), on behavioral changes, corticosterone, TNF-${\alpha}$ levels and tryptophan metabolism and disposition in bilateral ovariectomized rats compared to $17{\alpha}$-ethinylestradiol. Behavioral analysis by measuring immobility time in forced swimming test and open field test, serum and hippocampal corticosterone and TNF-${\alpha}$ along with hippocampal kynurenine/tryptophan ratio were determined in mature ovariectomized rats treated orally either by HP at three different doses 125, 250, and 500 mg/kg/day or by $17{\alpha}$-ethinylestradiol $30{\mu}g/kg/day$ for 30 days. Ovariectomized rats showed significant increase in immobility time in the forced swimming test. Along with elevation in serum and hippocampal TNF-${\alpha}$ and corticosterone levels associated with significant increase in hippocampal kynurenine/tryptophan ratio. Immobility time in the forced swimming test was decreased in rats treated by different doses of HP in a dose dependent manner and $17{\alpha}$-ethinylestradiol with no concomitant changes in the open field test. Only Rats treated with HP exhibited significant decrease in the elevated serum and hippocampal TNF-${\alpha}$ and corticosterone, which couldn't explain the associated insignificant effect on hippocampaus kynurenine/tryptophan ratio in comparison to ovariectomized untreated rats. It is concluded that increased tryptophan metabolism toward kynurenine secondary to elevated corticosterone and TNF-${\alpha}$ might be one of the pathohphysiological mechanisms that could explain depression like state observed in this rat model. Further, the observed attenuating effect of HP on TNF-${\alpha}$ and corticosterone could contribute in its antidepressant effect in this animal model by other ways than their effects on tryptophan-kynurenine metabolism pathway.

• Journal of Korean Society on Water Environment
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• v.23 no.5
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• pp.748-755
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• 2007

To develop an efficient pump operating rule for a retard basin, it is necessary to estimate inflow to the retard basin accurately which is affected by the backwater effect at the outlet of the conduit. The magnitude of the backwater effect is dependent on the water depth of a retard basin; however, the depth is determined by the amount of inflow and outflow. Thus, a real time simulation system that is able to simulate urban runoff and the pump operation with the consideration of the backwater effect is required to estimate the actual inflow to a retard basin. With this system, the efficient pump operating rule can be developed to diminish the possible flood damage on urban areas. In this study, a realtime simulation system is developed using the SWMM 5.0 DLL and Visual Basic 6.0 equipped with EXCEL to estimate inflow considering the backwater effect. The realtime simulation can be done by updating realtime input data such as minutely observed rainfall and the depth of a retard basin. Using those updated input data, the model estimates actual inflow, the amount of outflow discharged by pumps and gates, the depth of each junction, and flow rate at a sewer pipe on realtime basis. The developed model was applied to the Joonggok retard basin and demonstrated that it can be used to design a sewer system and to estimate actual inflow through the inlet sewer to reduce the inundation risk. As results, we find that the model can contribute to establish better operating practices for the pumps and the flood drainage system.