• Natural Product Sciences
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• v.8 no.2
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• pp.66-70
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• 2002

The in vitro anticoagulant and fibrinolytic activities of crude extracts from insects were evaluated in order to find effective therapeutic drugs for the treatment of myocardial and cerebral thrombosis. We prepared three types of extracts (water, methanol and ethylacetate) from 28 insects for use as raw materials for the activity assays. The fibrinolytic activity was tested using the fibrin plate method and the activated partial thromboplastin time and thrombin time were measured for blood clotting activity. With regards to the fibrinolytic system, water extracts of six kinds of insects displayed a remarkable level of activity with a plasmin-like action. The water extracts of [Catharsius molossus, Eupolyphaga sinensis, Huechys sanguinea, Mantidis $o\ddot{o}theca$, Mimela splendens, and Polistes mandarinus (Vespae Nidus)] exhibited the activity. On the other hand, the methanol extracts did not display any fibrinolytic activity. In terms of the coagulation system, an aqueous extract of silkworm Tongchunghacho (Paecilomyces japonica), Oxya japonica japonica and Buthus martensi (Scorpion) increased the clotting time significantly longer (181 times) than the control. These results suggest that crude drugs from insects are useful sources for the development of new drugs for use in treatments involving blood coagulation and fibrinolysis.

• KIPS Transactions on Computer and Communication Systems
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• v.7 no.8
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• pp.211-218
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• 2018

In this study, we propose an algorithm to detect eating activity and estimation mealtime using 6-axis inertial sensor. The eating activity is classified into three types: food picking, food eating, and lowering. The feature points of the gyro signal are selected for each gesture, and the eating activity is detected when each feature point appears in the sequence. Morphology technique is used to post-process to detect meal time. The proposed algorithm achieves the accuracy of 94.3% and accuracy of 84.1%.

• Nuclear Engineering and Technology
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• v.53 no.4
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• pp.1266-1276
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• 2021

The mask parameters of a coded aperture are critical design features when optimizing the performance of a gamma-ray camera. In this paper, experiments and Monte Carlo simulations were performed to derive the minimum detectable activity (MDA) when one seeks a real-time imaging capability. First, the impact of the thickness of the modified uniformly redundant array (MURA) mask on the image quality is quantified, and the imaging of point, line, and surface radiation sources is demonstrated using both cross-correlation (CC) and maximum likelihood expectation maximization (MLEM) methods. Second, the minimum detectable activity is also derived for real-time imaging by altering the factors used in the image quality assessment, consisting of the peak-to-noise ratio (PSNR), the normalized mean square error (NMSE), the spatial resolution (full width at half maximum; FWHM), and the structural similarity (SSIM), all evaluated as a function of energy and mask thickness. Sufficiently sharp images were reconstructed when the mask thickness was approximately 2 cm for a source energy between 30 keV and 1.5 MeV and the minimum detectable activity for real-time imaging was 23.7 MBq at 1 m distance for a 1 s collection time.

• Journal of Microbiology and Biotechnology
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• v.17 no.11
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• pp.1880-1884
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• 2007

This study was conducted to find the optimum extraction condition of Gold-Thread for antibacterial activity against Streptococcus mutans using The evolutionary operation-factorial design technique. Higher antibacterial activity was achieved in a higher extraction temperature ($R^2=-0.79$) and in a longer extraction time ($R^2=-0.71$). Antibacterial activity was not affected by differentiation of the ethanol concentration in the extraction solvent ($R^2=-0.12$). The maximum antibacterial activity of clove against S. mutans determined by the EVOP-factorial technique was obtained at $80^{\circ}C$ extraction temperature, 26 h extraction time, and 50% ethanol concentration. The population of S. mutans decreased from 6.110 logCFU/ml in the initial set to 4.125 logCFU/ml in the third set.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 1994.10a
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• pp.79-84
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• 1994

The purpose of this study is to find out the relation between the outdoor activity and independent behavior of infant and the physical charater of the intermediate-territory. Another purpose is to find out the estimate of infant smother to the intermediate-territory as the space of the infant's outdoor life. As the result of this study, the following points are confirmed :1) The outdoor activity. cognition. independent behavior of infant is affected by the physical character of the intermediate-territory.2) The time and frequency of outdoor activity is affected by the physical character of the intermediate-territory. 3) The cognition and the boundary of outdoor activity are affected by the physical character of the intermediate-territory.4) The time of independent behavior is affected by the physical character of the intermediate-territory.5) The estimate of infant's mother to the intermediate-territory as the space of infant’s activity is very bad. Therefore the physical environment of intermediate-territory is very poor.

• Journal of the Korean housing association
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• v.6 no.2
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• pp.43-49
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• 1995

The purpose of this study is to find out the relation between the outdoor activity and independent behavior of infant and the physical charater of the intermediate-territory. Another purpose is to find out the estimate of infant's mother to the intermediate-territory as the space of the infant's outdoor life. As the result of this study, the following points are confirmed: 1) The outdoor activity, cognition, independent behavior of infant is affected by the physical character of the intermediate-territory. 2) The time and frequency of outdoor activity is affected bu the physical character of the intermediate-territory. 3) The cognition and the boundary of outdoor activity are affected by the physical character of the intermediate-territory. 4) The time of independent behavior is affected by the physical character of the intermediate-territory. 5) The estimate of infant's mother to the intermediate-territory as the space of infant's activity is very bad. The physical environment of intermediate-territory is very poor.

• Proceedings of the Korean Society for Food Science of Animal Resources Conference
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• 2005.10a
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• pp.329-333
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• 2005

ACE inhibition activity of peptides was measured after 2 months of storage at $4^{\circ}C$ under condition of pH 6.0, 6.5, 7.0, 7.5, 8.0. and the ACE inhibitory activity were changed only slightly. After 2 months of chilled storage ($4^{\circ}C$), no dramatic change and significance was found. This indicates that acidic, neutral, weak alkali conditions did not affect ACE inhibitory activity of those peptides. Among peptide 1134, 1152, and 1155, peptides from thermolysin + protease A hydrolysates, inhibition activity of peptide 1134 and 1152 was decreased significantly at $60^{\circ}C$, however, they showed stable inhibition activity from $70^{\circ}C$ to $100^{\circ}C$ (P<0.001). Also, chromatogram of peptide 1134, 1152, and 1155 was shown that retention time of peptide of $60^{\circ}C$ was not correspond to the retention time of the rest of peptides. This indicated that temperature may change the inhibitory activity and profile of peptides.

• Journal of Sensor Science and Technology
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• v.16 no.6
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• pp.467-474
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• 2007

The real-time monitoring about the activity of the human provides useful information about the activity quantity and ability. The present study implemented a small-size and low-power acceleration monitoring system for convenient monitoring of activity quantity and recognition of emergent situations such as falling during daily life. For the wireless transmission of acceleration sensor signal, we developed a wireless transmission system based on a wireless sensor network. In addition, we developed a program for storing and monitoring wirelessly transmitted signals on PC in real-time. The performance of the implemented system was evaluated by assessing the output characteristic of the system according to the change of posture, and parameters and acontext recognition algorithm were developed in order to monitor activity volume during daily life and to recognize emergent situations such as falling. In particular, recognition error in the sudden change of acceleration was minimized by the application of a falling correction algorithm

• Biomolecules & Therapeutics
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• v.8 no.3
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• pp.223-227
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• 2000

Propolis, a natural resinous compound collected from honey bees, contains many biochemical constituents and has been used for traditional medicines as early as 300 B .C. Recently, it has been reported to possess many biological activities such as antibacterial, antiviral, fungicidal, local anaesthetic, immunostimulating, antiinflammatory and free radical scavenging properties. To investigate activities of chrysin, one of propolis effective compounds for blood coagulation system was injected endotoxin (4000 EU/kg, i.v.) in rats at 1 hr after administered chrysin (20 mg/kg, p.o.). This study was resulted that chrysin has antiplatelet aggregation activity in vitro, delay of blood clotting time and prothrombin time, and reduction of fibrinogen and FDP in vivo. Chrysin has increased SOD activity, GSH content and GST activity, and decreased MDA content in liver. The result suggests that the antithrombosis effect of chrysin is suppressive activity for a blood coagulation system and antioxidative activity.

• Physical Therapy Korea
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• v.28 no.1
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• pp.84-91
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• 2021

Background: A hip fracture may occur spontaneously prior to the hip impact, due to the muscle pulling force exceeding the strength of the femur. Objects: We conducted falling experiments with humans to measure the activity of the hip muscles, and to examine how this was affected by the fall type. Methods: Eighteen individuals fell and landed sideways on a mat, by mimicking video-captured real-life older adults' falls. Falling trials were acquired with three fall directions: forward, backward, or sideways, and with three knee positions at the time of hip impact, where the landing side knee was free of constraint, or contacted the mat or the contralateral knee. During falls, the activities of the iliopsoas (Ilio), gluteus medius (Gmed), gluteus maximus (Gmax) and adductor longus (ADDL) muscles were recorded. Outcome variables included the time to onset, activity at the time of hip impact, and timing of the peak activity with respect to the time of hip impact. Results: For Ilio, Gmed, Gmax, and ADDL, respectively, EMG onset averaged 292, 304, 350, and 248 ms after fall initiation. Timing of the peak activity averaged 106, 96, 84, and 180 ms prior to the hip impact, and activity at the time of hip impact averaged 72.3, 45.2, 64.3, and 63.4% of the peak activity. Furthermore, the outcome variables were associated with fall direction and/or knee position in all but the iliopsoas muscle. Conclusion: Our results provide insights on the hip muscle activation during a fall, which may help to understand the potential injury mechanism of the spontaneous hip fracture.