• Tuberculosis and Respiratory Diseases
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• 제49권2호
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• pp.246-252
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• 2000

저자들은 양측성 신혈관근지방종, 경련, 지능저하 및 피지선종을 동반한 결절성 경화증으로 진단된 26세 여자 환자에서 객혈을 주증상으로 하여 흉부 X-선 및 고해상도 흉부전산화단층 촬영상 폐림프관평활근종증이 의심되었던 1예와 분만후 호흡곤란과 객혈을 주소로 내원한 30세 여자 환자에서 흉부 X-선 촬영, 고해상도 흉부전산화단층 촬영 및 폐생검을 통해 확진한 폐임파관 평활근종증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Structural Engineering and Mechanics
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• 제83권3호
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• pp.305-326
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• 2022

To realize the recycling utilization of waste concrete and alleviate the shortage of resources, 11 specimens of steel reinforced recycled concrete (SRRC) filled circular steel tube columns were designed and manufactured in this study, and the cyclic loading tests on the specimens of columns were also carried out respectively. The hysteretic curves, skeleton curves and performance indicators of columns were obtained and analysed in detail. Besides, the finite element model of columns was established through OpenSees software, which considered the adverse effect of recycled coarse aggregate (RA) replacement rates and the constraint effect of circular steel tube on internal RAC. The numerical calculation curves of columns are in good agreement with the experimental curves, which shows that the numerical model is relatively reasonable. On this basis, a series of nonlinear parameters analysis on the hysteretic behaviors of columns were also investigated. The results are as follows: When the replacement rates of RA increases from 0 to 100%, the peak loads of columns decreases by 7.78% and the ductility decreases slightly. With the increase of axial compression ratio, the bearing capacity of columns increases first and then decreases, but the ductility of columns decreases rapidly. Increasing the wall thickness of circular steel tube is very profitable to improve the bearing capacity and ductility of columns. When the section steel ratio increases from 5.54% to 9.99%, although the bearing capacity of columns is improved, it has no obvious contribution to improve the ductility of columns. With the decrease of shear span ratio, the bearing capacity of columns increases obviously, but the ductility decreases, and the failure mode of columns develops into brittle shear failure. Therefore, in the engineering design of columns, the situation of small shear span ratio (i.e., short columns) should be avoided as far as possible. Based on this, the calculation model on the skeleton curves of columns was established by the theoretical analysis and fitting method, so as to determine the main characteristic points in the model. The effectiveness of skeleton curve model is verified by comparing with the test skeleton curves.

• Journal of Ginseng Research
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• 제47권1호
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• pp.81-88
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• 2023

Background: Air pollution has led to an increased exposure of all living organisms to fine dust. Therefore, research efforts are being made to devise preventive and therapeutic remedies against fine dust-induced chronic diseases. Methods: Research of the respiratory protective effects of KRG extract in a particulate matter (PM; aerodynamic diameter of <4 ㎛) plus diesel exhaust particle (DEP) (PM4+D)-induced airway inflammation model. Nitric oxide production, expression of pro-inflammatory mediators and cytokines, and IRAK-1, TAK-1, and MAPK pathways were examined in PM4-stimulated MH-S cells. BALB/c mice exposed to PM4+D mixture by intranasal tracheal injection three times a day for 12 days at 3 day intervals and KRGE were administered orally for 12 days. Histological of lung and trachea, and immune cell subtype analyses were performed. Expression of pro-inflammatory mediators and cytokines in bronchoalveolar lavage fluid (BALF) and lung were measured. Immunohistofluorescence staining for IRAK-1 localization in lung were also evaluated. Results: KRGE inhibited the production of nitric oxide, the expression of pro-inflammatory mediators and cytokines, and expression and phosphorylation of all downstream factors of NF-κB, including IRAK-1 and MAPK/AP1 pathway in PM4-stimulated MH-S cells. KRGE suppressed inflammatory cell infiltration and number of immune cells, histopathologic damage, and inflammatory symptoms in the BALF and lungs induced by PM4+D; these included increased alveolar wall thickness, accumulation of collagen fibers, and TNF-α, MIP2, CXCL-1, IL-1α, and IL-17 cytokine release. Moreover, PM4 participates induce alveolar macrophage death and interleukin-1α release by associating with IRAK-1 localization was also potently inhibited by KRGE in the lungs of PM4+D-induced airway inflammation model. KRGE suppresses airway inflammatory responses, including granulocyte infiltration into the airway, by regulating the expression of chemokines and inflammatory cytokines via inhibition of IRAK-1 and MAPK pathway. Conclusion: Our results indicate the potential of KRGE to serve as an effective therapeutic agent against airway inflammation and respiratory diseases.

• 한국임상수의학회지
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• 제23권3호
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• pp.349-354
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• 2006

5개월간의 일시적인 기절현상(syncope)을 주증상으로 내원한 9개월령의 1.97kg 미니어쳐 핀셔견에서 호흡곤란, 심초음파에서의 현저한 심실/심방의 확장, 전반적인 심비대, 약한 맥박, 폐수종 등 DCM의 진단 지표를 기준을 통해 확장성 심근병을 진단하였다. 본 증례에서 심초음파 검사는 심장의 확장과 심무력을 유발하는 다른 심장 질환을 배제하고 DCM을 확진 하는데 중요한 역할을 하였다. 치료를 위해 산소공급과, nitroglycerine patch, furosemide, pimobendan, benazepril, potassium gluconate gel을 19일간 처방한 결과 초기 내원시 보였던 대부분의 임상증상이 개선되었다.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1104-1113
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• 2020

Objective: To assess the regional ventilation in patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) using xenon-ventilation dual-energy CT (DECT), and to compare it to that in patients with COPD. Materials and Methods: Twenty-one patients with ACOS and 46 patients with COPD underwent xenon-ventilation DECT. The ventilation abnormalities were visually determined to be 1) peripheral wedge/diffuse defect, 2) diffuse heterogeneous defect, 3) lobar/segmental/subsegmental defect, and 4) no defect on xenon-ventilation maps. Emphysema index (EI), airway wall thickness (Pi10), and mean ventilation values in the whole lung, peripheral lung, and central lung areas were quantified and compared between the two groups using the Student's t test. Results: Most patients with ACOS showed the peripheral wedge/diffuse defect (n = 14, 66.7%), whereas patients with COPD commonly showed the diffuse heterogeneous defect and lobar/segmental/subsegmental defect (n = 21, 45.7% and n = 20, 43.5%, respectively). The prevalence of ventilation defect patterns showed significant intergroup differences (p < 0.001). The quantified ventilation values in the peripheral lung areas were significantly lower in patients with ACOS than in patients with COPD (p = 0.045). The quantified Pi10 was significantly higher in patients with ACOS than in patients with COPD (p = 0.041); however, EI was not significantly different between the two groups. Conclusion: The ventilation abnormalities on the visual and quantitative assessments of xenon-ventilation DECT differed between patients with ACOS and patients with COPD. Xenon-ventilation DECT may demonstrate the different physiologic changes of pulmonary ventilation in patients with ACOS and COPD.

• 자원환경지질
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• 제10권1호
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• pp.37-48
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• 1977

The earth's crust is unceasingly undergoing deformations because of the forces acting upon it. The relationship between the tectonic forces and the resulting deformations are found from the states of stresses in the earth's crust induced by these forces. The study has been attempted to analyze the deformations of the overlying sedimentary layers, which are deformed by the magma intrusion along its lower boundary. The elastic model is constructed to analyze the geologic structures, by means of the theory of elasticity, and then the appropriate boundary conditions are given. The solution of the Airy stress function which satisfies the given boundary conditions is derived from the analytic method. The internal stress distributions of the deformed elastic model layer are portrayed by principal stress trajetories, and then the corresponding potential faults and joints systems are predicted from the Coulomb-Mohr failure criterion. The internal displacement distributions are shown by the calculated displacement components vectors, namely horizontal, vertical and net components. Results of the numerical calculations show the developments of some geologic structures as follows; (1) one set of shear joints and or two sets of shear joints which are oppisite directions, and one set of extension joints parallel to the ${\sigma}_1$ direction, (2) one set of high angle thrusts and normal faults, (3) symmetric fold; both limbs are dipping in opposite direction with low angle. The field work at the Wall-A San area, located near Jinju City, in southern Korea, had accomplished to compare the field structures with the predicted ones. The results of the comparison exhibits the developments of joint and fault systems satisfactorily consistent with each others. But the area does not show any type of folding, in spite of the intrusion of a granodiorite massif, this fact is one of the important features of the whole Kyungsang sedimentary basins of Mesozoic age distributed at the south-eastern parts of Korea. For this reason, it is thought that the magma intrusion had occurred with extremly low pressure. The geologic structures have been modified by the erosion and weathering throughout the geologic time, and the conditions of the sedimentary layers (width, thickness and radius of magma) are not the same as before, being intruded by the magma. To enlighten this, it is preferable to study these geologic structures with analyses of various types of rheological models.

• 한국임상수의학회지
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• 제37권3호
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• pp.149-152
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• 2020

One-year-old male Cocker Spaniel dog was referred for the third eyelid enlargement and inflammation in the left eye (OS). It gradually swelled for 2 weeks after the cherry eye repair by conjunctival mucosa pocket procedure at a private animal clinic. Routine ophthalmic examinations including neuro-ophthalmic examination, Schirmer tear test, intraocular pressure and corneal fluorescein staining were all normal. No lesions were found on slit lamp biomicroscopy and indirect ophthalmoscopy except for third eyelid swelling in the OS. Ultrasonography revealed cystic structure within the OS nictitating membrane. Fluid from the cyst was aspirated and there were no microorganisms or neoplastic changes. Surgical intervention was performed under general anesthesia. On the day of the surgery, there was a deep corneal ulcer in the OS, which had not existed before. Ventral palpebral surface of the third eyelid was incised horizontally to the shaft of the T-shaped hyaline cartilage. And then, a full thickness of the cystic wall was incised and marsupialized. Additionally, a direct suture was performed on the ulcerated cornea. Topical and systemic antibiotics and anti-inflammatory drugs were prescribed. One month after the surgery, the third eyelid swelling and the discharge were improved. Marsupialization of the nictitating membrane cyst relieved the swelling of the third eyelid and inflammation. It could be a simple but effective surgical intervention for the cystic complication of conjunctival mucosa pocket procedure in dogs.

• 보존과학회지
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• 제34권1호
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• pp.11-21
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• 2018

등록문화재 제233호 '공주 중학동 구 선교사 가옥'의 유래와 보존현황에 관한 연구결과 건축연대는 1921년 10월 23일이 합당하며 일제 강점기 말기 최후 거주자는 그동안 Amendt 선교사로 알려져 왔으나, 1939년 작성된 Williams 선교사의 편지 및 새로운 증언에 의해 Alice Sharp 선교사가 1939년 은퇴시까지 사용하였던 건물로서 독신여선교사들의 주거는 물론 여학교역할도 하였던 건물로 밝혀졌다. 따라서 이 문화재의 명칭도 '공주 여선교사 기념관'으로 변경하는 것이 바람직하다. 본 문화재의 내 외부 보존현황 조사 결과 건물 벽체의 기울기에는 이상이 없으나 내부 목재상태가 상당부분 열화되어 있어 안전진단 후 전체적인 보수가 필요한 상황으로 판단된다. 특히, 창호시설의 경우 본래의 상하 미닫이 창호로 복원할 필요가 있으며, 건물의 남서측 계단과 데크 및 우물의 원형복원이 필요한 것으로 판단된다. 아울러 문화재의 하부지반의 안전성에 관한 지반 비파괴진단결과 이 선교유적이 2~5 m 두께의 불균등한 표토층 위에 건축되었으며 표토층과 그 하부의 풍화암과의 경계면이 지형경사 방향으로 기울어져 있는 현상이 발견되고 있다. 이러한 현상은 우기에 지반의 함수비가 증가하면 지반의 지지력이 저하되는 바 부등침하발생 가능성이 있으며, 특히 집중호우가 발생한다면 산사태를 초래할 가능성이 있다. 따라서 본 건물 부지의 남서단 경계부에 석축시설을 설치하는 것이 바람직하며 신속한 배수가 되도록 배수시설 설치가 필요하다.

• 한국임상수의학회지
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• 제11권2호
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• pp.529-537
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• 1994

Sector scanner which has a conical end is used to image through the intercostal space because heart is protected by the ribs. Cardiac data published all around the world were also obtained by sector scanner. Although scanners being used in every small animal practice and animal hospital at college in Korea include convex ape and linear type, linear type is not appropriate f3r cardiac scan because of a wide contact surface. The purpose of this study is to establish ultrasonographic images of normal cardiac structures by measuring shape, size of reflectable cardiac structure according to restraint position in scanning normal heart of the puppies with 6.5 MHz convex scanner(SonoAce 4500, Medison, Korea) used in our veterinary teaching hospital, Seoul national university. Seventeen male and female puppies considered having healthy hear by X-ray and clinical examination are used feom April to July 1994. Scanning point selection of probe head and the distinction of imaged cardiac structures were accomplished by necropsy and cardiac scanning performed through thoracotomy under general anesthesia. At 10 o'clock position of transducer(at an angle of 30$^{\circ}$ between imaginary line from elbow joint to 3rd sternum and probe head, 60$^{\circ}$ from body surface, 4th intercostal space of right thorax) with the marker of scanner toward the head of dogs right atrium, left atrium and left ventricle were observed in 2, 3, 4, 5 intercostal space(2cm from the sternum) of experimental dog positioned ventrodorsally under general anesthesia. Under these conditions, the numerical values of imaged diastolic hear are as follows : the distance from skin to apex(mean$\pm$S.D) 47.53$\pm$6.94mm, thickness of left ventricular wall 6.00$\pm$1.60mm, length of left ventricle 16.27$\pm$5.31mm, width of left ventricle 15,33$\pm$4.25mm, length of left atrium 12.33$\pm$3.82mm, width of left atrium 11. 33$\pm$3.94mm, length of right atrium 1.00$\pm$2.41mm, width of right atrium 11.21$\pm$2.76mm and the area of left ventricle 270.92$\pm$109.81mm$^2$, area of left atrium 98.00$\pm$41.08mm$^2$, area of right atrium 62.75$\pm$21.04mm$^2$.

• Animal Bioscience
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• 제35권6호
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• pp.902-915
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• 2022

Objective: Diet acidification supplementation is known to influence intestinal morphology, gut microbiota, and on phosphorus (P) utilization of broilers. Alterations in intestinal barrier and microbiota have been associated with systemic inflammation and thus regulating bone turnover. Hence the effect of acidifier addition to drinking water on tibia mass and the linkages between intestinal integrity and bone were studied. Methods: One-d-old male broilers were randomly assigned to normal water (control) or continuous supply of acidified water (2% the blend of 2-hydroxy-4-methylthiobutyric acid, lactic, and phosphoric acid) group with 5 replicates of 10 chicks per replicate for 42 d. Results: Acidification of drinking water improved the ash percentage and calcium content of tibia at 42 d. Broilers receiving acidified water had increased serum P concentration compared to control birds. The acidified group showed improved intestinal barrier, evidenced by increased wall thickness, villus height, the villus height to crypt depth ratio, and upregulated mucin-2 expression in ileum. Broilers receiving drinking water containing mixed organic acids had a higher proportion of Firmicutes and the ratio of Firmicutes and Bacteroidetes, as well as a lower population of Proteobacteria. Meanwhile, the addition of acidifier to drinking water resulted in declined ileal and serum proinflammatory factors level and increased immunoglobulin concentrations in serum. Concerning bone remodeling, acidifier addition was linked to a decrease in serum C-terminal cross-linked telopeptide of type I collagen and tartrate-resistant acid phosphatase reflecting bone resorption, whereas it did not apparently change serum alkaline phosphatase activity that is a bone formation marker. Conclusion: Acidified drinking water increased tibia mineral deposition of broilers, which was probably linked with higher P utilization and decreased bone resorption through improved intestinal integrity and gut microbiota and through decreased systemic inflammation.