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The Effects of Leukocyte Depleted Priming Solution on the Gastric Mucosal $Co_{2}$ Partial Pressure and Serum IL-8 Level during Cardiopulmonary Bypass in Korean Mongrel Dogs (한국산 잡견에서 백혈구 제거 충진액이 체외순환 중 위점막 이산화탄소 농도와 IL-8 수준에 미치는 영향)

  • Park Kuhn;Lee Jong Ho;Kim Jin Ho;Jin Ung;Kwon Jong Bum;Kim Chi Kyeong;Wang Young Pil
    • Journal of Chest Surgery
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    • v.38 no.12 s.257
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    • pp.807-814
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    • 2005
  • Background: Cardiopulmonary bypass is an essential process to maintain circulation for saving life during the cardiac surgery, But it is a process in which systemic inflammation was evoked inevitably because of the exposure of blood to foreign surface. The injuries to distal organs during the cardiopulmonary bypass were resulted from systemic inflammation and the disturbances of micro-circulations in the organs. We designed this study to research the effects of leukocyte depletion from pump-oxygenator priming solution on the systemic inflammation, and the micro-circulation of gastric mucosa that is suggested by the gastric mucosal $CO_{2}$ partial pressure and acidity. Material and Method: The dogs were divided into three groups according to the different pump-oxygenator priming solutions; non-hemic crystalloid solution; leukocyte-depleted homologous blood; and non leukocyte-depleted homo-logous blood. Each priming solution group contained five dogs. In all three groups, 2 hours of cardiopulmonary bypass, and 4 consecutive hours of general anesthesia was maintained on the mechanical ventilation. Each dog was evaluated for the gastric mucosal pH, $CO_{2}$ partial Pressure, arterial pH, $CO_{2}$ partial pressure, the exhaled air $CO_{2}$ partial pressure and the level of IL-8 on before the cardiopulmonary bypass, 1 hour after the cardiopulmonary bypass, 2 hours after the cardiopulmonary bypass, 2 hours after the restoration of normal circulation, and 4 hours after the restoration of normal circulation after the cardiopulmonary bypass. The levels of IL-8 were measured with ELISA (enzyme linked immunosorbent assay) technique. Result: 1. There were significant differences of gastric mucosal $CO_{2}$ partial pressure between the leukocyte-depleted homologous blood group and other two groups(vs non leukocyte-depleted homologous blood group; P=0.02, vs non-hemic crystalloid solution group; P=0,01). 2. The gastric mucosal pH of leukocyte-depleted homologous blood group was significantly different from non leukocyte-depleted homologous blood group (p=0.01). 3. The levels of IL-8, which examine the systemic inflammation, showed signi- ficantly better results in leukocyte-depleted homologous blood group and non-hemic crystalloid solution group than non leukocyte-depleted homologous blood group (p=0.01, 0.01). Conclusion: Based upon these results, we concluded that the leukocyte depletion from the pump-oxygenator priming solution has a beneficial effects in reducing systemic inflammation and the preserving of gastric mucosal micro-circulation.

Experimental Preservation of Isolated Rabbit Lung for Transplantation (이식을 위한 가토 적출 폐의 실험적 보존 방법)

  • 김수현;김송명
    • Journal of Chest Surgery
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    • v.29 no.9
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    • pp.931-939
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    • 1996
  • An experimental comparative study was done to determine the protective effects of three preservation solutions on isolated rabbit heart-lung bloc during acute ischemia and reperfusion of the lung during lung transplantation. Thirty Isolated rabbit heart-lung blocs were divided into 3 groups , group I(n:9) was preserved with Hartmann's solution, group II(n: 10) with modified University of Wisconsin solution, and group III(n: 1 1) with Kosin solution. The isolated heart-lung blocs were washed with Hartmann's so ution. Aftar infusion of each preservation solution into pulmonary artery, the heart-lung bloc was stored at 4'c cold preservation solution for each group for 4 hours and .then the heart-lung blocs were reventilated and reperfused. The changes of weight of heart-lung blocs, airway pressure, percent change of PCO2, level of lactate and adenosine deaminase(ADA) and microscopic structure of the lung parenchyme were evaluated. Results were as follows 1. A change of weight of the heart lung bloc after reperfusion was lowest in group 111(p< .05) 2. The airway pressure increased after reperfusion in group I but decreased in group II, and II. Especially in group II, post-reperfusion airway pressure returned to level lower than that of en-bloc resection. 3. Pulmonary artery pressure during reperfusion after 4 hour preservation was lowest in group III, and pulmonary artery pressure in group II was higher than in group I(P> 0.1). 4. The level of lactate and ADA in the lung tissue were higher in group III than in group I and II(P< .05) 5. The percent change of PCO2 in perfusate was slightly higher in group III than group I and II. 6. Microscopic changes in lung tissue after reperfusion were diffuse pulmonary edema, expansion of inter- stitial tissue, focal aggregation of erythrocytes, and basement membrane abnormalities, but no differences were found among the three groups. In conclusion, the protective effects of modified University of Wisconsin solution and Kosin solution were slightly superior to Hartmann's solution.

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Analysis on the source characteristics of three earthquakes nearby the Gyeongju area of the South Korea in 1999 (1999년 경주 인근에서 3차례 발생한 지진들의 지진원 특성 분석)

  • Choi, Ho-Seon;Shim, Taek-Mo
    • The Journal of Engineering Geology
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    • v.19 no.4
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    • pp.509-515
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    • 2009
  • Three earthquakes with local magnitude ($M_L$) greater than 3.0 occurred on April 24, June 2 and September 12 in 1999 nearby the Gyeongju area. Redetermined epicenters were located within the radius of 1 km. We carried out waveform inversion analysis to estimate focal mechanism of June 2 event, and P and S wave polarity and their amplitude ratio analysis to estimate focal mechanisms of April 24 and September 12 events. June 2 and September 12 events had similar fault plane solutions each other. The fault plane solution of April 24 event included those of other 2 events, but its distribution range was relatively broad. Focal mechanisms of those events had a strike slip faulting with a small normal component. P-axes of those events were ENE-WSW which were similar to previous studies on the P-axis of the Korean Peninsula. Considering distances between epicenters, similarities of seismic waves and sameness of polarities of seismic data recorded at common seismic stations, these events might occurred at the same fault. The seismic moment of June 2 event was estimated to be $3.9\;{\times}\;10^{14}\;N{\cdot}m$ and this value corresponded to the moment magnitude ($M_W$) 3.7. The moment magnitude estimated by spectral analysis was 3.8, which was similar to that estimated by waveform inversion analysis. The average stress drop was estimated to be 7.5 MPa. Moment magnitudes of April 24 and September 12 events were estimated to be 3.2 and 3.4 by comparing the spectrum of those events recorded at common single seismic station.

The development and application of the descriptive evaluation questionnaire on the Clothing and Textiles section of the middle school Technology & Home Economics textbook (중학교 기술.가정 의생활영역의 서술형 평가문항 개발 및 적용)

  • Lee, Soo-Kyung;Lee, Hye-Ja
    • Journal of Korean Home Economics Education Association
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    • v.23 no.3
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    • pp.69-90
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    • 2011
  • To develop the descriptive evaluation questionnaire with high validity and reliability on the Clothing and Textiles section of the middle school Technology & Hone Economics textbook, apply it to students and analyze its results. We made out a draft for descriptive evaluation questionnaire that was based upon the concrete establishment of the goal and the range of evaluation. We also made a rubric for scoring as well as sample answer-sheets. Finally, we completed a total of twenty three descriptive evaluation questions and we applied it to sixty five 2nd-grade students in two classes in a middle school. Descriptive evaluation questionnaire exhibited the relative high validity on each question. Moreover, three graders gave the same score on each question of descriptive evaluation, suggesting that descriptive evaluation questionnaire has the high inter-grader reliability and the strong correlation. But, low academic achievement was generally observed in the subjects. They had difficulty in describing their knowledge via their own language and drawing up accurate and detailed answers. They recognized the positive aspects of descriptive evaluation questionnaire, but they felt it uncomfortable due to study-burden and description itself. To overcome these limitations, it is required that students should experience various materials related to subject contents in classes as well as textbooks, concentrate themselves on finding solutions for problems, expand their scope, and practice describe them in advance. Therefore, the additional training for description evaluation questionnaire will be necessary for the more efficient and discriminative questionnaire. Also the questionnaire with high validity and reliability should be developed and the aggressive and voluntary participation of teachers will be needed.

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Effect of Fineness of Siliceous Materials on Correction of Soil Acidity under Submerged Condition (담수시(湛水時) 규산물질(珪酸物質)들의 입도별(粒度別) 토양산도교정능력(土壤酸度矯正能力))

  • Lee, Yun Hwan;Han, Ki Hak;Kim, Bok Jin
    • Korean Journal of Soil Science and Fertilizer
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    • v.5 no.2
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    • pp.59-64
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    • 1972
  • The liming effect of the four different siliceous materials with six grades of fineness were investigated in comparison with limestone under the submerged condition for three months, and the alkalinity extracted by 0.07N-EDTA and N-NaOAc solutions were determined to evaluate the neutralizing power of these materials. 1. Fused phosphate took 20 days with finer particles than 60 mesh (Tyler), 34 days with -40+48 mesh particles and 84 days with -20+25 mesh particles to reach the pH 5.5 from pH 4.0 of initial soil pH. These adjusted soil acidities were less 1.0-0.5 unit of pH compared with the pH of particles of limestone. 2. The basic reduction furnace slag increased the pH value to 5.5 in the finer particles than 100 mesh, but the other coarse particles appeared to have slow changes of the soil acidity to pH 4.5-4.7 for the three months. Wollastonite didn't affect the increase of soil pH in coarser particles than 25 mesh whereas other finer particles increased upto pH 4.5-5.0. Blast furnace slag is definitely slower through all sizes of particles. 3. In the relationship between the adjusted soil acidities and alkalinities dissolved in EDTA and NaOAc solution, NaOAc-alkalinity agreed quite closely to the activity of neutralizing value of silicates and limestone containing fineness of particles. The correlation coefficients between the amended soil acidities and NaOAc-alkalinities were stabilized with high significance at the 8 days after water logging and 16 days with the EDTA-alkalinities.

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User Centered Interface Design of Web-based Attention Testing Tools: Inhibition of Return(IOR) and Graphic UI (웹 기반 주의력 검사의 사용자 인터페이스 설계: 회귀억제 과제와 그래픽 UI를 중심으로)

  • Kwahk, Ji-Eun;Kwak, Ho-Wan
    • Korean Journal of Cognitive Science
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    • v.19 no.4
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    • pp.331-367
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    • 2008
  • This study aims to validate a web-based neuropsychological testing tool developed by Kwak(2007) and to suggest solutions to potential problems that can deteriorate its validity. When it targets a wider range of subjects, a web-based neuropsychological testing tool is challenged by high drop-out rates, lack of motivation, lack of interactivity with the experimenter, fear of computer, etc. As a possible solution to these threats, this study aims to redesign the user interface of a web-based attention testing tool through three phases of study. In Study 1, an extensive analysis of Kwak's(2007) attention testing tool was conducted to identify potential usability problems. The Heuristic Walkthrough(HW) method was used by three usability experts to review various design features. As a result, many problems were found throughout the tool. The findings concluded that the design of instructions, user information survey forms, task screen, results screen, etc. did not conform to the needs of users and their tasks. In Study 2, 11 guidelines for the design of web-based attention testing tools were established based on the findings from Study 1. The guidelines were used to optimize the design and organization of the tool so that it fits to the user and task needs. The resulting new design alternative was then implemented as a working prototype using the JAVA programming language. In Study 3, a comparative study was conducted to demonstrate the excellence of the new design of attention testing tool(named graphic style tool) over the existing design(named text style tool). A total of 60 subjects participated in user testing sessions where their error frequency, error patterns, and subjective satisfaction were measured through performance observation and questionnaires. Through the task performance measurement, a number of user errors in various types were observed in the existing text style tool. The questionnaire results were also in support of the new graphic style tool, users rated the new graphic style tool higher than the existing text style tool in terms of overall satisfaction, screen design, terms and system information, ease of learning, and system performance.

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A Study on Policies for Conservation Measures Based on the Status and Issues of Conserved Remains (보존유적 현황과 문제 인식을 통한 보존조치 제도 연구)

  • So, Jaeyun
    • Korean Journal of Heritage: History & Science
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    • v.53 no.3
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    • pp.110-127
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    • 2020
  • The term "conserved remains" refers to cultural remains that are preserved in accordance with the valuation of buried cultural properties when important remains are recognized in rescue excavations during construction work. South Korea's rapid economic growth and ensuing land development over the past few decades compelled a sharp increase in the number of rescue excavation cases, and, naturally, of conserved remains. Today, an increasingly large number of conserved remains have raised issues, including those concerning land expropriation as well as the management and utilization of such remains, but no clear solutions have been proposed. This study attempts to propose plans for improvement based mainly on the recognition of institutional issues rather than technical issues related to the conservation of cultural remains. This is because the identification and review of institutional deficiencies must be prioritized in order to efficiently manage conserved remains with limited resources and manpower. Among many possible proposals to demand improvement of conservation policies, one that must first be examined under the current system is the rapid transition, or review thereof, of "conserved remains" to "designated cultural properties." Unlike designated cultural properties, conserved remains are merely a temporary means of conservation, because they lack regulations for follow-ups subsequent to preliminary measures. Naturally, deferring the definition of relics as "conserved remains" for extended periods causes numerous problems. Measures to resolve such problems may include establishing a legal system to manage conserved remains at a level similar to designated cultural properties or seeking ways to improve management under the current system. This study focuses on areas where institutional improvement for conserved remains is possible by methods other than through the rapid transition to designated cultural properties and presents several proposals. Currently, conservation measures are divided into three categories: on-site conservation, relocation conservation, and record conservation. This study reclassifies these categories from three into four categories. On-site conservation includes only two categories: conserved remains and the newly-proposed soil-covered remains. Two remaining categories, the relocation conservation remains and the record conservation remains, are presented as classifications in which development projects are possible, and they are presented as alternative conservation types that contrast with on-site conservation. Unlike conserved remains, soil-covered conservation presented as a new category in which development projects are possible.

Competitive Adsorption Characteristics of Rapid Cooling Slag in Single- and Multi-Metal Solutions (단일 및 복합중금속용액에서 제강급랭슬래그의 경쟁흡착특성)

  • Park, Jong-Hwan;Kim, Hong-Chul;Kim, Seong-Heon;Lee, Seong-Tae;Kang, Byung-Hwa;Kang, Se-Won;Seo, Dong-Cheol
    • Korean Journal of Environmental Agriculture
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    • v.35 no.1
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    • pp.24-31
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    • 2016
  • BACKGROUND: Heavy metal adsorption not only depends on rapid cooling slag(RCS) characteristics but also on the nature of the metals involved and on their competitive behavior for RCS adsorption sites. The goal of this study was to investigate the competitive absorption characteristics of Cu, Cd and Zn in single- and multi-metal forms by RCS.METHODS AND RESULTS: Both single- and multi-metal adsorption experiments were conducted to determine the adsorption characteristics of RCS for the heavy metals. Adsorption behaviors of the heavy metals by RCS were evaluated using both the Freundlich and Langmuir adsorption isotherm equations. The maximum adsorption capacities of metals by RCS were in the order of Cu(16.6 mg/g) > Cd(8.1 mg/g) > Zn(6.2 mg/g) in the single-metal adsorption isotherm and Cu(14.5 mg/g) >> Zn(1.3 mg/g) > Cd(0.6 mg/g) in the multi-metal adsorption isotherm. Based on data obtained from Freundlich and Langmuir adsorption models and three-dimensional simulation, multi-metal adsorption behaviors differed from single- metal adsorption due to competition. Cadmium and Zn were easily exchanged and substituted by Cu during multi-metal adsorption.CONCLUSION: Results from adsorption experiments indicate that competitive adsorption among metals increases the mobility of these metals.

Three-Dimensional High-Frequency Electromagnetic Modeling Using Vector Finite Elements (벡터 유한 요소를 이용한 고주파 3차원 전자탐사 모델링)

  • Son Jeong-Sul;Song Yoonho;Chung Seung-Hwan;Suh Jung Hee
    • Geophysics and Geophysical Exploration
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    • v.5 no.4
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    • pp.280-290
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    • 2002
  • Three-dimensional (3-D) electromagnetic (EM) modeling algorithm has been developed using finite element method (FEM) to acquire more efficient interpretation techniques of EM data. When FEM based on nodal elements is applied to EM problem, spurious solutions, so called 'vector parasite', are occurred due to the discontinuity of normal electric fields and may lead the completely erroneous results. Among the methods curing the spurious problem, this study adopts vector element of which basis function has the amplitude and direction. To reduce computational cost and required core memory, complex bi-conjugate gradient (CBCG) method is applied to solving complex symmetric matrix of FEM and point Jacobi method is used to accelerate convergence rate. To verify the developed 3-D EM modeling algorithm, its electric and magnetic field for a layered-earth model are compared with those of layered-earth solution. As we expected, the vector based FEM developed in this study does not cause ny vector parasite problem, while conventional nodal based FEM causes lots of errors due to the discontinuity of field variables. For testing the applicability to high frequencies 100 MHz is used as an operating frequency for the layer structure. Modeled fields calculated from developed code are also well matched with the layered-earth ones for a model with dielectric anomaly as well as conductive anomaly. In a vertical electric dipole source case, however, the discontinuity of field variables causes the conventional nodal based FEM to include a lot of errors due to the vector parasite. Even for the case, the vector based FEM gave almost the same results as the layered-earth solution. The magnetic fields induced by a dielectric anomaly at high frequencies show unique behaviors different from those by a conductive anomaly. Since our 3-D EM modeling code can reflect the effect from a dielectric anomaly as well as a conductive anomaly, it may be a groundwork not only to apply high frequency EM method to the field survey but also to analyze the fold data obtained by high frequency EM method.

A Template-based Interactive University Timetabling Support System (템플릿 기반의 상호대화형 전공강의시간표 작성지원시스템)

  • Chang, Yong-Sik;Jeong, Ye-Won
    • Journal of Intelligence and Information Systems
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    • v.16 no.3
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    • pp.121-145
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    • 2010
  • University timetabling depending on the educational environments of universities is an NP-hard problem that the amount of computation required to find solutions increases exponentially with the problem size. For many years, there have been lots of studies on university timetabling from the necessity of automatic timetable generation for students' convenience and effective lesson, and for the effective allocation of subjects, lecturers, and classrooms. Timetables are classified into a course timetable and an examination timetable. This study focuses on the former. In general, a course timetable for liberal arts is scheduled by the office of academic affairs and a course timetable for major subjects is scheduled by each department of a university. We found several problems from the analysis of current course timetabling in departments. First, it is time-consuming and inefficient for each department to do the routine and repetitive timetabling work manually. Second, many classes are concentrated into several time slots in a timetable. This tendency decreases the effectiveness of students' classes. Third, several major subjects might overlap some required subjects in liberal arts at the same time slots in the timetable. In this case, it is required that students should choose only one from the overlapped subjects. Fourth, many subjects are lectured by same lecturers every year and most of lecturers prefer the same time slots for the subjects compared with last year. This means that it will be helpful if departments reuse the previous timetables. To solve such problems and support the effective course timetabling in each department, this study proposes a university timetabling support system based on two phases. In the first phase, each department generates a timetable template from the most similar timetable case, which is based on case-based reasoning. In the second phase, the department schedules a timetable with the help of interactive user interface under the timetabling criteria, which is based on rule-based approach. This study provides the illustrations of Hanshin University. We classified timetabling criteria into intrinsic and extrinsic criteria. In intrinsic criteria, there are three criteria related to lecturer, class, and classroom which are all hard constraints. In extrinsic criteria, there are four criteria related to 'the numbers of lesson hours' by the lecturer, 'prohibition of lecture allocation to specific day-hours' for committee members, 'the number of subjects in the same day-hour,' and 'the use of common classrooms.' In 'the numbers of lesson hours' by the lecturer, there are three kinds of criteria : 'minimum number of lesson hours per week,' 'maximum number of lesson hours per week,' 'maximum number of lesson hours per day.' Extrinsic criteria are also all hard constraints except for 'minimum number of lesson hours per week' considered as a soft constraint. In addition, we proposed two indices for measuring similarities between subjects of current semester and subjects of the previous timetables, and for evaluating distribution degrees of a scheduled timetable. Similarity is measured by comparison of two attributes-subject name and its lecturer-between current semester and a previous semester. The index of distribution degree, based on information entropy, indicates a distribution of subjects in the timetable. To show this study's viability, we implemented a prototype system and performed experiments with the real data of Hanshin University. Average similarity from the most similar cases of all departments was estimated as 41.72%. It means that a timetable template generated from the most similar case will be helpful. Through sensitivity analysis, the result shows that distribution degree will increase if we set 'the number of subjects in the same day-hour' to more than 90%.