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The Protective Effects of water Extracts of ZoaGumHwan (ZGH) on the Oxidized LDL-induced Monocyte Adhesion to Human Umbilical Vein Endothelial Cells

  • Ko, Yu-Jin;Park, Byung-Chul;Lee, Jong-Suk;Park, Su-Young;Shin, Heung-Mook;Yoo, Bong-Kyu;Kim, Jung-Ae
    • Biomolecules & Therapeutics
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    • v.15 no.3
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    • pp.162-168
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    • 2007
  • It is well known that oxidized low-density lipoprotein (oxLDL) is the most characterized humoral factor that plays an important role in the pathogenesis of atherosclerosis. The water extract of the Korean herbal remedy, ZoaGumHwan (ZGH), which is composed of roots of Coptis chinensis Franch and fruits of Evodia officinalis Dode with the ratio of 6 to 1, reduced the in vitro oxidation of low density lipoproteins (LDL). Also, the ZGH extract and berberine, one of the major components of ZGH, significantly prevented oxLDL-induced adhesion of monocytes to human umbilical vein endothelial cells (HUVEC). Furthermore, the ZGH water extract and berberine decreased oxLDL-induced expression of CC chemokine receptor 2 (CCR2), a dominant monocyte chemotaxis receptor, in U937 human monocytic cells. The protective effects of the ZGH water extract and berberine were similar to those of simvastatin, an effective lipid-lowering drug. The results suggest that Korean herbal remedy, ZGH, seems to have protective effect against oxLDL-induced monocyte chemoattractant protein (MCP)-1/CCR2-dependent monocyte recruitment onto endothelial cells.

Antioxidant Activity and Quality Characteristics of Cookies Prepared with Acorn(Quercus species) Powder (도토리 분말을 첨가한 쿠키의 항산화활성 및 품질특성)

  • Joo, Shin-Youn;Kim, Ok-Sun;Jeon, Hee-Kyung;Choi, Hae-Yeon
    • Korean journal of food and cookery science
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    • v.29 no.2
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    • pp.177-184
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    • 2013
  • This study was conducted to investigate the effects of acorn (fruits of Quercus species) powder on the antioxidant activity and quality characteristics of cookies. Cookies were prepared with different amounts (0, 0.5, 1, 3 and 5% to the flour quantity) of acorn powder. The antioxidant activity was estimated by DPPH free radical scavenging activity and the total phenolic acid content in acorn powder and cookies. For analyzing quality characteristics, bulk density, pH of the dough, spread factor, loss rate, leavening rate, color, texture profile analysis, and sensory evaluations were measured. The moisture contents, a values, total phenolic acid content and DPPH free radical scavenging activity of cookies significantly increased with increasing acorn powder (p<0.001), while the pH of the dough, L values and b values of the cookies significantly decreased with increasing acorn powder (p<0.001). The consumer acceptability score for the 3% acorn cookie groups ranked significantly (p<0.05) higher than the other groups in overall preference, appearance, flavor, taste and color. From these results, we suggest that acorn is a good ingredient for increasing the consumer acceptability and the functionality of cookies.

Dietary Intake Differences among Korean Male Smokers, Ex-smokers and Non-smokers

  • Kim, Jean-Chinock -Rim;Kim, Seonwoo;Lee, Soon-Young
    • Journal of Community Nutrition
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    • v.1 no.2
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    • pp.125-132
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    • 1999
  • This study investigated the differences in dietary intake, age, body mass index(BMI), marital status and education of 1,585 Korean healthy males among current smokers, ex-smokers and non-smokers. Dietary intake was determined by a food frequency questionnaire at the Samsung Medical Center in Seoul, Korea. A bioelectric impedance analyzer measured height, body weight and BMI. This study identified 50% of the study group as current smokers and 30% as ex-smokers and 20% as non-smokers. The mean body mass index was 23.7kg/㎡ and did not differ significantly among the three groups. THe current smokers were younger(44.9 years old) and contained a lower percentage(58.5%) of college graduate than that of ex-smokers or non-smokers. The percentage of non-consumers of meat, eggs, beans and bean products was higher in non-smokers than that of ex-smokers or current smokers. Smoking was to a significant degree positively related to the amount of coffee and alcoholic beverages consumed and negatively related to the amount of milk and milk products and fruits consumed. The intake of eggs, milk and milk products, fruit, coffee, sweets, fats and oils were significantly different among the three groups. after adjusting for age, education level, marital status, and alcohol consumption. There was a strong positive relationship between smoking intensity and the intake of coffee and alcoholic beverages(p<0.0005), and an inverse relationship between smoking intensity and fruit, milk and milk product intake(p<0.005). The current smokers were characterized by a higher intake of total energy and cholesterol, and a lower intake of dietary fibers, ${\beta}$-carotine and folate than those of non-smokers or ex-smokers. The nutrient intake of ex-smokers was moderate and highest in ${\beta}$-carotine and folate, which suggested that ex-smokers were trying to change their life style.

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Anti-Growth Effect of Kaempferol, a Major Component of Polygonati Rhizoma, in Hepatocarcinoma Cells (간암 세포주에서 황정(黃精)의 주요 성분인 Kaempferol의 성장 억제 효과)

  • Joo, Ye-Jin;Jeong, Ji-Cheon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.26 no.4
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    • pp.519-526
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    • 2012
  • Recently, herbal flavonoids have been implicated for anti-cancer therapy. Flavonoids as a commonly known for their anti-oxidant activity, are contained in the herbal medicine as well as root of plants, vegetables, fruits, grains, tea, and wine. Kaempferol, a component of Polygonati rhizoma, a member of the herbal flavonoids, has been studied for anti-hypercholesterol, anti-hypertension and anti-diabetes. It is also known to be effective in anti-cancer therapy for breast, prostate and other type of cancers. However, the anti-cancer therapeutic mechanisms are pooly understood. Here, we investigated the molecular mechanism underlying kaempferol-induced anti-cancer effects using the human liver cancer cell lines, Hep3B, HepG2, and Sk-Hep-1, and human Chang liver cell as a control. As shown by the FACS analysis, measurement of caspase activity, DAPI and trypan blue staining, and DNA fragmentation assay, kaempferol induced apoptosis in the liver cancer cells with the greater potential in Hep3B cells than other liver cancer cells. In addition, we performed microarray analysis to profile the genome-wide mRNA expression regulated by kaempferol. Many of the apoptosis-related genes were significantly induced in kaempferol-treated Hep3B cells, in particular, the genes associated with MAPK cascade. Additionally, kaempferol induced the mRNA expression of genes involved in MKK7-JNK cascade, MKK3-p38 cascade, and caspase signaling pathway, which are all known to trigger apoptosis. Overall, our data suggest that kaempferol has anti-liver cancer effects by inducing apoptosis through the MKK7-JNK cascade, MKK3-p38 cascade, and caspase signaling pathways.

A Study on the Relationship between Time Spent on Lunch and Degree of Obesity, Eating Habits in Culinary College Male Students (조리전공 남자대학생의 점심식사 소요시간과 비만지표, 식습관의 관련성에 관한 연구)

  • Kim, Sook-Hee
    • Korean Journal of Community Nutrition
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    • v.11 no.6
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    • pp.695-706
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    • 2006
  • This study was to investigate the relationship between time spent on lunch and degree of obesity, eating habits in culinary college male students. This survey was conducted using questionnaires for 106 male students in a Hongseung-located culinary college. Over 16 minutes of time spent on lunch group had significantly lower body weights, obesity degrees and body mass index (BMI) and tended to have lower body fat % than the other groups. It suggests that shorter time spent on lunch is related with lower body weight, obesity degree and BMI. Those who ate the meal prepared by mother had longer time spent on lunch. The shorter times spent on lunch group recognized their body shape was lean, the longer time spent on lunch group recognized the overweight or obesity significantly. The shorter time spent on lunch group tended to eat the cooked rice in the gug and recognized that they were not healthy. Those who had diseases in the past tended to have shorter time spent on lunch. The more they chewed cooked rice and then longer time spent on lunch they had, they recognized their eating speed was not significantly speedy. The shorter time spent on lunch they had, the fewer fruits and salty foods they ate significantly. This study suggests that more chewing time. slower eating speed and longer time spent on eatmg lunch is very related with lowering weight, BMI, body fat % and obesity degrees, so male college students should be educated to have correct eating habits.

Comparative Analysis between Healthy and Powdery Mildew-infected Plants of Strawberry Cultivar Seolhyang (딸기 설향품종의 흰가루병 건전 및 감염식물 비교 분석)

  • Nam, Myeong-Hyeon;Jeon, Yi-Nae;Lee, Hee-Chul;Lee, He-Duck;Kang, Hee-Kyoung
    • Research in Plant Disease
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    • v.18 no.2
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    • pp.80-85
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    • 2012
  • We examined the incidence of powdery mildew in strawberry cv. Seolhyang plants, and performed a comparative analysis on the temperature, photosynthesis rate, and nutrient content of healthy and powdery mildew-infected plants. Powdery mildew first infected the fruit of the strawberries in mid-January, and the disease severity increased in both fruits and leaves during the late harvest season. The rate of photosynthesis and leaf temperatures of healthy plants were higher than those of powdery mildew-infected leaves and significantly decreased with an increase in the disease severity. The healthy and powdery mildew-infected plants in the soil analysis were not significantly different in chemical compositions. The leaves of the healthy plants contained lower potassium and higher manganese and chlorophyll concentrations than the powdery mildew-infected plants. In particular, manganese was significantly higher in healthy leaves than in infected leaves. Therefore, the concentrations of potassium, manganese and chlorophyll in strawberry leaves may be an important factor for disease suppression.

Analysis of Dietary Behaviors, Food Consumption Frequency and Blood Clinical Indices by Residence Types of Female College Students in Seoul (서울지역 일부 여대생의 거주형태에 따른 식행동 및 식품섭취실태와 혈액 임상지표 비교 연구)

  • Lee, Ru Zi;Kim, Jung Hee
    • Korean Journal of Community Nutrition
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    • v.24 no.3
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    • pp.183-196
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    • 2019
  • Objectives: College is an important time for students to establish their identity as an independent subjects and develop a foundation to maintain a healthy adulthood. However, after female students become college students, their eating habits are likely to become more irregular and they may experience various health problems because of excessive weight control. Therefore, this study was conducted to investigate the dietary behaviors and blood clinical indices of female college students by residence types. Methods: A total of 374 subjects were classified as home group, self-boarding group or boarding group according to residence type. Dietary habits, frequency of food intake, and eating attitudes were examined through questionnaires and anthropometric measurements and blood clinical indices were analyzed. Results: The meal most frequently skipped by female college students was breakfast, and the frequency of skipping breakfast was significantly lower in the home group than other groups. Most college students recognized that their eating habits had worsened since becoming college students, with the self-boarding group in particular feeling that their eating habits changed negatively. The consumption frequencies of protein foods, fruits, dairy products, seaweed, and fatty meats were significantly lower in the self-boarding group than other groups. The home group ate food cut into smaller pieces, while the self-boarding group tried new and rich foods. Residence types did not affect blood clinical indices. Conclusions: The self-boarding group had inadequate dietary habits compared to the home group. Although residence type did not affect the blood clinical indices, the students still had poor dietary habits. Therefore, proper nutrition education is needed to improve the nutritional status of college students, especially those that self-board.

A HARMS-based heterogeneous human-robot team for gathering and collecting

  • Kim, Miae;Koh, Inseok;Jeon, Hyewon;Choi, Jiyeong;Min, Byung Cheol;Matson, Eric T.;Gallagher, John
    • Advances in robotics research
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    • v.2 no.3
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    • pp.201-217
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    • 2018
  • Agriculture production is a critical human intensive task, which takes place in all regions of the world. The process to grow and harvest crops is labor intensive in many countries due to the lack of automation and advanced technology. Much of the difficult, dangerous and dirty labor of crop production can be automated with intelligent and robotic platforms. We propose an intelligent, agent-oriented robotic team, which can enable the process of harvesting, gathering and collecting crops and fruits, of many types, from agricultural fields. This paper describes a novel robotic organization enabling humans, robots and agents to work together for automation of gathering and collection functions. The focus of the research is a model, called HARMS, which can enable Humans, software Agents, Robots, Machines and Sensors to work together indistinguishably. With this model, any capability-based human-like organization can be conceived and modeled, such as in manufacturing or agriculture. In this research, we model, design and implement a technology application of knowledge-based robot-to-robot and human-to-robot collaboration for an agricultural gathering and collection function. The gathering and collection functions were chosen as they are some of the most labor intensive and least automated processes in the process acquisition of agricultural products. The use of robotic organizations can reduce human labor and increase efficiency allowing people to focus on higher level tasks and minimizing the backbreaking tasks of agricultural production in the future. In this work, the HARMS model was applied to three different robotic instances and an integrated test was completed with satisfactory results that show the basic promise of this research.

Nutritional Status of Young Adults by Food Security Level: Analysis of Data from the Korea National Health and Nutrition Examination Survey (2008-2018) (식품안정성 수준에 따른 청년의 영양섭취상태: 국민건강영양조사 2008-2018년 자료 활용)

  • Kim, Eun-kyung;Kim, Se-Na;Kwon, Yong-seok;Park, Young Hee;Lee, Jin-Young
    • Journal of the Korean Society of Food Culture
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    • v.36 no.5
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    • pp.455-463
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    • 2021
  • This study was conducted to examine the status of food consumption and nutrition intake of young adults according to food security using data from the Korea National Health and Nutrition Examination Survey (KNHANES) (2008~2018). A total of 10,655 young adults aged 19~34 years participated in the study. The subjects in the moderately/severely food insecure group consumed less fruits, vegetables, meat, nuts and seeds than those in food secure/mildly food insecure group after adjusting for confounding factors. The moderately/severely food insecure group significantly decreased mean adequacy ratio (MAR) and nutrient adequacy ratio (NAR) for protein, vitamin A, riboflavin, niacin, vitamin C, calcium, phosphorus and iron compared to the food secure/ mildly food insecure group. The percentages of the participants consuming a daily diet with carbohydrate, protein, vitamin A, thiamin, riboflavin, niacin, vitamin C, phosphorus and iron less than the estimated average requirement (EAR) increased in the moderately/severely food insecure group compared with the food secure group. This study suggested that the nutrition intake of young adults was related to food security status. These findings can be used as basic data for developing nutritional policies for young adults.

Promotion and Utilization of Eggs according to Egg Dish Preference among University Students (수도권 일부 남녀 대학생의 달걀요리 선호도와 이용실태에 따른 활용 촉진)

  • Han, Su-Jin;Lee, In-Sook;Kang, Eun-Zoo;Ahn, Hyo-Ri;Om, Ae-Son
    • Journal of the FoodService Safety
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    • v.2 no.1
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    • pp.30-35
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    • 2021
  • This study was conducted to understand the perception and the usage pattern of egg dishes in university students. The questionnaires were collected from 200 university students residing in Seoul. The age group was 118 (59.0%) in 20s, 50 (25.0%) in 30s, and 32 (16.5%) in 40s and older. Also, 179 (89.5%) were undergraduate students and 21 (10.5%) were graduates. The result of food preferences in the overall survey was as follows: Meats and Poultry (4.46±1.03) > Seafoods (2.92±1.41) > Fruits (2.91±1.17) > Eggs (2.50±1.10) > Vegetables (2.21±1.17). The preference of foods using eggs as the main ingredient was as follows: Rolled egg (4.07±0.81) > Steamed egg (4.05±0.91) > Scrambled egg (3.83±1.03) > Rice omelet (3.77±1.03). The preference of foods using eggs as sub-ingredient was Egg in Ramyeon (4.11±1.08) > Fried egg over Bibimbob (3.87±0.91) > Sliced boiled egg in Naengmyeon (3.78±1.11). The preference of eggs as desserts was Egg tart (4.01±1.08) > Sponge cake (3.72±1.09) > Egg bread (3.63±1.13). The result of the frequency of eating eggs indicating that approximately two-thirds of university students consumed eggs more than 3 times a week. Although there was no significant difference, male students not only consumed eggs more frequently than female students, but also consumed a higher amount. In recent years, since one-person household in college students tends to increase, it is more important to save cooking time and food quality. Thus, the development and dissemination of various egg recipes should be prioritized for university students.