• Korean Journal of Veterinary Research
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• v.34 no.2
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• pp.307-313
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• 1994

We have previously shown that crude water extract of Euonymus alatus (EA) had strong prophylactic effect against chemically induced-and tumor cell implanted-cancer, and that the mechanisms responsible for its antitumor effects were due to nonspecific enhancement of the NK cell activities and the cell mediated immunity. However, it was unknown that any components of crude extract did work so, since it consisted of several components. In this paper, we fractionated the crude watar EA-extract into several fraction such as hexane-, ethylether-, ethyl acetate-, n-butanol- and water soluble-fraction, and screened the immune regulating activities of each fraction by the evaluation of lymphokine production and activated lymphocyte proliferation. As a result of the component fraction of EA-extract, it was found that n-butanol fraction was a potent immunostimulator, and the remained water soluble fraction also contained some stimulator, But, other fraction did not showed any remarkable effect. It is therefore suggested that EA-glycosides in n-butanol fraction may be new one of the potent biological response modifiers. The present study was also undertaken in an efforts to investigate the effects of elm-bark(EB, Ulmus clavidiana var japonica), which has been used for curing ulcer and inflammation as a folk medicine without any kind of experimental evidence to support this, on the cellular- and humoral-immune responses, lymphocyte function and NK cell activities in mice. Regardless of time and duration of EB-treatment, Arthus reaction and antibody response to SRBC were not modified by EB, but delayed hypersensitivity to SRBC was significantly enhanced only when EB was treated prior to SRBC-sensitization. EB slightly inhibited the proliferation responses of splenocytes to PHA-stimulation, but it significantly augmented the responses of these cells to S aureus Cowan 1 and Con A-activation, and these effects were manifested only when EB was added at culture initiation. EB did not influence Ig secretion of spleen cells but it significantly augmented the Con A-induced 1L 2 and MIF production of splenocytes. NK cell activities of splenocytes were markedly riled when effector cells were pretreated with EB and this augmentation was dine to the increase of binding affinity of effector cells to target cells and the target cell lytic activities of effector cells. These results led to the conclusion that EB triggers increase of cellular immune responses, such as delayed hypersensitivitiy, lymphokine production and NK cell activities. Also these results suggested that EB contains potent immune stimulants, which may provide the rational basis for their therapeutic use as one of the new biological response modifiers.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.1737-1741
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• 2007

Using kinematic wave equation, the influence of moving rainstorms to runoff was analysised with a focus on watershed shapes and rainfall distribution types. Watershed shapes used are the oblong, square and elongated shape, and the distribution types of moving storms used are uniform, advanced and intermediate type. The runoff hydrographs according to the rainfall distribution types were simulated and the characteristics were explored for the storms moving down, up and cross the watershed with various velocity. And the hydrographs were compared in the case of varing the rainstorm intensity and varing the rainstorm length in order to make the same total runoff volume. When the rainstorm intensity was varied the shape, peak time and peak runoff of a runoff hydrograph are significantly influenced by spatial and temporal variability in rainfall and watershed shapes. The peak time of down and upstream moving strorms appeared latest in the case of the elongated shape basin, meanwhile at cross stream moving storms, the peak time of elongated shape basin is earlier than the others. For storms moving downstream peak time was more delayed than for other storm direction in the case of elongated watershed. The runoff volume and time base of the hydrograph decreased with the increasing storm speed.

• Korean Journal of Food Science and Technology
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• v.47 no.1
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• pp.81-86
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• 2015

Intense pulsed light (IPL), a nonthermal technology, has attracted increasing interest as a food processing technology. However, its efficacy in inactivating microorganisms has not been evaluated thoroughly. In this study, we investigated the influence of IPL treatment on the inactivation of Escherichia coli O157:H7 depending on light intensity, treatment time, and pulse number. Increased light intensity from 500 V to 1,000 V, raised the inactivation rate at room temperature. At 1000 V, the cell numbers were reduced by 7.1 log cycles within 120 s. In addition, increased pulse number or decreased distance between the light source and sample surface also led to an increase in the inactivation rate. IPL exposure caused a significant increase in the absorption at 260 nm of the suspending agent used in our experiments. This indicates that IPL-treated cells were damaged, consequently releasing intracellular materials. The growth of IPL-irradiated cells were delayed by about 5 h. The degree of damage to the cells after IPL treatment was confimed by transmission electron microscopy.

• KSBB Journal
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• v.22 no.1
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• pp.43-47
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• 2007

The effect of surfactant on the hydrolysis of used newspaper was investigated. The most suitable surfactant for the pretreatment stage was found to be NP-series surfactants among 9 kinds of non ionic surfactants. Process parameters such as surfactant concentration, mixing speed, pretreatment temperature and time were tested to optimize for maximum digestibility and 0.5%, 100rpm, 30$^{\circ}C$, and 1 h were found to be optimum, respectively. In order to maximize digestibility, substrate was pretreated with NP-20 and then the pretreated substrate was hydrolyzed by adding TW-80. The effect of surfactant on the hydrolysis of previously surfactant-pretreated newspaper was marginal. Therefore, the digestibility with the addition order of enzyme and surfactant was investigated by using surfactant only in hydrolysis stage. The results show that digestibility was more lowered as the surfactant addition after adding enzyme to substrate was more delayed.

• Journal of the Korean Society of Hazard Mitigation
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• v.7 no.5
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• pp.167-178
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• 2007

Based on the kinematic wave equations, the influence of moving rainstorms on the surface runoff were analyzed with a focus on the rainfall distribution types. Applied hypothetical rainfall distribution types of moving rainstorms used are uniform, advanced, delayed and intermediate type. The moving rainstorm velocities applied in this study were $0.125{\sim}2.0m/s$ of moving upstream and downstream direction of plane surface. Simulations were undertaken by varying the rainfall distribution type, moving rainstorm velocity and moving direction, and the results were compared with that of stationary rainfall. The results indicate significant differences in peak discharges and hydrograph shapes for moving rainstorms of various rainfall patterns and moving directions. It shows that the moving rainstorms of downstream direction generate the largest peak runoff at all rainfall distributions. The sensitivity of runoff to rainfall distribution types decreases as storm velocity increases. It is clear that faster rainstorm velocity generates faster peak time and becomes thin hydrographs rapidly.

• Journal of Korean Neurosurgical Society
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• v.40 no.5
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• pp.357-362
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• 2006

Objective : The incidence of aneurysmal subarachnoid hemorrhage has been increasing. At the same time, surgical results for elderly patients are unsatisfactory and no guidelines of treatment are available. We carried out a study comparing variable factors and surgical results between young and old age groups to find ways to improve prognosis. Methods : A retrospective study was carried out on 754 patients who were operated on between 1990 and 2004 by the same surgeon in our hospital. The patients were divided into seven groups according to age : 93 patients below 40 years of age [Group I], 419 patients aged $40{\sim}59$ [Group II], 115 patients aged $60{\sim}64$ [Group III], 82 patients aged $65{\sim}69$ [Group IV], 28 patients aged $70{\sim}74$ [Group V], 12 patients aged $75{\sim}79$ [Group VI] and 5 patients over the age of 80 [Group VII]. We then checked their medical history, Fisher's grade, Hunt-Hess grade, postoperative complications, and Glasgow Outcome Scale. Results : Age was not a statistically significant factor among patients below 70 years of age [P $value{\ge}0.05$]. But for those aged 70 and older, the age factor had a statistical value [P $value{\le}0.001$]. In addition, there was a close correlation between Hunt-Hess grade IV and V patients, and those with vasospasm, and hydrocephalus after surgery, with poor prognosis in elderly patients as well as young patients [P $value{\le}0.001$]. Conclusion : Advanced age [under the age of 70] dose not precluded adequate surgical treatment in patient with AN SAH, and we should be also alert to preventable causes of delayed neurological deterioration for improving the outcome in all elderly groups.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.61 no.3
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• pp.163-170
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• 2016

Heading time is important element for yield and quality in crops. Among day length and temperature which influence on heading, temperature effect has not been investigated well. To investigate temperature effect on heading, heading date and plant growth characters were checked under the low and high temperature conditions in short day length. Analyzing heading date of six Korean varieties under the high and low temperature condition, heading date of varieties were delayed under low temperature. In the low temperature condition, dry weight and area of leaf were reduced. Varieties showing more delay of heading under low temperature also showed more reduction in leaf area. After selecting three varieties showing significant difference in leaf growth and heading date under different temperature conditions, nutrient contents of plant were analyzed. Nitrogen content was reduced in leaf and shoot under the low temperature condition. OsNRT2.3, nitrate transporter, was significantly down regulated in varieties showing more heading delay. Available phosphate content was decreased in leaf, but increased in shoot due to reduction of phosphate mobility. OsPT1, phosphate transporter regulating phosphate uptake, was more down regulated in varieties showing more heading delay. OsPT6, phosphate transporter regulating phosphate transport in plant, was also significantly down regulated in those varieties. With these data, we expected that active nitrogen and available phosphate uptake and transport in plant would increase leaf growth then might reduce heading delay under the low temperature condition.

• Sleep Medicine and Psychophysiology
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• v.27 no.1
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• pp.1-7
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• 2020

Mobile digital devices are very familiar and useful devices in the daily life of modern people, and are used for various tasks such as communication, reading, writing, and playing media. As the use of mobile digital devices has become more prevalent, user time has also been increasing. In particular, the number of people who use digital devices before sleep is growing. The light pollution associated with these devices is classified into four categories: urban sky glow, glare, light trespass, and clutter. The pattern in which modern people use digital devices corresponds to light pollution caused by light trespass and clutter from light exposure to artificial light at night. The light pollution caused by digital devices can cause melatonin secretion suppression, delayed sleep onset, reduction of sleepiness before bedtime, and periodic rhythm and cognitive function disturbances. In addition, a study of children and adolescents showed there may be disturbances in the sleep-wake cycle and circadian rhythm, deterioration of sleep quality, and daytime fatigue due to light pollution caused by artificial light at night from mobile digital devices. A multi-faceted research effort is also necessary to investigate the healthy use of mobile digital devices based on research evidence and insights with an accurate evaluation of the influence of mobile digital devices as a form of light pollution.

• 한국정보디스플레이학회:학술대회논문집
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• 2000.01a
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• pp.119-120
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• 2000

Influences of sustain voltage on wall charges and wall voltages are experimentally investigated in surface AC plasma display panels(AC-PDPs), in which electrode gap and width are $80\;{\mu}m$ and $270\;{\mu}m$, respectively. The filling gas is Ne-Xe gas mixture, and total pressures 300 Torr. Also it is found that the more amount of Xe mixing ratio makes the less wall charge and voltage for sustain voltage ranged from 140 V to 222 V. The response time has been delayed by adding a small amount of Xe to Ne in comparison with that without Xe. It is also found that the wall charge and voltage are reduced by adding a small amount of Xe to Ne in comparison with those without Xe.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.8
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• pp.1094-1097
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• 2007

Vibration at frequency of 20 Hz and 0.18 g of acceleration was applied to 600 g watery kimchi contained in a glass jar of 1 L at subfreezing temperature (-3 and $-6^{\circ}C$) and $10^{\circ}C$ in order to see its effect on freezing and fermentation behaviors, respectively. The vibration at the subfreezing temperature delayed the freezing process and contributed to maintaining small ice crystal slurry in subsequent frozen storage. The vibration at $10^{\circ}C$ accelerated the acid and carbon dioxide production from the watery kimchi, which may be beneficial in shortening ripening time and attaining fresh cool taste.