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Development of Vaccinium uliginosum L. extracts for whitening & anti-wrinkle functional food

  • Choung Se-Young
    • 한국응용약물학회:학술대회논문집
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    • 한국응용약물학회 2005년도 춘계학술대회
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    • pp.131-148
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    • 2005
  • This study is peformed to investigate the effect of water extract from Vaccinium uliginosum L., on melanin production in B 16 melanoma cells, procollagen production and matrix metalloproteinase-1(MMP-1) inhibition in human fibroblast cells. One hundred grams of the Vaccinium uliginosum L. was extracted with 2000 mL of water($90^{\circ}C$, 16h, 2times). The water extracts were lyophilized and stored at $4^{\circ}C$ until used. Dry weight yields of extracts of Vaccinium uliginosum L. were $3\%$(w/w). Extracts from Vaccinium uliginosum L. showed scavenger activities on DPPH radical, superoxide anion radical, hydroxyl radical, hydrogen peroxide and singlet oxygen radical. And these substances inhibited release of cyiokines from human keratinocyte after UV B exposure. Therefore we confirmed that extracts from Vaccinium uliginosum L. had antioxidative effect. These substances inhibited purified tyrosinase activity and melanogenesis in B 16 melanoma cells treated/untreated IL-$1{\alpha}$. Moreover this extract stimulated procollagen production and inhibited MMP-1 production in human fibroblast cells treated/untreated IL-$1{\beta}$. Therefore we confirmed that extracts from Vaccinium uliginosum L. had whitening effect. And these substances decreased degree of wrinkle in hairless mouse skin that induced by UV B irradiation. Therefore we confirmed that extracts from Vaccinium uliginosum L. had anti-wrinkle effect. From the above results, it is possible that Vaccinium uliginosum L. may be developed to be an anti-melanogenesis agent and anti-wrinkle agent.

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제조물책임법상 제조물로서의 의약품의 개념 (Study on the Concept of Medical Supplies in the Product Liability Law)

  • 전병남
    • 의료법학
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    • 제7권2호
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    • pp.331-364
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    • 2006
  • Medical supplies have contradiction of efficacy and side effect to the various diseases together. Therefore, people have tried to reduce the side effects and also provide various methods to cope with any damages from the medicine quickly. In the case of accidents by medical supplies, the victim can be protected with advantage by the Product Liability Law rather than the Torts. The limit of Product Liability Law's application depends on whether medical supplies belong to the product or not. According to Product Liability Law, the product should be processed. Therefore, medical supplied should be processed to be the category of product. It can be said that the medical supplies in pharmacy, Chinese medicine, medical herbs, biological medicine manufactures, blood manufactured medicine, cord blood, hemopoietic progenitior cell and stem cell belongs to the manufactured products. The mixture by the prescription of doctor or preparation of pharmacist can be recognized as the product because prescription or preparation is a manufacturing act. Therefore, applying Product Liability Law to manufacturer, doctor or pharmacist would achieve the goal which is protecting the victims extensively.

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실내 난방시 온열쾌적성 평가에 관한 연구(part I;실내 난방시 실온변화에 따른 감성이미지 평가) (Experimental Study on Thermal Sensation Evaluation in Heating(part I: Emotion & Sensibility Image Evaluation by Indoor Temperature Change in Heating))

  • 한남규;금종수;김형철;김동규;김창연
    • 한국감성과학회:학술대회논문집
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    • 한국감성과학회 2003년도 춘계학술대회 논문집
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    • pp.41-46
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    • 2003
  • In recently, Is inhabiting more than 70% indoors during a day in case of company employee and ordinary people which is looking at usual business. Therefore Thermal comfort of human body about indoor temperature and air flow acting very heftily. When intestine temperature is fallen for external low temperature and air flow in winter in case enter into heated room feel comfort by effect of temperature and feel comfort or discomfort by room heating condition gradually. Therefore it is important that grasp thermal comfort about temperature and air flow in heating to keep continuous comfort in indoor dwelling. Temperature and thermal comfort factor of emotion & sensitivity image exert fair effect since heating middle although thermal comfort change greatly effect on sensation about temperature at actuality heating early. Need much study yet in vantage point of emotion & sensitivity although much study were held about thermal and comfort sensibility and when heat in existing research until now. Therefore this study is targeting that evaluate thermal comfort through introduction of estimation method by emotion & sensibility image real and synthetic sensibility about thermal environment that is becoming winter heating.

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『금궤요약(金匱要略)』의 '양기쇠자위광(陽氣衰者爲狂)'에 대한 고찰(考察) - '양기(陽氣)'의 개념(槪念)을 중심으로 - (A Study on "Weakness of Yangqi causes Kuang(陽氣衰者爲狂)" in Jinkuiyaolue(金匱要略) - Focused on the concept of 'Yangqi' -)

  • 신상원;김종현
    • 대한한의학원전학회지
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    • 제30권4호
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    • pp.35-48
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    • 2017
  • Objective : Korean medicine normally explained Kuang as a symptom arising from the exaltation caused by excessive yangqi. Therefore, a lot of arguments existed surrounding Jinkuiyaolue's explanation of Kuang as Yangqishuai. Therefore, the paper will review the exisitng opinions regarding this issue, and studied the original meaning of Jinkuiyaolue. Method : First, the opinions of the historical doctors related to the clauses within Jinkuiyaolue are reviewed. Existing opinions are divided into categories, and their meanings and limitations are analyzed. Followed by this, Huangdineijing and later generations' annotations were studied to discover a way to distinquish Yin and Yang of Jinkuiyaolue's Yangqi within the Sinqi. Result & Conclusion : The disease pathogen as explained within Jinkuiyaolue can be understood as an activity of Simqi, and it's difficult to view it as the Yin and Yang in terms of blood qi. Therefore, Jinkuiyaolue refers to the deficiency in terms of the aspect of Yang within the activity of Sinqi. The Yangqi of this can be viewed as an activity of Shenming.

3자유도 모터 제어를 위한 철심 솔레노이드 특성의 실험적 해석에 관한 연구 (A Study of the Iron-Core Solenoid Analysis for 3 D.O.F. Motor Control with Experimental Method)

  • 백윤수;박준혁
    • 대한기계학회논문집A
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    • 제25권9호
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    • pp.1334-1340
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    • 2001
  • In this paper, the experimental modeling of the force between permanent magnet and iron-core solenoid is suggested for more accurate control of 3 D.O.F. motor using the electromagnetic force. In the case of iron-core solenoid, the general equation of solenoid cant be used simply because of its nonlinearity. Therefore, the magnetic flux density is estimated through the concept of equivalent permanent magnet. The force distribution between permanent magnet and iron-core solenoid is more dependent on the magnetization of iron core caused by the permanent magnet than any other parameters. Therefore, the equation of the force estimation between these magnetic systems can be modeled by the experimental function of the magnetization of iron core. Especially, if the distance between iron-core solenoid and permanent magnet is far enough, the force equation through experiment can be expressed from only the current of coil and the distance between iron-core solenoid and permanent magnet. It means that Coulombs law can be used for magnetic systems and it is validated through the experiment. Therefore, force calibration is performed by the concept of Coulombs law.

국제대금결제 추세와 국제팩토링에 의한 신용위험 대처방안에 관한 연구 (A study on International Payment Trend and Measures to Protect Credit Risk by International Factoring)

  • 박세훈;한기문
    • 무역상무연구
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    • 제44권
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    • pp.85-107
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    • 2009
  • L/C allows the exporter to have a bank's payment undertaking against shipping documents required by L/C. This means that the exporter can take export proceeds from a L/C issuing bank regardless of importer's payments and therefore the L/C better mitigate importer's credit risk compared to remittance and collections. Recently the use of L/C has been on down trend in line with increasing use of T/T, causing a big change of payment system. This tells that the payment method change in Korea is positive as the change also happens same in developed countries. This however gives more buyer's credit risk to exporters and therefore a systematic solution to this negative effect is required. In Korea, export credit insurance has been widely used to cover the buyer's credit risk. But the export credit insurance is limited because of lack of government's financial support and strict evaluation of buyer and exporter. Now Korea is ranked 10the largest trading country and therefore the exporters shall find another source for credit risk protection elsewhere. And as such this paper suggest International Factoring as a tool for the credit risk protection. The International Factoring gives advantages to the exporter in terms of credit protection and advances by purchasing account receivables on a without recourse basis.

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$\mu$-합성법을 이용한 사장교의 지진응답 제어 (Seismic Response Control of a Cable-Stayed Bridge using a $\mu$-Synthesis Method)

  • 박규식;정형조;윤우현;이인원
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 2004년도 가을 학술발표회 논문집
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    • pp.476-483
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    • 2004
  • This paper presents a hybrid system combining lead rubber bearings and hydraulic actuators controlled by a μ-synthesis method for seismic response control of a cable-stayed bridge. A hybrid system could alleviate some of restrictions and limitations that exist when each system is acting alone because multiple control devices are operating. Therefore, the overall control performance of a hybrid system may be improved compared to each system, however the overall system robustness may be negatively impacted by active device in the hybrid system or active controller may cause instability due to small margins. Therefore, a f-synthesis method that guarantees the robust performance is considered to enhance the possibility of real applications of the control system. The control performances of the proposed control system are compared with those of passive, active, semiactive control systems and hybrid system controlled by LQG algorithm and an extensive robust analysis with respect to stiffness and mass matrices perturbation and time delay of actuator is performed. Numerical simulation results show that the control performance of the proposed control system is superior to that of the passive system and slightly better than that of the active and semiactive systems and two hybrid systems show similar control performances. Furthermore, the hybrid system controlled by a μ-synthesis method shows the good robustness without loss of control performances. Therefore, the proposed control system could effectively be used to seismically excited cable-stayed bridge which contains many uncertainties.

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국내·외 BIM 적용 프로젝트의 BIM 적용수준 비교분석 - BIM 저널 및 Awards 수상작 사례를 중심으로 - (Comparison Analysis of BIM Level in the Domestic and Overseas BIM Projects - Focused on BIM Journals and Award Winning Projects -)

  • 고성훈;함남혁;이주성;윤수원;김재준
    • 한국BIM학회 논문집
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    • 제7권2호
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    • pp.25-35
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    • 2017
  • Building information modeling (BIM) can improve to communicate with project participants by early construction involvement (ECI) from the beginning of the project. Therefore, they can minimize design changes and improve design quality and construction. However, because there is insufficient research on the scope and application level of BIM according to project delivery system and project characteristics, construction companies have efficiently not been using the BIM. Therefore, this study intends to conduct basic research as a basis for confirming appropriate BIM application and level according to project delivery system and project characteristics. To do this, we investigated the project delivery system and project characteristics of domestic and foreign projects that have successfully applied BIM, and compare and analyze them based on BIM application and BIM level framework derived from theory reviews and experts. Therefore, this study can be used as a basis for strategically establishing the scope and level of BIM according to project delivery system and project characteristics through the result of this study.

Metro Sexual Formative Beauty Expressed in Men's Fashion on the 21C

  • Lee Hyo-Jin
    • International Journal of Costume and Fashion
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    • 제4권2호
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    • pp.18-29
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    • 2004
  • The purpose of this study was to analyze the formative beauty of metro sexual expressed on the 21C men's fashion. in 21C, metro sexual is being accepted as an object to lead the world consumption culture, and it is said to be most appropriate to the definition as a model that can determine the most modern men. Moreover, with well being life style, it shows characteristic that expresses chic sense through fashion. The results of the study were as below. 1. In recent men's wear, sensory feminine that looks young and trendy is being presented through clothes, rather than the image of men who are strong. Therefore, by wearing splendid flower print, bold color and gorgeous accessories, men send off their attractions. 2. The recent body king syndrome gave new aesthetic value on men's body. Therefore, men's body is becoming cultural icon of metro sexual as another face that shows social status and cultural taste. 3. The men's image of metro sexual that is felt from softer skin and hair than women, and well-built body is appealing more through body conscious look. Here, men's body silhouette is being sublimated aesthetically through design with various materials such as see-through and leather etc., and this is body conscious image that can be seen only in metro sexual. Like this, metro sexual fashion sense was expressed by feminine softness sometimes, and beautiful body silhouette sometimes by expressing one's sexiness enough, being away' from conceptual masculine. Therefore, the appearance of metro sexual can be understood that men's body exposure is becoming a social virtue that expresses beauty.

한의진단 Ontology 구축을 위한 추론과 탐색에 관한 연구 (Study on Inference and Search for Development of Diagnostic Ontology in Oriental Medicine)

  • 박종현
    • 동의생리병리학회지
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    • 제23권4호
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    • pp.745-750
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    • 2009
  • The goal of this study is to examine on reasoning and search for construction of diagnosis ontology as a knowledge base of diagnosis expert system in oriental medicine. Expert system is a field of artificial intelligence. It is a system to acquire information with diverse reasoning methods after putting expert's knowledge in computer systematically. A typical model of expert system consists of knowledge base and reasoning & explanatory structure offering conclusion with the knowledge. To apply ontology as knowledge base to expert system practically, consideration on reasoning and search should be together. Therefore, this study compared and examined reasoning, search with diagnosis process in oriental medicine. Reasoning is divided into Rule-based reasoning and Case-based reasoning. The former is divided into Forward chaining and Backward chaining. Because of characteristics of diagnosis, sometimes Forward chaining or backward chaining are required. Therefore, there are a lot of cases that Hybrid chaining is effective. Case-based reasoning is a method to settle a problem in the present by comparing with the past cases. Therefore, it is suitable to diagnosis fields with abundant cases. Search is sorted into Breadth-first search, Depth-first search and Best-first search, which have respectively merits and demerits. To construct diagnosis ontology to be applied to practical expert system, reasoning and search to reflect diagnosis process and characteristics should be considered.