• Title/Summary/Keyword: time dependent therapy

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Negative noxiousness of aldosterone analogue-induced hypertension and inhibition of aldosterone by silver spike point electrical stimulation (Aldosterone 유도체-고혈압의 음성적 유해와 은침점전기자극의 aldosterone 억제)

  • Chon, Ki-Young;Kim, Jung-Hwan;Kim, Soon-Hee;Min, Kyung-Ok
    • Journal of Korean Physical Therapy Science
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    • v.10 no.2
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    • pp.199-207
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    • 2003
  • The present study examined that in vivo/vitro test is investigated in normotensive sham-operated rats(NSR) and aldosterone-analogue deoxycorticosterone acetate (DOCA)-salt hypertensive rats(ADHR) and that the antiliypertensive effect was induced by silver spike point(SSP) electrical stimulation at meridian points(CV-3, -4, Ki-12, SP-6, LR-3, BL-25, -28, -32, -52), specifically, such as aldosterone in 24 hour urine analysis from normal volunteer. The heart weight, the tickness of vascular wall, collagen fiber and the systolic blood pressure were significantly increased in ADHR than that in NSR. The required time of PSS-induced resting tone and the phosphorylation of stress-activated protein kinase/c-Jun N-terminal protein kinase(SAPK/JNK) were significantly increased in ADHR than that in NSR. However, the Kv currents were significantly decreased in ADHR than that in NSR. The current of 1 Hz continue type of SSP electrical stimulation significantly decreased in excretion of urine aldosterone from normal volunteer. These results suggest that the development of aldosterone analogue-induced hypertension is associated with changed heart weight, content of collagen fiber, tickness of vascular wall, blood pressure, resting tone, voltage-dependent K+ current(Kv) and phosphorylation of SAPK/JNK, which directly affects blood pressure. Therefore the hypertension is a risk factor on cerebrovascular disease. Moreover, These results suggest that the SSP electrical stimulation, especially current of 1 Hz continue type, significantly regulates excretion of urine aldosterone from volunteer.

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The Influence of Different Objects and Target Locations of Dominant Hand on the Non-Dominant Hand Movement Kinematics in Bimanual Reaching (양손으로 물체 옮기기 과제 수행 시 우세손이 옮기는 물체의 종류와 목표점의 위치 변화가 비우세손의 팔뻗기 동작에 미치는 영향)

  • Kim, Min-Hee;Jeon, Hye-Seon
    • Physical Therapy Korea
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    • v.15 no.3
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    • pp.44-52
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    • 2008
  • The purpose of this study was to investigate the effects of different objects and target location of dominant hand on the non-dominant hand movement kinematics in a bimanual reaching task. Fifteen right-handed volunteers were asked to reach from same starting point to the different target point of right and left hand with grasping the objects of different size. Independent variables were 1) three different object types (small mug cup, name pen, and PET bottle), and 2) three different target locations (shorter distance, same distance, and longer distance than the non-dominant hand) of the dominant hand. Dependent variables were movement time (MT), movement distance (MD), movement mean velocity ($MV_{mean}$), and movement peak velocity ($MV_{peak}$) of the non-dominant hand. Repeated measures two-way analysis of variance (ANOVA) was used to test for differences in the non-dominant hand movement kinematics during bimanual reaching. The results of this study were as follows: 1) MT of the non-dominant hand was increased significantly when traveling with grasping the mug cup and reaching the far target location, and was decreased significantly when traveling with grasping the PET bottle and reaching the near target location of the dominant hand. 2) MD of the non-dominant hand was significantly increased during reaching the far target location, and significantly decreased during reaching the near target location with dominant hand. 3) $MV_{mean}$ of the non-dominant hand was increased significantly when traveling with grasping the PET bottle, and was decreased significantly when traveling with grasping the mug cup of the dominant hand. Therefore, it can be concluded that the changes of the ipsilateral hand movement have influence on coupling of the contralateral hand movement in bimanual reaching.

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Modulation of Cellular Immune Response by Inosiplex (Inosiplex에 의한 세포성 면역반응의 변화)

  • Lee, Hern-Ku;Lee, Jeong-Ho;Kim, Hak-Kun;Ha, Tai-You
    • The Journal of the Korean Society for Microbiology
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    • v.21 no.2
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    • pp.251-259
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    • 1986
  • This study was performed to assess the effect of inosiplex(ISP) on the resistance of mice Candida albicans infection, the migration of chicken leukocytes, the production of leukocyte migration inhibitory factor(LIF), and the cell-mediated immunity(CMI) to lepomin in multibacillary lepromatous leprosy patients. The treatment with ISP before or on the time of infection with C. albicans had no or deliterious effect, and treatment with ISP after infection had no effect on the recovery of C. albicans from the kidneys of mice. The migratory ability of chicken leukocytes and the production of LIF from splenocytes of mice were not affected by ISP treatment. However, ISP decreased the migration of chicken leukocytes in vitro, and this decrease was dose-dependent. The therapy of lepromatous leprosy patients with ISP for 10 or 30 days clearly showed the increase of the significant positive rate of Mitsuda skin test to lepromin. The immune recovery as a result of the therapy was found to be the best in the group of patients treated for 30 days. This results suggest that (1) the effect of ISP in renal candidiasis can vary depending on the time of treatment relative to infection, (2) ISP can primarily change the migratory ability of chicken leukocytes but does not affect the production of LIF in mice, and (3) the classical therapy combined with ISP can reinforce or restore the defences of lepromatous leprosy patients against Mycobacterium leprae.

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Comparison of the Immediate Effects of the Assisting Method for Center of Body Weight on Vastus Medialis Oblique and Vastus Lateralis Muscle Activation Variables and Muscle Onset Time During Stair Ascending (체중심의 보조 방법에 따른 계단 오르기 시 안쪽넓은근과 가쪽넓은근의 근활성 변수들과 개시시간에 미치는 즉각적인 영향 비교)

  • Ji-Won Shin;Sam-Won Yoon
    • PNF and Movement
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    • v.21 no.1
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    • pp.107-117
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    • 2023
  • Purpose: The aim of this study is to compare the immediate effects of weight-assisting methods on vastus medialis oblique (VMO) and vastus lateralis (VL) muscle activation, on the VMO/VL muscle activation ratio, and on muscle onset time in healthy subjects when ascending stairs. Methods: Healthy participants were randomly assigned to the belt group (n = 11), hand group (n = 11), and control group (n = 11). In the belt group, a belt was wrapped around the sacrum and pulled forward with both hands, moving the center of weight forward, while ascending stairs. The hand group grasped the hips with both hands and climbed stairs, assisting their weight from the rear and moving the center of weight backward, and the control group climbed the stairs without any intervention. Results: Muscle activation of the VMO decreased significantly after the intervention in the belt and hand groups, and activation of the VL muscle in both groups showed a greater decrease than that of the VMO muscle. Further, the VMO/VL muscle activation ratio increased significantly, with an improvement shown in the order of the belt group, hand group, and control group, while muscle onset time also improved in the order of the belt group, hand group, and control group. Conclusion: The belt group demonstrated the greatest effect across all dependent variables, confirming that in clinical practice, these two weight-assisting methods are more effective interventions during stair ascent for patients with knee joint instability, pain, and imbalance than no assistance.

Effects of a Five Times Sit to Stand Test on the Daily Life Independence of Korean Elderly and Cut-Off Analysis

  • Nam, Seung-Min;Kim, Seong-Gil
    • Journal of the Korean Society of Physical Medicine
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    • v.14 no.4
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    • pp.29-35
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    • 2019
  • PURPOSE: The aim of this study was to provide the standard value of the Five Times Sit to Stand Test (FTSST) measurement on the daily life independence of the elderly in Korea and examine the effects of this test on their daily lives. METHODS: This study was conducted on elderly people over 65 years of age living in Gyeongsangbuk-do, Korea. FTSST was performed while sitting position on a chair. The subjects were classified into independent and dependent living groups according to their lifestyle, and their influence was then examined through logistic regression analysis. To determine the usefulness and cut-off value of the FTSST, the analysis was performed using the ROC curve. RESULTS: The elderly were more likely to live in a group rather than independently as the FTSST time increased (p<.05) (OR=1.098). The area of the lower part of the ROC curve was .707, and as the FTSST increased, a subject was more likely to live in a group rather than independently (p<.05). The cut-off value was assigned to the point where both the specificity and sensitivity were at the coordinates. The sensitivity and specificity were .626 and .753, respectively at 15.62 seconds. CONCLUSION: The elderly in Korea are more likely to live a group-dependent lifestyle than live independently; the likelihood of this outcome is increased further for every additional second beyond 15.62 seconds. The loss of independence of daily life could be predicted based on the status of a subject's lower leg strength using the FTSST.

Effect of Taping Therapy and Inner Arch Support on Plantar Lower Body Alignment and Gait

  • Lee, Sojung;Jeong, Dawun;Kim, Dong-Eun;Yi, Kyungock
    • Korean Journal of Applied Biomechanics
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    • v.27 no.3
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    • pp.229-238
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    • 2017
  • Objective: The purpose of this study was to identify the effects of taping therapy and inner arch support on pes planus lower extremity alignment and gait. Method: The study was conducted on 13 women in their 20s who had pes planus and no gait problems. Independent variables were the condition of wearing basic socks (S1) and the condition of wearing socks with taping therapy and inner arch support (S2). The dependent variables were resting calcaneal stance position (RCSP), plantar pressure distribution during gait, and underlying and medial longitudinal arch angle measured using radiography. Statistical analysis was performed using the Wilcoxon test with SPSS 23.0 for comparison of S1 and S2. Results: In the RCSP measurement, the angle range of S2 changed to normal. Meary's angle appeared to be less than the angle of S1, indicating alleviation of the degree of pes planus. The calcaneal pitch angle increased at S2 from that at S1. The plantar pressure distribution was divided into four areas (toe, forefoot, midfoot, and hindfoot). At S2, the maximum pressure increased in the toe and midfoot. The maximum force increased significantly in the toe and midfoot but decreased significantly in the forefoot and hindfoot. In addition, the contact area increased overall especially at the midfoot and hindfoot. Contact time decreased in the toe and forefoot, but increased in the midfoot and hindfoot. Conclusion: Taping therapy and inner arch support showed structural improvement of the pes planus. In addition, the force and pressure applied to the foot during walking are distributed evenly in the area of the sole, thus positively affecting walking.

Comparison of the Pelvic Height Difference in Subjects with Lower Back Pain and in Normal Subjects in Different Postures (체중부하 자세에 따른 요통환자와 정상인의 양측골반높이에 대한 연구)

  • Lee, Ju-Hui;Lee, Wan-Hee
    • Journal of Korean Physical Therapy Science
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    • v.11 no.3
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    • pp.28-37
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    • 2004
  • Background: Lumbar joint dysfunction is reported to be the main cause of lower back pain (LBP). The purpose of this study was to evaluate the effect of joint dysfunction on the postural balance of the lower hack and pelvis in different normal activities such as walking or stair management. Also it was studied whether the status of LBP (intensity and duration of LBP, length of treatment) contributes to die pelvic height difference (PHD) in various postures. Subjects: 28 patients with LBP and 32 normal adult volunteers, 60 years of age or younger, who came to the Community Health Center and orthopedic clinics in Incheon, South Korea. Methods: In order to determine the accuracy of the manual angulometer method in measuring the PHD, it was compared to the pelvic x-ray method in selected subjects. In the manual angulometer method, the arm of the angulometer was placed on the top of both iliac crests. The PHD was measured in static upright stance, then one-legged stance, on the affected leg or unaffected leg each time. Information regarding the disease status was obtained through interviews. Visual assessment scale was used to grade the intensity of LBP. Data analysis was performed using SPSS 10.0/PC program. Homogeneity between the two groups was tested by 2-test and t-test. To compare the PHD of the subgroups, we used t-test, F-test and two-way ANOVA. Relationships among dependent variables were analyzed by Pearson correlation analysis. Conclusion: In patients with LBP, lumbar joint dysfunction causes lumbar and pelvic postural asymmetry during normal activities.

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The Noxiousness of Aldosterone Analogue-induced Senile Disease-related Hypertension and Inhibition of the Aldosterone by Silver Spike Point Electrical Stimulation in Elderly People -The Approach of Basic Physical Therapy for the Study of Cardiovascular Disease-related Specialized Physical Therapy- (알도스테론 동족체-유도 노인성질환-연관 고혈압의 유해와 노인에 적용한 은침점전기자극의 알도스테론 억제 -심혈관질환전문물리치료 연구를 위한 기초물리치료학적 접근을 중심으로-)

  • Lee, Sook-Hee;Kang, Joon-Hwan;Lee, Sang-Bin;An, Ho-Jung;Kim, Moo-Gi;Kim, Soon-Hee;Kim, Jung-Hwan
    • Journal of Korean Physical Therapy Science
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    • v.13 no.2
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    • pp.67-83
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    • 2006
  • The present study examined that in Vivo/Vitro test is investigated in normotensive sham-operated rats (NSR) and aldosterone-analogue deoxycorticosterone acetate (DOCA)-salt hypertensive rats (ADHR) and that the antihypertensive effect was induced by silver spike point (SSP) electrical stimulation at meridian points(CV-3, -4, Ki-12, SP-6, LR-3, BL-25, -28, -32, -52), specifically, such as aldosterone in 24 hour urine analysis from healthy volunteer. The gross examination and morphometric-histological changes, such as hypertrophy, production of necrotic tissues, and the changes of cell arrangement on the kidney, and adrenal gland were markedly observed in aldosterone-analogue DOCA-salt hypertensive rats compared with those from normotensive sham-operated rats. The systolic blood pressure, weight of kidney and adrenal gland were significantly increased in ADHR than that in NSR. The required time of PSS-induced resting tone was significantly increased in ADHR than that in NSR. However, the voltage-dependent K+ (Kv) currents were significantly decreased in ADHR than that in NSR. The urine analysis showed that the concentration of aldosterone was significantly decreased in resting state from the elderly people compared with those from the adolescent healthy volunteer. The current of 1 Hz continue type of SSP electrical stimulation significantly decreased in the concentration of aldosterone of 24 hour urine from the elderly people. These results suggest that the development of aldosterone analogue-induced hypertension is associated with changed the weight of kidney and adrenal gland, blood pressure, resting tone and Kv currents, which directly affects blood pressure. Therefore, the hypertension is a risk factor on cerebrovascular disease. Moreover, these results suggest that the diminished responsiveness to SSP electrical stimulation, especially current of 1Hz continue type, in elderly people may be, in part, related by the increased of antihypertensive effects.

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Color therapy and application of color to oriental medical science (색채치료(色彩治療)와 한의학(漢醫學)에서의 색(色)의 적용(適用))

  • Park, Seung Lim;Kang, Jung Soo
    • Journal of Haehwa Medicine
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    • v.12 no.1
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    • pp.79-102
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    • 2003
  • It has been believed that the human body can be effected by color, sound, smell, and taste - each of them is based on the original character. Out of these elements, the color can be a mediation that absorbs energy into human body and adapts it to the creatures whose life are definitely based on the solar energy. This thesis makes a study of the possibility of applying the color to the oriental medical science by researching the color psychology and therapy which are studied in the west medical science, the recognition and application of color developed from orientalism, and the opinion of color in the oriental medical science. Color therapy is one of the psychological treatment techniques that are able to recover and maintain the health with the rays of the sun rays and the color. The light and the color have its energy that may relax, harmonize, encourage, or excite a human being. This is because the wavelength and the vibration of each color will take effects to human body. The core energy of absorbing and distributing the color vibration is made in the 7 "chakras" in the body, which are the pith and marrow of bio-energy directly connected with the center of the nervous system. There are several methods in the color therapy - the treatment of solar ray, the color-bath, the water-therapy using color energy, the inducement of the solar energy into the body, the acupuncture, the therapy of crystal and jewel, and the self-suggestion dependent upon the color. The color therapy can help us to keep our balance by changing the emotion into the positive energy that will cure the disease with color. As a result, this method not only must be useful to cure physical disease, or develop into good health but also will be used in conforming itself to the mental disease. The color therapy mainly uses the eight colors, which are made by mixing Red, Yellow and Blue basic colors in the field. They are never used in the treatment, but they will go along with complementary colors. This rule is closely connected with the theory of yin and yang which lies at the root of oriental philosophy, and with the treatment principle of oriental medical science whose field is focused on the balancing the body mentally as well as physically. In the East, it is the Obangsaek - the color of blue, red, yellow, white, and black in the theory of yin and yang and the five elements that have been used in helping people having trouble with their health for a long time. In the view of the oriental medical science, these five colors attached the theory of five-elements have been very useful to the physiology, the pathology, or the diagnosis, and been applied to the medical treatment, combining themselves with a five-taste in medicinal herbs. Since the study of color and human physiology has been made in some different interest and fields these days, it goes to prove that the different function of color we couldn't have got before becomes very useful to the medical science. The color must be worth researching the diversity for applying itself to the oriental medical science.

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Silibilin-Induces Apoptosis in Breast Cancer Cells by Modulating p53, p21, Bak and Bcl-xl Pathways

  • Pirouzpanah, Mohammad Bagher;Sabzichi, Mehdi;Pirouzpanah, Saeed;Chavoshi, Hadi;Samadi, Nasser
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.2087-2092
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    • 2015
  • Nowadays herbal-derived medicines are attracting attention as new sources of drugs with few side effects. Silibinin is a flavonoid compound with chemotheraputic effects on different cancers such as examples in the prostate, lung, colon and breast. In the present study, the cytotoxic effects of silibinin on MCF7 breast cancer cells were investigated. Apoptosis was determined by flow cytometry and the impact of silibinin on the expression of pivotal genes including Bak, P53, P21, BRCA1, BCL-X1 and ATM was analyzed. Treatment for 24h had a significant dose-dependent inhibitory effect on cell growth (p<0.05) with dose- and time- dependent induction of apoptosis (p<0.05). In addition, there were significant increases in BRCA1, ATM, Bak and Bcl-XL gene expression at the mRNA level with different concentrations of silibinin for 24 or 48 h (p<0.05). Taken together, the results suggest that silibinin inhibits the proliferation and induces apoptosis of MCF-7 cells by down-regulating Bak, P53, P21, BRCA1, BCL-Xl and thus may be considered as an effective adjuvant drug to produce a better chemopreventive response for the cancer therapy.