• 핵의학기술
• /
• 제14권1호
• /
• pp.28-34
• /
• 2010

갑상선암 환자가 증가함에 따라 고용량 방사성옥소 치료환자 또한 적체되고 있는 추세이다. 따라서 현재 시설의 수용 능력을 고려하여 치료할 수 있는 병실의 최대치를 산출해 보고자 한다. 본원에 입원하는 고용량 방사성옥소 치료 환자의 방출 오 폐수량과 오 폐수의 방사능을 측정하고 고용량 방사성옥소 치료 병실에서 대기 중으로 방출하는 공기 중의 방사능 농도를 측정한다. 측정된 오 폐수의 방사능과 방출하는 공기 중의 농도가 교육과학기술부에서 고시하는 기준인 배수 중의 배출 관리 기준 30 Bq/L 및 배기 중의 배출관리기준 3 $Bq/m^3$을 만족할 때 치료 가능한 병실의 최대치를 계산한다. 가장 보수적인 수치로 계산하여 환자 1명을 치료할 경우 배출되는 오 폐수의 평균 방사능의 농도는 8 MBq/L였으며, 정화조에서 117일의 감쇠 시간을 거친 후의 평균 방사능의 농도는 29.5 Bq/L였다. 환자 2명을 치료할 경우 배출되는 오 폐수의 평균 방사능의 농도는 16 MBq/L였으며, 정화조에서 70일의 감쇠 시간을 거친 후의 평균 방사능의 농도는 29.7 Bq/L였다. 또한 같은 조건일 경우 치료 병실에서 RI 배기 filter를 통과하여 방출된 공기 중의 방사능 농도는 0.38 $Bq/m^3$였다. 수용 능력을 고려하여 치료할 수 있는 고용량 방사성옥소 치료 병실의 최대치를 산출하여 현재의 시설에 적용하고 병실 내 구조개선 등으로 2인실로 운영한다면 적체되어 있는 환자의 치료 대기 기간을 단축할 수 있으리라 사료된다.

• 대한두경부종양학회지
• /
• 제5권1호
• /
• pp.5-13
• /
• 1989

Carotid body paraganglioma is uncommon, with appoximately 900 reports of it in the world literature, and with only 7 documented cases in the Korean literature. The classic carotid body paraganglioma develops in the bifurcation of common carotid artery and involves both the internal and external carotid arteries at it expands. The diagnosis may almost always be established preoperatively by selective angiography which shows a widening of the carotid bifurcation with a well defined vascular mass. Differential consideration of a single, lateral cervical mass in this location include branchial cleft cyst, neurogenic tumor, metastatic thyroid cancer, carotid body aneurysm and salivary gland tumor. Surgical therapy is the preferred method of treatment as these tumors are regarded as radioresistant. Because of their high vascularity and anatomical location, surgical removal of these tumors reguires a considerable degree of caution and a high degree of surgical expertise. With improved diagnostic and surgical technique, the morbidity and mortality has been reduced lately. This report details the management of 3 patients with carotid body paraganglioma who underwent safe resection by subadventitial dissection or using an internal vascular shunt.

• 대한한방내과학회지
• /
• 제38권4호
• /
• pp.501-508
• /
• 2017

Objective: This study evaluated the effects of traditional Korean medicine on a patient with hyperthyroidism, who could not use antithyroid medication due to an adverse reaction to methimazole. Methods: Herbal medicine was administered and acupuncture was carried out. A thyroid function test was used to evaluate the effects of the treatment. Results: After treatment with traditional Korean medicine and therapy, the patient showed significant improvements in symptoms and FT4 levels. Conclusion: This case proved that traditional Korean medicine can be used for patients who have adverse reactions to antithyroid medication; however, studies of larger populations are required in the future.

• 대한핵의학회지
• /
• 제25권1호
• /
• pp.122-128
• /
• 1991

Multiple endocrine neoplasia type 2 (MEN type 2, Sipple's syndrome) is a rare disorder characterized by the association of medullary carcinoma of the thyroid, parathyroid hyperplasia and can be diagonsed in early stage of the disease by meticulous screening tests of the family. This case report describes the location and categorization of tumors using $^{99m}Tc-pertechnetate,\;^{131}I-NaI,\;^{99m}Tc-pentavalent(V)$, DMSA $^{131}I-MIBG$ scans in two cases of MEN type 2 occurred in a 32-year old women and her 29-year old brother. In MEN type 2, we think, combined use of $^{99m}Tc-(V)-DMSA,\;^{99m}Tc-pertechnetate\;and\;^{131}I-MIBG$ may be useful for the categorization of tumor mass lesions and planning appropriate therapy.

• 대한두경부종양학회지
• /
• 제27권1호
• /
• pp.80-83
• /
• 2011

Paraganglioma is a relatively rare, generally benign and slow growing tumor arising from widely distributed paraganglionic tissue thought to originate from the neural crest. In the head and neck region, paraganglionic tissue is distributed in the superior and inferior paraganglia such as the carotid body, the vagal body, and the jugulotympanic region. Approximately 10% of patients with paraganglioma have a family history of such tumors. Multiple lesions can be found in 26% of patients with family history. It is important to distinguish between paraganglioma and atypical carcinoid tumor and medullary thyroid cancer. This can be done with histopathologic evaluation and immunohistochemical markers. Complete excision is recommended for the treatment of this tumor. Paraganglioma is particularly aggressive and rapid recurrence of paraganglioma is common after local resection. We present a case of malignant paraganglioma in the neck which recurred 2 months after local resection. We suppose that radiation therpay could be the last option for the treatment in this clinical setting.

• 대한암한의학회지
• /
• 제26권1호
• /
• pp.49-59
• /
• 2021

Objective: Insomnia is a very common symptom of cancer and has a substantial effect on the patients' quality of life. This study aimed to identify the effects of foot reflexology on insomnia in cancer patients. Methods: The study employed a before-after test design on a single group of 13 cancer patients with insomnia, selected by convenience sampling in Daegu. The foot reflexology treatment comprised 30-min sessions twice a week over four weeks. Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) were measured at the baseline, at 2 and 4 weeks, and after 4 weeks post treatment completion. Brief Fatigue Inventory-Korean (BFI-K), Functional Assessment of Cancer Therapy-General (FACT-G), and Heart Rate Variability (HRV) were measured at baseline, post-treatment, and 4 weeks after completing treatments. Results: Thirteen patients (mean age 44.77 ± 6.70 years), with thyroid, breast or cervical cancer, were included in the study. Post-treatment, PSQI (from 12.33 ± 3.17 to 8.54 ± 3.43, p<0.001), ISI (from 20.33 ± 3.88 to 13.38 ± 4.23, p<0.001), FACT-G (from 49.6 ± 13.27 to 61.35 ± 14.45, p<0.001), and BFI (from 6.46 ± 0.91 to 5.00 ± 2.02, p<0.001) scores improved significantly over those at the baseline. Conclusion: Foot reflexology can be a good alternative treatment to improve insomnia, fatigue, and quality of life in cancer patients

• 한국임상수의학회지
• /
• 제38권4호
• /
• pp.189-193
• /
• 2021

An 11-years old spayed female Persian chinchilla cat presented with acute onset of blindness from bilateral retinal detachment and systemic hypertension. On physical examination, the cat was tachycardic (240 beats/min) with a systolic blood pressure of around 250 mmHg. Clinical findings, blood works, urinalysis, thyroid function test, radiography, echocardiogram, and ultrasonography were performed to rule out underlying diseases. Organ injury induced by systemic hypertension including bilateral retinal detachment and left ventricular hypertrophy were confirmed by ultrasound. Based on these results, it was diagnosed as feline idiopathic hypertension with target organ damage (TOD). The cat was treated with a combination therapy using high doses of amlodipine, telmisartan, and atenolol. After the treatment, its hypertension and TOD were improved. This case showed that appropriate therapeutic management can help prevent TOD associated with feline hypertension.

• BMB Reports
• /
• 제56권9호
• /
• pp.508-513
• /
• 2023

The phytochemical quercetin has gained attention for its anti-inflammatory and anti-tumorigenic properties in various types of cancer. Tumorigenesis involves the aberrant regulation of kinase/phosphatase, highlighting the importance of maintaining homeostasis. Dual Specificity Phosphatase (DUSP) plays a crucial role in controlling the phosphorylation of ERK. The current study aimed to clone the DUSP5 promoter, and investigate its transcriptional activity in the presence of quercetin. The results revealed that quercetin-induced DUSP5 expression is associated with the serum response factor (SRF) binding site located in the DUSP5 promoter. The deletion of this site abolished the luciferase activity induced by quercetin, indicating its vital role in quercetin-induced DUSP5 expression. SRF protein is a transcription factor that potentially contributes to quercetin-induced DUSP5 expression at the transcriptional level. Additionally, quercetin enhanced SRF binding activity without changing its expression. These findings provide evidence of how quercetin affects anti-cancer activity in colorectal tumorigenesis by inducing SRF transcription factor activity, thereby increasing DUSP5 expression at the transcriptional level. This study highlights the importance of investigating the molecular mechanisms underlying the anti-cancer properties of quercetin, and suggests its potential use in cancer therapy.

• IMMUNE NETWORK
• /
• 제20권1호
• /
• pp.9.1-9.21
• /
• 2020

Immune checkpoint inhibitors (ICIs) have been changing the paradigm of cancer treatment. However, immune-related adverse effects (irAEs) have also increased with the exponential increase in the use of ICIs. ICIs can break up the immunologic homeostasis and reduce T-cell tolerance. Therefore, inhibition of immune checkpoint can lead to the activation of autoreactive T-cells, resulting in various irAEs similar to autoimmune diseases. Gastrointestinal toxicity, endocrine toxicity, and dermatologic toxicity are common side effects. Neurotoxicity, cardiotoxicity, and pulmonary toxicity are relatively rare but can be fatal. ICI-related gastrointestinal toxicity, dermatologic toxicity, and hypophysitis are more common with anti- CTLA-4 agents. ICI-related pulmonary toxicity, thyroid dysfunction, and myasthenia gravis are more common with PD-1/PD-L1 inhibitors. Treatment with systemic steroids is the principal strategy against irAEs. The use of immune-modulatory agents should be considered in case of no response to the steroid therapy. Treatment under the supervision of multidisciplinary specialists is also essential, because the symptoms and treatments of irAEs could involve many organs. Thus, this review focuses on the mechanism, clinical presentation, incidence, and treatment of various irAEs.

• 대한핵의학회지
• /
• 제29권3호
• /
• pp.343-349
• /
• 1995

배경 : 방사선 외부 피폭에 대한 생물학적 선량측정방법에는 혈액학적 지표인 림프구 변화와 세포유전학적 지표인 염색체 분석을 통한 Ydr값이 가장 많이 사용되고 있다. 방사성 옥소 투여시와 같은 방사선 내부 피폭에 대해서는 생물학적 선량측정 방법에 대한 연구가 미흡하여 피폭정도는 물론 방사성 옥소 투여용량을 반영할 수 있는지의 여부도 알려져 있지 못하다. 목적 : 갑상선 질환자에게 방사성 옥소 투여후 림프구 변화와 Ydr값을 추적관찰하여 이들을 방사선 내부 피폭에 대한 지표로 이용할 수 있는지 알아보고자 하였다. 방법 : 갑상선 기능항진증 5명과 갑상선암 수술을 받은 35명의 환자를 대상으로 방사성 옥소 투여후 말초혈액 림프구 수를 2개원이상 추적검사 하였고, 림프구의 염색체 분석을 통해 Ydr값을 구했다. 결과: 1) 림프구 수는 방사성 옥소 투여 2주후 부터 감소되기 시작하여 6주와 8주후에 최대로 감소된후 점차 회복되었다. 2) 방사성 옥소량이 증가할 수록 림프구 수는 감소했다 (P<0.01) 3) Ydr값은 2주-8주 사이에는 대체로 일정하였다. 4) 방사성옥소 투여량에 따른 최대 Ydr값의 변화는 유의한 상관관계를 보였다 (p<0.00) 5) 2주째 Ydr값은 방사성옥소 투여량이 증가할 수록 증가하였다 (p<0.00) 6) 2주째 Ydr값은 2주째 림프구 수의 감소정도와 비례관계를 보였다 (p<0.00) 결론: 1) 방사성 옥소의 통상적 치료용량은 일시적 골수부전과 경도의 염색체이상을 초래하므로 8주 이상의 면밀한 추적관찰이 요구된다. 2) 생물학적 선량측정 방법으로서의 최대 림프구 감소치와 2주째 Ydr값과 최대 Ydr값은 방사성옥소 투여용량을 반영하는 지표로 사용할 수 있다.