Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Primary Dilated Cardiomyopathy in a Miniature Pinscher Dog

미니어쳐 핀셔견에서 발생한 확장성 심근질환

  • Kim, Jung-Hyun (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Park, Chul (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Ko, Ki-Jin (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Kang, Byeong-Teck (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Jung, Dong-In (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Kim, Ju-Won (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Kim, Ha-Jung (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Lim, Chae-Young (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Lee, So-Young (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Cho, Sue-Kyung (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University) ;
  • Park, Hee-Myung (Department of veterinary infernal medicine, College of veterinary medicine, Konkuk University)
  • 김정현 (건국대학교 수의과대학) ;
  • 박철 (건국대학교 수의과대학) ;
  • 고기진 (건국대학교 수의과대학) ;
  • 강병택 (건국대학교 수의과대학) ;
  • 정동인 (건국대학교 수의과대학) ;
  • 김주원 (건국대학교 수의과대학) ;
  • 김하정 (건국대학교 수의과대학) ;
  • 임채영 (건국대학교 수의과대학) ;
  • 이소영 (건국대학교 수의과대학) ;
  • 조수경 (건국대학교 수의과대학) ;
  • 박희명 (건국대학교 수의과대학)
  • Published : 2006.09.30
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Abstract

A 9-month-old, female Miniature Pinscher(MP) dog weighing 1.97kg was presented because of periodic syncopal episode for 5 months. This case was diagnosed as primary dilated cardiomyopathy based on respiratory distress history, weak femoral pulse, generalized cardiomegaly, pulmonary edema, marked dilation of left atrium(LA) and left ventricle(LV), decreased wall thickness of LV and interventricular septum(IVS), increased EPSS in echocardiography, and young age of onset in the absence of other cardiovascular disorders. The patient was stabilized by application of diuretics(Furosemide, 2 mg/kg, SC, q 1 hr) and venodilator(Nitroglycerine patch, 0.5 mg/kg, q 12 hrs). Clinical signs were improved with medical management of positive inotropic vasodilator(Pimobendan, 0.2 mg/kg, PO, q 12 hrs) and angiotensin-converting enzyme(ACE) inhibitor(benazepril, 0.5 mg/kg, PO, q 12 hrs), potassium gluconate gel(2 mEq/dog, PO, q 12 hrs) and, L-carnitine(50 mg/kg, PO, q 12 hrs). The dog still maintains stable clinical status 10 months after the first visit. We report the rare case of DCM in small breed dog, which corresponds to the diagnosis and treatment of typical DCM in large breed dog.

5개월간의 일시적인 기절현상(syncope)을 주증상으로 내원한 9개월령의 1.97kg 미니어쳐 핀셔견에서 호흡곤란, 심초음파에서의 현저한 심실/심방의 확장, 전반적인 심비대, 약한 맥박, 폐수종 등 DCM의 진단 지표를 기준을 통해 확장성 심근병을 진단하였다. 본 증례에서 심초음파 검사는 심장의 확장과 심무력을 유발하는 다른 심장 질환을 배제하고 DCM을 확진 하는데 중요한 역할을 하였다. 치료를 위해 산소공급과, nitroglycerine patch, furosemide, pimobendan, benazepril, potassium gluconate gel을 19일간 처방한 결과 초기 내원시 보였던 대부분의 임상증상이 개선되었다.

Keywords

References

  1. Borgarelli M, Santilli R.A, Chiavegato D, D'Agnolo G, Zanatta R, Mannelli A, Tarducci A. Prognostic Indicators for Dogs with Dilated Cardiomyopathy. J Vet Intern Med 2006; 20: 104-110 https://doi.org/10.1892/0891-6640(2006)20[104:PIFDWD]2.0.CO;2
  2. Borgarelli M, Tarducci A, Santilli RA, Priano L. Fattori prognostici ecocardiografici ed eco Doppler in cani conmiocardiopatia dilatativa. Atti S I S Vet 1998; 52: 233
  3. Borgarelli M, Tarducci A, Tidholm A, Haggstrom J. Canine Idiopathic Dilated Cardiomyopathy. Part II: Pathophysiology and therapy. Vet J 2001; 162: 182-195 https://doi.org/10.1053/tvjl.2001.0616
  4. Broschk C, Distl O. Dilated cardiomyopathy in dogs: pathological, clinical, diagnosis and genetic aspects. Dtsch Tierarztl Wochenschr 2005; 112: 380-385
  5. Calvert CA, Chapman WL, Total RL. Congestive cardiomyopathy in Doberman Pinscher dogs. J Am Vet Med Assoc 1982; 181: 598-602
  6. Calvert CA, Hall G, Jacobs G, Pickus C. Clinical and pathologic findings in Doberman pinschers with occult cardiomyopathy that died suddenly or developed congestive heart failure 54 cases (1984-1991). J Am Vet Med Assoc 1997; 210: 505-511
  7. Calvert CA, Jacobs GJ, Pickus CW. Bradycardia-associated episodic weakness, syncope, and aborted sudden death in cardiomyopathic Doberman Pinschers. J Vet Intern Med 1996; 10: 88-93 https://doi.org/10.1111/j.1939-1676.1996.tb02034.x
  8. Calvert CA., Pickus CW, Jacobs G.J, brown J. Signalement, survival and prognostic factors in Doberman Pinschers with end-stage cardiomyopathy. J Vet Intern Med 1997; 11: 323-326 https://doi.org/10.1111/j.1939-1676.1997.tb00474.x
  9. Dominique GJ, Josee and Jean PV. The royal canin Dog encyclopedia. Aniwa publishing: 67-68
  10. Freeman LM, Michel KE, Brown DJ, Kaplan PM, Stamoulis ME, Posenthal SL, Keene BW, Rush JE. Idiopathic dilated cardiomyopathy in dalmatians: nine cases (1990-1995). J Am Vet Med Assoc 1996; 209: 1592
  11. Joanna Dukes-McEwan. Dilated Cardiomyopathy: European Experience. The 23rd Proceedings of American College of Veterinary Internal Medicine Forum 2005: 101-103
  12. Keene BW, Panciera DP, Atkins CE, Reqitz V, Schmidt MJ, Shug AL. Myocardial carnitine deficiency in a family of dog with dilated cardiomyopathy. J Am Vet Med Assoc. 1991; 198: 647-650
  13. Keene BW. L-carnitine deficiency in canine dilated cardiomyopathy. In Kirk RW, Bonagura JD (Eds). Kirk's Current Veterinary Therapy XI WB Saunders Co Philadelphia 1992: 780
  14. Keene BW, Panciera DP, Atkins CE. Myocardial L-carnitine deficiency in a family of dogs with dilated cardiomyopathy. J Am Vet Med Assoc 1991; 198: 647-650
  15. Kittelson MD, Keene B, Pion PD, Loyer CG. Results of the multicenter spaniel trial (MUST): taurine and carnitine responsive dilated cardiomyopathy in American Cocker Spaniels with decreased plasma taurine concentration. J Vet Intern Med 1997; 11: 204-211 https://doi.org/10.1111/j.1939-1676.1997.tb00092.x
  16. Kittleson MD. Primary myocardial disease leading to chronic myocardial failure (dilated cardiomyopathy and realated diseases). In: Kittleson MD, Kienle RD, editors. Small animal cardiovascular medicine. St Louis Mosby; 1998: 319-346
  17. Limas CJ, Goldenberg IF, Limas C. Autoantibodies against beta-adrenoseptors in human idiopathic dilated cardiomyopathy. Cir Res 1989; 64: 97-103 https://doi.org/10.1161/01.RES.64.1.97
  18. Lazaros A. Nikolaidis, MD. Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykini-mediated, Nitric Oxide-Dependent Mechanism. Circulation 2002: 2785-2790
  19. Michael R. O'Grady, and Lynne O'sullivan M. Dilated cardiomyopthy: an update. Vet Clin Small Anim 2004; 34: 1187-1207 https://doi.org/10.1016/j.cvsm.2004.05.009
  20. Monnet E, Orton C, Salman M, et al. Idiopathic dilated cardiomyopathy in dogs: survival and prognostic indicators. J Vet Intern Med 1995; 9: 12-17 https://doi.org/10.1111/j.1939-1676.1995.tb03266.x
  21. Morales M, Ynaraja E, Montoya JA. Dilated cardiomyopathy in Presa Canario dogs: ECG findings. J Vet Med Assoc 2001; A 48: 577-580
  22. O'Grady MR, Minors SL. Resting and dobutamine stress echocardiographic factors associated with the development of occult dilated cardiomyopathy in healthy Doberman pinscher dogs. J Vet Intern Med 1998; 12: 369-380 https://doi.org/10.1111/j.1939-1676.1998.tb02137.x
  23. O'Grady MR, O'Sullivian ML. Dilataed cardiomyoopathy: an update. Vet Clin North Am Samll Anim Prac 2004; 34: 1187-1207 https://doi.org/10.1016/j.cvsm.2004.05.009
  24. Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT. Actin mutations in dilaed cardiomyopathy, a heretable form of heart failure. Science 1998; 280: 750-752 https://doi.org/10.1126/science.280.5364.750
  25. Sandusky GE, Cho DY. Congestive cardiomyopathy in a dog associated with pregnancy. Cornell Vet 1984; 74: 60-64
  26. Schultheiss HP, Bolte HD. Immunological analysis of auto-antibodies against the adenine nucleotide trans locator in dilated cardiomyopathy. J Mol Cell Cardiol 1985; 17: 603-617 https://doi.org/10.1016/S0022-2828(85)80029-8
  27. Sisson D, O'Grady MR, and Calvert CA. Myocardial disease of dogs. In: Fox PR., Sisson D, and Moise NS, (eds), Canine and Feline Cardilolgy 2nd edn. WB Saunders Philadelphia 1999: 581-619
  28. Sisson DD, Thomas WP, Keene BW. Primary myocardial disease in the dog. In: Ettinger SJ, Felman EC, editors. Textbook of veterinary internal medicine 5th edition Philadelphia. WB Saunders 2000: 874-895
  29. Staaden RV. Cardiomyopathy of English Cocker Spaniels. J Am Vet Med Assoc 1981; 178: 1289-1292
  30. Tidholm A, Haggstrom J, Borgarelli M, Tarducci A. Canine Idiopathic Dilated Cardiomyopathy. Part I: Aetiology, Clinical Characteristics, Epidemiology and Pathology. Vet J 2001; 162: 92-107 https://doi.org/10.1053/tvjl.2001.0571
  31. Tidholm A, Jonsson L. Dilated cardiomyopathy in the Newfoundland: a study of 37 cases (1983-1994). J Am Anim Hosp Assoc 1996; 32: 465-470
  32. Wynne J, Braunwald E. The cardiomyopathies and myocarditides. In: Braunwald E, Zipes DP, Libby P, editors. Heart disease: a textbook of cardiovascular medicine. 6th edition. Philadelphia. WB Saunders 2001: 1751-1806