• Progress in Superconductivity
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• v.13 no.3
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• pp.139-145
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• 2012

Electric activity of cardiac muscles generates magnetic fields. Magnetocardiography (or MCG) technology, measuring these magnetic signals, can provide useful information for the diagnosis of heart diseases. It is already about 40 years ago that the first measurement of MCG signals was done by D. Cohen using SQUID (superconducting quantum interference device) sensor inside a magnetically shielded room. In the early period of MCG history, bulky point-contact RF-SQUID was used as the magnetic sensor. Thanks to the development of Nb-based Josephson junction technology in mid 1980s and new design of tightly-coupled DC-SQUID, low-noise SQUID sensors could be developed in late 1980s. In around 1990, several groups developed multi-channel MCG systems and started clinical study. However, it is quite recent years that the true usefulness of MCG was verified in clinical practice, for example, in the diagnosis of coronary artery disease. For the practical MCG system, technical elements of MCG system should be optimized in terms of performance, fabrication cost and operation cost. In this review, development history, technical issue, and future development direction of MCG technology are described.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2000.11a
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• pp.56-58
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• 2000

Post-genomics may be defined in different ways depending on how one views the challenges after the genome. A popular view is to follow the concept of the central dogma in molecular biology, namely from genome to transcriptome to proteome. Projects are going on to analyze gene expression profiles both at the mRNA and protein levels and to catalog protein 3D structure families, which will no doubt help the understanding of information in the genome. However complete, such catalogs of genes, RNAs, and proteins only tell us about the building blocks of life. They do not tell us much about the wiring (interaction) of building blocks, which is essential for uncovering systemic functional behaviors of the cell or the organism. Thus, an alternative view of post-genomics is to go up from the molecular level to the cellular level, and to understand, what I call, the "interactome"or a complete picture of molecular interactions in the cell. KEGG (http://www.genome.ad.jp/kegg/) is our attempt to computerize current knowledge on various cellular processes as a collection of "generalized"protein-protein interaction networks, to develop new graph-based algorithms for predicting such networks from the genome information, and to actually reconstruct the interactomes for all the completely sequenced genomes and some partial genomes. During the reconstruction process, it becomes readily apparent that certain pathways and molecular complexes are present or absent in each organism, indicating modular structures of the interactome. In addition, the reconstruction uncovers missing components in an otherwise complete pathway or complex, which may result from misannotation of the genome or misrepresentation of the KEGG pathway. When combined with additional experimental data on protein-protein interactions, such as by yeast two-hybrid systems, the reconstruction possibly uncovers unknown partners for a particular pathway or complex. Thus, the reconstruction is tightly coupled with the annotation of individual genes, which is maintained in the GENES database in KEGG. We are also trying to expand our literature surrey to include in the GENES database most up-to-date information about gene functions.

• The Korean Journal of Community Living Science
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• v.21 no.3
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• pp.365-377
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• 2010

This study examined the changes in sleeping and studying patterns of young students and their mothers after moving to foreign countries. This study analyzed the relational characteristics of Geese Family members which are summarized as follows: 1) Sleeping Pattern: At the early stages of settling into foreign countries, students begin to sleep in the same bedroom with their mothers, who had used to sleep in separate bedrooms back in Korea. This change in pattern may slightly vary according to the age and gender of the students, and type of residence. Relationships between young students and mothers become more tightly coupled. However, relationships between students and fathers become less tightened. 2) Studying Pattern: Students tend to study in the public space such as the living room and dining areas, rather than in their own private rooms. This is because mothers want to support and focus upon their children's study by sacrificing normal family activities. These patterns appear stronger as their period of study in the foreign country becomes shorter and the ages of the students become younger. These studying patterns also contribute to the coupling between mothers and young students. 3) Family Relationships: From the period as Geese Families, the relation between mothers and young students become closer both physically and emotionally. The relation between fathers and children become less close. The role of fathers is degraded to that of supporter or negotiator for the time period of the mothers and child students in the foreign country.

• Journal of Korean Physical Therapy Science
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• v.11 no.1
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• pp.20-27
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• 2004

It is widely accepted that smooth muscle contraction is triggered by intracellular $Ca^{2+}$ ($[Ca^{2+}]_i$) released from intracellular $Ca^{2+}$ stores such as sarcoplasmic reticulum (SR) and from the extracellular space, The increased $[Ca^{2+}]_i$ can phosphorylate the 20-kDa myosin light chain ($MLC_{20}$) by activating MLC kinase (MLCK), and this initiates smooth muscle contraction. In addition to the $[Ca^{2+}]_i$-MLCK-tension pathway, a number of intracellular signal molecules, including mitogen-activated protein kinase (MAPK), protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K), and Rho-associated coiled coil-forming protein kinase (ROCK), play important roles in the regulation of smooth muscle contraction. However, the mechanisms regulating contraction of caldesmon (CaD), actin-binding protein, are not entirely elucidated in the presence of $Ca^{2+}$. It is known that CaD tightly interacts with actin and inhibits actomyosin ATPase activity. Therefore, the purpose of the present study was to investigate the roles of $Ca^{2+}$-dependent CaD in smooth muscle contraction. Endothelin-1 (ET-1), G-protein coupled receptor agonist and vasoconstrictor, increased both vascular smooth contraction and phosphorylation of CaD in the presence of $Ca^{2+}$. These results suggest that ET-1 induces contraction and phosphorylation of CaD in rat aortic smooth muscle, which may he mediated by the increase of $[Ca^{2+}]_i$.

• Journal of Korean Society of Transportation
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• v.26 no.6
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• pp.93-101
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• 2008

With a spread of mobile devices, the growing trend of integrating wireless communications technologies into transportation systems is advanced. In particular, vehicular ad hoc networks (VANETs) enable vehicles to share traffic information that they have through intervehicle communications. This research focused on the design of an integrated transportation and communication simulation framework to build an environment that is more realistic than previous studies developed for studying VANETs. Developing a VANET-based information model, this research designed an integrated transportation and communication simulation framework in which these independent simulation tools not supporting High Level Architecture (HLA) were tightly coupled and finely synchronized. As a case study, a VANET-based traffic information system was demonstrated based on a real road network and real traffic data. The experiment results showed that the simulation framework was well integrated. The simulation framework designed in this study is expected to contribute to developing the environment to experiment a wide range of VANET applications.

• The Journal of the Korea Contents Association
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• v.7 no.3
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• pp.17-24
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• 2007

SIP-based tightly coupled conference, which has a centrally located conference server for controlling and management, can be classified several models according to location of focus and mixer. These are centralized server model, endpoint server model, media server component model and distributed mixing model. However each model has its strength and weakness. In this paper, we propose and implement a SIP-based effective hybrid-type conference model which decreases amount of SIP signaling messages, lowers load of server media mixer, and can be easily expandable to large scale conference. In this model, when the number of participants exceeds a pre-defined limit, the conference server selects some participants which posses specific functions and let them share functions of notifications of conference state event package and media mixing. When each participant subscribes conference state event package to the server, it can indicates its possession of such functions by a specific header message. The server stores the indication to the conference information database, and later uses it to select participants for load sharing. The performance of our proposed model is evaluated by experiments.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.37 no.8
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• pp.24-32
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• 2000

In this paper, we have designed and fabricated a new type power divider to be efficient to a size and electrical performance by folding each quarter-wavelength 70.7 Ω section into a tightly-coupled "meander-line" and inserting a slit. In this type, because of coupling, the electrical phase of quarter -wavelength line and the performance change. For this reason, with the inductive slit and the tuning of quarter-wavelength line length, we have compensated for those. The inductance value of the inserted slit is decided by its width and depth, therefore, we could improve the electrical performance through optimization of inductance. Input and output return losses of the designed power divider were -34.2 dB, -34.3 dB respectively, and isolation was -36.7 dB at 1.75 GHz. Besides, a new design approach reduced occupied substrate area by 3:1 approximately.

• Journal of the Korea Society for Simulation
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• v.27 no.3
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• pp.1-11
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• 2018

Discrete event system specification (DEVS) has been used in many simulations including hybrid systems featuring both discrete and continuous behavior that require a lot of time to get results. Therefore, in this study, we proposed the acceleration of a DEVS-based hybrid system simulation using multi-cores and GPUs tightly coupled computing. We analyzed the proposed heterogeneous computing of the simulation in terms of the configuration of the target device, changing simulation parameters, and power consumption for efficient simulation. The result revealed that the proposed architecture offers an advantage for high-performance simulation in terms of execution time, although more power consumption is required. With these results, we discovered that our approach is applicable in hybrid system simulation, and we demonstrated the possibility of optimized hardware distribution in terms of power consumption versus execution time via experiments in the proposed architecture.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.33 no.3
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• pp.18-25
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• 2005

Existing methods have performed the reliability analysis using nonlinear optimization techniques. This is mainly due to the fact that they directly apply Multidisciplinary Design Optimization(MDO) frameworks to the reliability analysis formulation. Accordingly, the reliability analysis and the Multidisciplinary Analysis(MDA) are tightly coupled in a single optimizer, which hampers utilizing the recursive and function-approximation based reliability analysis methods such as the Advanced First Order Reliability Method(AFORM). In order to utilize the efficient reliability analysis method under multidisciplinary analysis systems, we propose a new strategy named Sequential Approach on Reliability Analysis under Multidisciplinary analysis systems(SARAM). In this approach, the reliability analysis and the MDA are decomposed and arranged in a sequential manner, making a recursive loop. The efficiency of the SARAM method was verified using three illustrative examples taken from the literatures. Compared with existing methods, it showed the least number of subsystem analyses over other methods while maintaining accuracy.

• International conference on construction engineering and project management
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• 2022.06a
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• pp.344-352
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• 2022

Accurate indoor localization of construction workers and mobile assets is essential in safety management. Existing positioning methods based on GPS, wireless, vision, or sensor based RTLS are erroneous or expensive in large-scale indoor environments. Tightly coupled sensor fusion mitigates these limitations. This research paper proposes a state-of-the-art positioning methodology, addressing the existing limitations, by integrating Stereo Visual Inertial Odometry (SVIO) with fiducial landmarks called AprilTags. SVIO determines the relative position of the moving assets or workers from the initial starting point. This relative position is transformed to an absolute position when AprilTag placed at various entry points is decoded. The proposed solution is tested on the NVIDIA ISAAC SIM virtual environment, where the trajectory of the indoor moving forklift is estimated. The results show accurate localization of the moving asset within any indoor or underground environment. The system can be utilized in various use cases to increase productivity and improve safety at construction sites, contributing towards 1) indoor monitoring of man machinery coactivity for collision avoidance and 2) precise real-time knowledge of who is doing what and where.