• 대한화학회지
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• 제62권3호
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• pp.187-190
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• 2018

A three-component coupling reaction of phenylacetylene, p-toluenesulfonyl azide, and water through copper catalysis is described to provide knowledge of spectroscopy and catalytic reactions and to introduce current research topics in organic chemistry for second-year undergraduate students. In the presence of stoichiometric amounts of phenylacetylene, p-toluenesulfonyl azide, and triethylamine, the reaction was performed with 4 mol% CuCl in water as the sole solvent and was completed in 1.5 h. A practical purification method and recrystallization of the crude reaction mixture resulted in the rapid isolation of the desired product with yields of 42~65%. Students characterized 4-methyl-N-(phenylacetyl)benzenesulfonamide by using melting-point determination, infrared spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. This experimental procedure and spectroscopic data analysis will serve as a platform for students to apply classroom knowledge in practical state-of-the-art research.

• 한국임상수의학회지
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• 제41권4호
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• pp.246-251
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• 2024

Herein, we present the ultrasonography and computed tomography (CT) characteristics of an intramural calcified leiomyoma of the bladder in a dog. A 16-year-old, neutered male, Shih Tzu dog was referred to our hospital owing to corneal perforation. Serum chemistry findings and complete blood counts were unremarkable. A rounded hypoechoic intramural mass with internal hyperechoic foci was incidentally discovered on the ventral aspect of the bladder neck on abdominal ultrasonography performed for screening prior to corneal surgery. CT revealed a rounded hypoattenuated mass with central hyperattenuated foci at the level of the bladder neck. The mass was surgically excised and was diagnosed as leiomyoma based on histopathological findings.

• 한국임상수의학회지
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• 제36권5호
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• pp.278-281
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• 2019

A 12-year-old castrated male Maltese dog was presented with a small-sized mass at the left fifth mammary gland. The dog had concurrent poorly responsive pruritus affecting the feet, pinnae, and trunk, a cystolith, and biliary sludge. Serum chemistry revealed elevated liver enzymes. The mammary gland mass was cytologically diagnosed as an early-stage mammary simple carcinoma and was surgically excised. Nine months after the diagnosis of the mammary carcinoma, hyperadrenocorticism was confirmed by adrenocorticotropic hormone stimulation test. This report describes the clinical signs, diagnostic imaging findings, and prognosis in a castrated male Maltese dog with mammary carcinoma.

• 한국임상수의학회지
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• 제21권1호
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• pp.62-65
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• 2004

A 13-year-old, male Maltese was refered to Veterinary Teaching Hospital of Konkuk University with inappropriate urination and hematuria. CBC, serum chemistry profile, urinalysis and urine culture were performed. Malignant cells were found in the urine sediment. Thoracic and abdominal radiography, retrograde positive-contrast cystography, retrograde double-contrast cystography, excretory urography, ultrasonography were performed. On the retrograde positive-contrast cystography examination, irregular filling defects were present on the left side of the cranial part of the bladder. Partial cystectomy performed and then medical therapy was conducted. On histopathological examinations, the lesion was confirmed as a transitional cell carcinoma of the urinary bladder.

• 한국임상수의학회지
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• 제38권6호
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• pp.290-294
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• 2021

An 8-year-old neutralized male Dachshund was presented with severe vomiting, anorexia, and weight loss for two weeks. The patient had to feed in a standing position due to problem of vomiting immediately after meal. Serum chemistry and CBC results were all within reference limits. CT imaging revealed a mass distributed widely in the caudal part of the esophagus including the sphincter and the gastric cardia. Complete surgical removal was difficult because of adhesion to the caudal vena cava. A partial surgical excision and gastropexy with MIC-key feeding tube were performed under the owner's permission. Histologically, the mass was interpreted as leiomyoma. This patient is doing well at present time, six years after the tube installation in 2015.

• 한국임상수의학회지
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• 제38권1호
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• pp.41-44
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• 2021

Pituitary pars intermedia dysfunction (PPID), often referred to as equine Cushing's disease, is a common endocrine disorder often diagnosed in older horses. A 13-year-old 460 kg Warmblood gelding showed clinical signs suggestive of PPID, including hypertrichosis, fat redistribution, polyuria and polydipsia (PU/PD), and weight loss. Physical examination, complete blood cell count, and serum chemistry results were normal. However, dexamethasone suppression and plasma adrenocorticotropic hormone (ACTH) level tests confirmed PPID. Three months after the confirmed diagnosis, the horse was referred again with symptoms of laminitis. Radiography and venography were performed to evaluate the laminitis severity level. However, the foot condition continued to worsen, and the horse was eventually euthanized. The purpose of this case report is to describe clinical signs and diagnosis of PPID with laminitis.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2003년도 춘계종합학술대회논문집
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• pp.298-302
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• 2003

화학분야 정보 중 무기재료 합성 및 물성 연구에 필수적으로 사용되는 무기결정구조 데이터베이스를 구축하였다. 또한 국내 연구자들이 무기결정구조 정보를 웹에서 손쉽게 검색할 수 있는 웹 검색 시스템을 개발하였다. 데이터 소스는 독일의 FIZ-Karlsruhe에 의해 수집된 1915년부터의 데이터 약 65,000건을 확보하였으며 빠르고 효율적인 화합물 검색이 가능하도록 데이터베이스를 설계, 검색 시스템을 개발하였고 특히 결정구조에 대한 수치검색이 가능하도록 개발하였다.

• 한국임상수의학회지
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• 제16권2호
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• pp.506-508
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• 1999

An one-year-old, female pointer dog with conjunctival hyperemia, corneal opaque and ocular pain in right eye was referred to Veterinary Medical Teaching Hospital, Chungbuk National University. In the ophthalmic examination the worm was observed in anterior chamber, The heart worm antigen test was positive. A modified Knott's test was negative. The values of complete blood count and serum chemistry (TP, BUN, creatinine, AST, ALT, ALP, albumin, globuline) showed normal ranges. Any abnormality was not detected in the heart using a thoracic radiography and cardiac sonography. Therefore, this dog was diagnosed as ocular filariasis. The worm was removed by surgical incision through a limbus of cornea. The closure of limbal incision was sutured in a simple interrupted suture pattern with 6-0 silk and the eye was reinflated with sterile saline solution. Antibiotics and dexamethasone ophthalmic solution were applied to right eye every 24 hours for 7 days. To prevent latent filariasis, ivermectin was also administered on day 14 of operation. The heart worm antigen test on day 60 was negative. The dog was successfully cured.

• Bulletin of the Korean Chemical Society
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• 제27권3호
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• pp.386-388
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• 2006

Membrane proteins in highly oriented lipid bilayer samples are useful for membrane protein structure determination. We used in the past planar lipid bilayers which were aligned and supported on the glass slide. These samples were mechanically aligned in a magnetic field. However, these stacks of glass slides with planar lipid bilayers are not well suited for use with a commercial solid-state NMR probe with a round coil. Therefore, a homebuilt solid-state NMR probe was built and used with a stack of thin glass plates wherein the RF coil was wrapped directly around the flat square sample. Recently, we began to use magnetically aligned bicelles that are suitable for the structure determination of membrane proteins by solid-state NMR spectroscopy without any effort to build a flat square coil probe. These bicelle samples are well suited for use with a commercial solidstate NMR probe with a round coil, are very easy to prepare and are very stable, so that they can be kept for more than a year. In this paper, we present the solid-state NMR spectra of optimized and magnetically oriented bicelle samples of membrane proteins.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권1호
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• pp.61-64
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• 2013

Infection-induced acute hepatitis complicated with acute pancreatitis is associated with hepatitis A virus, hepatitis B virus or hepatitis E virus. Although rare, Epstein-Barr virus (EBV) infection should be considered also in the differential diagnosis if the patient has acute hepatitis combined with pancreatitis. We report a case of EBV infection with cholestatic hepatitis and pancreatitis with review of literature. An 11-year-old female was admitted due to 1-day history of abdominal pain and vomiting without any clinical symptoms of infectious mononucleosis. Diagnosis of reactivated EBV infection was made by the positive result of viral capsid antigen (VCA) IgM, VCA IgG, Epstein-Barr nuclear antigen and heterophile antibody test. We performed serologic tests and magnetic resonance cholangiopancreatography to exclude other viral or bacterial infection, autoimmune disorder, and structural problems. The patient's symptoms recovered rapidly and blood chemistry returned to normal with conservative treatment similar to previously reported cases.