• Journal of Korean Society of Transportation
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• v.22 no.4 s.75
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• pp.135-146
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• 2004

For improving the effectiveness of travel information, some rational paths are needed to provide them to users driving in real road network. To meet it, k-shortest path algorithms have been used in general. Although the k-shortest path algorithm can provide several alternative paths, it has inherent limit of heavy overlapping among derived paths, which nay lead to incorrect travel information to the users. In case of considering the network consisting of several turn prohibitions popularly adopted in real world network, it makes difficult for the traditional network optimization technique to deal with. Banned and penalized turns are not described appropriately for in the standard node/link method of network definition with intersections represented by nodes only. Such problem could be solved by expansion technique adding extra links and nodes to the network for describing turn penalties, but this method could not apply to large networks as well as dynamic case due to its overwhelming additional works. This paper proposes a link-based shortest path algorithm for the travel information in real road network where exists turn prohibitions. It enables to provide efficient alternative paths under consideration of overlaps among paths. The algorithm builds each path based on the degree of overlapping between each path and stops building new path when the degree of overlapping ratio exceeds its criterion. Because proposed algorithm builds the shortest path based on the link-end cost instead or node cost and constructs path between origin and destination by link connection, the network expansion does not require. Thus it is possible to save the time or network modification and of computer running. Some numerical examples are used for test of the model proposed in the paper.

• Journal of the Korea Convergence Society
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• v.11 no.7
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• pp.259-272
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• 2020

In fostering dynamic, innovative SMEs, hidden champion companies can be an appropriate model for SMEs to learn the success factors. On the other hand, the need for intellectual property management is becoming important as the value of a company is changing from a financial asset to an intellectual property. Therefore, in this study, the patent portfolio analysis of the hidden champion companies mentioned in Herman Simmon's book "Hidden Champion" was performed. As a result of the analysis, it was confirmed that patents are not possessed or patent activities are actively carried out and a differentiated intellectual property management strategy is implemented to improve patent quality depending on the characteristics of the technology possessed. The results of these studies can be used as basic data to prepare an intellectual property management strategy for companies that want to create opportunities to acquire monopoly rights and reduce patent maintenance and management costs. In addition, in this study, the patent IPC analysis verified that Herman Simmon's claim that "Hidden champions have the ability to focus on core competencies and focus on one technology" is valid.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.794-805
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• 2017

This paper proposes a Hardware-In-Loop(HIL) Simulator for a Wind Turbine and an operational control algorithm to evaluate the performance of a wind turbine control system. It provides not only for the validation of the control logics, safety functions and H/W failure, but also for the high reliability of the wind turbines (by reducing/and the reduction of the operating expense(OPEX) through performance evaluation tests with complex scenarios. On the other hand, the proposed simulator uses MATLAB, CODER, and the PLC library to operate in synchronization with the hardware, and a real-time processing-based wind turbine module including a dynamic model and control system, wind module, grid module and host PC to manage the HIL-simulator. Several experiments were carried out under the above concept to verify the effectiveness of the proposed WT HIL-simulator.

• Molecules and Cells
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• v.42 no.12
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• pp.893-905
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• 2019

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion processes that closely related to their function. Disruption of mitochondrial dynamics has been demonstrated in acute kidney injury (AKI), which could eventually result in cell injury and death. Previously, we reported that augmenter of liver regeneration (ALR) alleviates renal tubular epithelial cell injury. Here, we gained further insights into whether the renoprotective roles of ALR are associated with mitochondrial dynamics. Changes in mitochondrial dynamics were examined in experimental models of renal ischemia-reperfusion (IR). In a model of hypoxia-reoxygenation (HR) injury in vitro, dynamin-related protein 1 (Drp1) and mitochondrial fission process protein 1 (MTFP1), two key proteins of mitochondrial fission, were downregulated in the Lv-ALR + HR group. ALR overexpression additionally had an impact on phosphorylation of Drp1 Ser637 during AKI. The inner membrane fusion protein, Optic Atrophy 1 (OPA1), was significantly increased whereas levels of outer membrane fusion proteins Mitofusin-1 and -2 (Mfn1, Mfn2) were not affected in the Lv-ALR + HR group, compared with the control group. Furthermore, the mTOR/4E-BP1 signaling pathway was highly activated in the Lv-ALR + HR group. ALR overexpression led to suppression of HR-induced apoptosis. Our collective findings indicate that ALR gene transfection alleviates mitochondrial injury, possibly through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis. Additionally, fission processes are potentially mediated by promoting tubular cell survival through activating the mTOR/4E-BP1 signaling pathway.

• KSBB Journal
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• v.19 no.4
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• pp.274-283
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• 2004

Six lumbrokinase (LK) fractions from Lumbricus rubellus lysates were purified by a series of column chromatographies. The molecular weights of the six LK fractions appeared to range from 24.6 to 33.1 kDa. In the experimental model of rat venous thrombosis, the thrombus weight and PAI activity decreased significantly when the LK was administered orally. However, the activities of APTT, PT and plasmin showed a significant increase. The aggregation of rat platelets pretreated with various LK doses was inhibited by thrombin, and the MDA generation decreased. The rat thoracic aorta and mesentric arteries contracted with phenylephrine relaxed due to the treatment of the LK fractions. These results suggest that the fibrinolytic effects of LK were mediated not only by proteolytic activity, but also by the inhibition of platelet agregation and the relaxation of blood vessels. It is concluded that the LK may be useful as a hemolytic agent for treatment of fibrin clot.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.38 no.1
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• pp.43-57
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• 2002

This paper introduces an analysis method to predicting the flow characteristic of flow field around otter board In order to develope a high performance model. In this experiment, it is used a numerical analysis of flow field through CFD(Computational Fluid Dynamic), PIV method in which quantitative, qualitative evaluation is possible. In this experiment, it is used PIV method with flow filed image around otter board in order to analysis of flow characteristic. The result compared flow pattern with analysis result through CFD and also measurement result of lift and drag force coefficient carried out in CWC(Circulating Water Channel). The numerical analysis result is matched well with experiment result of PIV in the research and it is able to verify In the physical aspect. The result is as follows ; (1) It was carried out visibility experiment using laser light sheet, and picture analysis through PIV method in order to analysis fluid field of otter-board. As a result, the tendency of qualitative fluid movement only through the fluid particle's flow could be known. (2) Since PIV analysis result is quantitative, this can be seen in velocity vector distributions, instantaneous streamline contour, and average vorticity distributions through various post processing method. As a result, the change of flow field could be confirmed. (3) At angle of attack 24$^{\circ}$ where It Is shown maximum spreading force coefficient, the analysis result of CFD and PIV had very similar flow pattern. In both case, at the otter-board post edge a little boundary layer separation was seen, but, generally they had a good flow (4) As the result of post processing with velocity vector distributions, instantaneous streamline contour and average vorticity distributions by PIV, boundary layer separation phenomenon started to happen from angle of attack 24$^{\circ}$, and from over angle of attack 28$^{\circ}$, it happen at leading edge side with the width enlarged.

• Journal of Biomedical Engineering Research
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• v.25 no.4
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• pp.295-300
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• 2004

Coil embolization technique has been used recently to treat cerebral aneurysms. When a giant or a multilobular aneurysm are treated by roils, filling an aneurysm sac completely with coils is difficult and partial blocking of an aneurysm sac is inevitable. Blood flow characteristics, which nay affect the embolization process of an aneurysm sac, are changed by the locations of coils for the Partially blocked aneurysms. Blood flow fields are also influenced by the geometry of a parent vessel. In order to suggest the coil locations effective for aneurysm embolization, the blood flow fields of lateral aneurysm models were analyzed for the different coil locations and parent vessel geometries. Three dimensional pulsatile flow fields are analyzed by numerical methods considering non-Newtonian viscosity characteristics of blood. Flow rate into the aneurysm sac (inflow rate) and wall shear stress, which are suspected as flow dynamic factors influencing aneurysm embolization, are also calculated. Inflow rates were smaller and the low wall shear stress zones were larger in the neck blocked models compared to the dome blocked models. Smaller inflow and larger low wall shear stress zones in the distal neck blocked model imply that the distal neck should be the effective coil locations for aneurysm embolization.

• Journal of Korean Society on Water Environment
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• v.32 no.3
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• pp.243-252
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• 2016

In cases of water pollution accidents, accurate prediction for arrival time and concentration of contaminants in a river is essential to take proper measures and minimize their impact on downstream water intake facilities. It is critical to fully understand the behavior characteristics of contaminants on river surface, especially in case of oil spill accidents. Therefore, in this study, the effects of main parameters of advection and diffusion of contaminants were analyzed and validated by comparing the results of Lagrangian particle tracking (LPT) simulation of Environmental Fluid Dynamic Code (EFDC) model with those of Global Position System (GPS)-equipped drifter experiment. Prevention scenario modeling was accomplished by taking cases of movable weir operation into account. The simulated water level and flow velocity fluctuations agreed well with observations. There was no significant difference in the speed of surface particle movement between 5 and 10 layer modeling. Therefore, 5 layer modeling could be chosen to reduce computational time. It was found that full three dimensional modeling simulated wind effects on surface particle movements more sensitively than depth-averaged two dimensional modeling. The diffusion range of particles was linearly proportional to horizontal diffusivity by sensitivity analysis. Horizontal diffusivity estimated from the results of GPS-equipped drifter experiment was 0.096 m²/sec, which was considered to be valid for applying the LPT module in this area. Finally, the scenario analysis results showed that particle movements could be stagnant when discharge from the upstream weir was reduced, implying the possibility of securing time for mitigation actions such as oil boom installation and wiping oil contaminants. The outcomes of this study can help improve the prediction accuracy of particle tracking simulation to establish the most suitable mitigation plan considering the combination of movable weir operation.

• Journal of the Korea Convergence Society
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• v.10 no.12
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• pp.387-397
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• 2019

The purpose of this study is to analyze the relationship between health related physical fitness, cognitive function, depression and quality of life variables of elderly people in a comprehensive way based on quantitative evaluation. The subjects of this study were 385 people who voluntarily participated in the elderly welfare center in Gyeonggi and Seoul the elderly people. As for the data collection methods, were measured the characteristics, depression and quality of life, cognitive function questionnaires along with measures of lower and upper body strength, dynamic equilibrium and agility, total endurance and grip strength. As a result, the first was a statistically significant correlation between integrated health of the elderly, cognitive function, quality of life and depression. Second, the analysis of cognitive function, elderly integrated health, quality of life, and depression revealed statistical significance among all variables. Third, there was the partial intervention effect of function in the quality of life and depression of the elderly.

• The Journal of the Convergence on Culture Technology
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• v.6 no.4
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• pp.677-684
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• 2020

Our country is already in the aging corner and fall down is the elderly personal, social and economic problems are causing. therefore, executed this study for inquiring into an athletic effect for the balance ability increase that was a main variable of an fall down. The purpose of this study, to find the effect of balance training using visual feedback and somatosensory. Experimental group divided the three groups, objects measured balance ability of each experimental groups before experiment, the balance exercise group used visual feedback by Nintendo Wii(company - model), the balance exercise group used visual and TOGU, the balance exercise group used blind and TOGU. 4 experimental of each groups measured MFT and EMG value after training. having rest time, 4 experimental of each groups measured MFT and EMG value after training used balance pad. MFT - visual feedback with somatosensory training is most efficient but, indifferent both balance training with visual feedback and balance training with somatosensory. EMG - training with somatosensory is more efficient than training with visual feedback. Conclusion : in the process of improving equilibrium ability of patient who is lack of balance ability, somatosensory training is effective to correct different of left, right and frequency of left, right. visual feedback is the most effective way to improve dynamic balance sensory, so parallel of these two practice is thought to be the most effective.