• Title/Summary/Keyword: threshold effect

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Effects of Palonosetron, a 5-HT3 Receptor Antagonist, on Mechanical Allodynia in a Rat Model of Postoperative Pain

  • Jung, Ki Tae;Yoon, Myung Ha;Lee, Hyun Young;Yu, Bo Yeon;Kim, Dong Kyu;Lim, Kyung Joon
    • The Korean Journal of Pain
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    • v.26 no.2
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    • pp.125-129
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    • 2013
  • Background: 5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly. Methods: An intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 ${\mu}g$ intrathecally; 0.5 ${\mu}g$ intraplantarly) was administered and the thresholds were observed for 4 hours. Results: Mechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 ${\mu}g$ and 0.1 ${\mu}g$) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 ${\mu}g$) also did not change the paw withdrawal threshold. Conclusions: Intrathecal and intraplantar palonosetron (0.5 ${\mu}g$) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.

Changes in the Cervical and Lumber Flexion-Relaxation Ratio, Range of Motion, Pressure Pain Threshold, and Perceived Comfort Following the Wearing of a Trunk Brace during Smartphone Watching (스마트폰 시청 시 몸통 교정기 착용에 따른 목, 허리 굽힘-이완 비율, 관절가동범위, 압통, 착용감 변화)

  • Park, Jin-Seong;Park, Du-Jin
    • PNF and Movement
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    • v.19 no.3
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    • pp.413-422
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    • 2021
  • Purpose: This study was conducted to investigate changes in the cervical and lumbar flexion-relaxation ratio, range of motion, pressure pain threshold, and perceived comfort following the wearing of a trunk brace during smartphone watching. Methods: To calculate the number of subjects for this study, an analysis with G*Power was performed at a statistical power of 0.8, an effect size of 0.5, and a significance level of 0.05, based on the results of a preliminary experiment on five subjects. In total, 27 adult men and women were recruited who had been informed of the study's purpose and process and had agreed to participate. All subjects watched content on a smartphone for 20 minutes in the same posture and conditions while wearing and not wearing a trunk brace, and then their cervical and lumbar flexion-relaxation ratio, range of motion, pressure pain threshold, and perceived comfort were measured. Results: Compared to the non-wearing of a trunk brace, the wearing of a trunk brace resulted in a statistically significant smaller decline in cervical extension and right-side cervical rotation (p<0.05). When the subjects wore a trunk brace, their right- and left-side cervical and right-side lumbar pressure pain statistically significantly improved when compared to not wearing a trunk brace (p<0.05). They also perceived a significantly lowered level of comfort 20 minutes after wearing a trunk brace compared to immediately after wearing it (p<0.05). Conclusion: The trunk brace was effective in reducing declines in right-side cervical rotation and the occurrence of left- and right-side cervical and right-side lumbar pressure pain. The findings indicate the need to improve the perceived comfort of trunk braces.

Health Risk Estimation for Daily Maximum Temperature in the Summer Season using Healthcare Big Data (보건의료빅데이터를 이용한 여름철 일최고기온에 대한 건강위험도 평가)

  • Hwang, Mi-Kyoung;Kim, Yoo-Keun;Oh, Inbo
    • Journal of Environmental Science International
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    • v.28 no.7
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    • pp.617-627
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    • 2019
  • This study investigated the relationship between heat-related illnesses obtained from healthcare big data and daily maximum temperature observed in seven metropolitan cities in summer during 2013~2015. We found a statistically significant positive correlation (r = 0.4~0.6) between daily maximum temperature and number of the heat-related patients from Pearson's correlation analyses. A time lag effect was not observed. Relative Risk (RR) analysis using the Generalized Additive Model (GAM) showed that the RR of heat-related illness increased with increasing threshold temperature (maximum RR = 1.21). A comparison of the RRs of the seven cities, showed that the values were significantly different by geographical location of the city and had different variations for different threshold temperatures. The RRs for elderly people were clearly higher than those for the all-age group. Especially, a maximum value of 1.83 was calculated at the threshold temperature of $35^{\circ}C$ in Seoul. In addition, relatively higher RRs were found for inland cities (Seoul, Gwangju, Daegu, and Daejeon), which had a high frequency of heat waves. These results demonstrate the significant risk of heat-related illness associated with increasing daily maximum temperature and the difference in adaptation ability to heat wave for each city, which could help improve the heat wave advisory and warning system.

The effect of resistance inspiratory muscle training on respiratory function in stroke (저항성 들숨근 훈련이 뇌졸중 환자의 호흡기능에 미치는 영향)

  • Lee, So Yun;Han, Jin Tae
    • Journal of Korean Physical Therapy Science
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    • v.27 no.3
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    • pp.1-11
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    • 2020
  • Background: The purpose of this study was to investigated the effects of threshold resistance inspiratory muscle training on respiratory function in chronic stroke patients. Design: Randomized Controlled Trial Methods: Eighteen patient with stroke were randomly assigned to the experimental group (n=9) and control group (n=9) all testing and training. The experimental group underwent threshold resistance inspiratory muscle training with resistance adjusted of maximal inspiratory pressure, 60 breathing a day and general physical therapy 30 minutes a day, 5 times a week for 4 weeks. The control group was taken general respiratory muscle training and general physical therapy for 4 weeks in the same way. Respiratory function, walking ability were evaluated before and after the intervention. Statistical significance of the results were evaluated by ANCOVA between control group and experimental group after intervention. Results: There was a significant increase in FVC and FEV1 in the experimental group in pulmonary function tests (p<0.05). There was a significant difference with the maximum inspiratory pressure and the maximum inspiratory flow rate between experimental and control group (p<0.05). There was no significant difference with the maximum inspiratory capacity between experimental and control group (p>0.05) but the maximum inspiratory capacity of experimental group some increased than that of control group. Conclusion: These finding gave some indications that the threshold resistance inspiratory training may benefit on pulmonary function in people with stroke, and it is feasible to be included in rehabilitation interventions with this population.

Compairison of Effect of Manual Myofascial Release and Self Myofascial Release Technique Using a Foam Roller on Pain Thresholds and Body Schema in Subjects with Chronic Tension-type Headache (도수근막이완기법과 폼롤러를 이용한 자가근막이완기법이 만성 긴장성 두통 환자의 통증문턱값 및 신체 도식에 미치는 효과 비교)

  • Ju-Ri Eom;Kang-Hoon Kim
    • Journal of The Korean Society of Integrative Medicine
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    • v.11 no.4
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    • pp.147-155
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    • 2023
  • Purpose: Headache is a very common disease experienced at least once in daily life, and tension-type headaches have a high and increasing prevalence. Chronic headaches can cause functional damage and huge socioeconomic impacts. This study aimed to compare the effects of myofascial release technique with manual therapy and self-myofascial release technique using a foam roller on the pain threshold and body schema in patients with chronic tension-type headaches. Methods: The study was conducted on 20 patients living in Busan with chronic tension headaches. Myofascial release technique with manual therapy was performed on the suboccipital, sternocleidomastoid, scalene, and upper trapezius muscles. The self -myofascial release technique using a foam roller was applied to the cervical and thoracic muscles. A laterality test was performed using a recognized neck application developed to evaluate body schema ability. A pressure-pain threshold test was performed using an electronic pressure algometer to compare the results before and after the myofascial release technique. Results: After applying myofascial release with manual therapy and a foam roller, the pressure-pain threshold values showed significant changes in both groups (p<.05). As a result of the laterality test, myofascial release with manual therapy and a foam roller were applied to the painful area. The values showed significant changes in both groups (p<.05), but only the group using the foam roller showed a significant difference (p<.05) in painless areas. Conclusion: The myofascial release technique with manual therapy can be the primary treatment technique for pain control in painful areas. The self-muscle release technique using a foam roller can be an effective method when there is no pain or when maintenance is needed after pain control.

Effects of Elastic Band-Resistive Exercise using Audio-visual Medium on Pain, Proprioceptive Sense, and Motor Function in Adult Females with Chronic Neck and Shoulder Pain (만성 목-어깨 통증이 있는 여성 성인에게 시청각 매체를 활용한 탄력밴드 저항운동이 통증, 고유수용성 감각과 운동기능에 미치는 영향)

  • Nam Gi Lee;Jeong-Woo Lee
    • Journal of Korean Physical Therapy Science
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    • v.31 no.1
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    • pp.33-45
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    • 2024
  • Background: This study aimed to investigate the effect of elastic band-resistive exercise using audio-visual medium on pain, proprioception, and motor function in adults with chronic neck and shoulder pain. Design: One group pretest-posttest follow-up experimental design. Method: Twenty adult women with neck and shoulder pain voluntarily participated in this study. Elastic band-resistive exercise using audio-visual medium including cervical flexion and extension, shoulder external rotation, and scapular retraction-protraction motions was conducted 5 times a week for 3 weeks. The Numerical Rating Scale, pressure threshold tool, CROM goniometer, and Image J software were used to assess subjective pain level, tenderness threshold (pain), joint position sense error (proprioception), joint range of motion, and postural alignment (motor function), respectively. Result:: The pain intensity and threshold and joint position sense error showed significant decreases after the intervention, whereas the joint range of motion angle revealed significant increases. The postural alignment including forward head posture and rounded shoulder revealed significant improvements after the intervention. Conclusions: Therefore, we suggest that elastic band-resistive exercise through audio-visual medium would be helpful in preventing and managing pain and physical dysfunction in individuals with chronic neck and shoulder pain, and then it would support the development of health management-related online education content.

The Influence of Silicon Doping on Electrical Characteristics of Solution Processed Silicon Zinc Tin Oxide Thin Film Transistor

  • Lee, Sang Yeol;Choi, Jun Young
    • Transactions on Electrical and Electronic Materials
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    • v.16 no.2
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    • pp.103-105
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    • 2015
  • Effect of silicon doping into ZnSnO systems was investigated using solution process. Addition of silicon was used to suppress oxygen vacancy generation. The transfer characteristics of the device showed threshold voltage shift toward the positive direction with increasing Si content due to the high binding energy of silicon atoms with oxygen. As a result, the carrier concentration was decreased with increasing Si content.

Impact of Gamma Irradiation Effects on IGBT and Design Parameter Considerations

  • Lho, Young-Hwan
    • ETRI Journal
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    • v.31 no.5
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    • pp.604-606
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    • 2009
  • The primary dose effects on an insulated gate bipolar transistor (IGBT) irradiated with a $^{60}Co$ gamma-ray source are found in both of the components of the threshold shifting due to oxide charge trapping in the MOS and the reduction of current gain in the bipolar transistor. In this letter, the IGBT macro-model incorporating irradiation is implemented, and the electrical characteristics are analyzed by SPICE simulation and experiments. In addition, the collector current characteristics as a function of gate emitter voltage, VGE, are compared with the model considering the radiation damage of different doses under positive biases.

A moving image compression algorithm using subband coding (부대역 부호화를 이용한 동영상 압축 알고리즘)

  • 장세봉;최재윤;김태효
    • Proceedings of the IEEK Conference
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    • 1998.06a
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    • pp.655-658
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    • 1998
  • This paper proposes a moving image compression algorithm using subband coding that divides and processes the differential image of each moving image frame into subband frequency. This method decomposes the original image with each subband and performs DCT. The moving blocks are detected from each of wubband using threshold value which is select from the variance of difference between frames. then they are performed SBDCT and huffman coding in order to reduce the data. As the result of simulation, we confirmed that this method improved the blocking effect of reconstructed image in low bit rate.

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