• Journal of the Korean Chemical Society
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• v.46 no.2
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• pp.117-124
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• 2002

Counterflow oxidation was developed and evaluated for treatment of organics that adsorbed in/on granular activated carbon(GAC). This reaction is a method that destructs and removes organics adsorbed, at the same time, regenerates waste carbon, uti lizing a self-sustained flame which propagates itself ina direction counter to the oxygen flow. The results showed that the mass loss of carbon and flam temperature were strongly dependent on the flow rate of oxyen, adsorptive capability of regenerated carbon completely was recovered, as well as destrution and removal efficiency of thermally stable PCBs was achieved with the value of better than 99.99%.

• Aerospace Engineering and Technology
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• v.1 no.2
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• pp.51-56
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• 2002

Satellite propulsion system is employed for orbit transfer, orbit correction, and attitude control. The monopropellant feeding system in the low-earth-orbit satellite blowdowns fuel to the thrust chamber. The thrust produced by the thruster depends on fuel amount flowed into the combustion chamber. If the thruster valve be given on-off signal from on-board commander in the satellite, valve will be opened or closed. When the thrusters fire fuel flows through opened thruster valve, instantaneous stoppage of flow in according to valve actuation produces transient pressure due to pressure wave. This paper describes transient pressure predictions of the KOMPSAT-2 propulsion system resulting from latching valve and thrust control valve operations. The time-dependent set of the fluid mass and momentum equations are calculated by MOC.

• Nuclear Engineering and Technology
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• v.45 no.2
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• pp.191-202
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• 2013

A numerical analysis of thermal stratification in the upper plenum of the MONJU fast breeder reactor was performed. Calculations were performed for a 1/6 simplified model of the MONJU reactor using the commercial code, CFX-13. To better resolve the geometrically complex upper core structure of the MONJU reactor, the porous media approach was adopted for the simulation. First, a steady state solution was obtained and the transient solutions were then obtained for the turbine trip test conducted in December 1995. The time dependent inlet conditions for the mass flow rate and temperature were provided by JAEA. Good agreement with the experimental data was observed for steady state solution. The numerical solution of the transient analysis shows the formation of thermal stratification within the upper plenum of the reactor vessel during the turbine trip test. The temporal variations of temperature were predicted accurately by the present method in the initial rapid coastdown period (~300 seconds). However, transient numerical solutions show a faster thermal mixing than that observed in the experiment after the initial coastdown period. A nearly homogenization of the temperature field in the upper plenum is predicted after about 900 seconds, which is a much shorter-term thermal stratification than the experimental data indicates. This discrepancy may be due to the shortcoming of the turbulence models available in the CFX-13 code for a natural convection flow with thermal stratification.

• Land and Housing Review
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• v.1 no.1
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• pp.59-65
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• 2010

The paper presents a comparison between a semi-implicit time integration linear finite element implementation and fully-implicit nonlinear Newton-Raphson finite element implementation of a triphasic small strain mixture formulation of an elastic partially saturated porous medium. The pore air phase pressure pa is assumed atmospheric, i.e., $p_a$ = 0, although the formulation and implementation are general to handle increase in pore air pressure as a result of loading, if needed. The solid skeleton phase is assumed linear isotropic elastic and partially saturated 'consolidation' in the presence of surface infiltration and traction is simulated. The verification of the implementation against an analytical solution for partially saturated pore water flow (no deformation) and comparison between the two implementations is presented and the important of the porosity-dependent nature of the partially saturated permeability is assessed on comparison with a commercial code for the partially saturated flow with deformation. As a result, the response of partially saturated permeability subjected to the porosity influences on the saturation of a soil, and the different behaviors of the partially saturated soil between staggered and monolithic coupled programs is worth of attention because the negative pore water pressure in the partially saturated soil depends on the difference.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.68-72
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• 2023

Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there is an urgent need to develop novel therapies. In this study, we investigated the antitumor activity of MS-5, a naphthalene derivative, on BxPC-3, a human pancreatic cancer cell line. We observed that MS-5 was cytotoxic to BxPC-3 cells, as well as inhibited the growth of cells in a concentration- and time- dependent manner. Flow cytometry analysis revealed that the percentage of annexin V-positive cells increased after MS-5 treatment. We also observed cleavage of caspases and poly (ADP-ribose) polymerase, and downregulation of Bcl-xL protein. Flow cytometry analysis of intracellular levels of reactive oxygen species (ROS) and mitochondrial superoxide suggested that MS-5 induced the generation of mitochondrial superoxide while lowering the overall intracellular ROS levels. Thus, MS-5 may be potential candidate for pancreatic cancer treatment.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.937-944
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• 2022

Electric vehicles (EVs) have been growing to reduce energy consumption and greenhouse gas (GHG) emissions in the transportation sector. The increasing number of EVs requires adequate recharging infrastructure, and at the same time, adopts low- or zero-emission electricity production because the GHG emissions are highly dependent on primary sources of electricity production. Although previous research has studied solar photovoltaic (PV) -integrated EV charging stations, it is challenging to optimize spatial areas between where the charging stations are required and where the renewable energy sources (i.e., solar photovoltaic (PV)) are accessible. Therefore, the primary objective of this research is to support decisions of siting EV charging stations using a spatial data clustering method integrated with Geographic Information System (GIS). This research explores spatial relationships of PV power outputs (i.e., supply) and traffic flow (i.e., demand) and tests a community in the state of Indiana, USA for optimal sitting of EV charging stations. Under the assumption that EV charging stations should be placed where the potential electricity production and traffic flow are high to match supply and demand, this research identified three areas for installing EV charging stations powered by rooftop PV in the study area. The proposed strategies will drive the transition of existing energy infrastructure into decentralized power systems. This research will ultimately contribute to enhancing economic efficiency and environmental sustainability by enabling significant reductions in electricity distribution loss and GHG emissions driven by transportation energy.

• Journal of Distribution Science
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• v.21 no.12
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• pp.59-69
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• 2023

Purpose: Consumers can experience better service for distribution of products with payment technology such as QRIS (Quick Response Code Indonesian Standard) compared to conventional purchase methods. This research aims to determine the experience of QRIS service users in Indonesia. Perceived Usefulness, Ease of Use, and Perceived Security were independent factors. Behavioral Intention to Use is the dependent variable. Furthermore, Word of Mouth Attitude is an intervening variable. Research Design, Data, and Methodology: Involving active QRIS users in a survey-based quantitative study in Indonesia. A survey sample of 400 people was taken from data records of 30.87 million QRIS users in Indonesia. Data were analyzed using SEM-PLS. Results: Show that Perceived Usefulness and Perceived Ease of Use significantly impact Attitudes Word of Mouth, and Behavioral Intention to Use. This research also found that Behavioral Intention to Use does not significantly impact Perceived Security. Conclusion: QRIS, as a revolutionary innovation, offers faster payments than previous methods, with a payment time of no more than one minute. QRIS is seen as valuable, simple, and safe, disseminating information to the public and continuing to use QRIS. The implications of this research are very significant in accelerating the flow of distribution of goods and services and facilitating transactions.

• Nuclear Engineering and Technology
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• v.56 no.3
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• pp.873-879
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• 2024

A sodium-cooled fast reactor (SFR) core has a potential of prompt criticality due to a change of core material distribution during a severe accident, and the resultant energy release has been one of the safety issues of SFRs. In this study, the safety assessment of an unprotected loss-of-flow (ULOF) in a small SFR (SSFR) has been performed using the SIMMER-IV computer code, which couples the models of space- and time-dependent neutronics and multi-component, multi-field thermal hydraulics in three dimensions. The code, therefore, is applicable to the simulations of transient behaviors of extended disrupted core material motion and its reactivity effects during the transition phase (TP) of ULOF, including a potential of prompt-criticality power excursions driven by fuel compaction. Several conservative assumptions are used in the TP analysis by SIMMER-IV. It was found out that one of the important mechanisms that drives the reactivity-inserting fuel motion was sodium vapor pressure resulted from a fuel-coolant interaction (FCI), which itself was non-energetic local phenomenon. The uncertainties relating to FCI is also evaluated in much conservative way in the sensitivity analysis. From this study, the ULOF characteristics in an SSFR have been understood. Occurrence of recriticality events under conservative assumptions are plausible, but their energy releases are limited.

• Journal of Korean Society for Atmospheric Environment
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• v.19 no.1
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• pp.67-76
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• 2003

Recently consideration of health and interest on bio aerosols have been growing steadily. In this study, inertial impactor, which can be used to collect airborne particles and bio aerosols, was newly devised for real-time observation on the particles collected on impaction plate. and named Visual Impactor. Flow field and particle trajectory in the space between nozzle and impaction plate was analyzed numerically, and the collection effciencies were calculated. Calibration and performance evaluation of the Visual Impactor was conducted with polydisperse aerosols generated from 0.1％ sodium chloride solution. Cut-off diameter from numerical simulation was in good agreement with that from experimental results. Because of particle bounce and particle deposition on nozzle tip due to short jet-to-plate distance, the collection efficiencies from numerical and experimental analyses were different slightly. Visual Impactor was used to collect airborne particles, and the features of collected particles could be seen in real-time. Airborne particles in different weather conditions (fine, cloudy, and rainy) were sampled and compared one another The features of collected airborne particles were dependent strongly upon relative humidity. In addition, with hours elapsing, shapes and colors of collected particles were changed by evaporation and surface tension, etc.

• Archives of Pharmacal Research
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• v.24 no.2
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• pp.126-135
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• 2001

Quinacrine (QU), a phospholipase-A2 (PLA-2) inhibitor has been used clinically as a chemotherapeutic adjuvant. To understand the mechanisms leading to its chemotherapeutic effect, we have investigated QU-induced apoptotic signaling pathways in human cervical squamous carcinoma HeLa cells. In this study, we found that QU induced cytochrome c-dependent apoptotic signaling. The release of pro-apoptotic cytochrome c was QU concentration- and time-dependent, and preceded activation of caspase-9 and -3. Flow cytometric FACScan analysis using fluorescence intensities of $DiOC_6$/ demonstrated that QU-induced cytochrome c release was independent of mitochondrial permeability transition (MPT), since the concentrations of QU that induced cytochrome c release did not alter mitochondrial membrane potential (${\blacktriangle}{\Psi}_m$). Moreover, kinetic analysis of caspase activities showed that cytochrome c release led to the activation of caspase-9 and downstream death effector caspase-3, Caspase-3 inhibitor (Ac-DEVD-CHO) partially blocked QU-induced apoptosis, suggesting the importance of caspase-3 in this apoptotic signaling mechanism. Supplementation with arachidonic acid (AA) sustained caspase-3 activation induced by QU. Using inhibitors against cellular arachidonate metabolism of lipooxygenase (Nordihydroxyguaiaretic Acid, NDGA) and cyclooxygenase (5,8,11,14-Eicosatetraynoic Acid, ETYA) demonstrated that QU-induced apoptotic signaling may be dependent on its role as a PLA-2 inhibitor. Interestingly, NDCA attenuated QU-induced cytochrome c release, caspase activity as well as apoptotic cell death. The blockade of cytochrome c release by NDCA was much more effective than that attained with cyclosporin A (CsA), a MPT inhibitor. ETYA was not effective in blocking cytochrome c release, except under very high concentrations. Caspase inhibitor z-VAD blocked the release of cytochrome c suggesting that this signaling event is caspase dependent, and caspase-8 activation may be upstream of the mitochondrial events. In summary, we report that QU induced cytochrome c-dependent apoptotic signaling cascade, which may be dependent on its role as a PLA-2 inhibitor. This apoptotic mechanism induced by QU may contribute to its known chemotherapeutic effects.